Alexander A Boldyrev

Summary

Country: Russia

Publications

  1. ncbi request reprint Molecular mechanisms of homocysteine toxicity
    A A Boldyrev
    Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 74:589-98. 2009
  2. ncbi request reprint Glutamate receptors regulate Na/K-ATPase in cerebellum neurons
    Elena Bulygina
    Department of Biochemistry, M V Lomonosov Moscow State University, Russia
    Ann N Y Acad Sci 986:611-3. 2003
  3. pmc Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids
    Anastasia G Konshina
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    PLoS ONE 6:e19064. 2011
  4. pmc S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity
    Irina Yu Petrushanko
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 11999 Moscow, Russia
    J Biol Chem 287:32195-205. 2012
  5. doi request reprint Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling
    Konstantin Kulebyakin
    Department of Biochemistry, School of Biology, Room 141, M V Lomonosov Moscow State University, Lenin s Hills, Bldg 1 12, 119992, Moscow, Russia
    Amino Acids 43:91-6. 2012
  6. ncbi request reprint Why is homocysteine toxic for the nervous and immune systems?
    Alexander Boldyrev
    Department of Biochemistry and International Biotechnological Center, M V Lomonosov Moscow State University, Moscow, Russia
    Curr Aging Sci 6:29-36. 2013
  7. doi request reprint NMDA receptors in immune competent cells
    A A Boldyrev
    International Biotechnological Center, Lomonosov Moscow State University, Russia
    Biochemistry (Mosc) 77:128-34. 2012
  8. ncbi request reprint Glutamate receptors communicate with Na+/K+-ATPase in rat cerebellum granule cells: demonstration of differences in the action of several metabotropic and ionotropic glutamate agonists on intracellular reactive oxygen species and the sodium pump
    Alexander Boldyrev
    Center for Molecular Medicine and International Biotechnological Center of M V Lomonosov Moscow State University Department of Biochemistry, Lenin s Hills, 119992 Moscow, Russia
    J Mol Neurosci 21:213-22. 2003
  9. ncbi request reprint Protection of neuronal cells against reactive oxygen species by carnosine and related compounds
    Alexander Boldyrev
    Department of Aquatic Bioscience, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Comp Biochem Physiol B Biochem Mol Biol 137:81-8. 2004
  10. ncbi request reprint Functional relationship between Na/K-ATPase and NMDA-receptors in rat cerebellum granule cells
    A Boldyrev
    Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow 119992, Russia
    Biochemistry (Mosc) 69:429-34. 2004

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Molecular mechanisms of homocysteine toxicity
    A A Boldyrev
    Biological Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 74:589-98. 2009
    ..Treatment of pregnant rats with carnosine under conditions of alimentary hyperhomocysteinemia increases viability and functional activity of their progeny...
  2. ncbi request reprint Glutamate receptors regulate Na/K-ATPase in cerebellum neurons
    Elena Bulygina
    Department of Biochemistry, M V Lomonosov Moscow State University, Russia
    Ann N Y Acad Sci 986:611-3. 2003
  3. pmc Snake cytotoxins bind to membranes via interactions with phosphatidylserine head groups of lipids
    Anastasia G Konshina
    M M Shemyakin and Yu A Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    PLoS ONE 6:e19064. 2011
    ..This feature together with the diverse binding affinities of the sites to a wide variety of anionic targets on the membrane surface appears to be functionally meaningful and may adjust CT action against different types of cells...
  4. pmc S-glutathionylation of the Na,K-ATPase catalytic α subunit is a determinant of the enzyme redox sensitivity
    Irina Yu Petrushanko
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 11999 Moscow, Russia
    J Biol Chem 287:32195-205. 2012
    ..The rat α2 isoform was more sensitive to GSSG than the α1 isoform. Our findings imply that regulatory S-glutathionylation of the catalytic subunit plays a key role in the redox-induced regulation of Na,K-ATPase activity...
  5. doi request reprint Carnosine protects neurons against oxidative stress and modulates the time profile of MAPK cascade signaling
    Konstantin Kulebyakin
    Department of Biochemistry, School of Biology, Room 141, M V Lomonosov Moscow State University, Lenin s Hills, Bldg 1 12, 119992, Moscow, Russia
    Amino Acids 43:91-6. 2012
    ..Its analogs, β-alanyl-D-histidine (D-carnosine) and L-histidyl-β-alanine, restricted accumulation of free radicals and delayed activation of ERK1/2 and JNK in neuronal cells, but did not promote neuronal viability...
  6. ncbi request reprint Why is homocysteine toxic for the nervous and immune systems?
    Alexander Boldyrev
    Department of Biochemistry and International Biotechnological Center, M V Lomonosov Moscow State University, Moscow, Russia
    Curr Aging Sci 6:29-36. 2013
    ..The efficiency of carnosine has also been demonstrated in clinical trials of chronic brain ischemia and Parkinson's disease. ..
  7. doi request reprint NMDA receptors in immune competent cells
    A A Boldyrev
    International Biotechnological Center, Lomonosov Moscow State University, Russia
    Biochemistry (Mosc) 77:128-34. 2012
    ..It is suggested that homocysteine ​​acts as modulator of these receptors, and its toxicity is largely explained by hyperactivation of the NMDA-type glutamate receptors...
  8. ncbi request reprint Glutamate receptors communicate with Na+/K+-ATPase in rat cerebellum granule cells: demonstration of differences in the action of several metabotropic and ionotropic glutamate agonists on intracellular reactive oxygen species and the sodium pump
    Alexander Boldyrev
    Center for Molecular Medicine and International Biotechnological Center of M V Lomonosov Moscow State University Department of Biochemistry, Lenin s Hills, 119992 Moscow, Russia
    J Mol Neurosci 21:213-22. 2003
    ..Thus, the data presented illustrate the existence of diverse mechanisms of the cross talk between Na+/K+-ATPase and different glutamate receptors, as well as that between glutamate receptors of different classes...
  9. ncbi request reprint Protection of neuronal cells against reactive oxygen species by carnosine and related compounds
    Alexander Boldyrev
    Department of Aquatic Bioscience, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Comp Biochem Physiol B Biochem Mol Biol 137:81-8. 2004
    ..These differences suggest that the similar ability of carnosine and its N-methylated derivatives to protect neuronal cells against the excitotoxic effect of NMDA is not solely related to the antioxidant properties of these compounds...
  10. ncbi request reprint Functional relationship between Na/K-ATPase and NMDA-receptors in rat cerebellum granule cells
    A Boldyrev
    Department of Biochemistry, Faculty of Biology, Lomonosov Moscow State University, Moscow 119992, Russia
    Biochemistry (Mosc) 69:429-34. 2004
    ..It is concluded that in cerebellum neurons, ouabain-resistant Na/K-ATPase is responsible for suppression of intracellular level of ROS, which, in turn, inhibit ouabain-sensitive Na/K-ATPase...
  11. ncbi request reprint Glutamate receptors modulate oxidative stress in neuronal cells. A mini-review
    A Boldyrev
    International Biotechnological Center, Department of Biochemistry, School of Biology Room 141, M V Lomonosov Moscow State University, 119992 Lenin s Hills, Moscow, Russia
    Neurotox Res 6:581-7. 2004
    ..The Na+/K(+)-pump is able to prevent over-production of intracellular ROS, thus increasing oxidative stability of neuronal cells...
  12. ncbi request reprint Amyloid-beta induced cell death is independent of free radicals
    Alexander Boldyrev
    International Biotechnological Center, M V Lomonosov Moscow State University, Department of Biochemistry, 119992 Moscow, Russia
    J Alzheimers Dis 6:633-8; discussion 673-81. 2004
    ..We conclude that amyloid-beta causes a relatively acute loss of cell viability in cerebellar granule cell neurons, which does not result from either elevation of intracellular calcium concentration or generation of ROS...
  13. ncbi request reprint Effect of homocysteine and homocysteic acid on glutamate receptors on rat lymphocytes
    E A Vladychenskaya
    Institute of Neurology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 142:47-50. 2006
    ....
  14. ncbi request reprint Na/K-ATPase regulates intracellular ROS level in cerebellum neurons
    Alexander Boldyrev
    M V Lomonosov Moscow State University, Russia
    Ann N Y Acad Sci 986:519-21. 2003
  15. doi request reprint Carnosine [corrected] increases efficiency of DOPA therapy of Parkinson's disease: a pilot study
    Alexander Boldyrev
    Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia
    Rejuvenation Res 11:821-7. 2008
    ..The combination of carnosine with basic therapy may be a useful way to increase efficiency of PD treatment...
  16. ncbi request reprint Protection of proteins from oxidative stress: a new illusion or a novel strategy?
    Alexander A Boldyrev
    M V Lomonosov Moscow State University and Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia
    Ann N Y Acad Sci 1057:193-205. 2005
    ..It can be considered a potent natural geroprotector...
  17. ncbi request reprint Homocysteine and its derivatives as possible modulators of neuronal and non-neuronal cell glutamate receptors in Alzheimer's disease
    Alexander A Boldyrev
    Department of Biochemistry, M V Lomonosov Moscow State University, Moscow, Russia
    J Alzheimers Dis 11:219-28. 2007
    ....
  18. ncbi request reprint The excitotoxic effect of NMDA on human lymphocyte immune function
    Anna P Mashkina
    Department of Biochemistry, Moscow State University, 119992 Moscow, Russia
    Neurochem Int 51:356-60. 2007
    ..We conclude that NMDA-activated glutamate receptor activation, accompanied by the changes in intracellular calcium and ROS levels, may be involved in the modification of immune functions of human T and NK cells...
  19. ncbi request reprint Rodent lymphocytes express functionally active glutamate receptors
    Alexander A Boldyrev
    Department of Biochemistry, Center for Molecular Medicine and International Biotechnological Center, M V Lomonosov Moscow State University, 119992 Moscow, Russia
    Biochem Biophys Res Commun 324:133-9. 2004
    ..These results show that lymphocyte iGluR NR1 and mGluR Group III receptors may be involved in controlling rodent lymphocyte functions and longevity as they regulate events in cell proliferation, maturation, and death...
  20. pmc Carnosine prevents necrotic and apoptotic death of rat thymocytes via ouabain-sensitive Na/K-ATPase
    Larisa V Smolyaninova
    Department of Biochemistry, M V Lomonosov Moscow State University, Moscow, Russia
    Cell Biochem Funct 31:30-5. 2013
    ..Moreover, the long-term incubation with ouabain leads to the cell death by necrosis and apoptosis. Ouabain-mediated apoptosis and necrosis were also abolished by carnosine...
  21. ncbi request reprint Emerging evidence for a similar role of glutamate receptors in the nervous and immune systems
    Alexander A Boldyrev
    Center for Molecular Medicine and International Biotechnological Center Department of Biochemistry, M V Lomonosov Moscow State University, Moscow, Russia
    J Neurochem 95:913-8. 2005
    ..In addition, glutamate may serve as a signaling agent between the immune and nervous systems...
  22. ncbi request reprint Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells
    A A Boldyrev
    Department of Biochemistry, International Biotechnological Center of M V Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochem Biophys Res Commun 256:320-4. 1999
    ..These studies suggest that there is a multiplicity of routes for Ca2+-dependent ROS production in neurons but that ROS generation by cyclooxygenase and monoamine oxidase is not controlled by protein kinase C...
  23. ncbi request reprint Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo
    S L Stvolinskii
    Institute of Neurology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 135:130-2. 2003
    ..Administration of carnosine preventing Cu,Zn-SOD inactivation reduced mortality in rats and prolonged average life span in SAMP-mice...
  24. ncbi request reprint Homocysteinic acid causes oxidative stress in lymphocytes by potentiating toxic effect of NMDA
    A A Boldyrev
    Laboratory of Clinical Neurochemistry, Institute of Neurology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 140:33-7. 2005
    ..Oxidative stress produced by these substances can result from activation of NMDA glutamate receptors that were recently detected on lymphocytes...
  25. ncbi request reprint Glutamate receptors regulate the level of reactive oxygen species in neurons of senescence accelerated mice (SAM) strain
    A V Kulikov
    Institute of Neurology, Russian Academy of Medical Sciences, Moscow, 125567 Russia
    Dokl Biochem Biophys 407:106-8. 2006
  26. doi request reprint Different neuronal Na(+)/K(+)-ATPase isoforms are involved in diverse signaling pathways
    Larisa V Karpova
    Department of Biochemistry, M V Lomonosov Moscow State University, Moscow, Russia
    Cell Biochem Funct 28:135-41. 2010
    ..These data are the first demonstration showing participation of ouabain-resistant (alpha1) and ouabain-sensitive (alpha3) Na(+)/K(+)-ATPase isoforms in diverse signaling pathways in neuronal cells...
  27. ncbi request reprint Antioxidant systems in tissues of senescence accelerated mice
    A A Boldyrev
    Department of Biochemistry, School of Biology, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 66:1157-63. 2001
    ..The results demonstrate that the accelerated ageing of SAMP1 animals is connected to a significant extent with the decreased efficiency of the systems utilizing reactive oxygen species (ROS) in tissues...
  28. ncbi request reprint Na/K-ATPase as an oligomeric ensemble
    A A Boldyrev
    Center for Molecular Medicine and International Biotechnological Center, Lomonosov Moscow State University, Moscow, 119899 Russia
    Biochemistry (Mosc) 66:821-31. 2001
    ..Some of the major factors of such regulation are microviscosity of the lipid environment, reactive oxygen species, and intracellular protein kinases...
  29. doi request reprint Biological activity of novel synthetic derivatives of carnosine
    S L Stvolinsky
    Laboratory of Neurochemistry, Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, 125367, Russia
    Cell Mol Neurobiol 30:395-404. 2010
    ..STC and RTC were concluded to demonstrate higher antioxidant capacity and better ability to prevent cerebellar neurons from ROS accumulation than their precursors, carnosine and trolox...
  30. ncbi request reprint Carnosine protects erythrocytes from the oxidative stress caused by homocysteic acid
    E S Arzumanyan
    International Biotechnology Center, Moscow State University, Moscow 119992, Russia
    Dokl Biochem Biophys 418:44-6. 2008
  31. ncbi request reprint [Role of reactive oxygen species in functional activity of neurons]
    A A Boldyrev
    International Biotechnological Center, V V Lomonosov Moscow State University, Department of Biochemistry, Moscow
    Usp Fiziol Nauk 34:21-34. 2003
    ..Under normal conditions, ROS become involved in implementation of signal transduction, mechanisms ensuring metabolic response of cells to the external factors...
  32. ncbi request reprint Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells
    E R Bulygina
    International Training Center of Biotechnology Department of Biochemistry, School of Biology and Center for Molecular Medicine, Lomonosov Moscow State University, Moscow, 119992, Russia
    Biochemistry (Mosc) 67:1001-5. 2002
    ..It is concluded that ionotropic receptors inhibit Na/K-ATPase because of intracellular production of reactive oxygen species, and metabotropic receptors mediate their effect via protein kinase C...
  33. doi request reprint NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo
    Anna P Mashkina
    Department of Biochemistry, M V Lomonosov Moscow State University, 119992, Moscow, Russia
    Cell Mol Neurobiol 30:901-7. 2010
    ..We suggest that expression of NMDA receptors in lymphocytes is regulated by central nervous system, which controls the inflammation process...
  34. ncbi request reprint Effect of ethanol on the hemolytic stability of erythrocytes
    O V Tyulina
    The International Biotechnological Center and Center for Molecular Medicine of Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 65:180-5. 2000
    ..Possible mechanisms of ethanol and acetaldehyde effects on erythrocyte stability are discussed...
  35. doi request reprint Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials
    A A Boldyrev
    International Biotechnological Center of MV Lomonosov Moscow State University, Moscow, Russia
    Rejuvenation Res 13:156-8. 2010
    ..We conclude that carnosine can be recommended for patients under oxidative stress as a natural remedy having high efficiency and no side effects...
  36. ncbi request reprint Natural dipeptides as mini-chaperones: molecular mechanism of inhibition of lens βL-crystallin aggregation
    Antonina K Dizhevskaya
    International Biotechnological Center, MV Lomonosov Moscow State University, Moscow, Russia
    Curr Aging Sci 5:236-41. 2012
    ..We suppose that N-acetylcarnosine and anserine inhibit βL-crystallin aggregation via formation of a protein-dipeptide complex that prevents macromolecular conformational changes and ensuing protein aggregation...
  37. ncbi request reprint Erythrocyte and plasma protein modification in alcoholism: a possible role of acetaldehyde
    Olga V Tyulina
    MV Lomonosov Moscow State University, 119992 Moscow, Russia
    Biochim Biophys Acta 1762:558-63. 2006
    ..These effects can be ascribed, in part, to exposure of erythrocytes to circulatory acetaldehyde which is a product of ethanol metabolism...
  38. ncbi request reprint Discrimination between apoptosis and necrosis of neurons under oxidative stress
    A A Boldyrev
    International Biotechnological Center and Center of Molecular Medicine, Lomonosov Moscow State University, Moscow, 119899 Russia
    Biochemistry (Mosc) 65:834-42. 2000
    ..Histidine containing neuropeptides were found to regulate cell stability, taking part in selection of the preferable way of neuronal death under oxidative stress...
  39. ncbi request reprint Lipid peroxidation in experimental ischemia of the brain
    T N Fedorova
    Institute of Neurology, Russian Academy of Medical Sciences, Moscow, 123367, Russia
    Biochemistry (Mosc) 64:75-9. 1999
    ..Thus, the destructive effect of free radicals may occur even during the early stage of ischemic injury of the brain...
  40. ncbi request reprint Carnosine protects from the oxidative stress induced by prenatal hypoxia
    T N Fedorova
    Institute of Neurology, Russian Academy of Medical Sciences, Moscow, 115478 Russia
    Dokl Biol Sci 408:207-10. 2006
  41. ncbi request reprint Carnosine, the protective, anti-aging peptide
    A A Boldyrev
    Center for Molecular Medicine, Department of Biochemistry, Biological Faculty, MV Lomonosov, Moscow State University, Vorobjovy Gory, Russia
    Biosci Rep 19:581-7. 1999
    ..Carnosine has a similar effect on mice of the control strain, but this is less pronounced due to the non-accelerated character of their senescence processes...
  42. ncbi request reprint Effect of nitroso compounds on Na/K-ATPase
    A A Boldyrev
    Department of Biochemistry, School of Biology, International Biotechnological Center of M V Lomonosov Moscow State University, Russia
    Biochim Biophys Acta 1321:243-51. 1997
    ..The possibility that this blockade results in disordering of interprotomer interactions within the oligomeric complexes of Na/K-ATPase is suggested. Possible regulatory meaning of the effect of NO. derivatives is discussed...
  43. ncbi request reprint Problems and perspectives in studying the biological role of carnosine
    A A Boldyrev
    International Center for Biotechnology, Department of Biochemistry, Lomonosov Moscow State University, Moscow, 119899, Russia
    Biochemistry (Mosc) 65:751-6. 2000
    ....
  44. ncbi request reprint Peculiarities of carnosine metabolism in a patient with pronounced homocarnosinemia
    G G Kramarenko
    Institute of Neurology, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 132:996-9. 2001
    ..These metabolic disturbances were accompanied by moderate neurological disorders. Changes in carnosine metabolism in family members were less pronounced and not accompanied by neuropathological symptoms...
  45. ncbi request reprint Functional interaction between various glutamate receptors
    A A Boldyrev
    Center of Molecular Medicine and International Biotechnological Center, Department of Biochemistry, M V Lomonosov Moscow State University, Moscow
    Bull Exp Biol Med 130:823-9. 2000
    ..It is hypothesized that metabotropic receptors perform defensive functions in the brain by protecting neurons from neurotoxic effects caused by excessive glutamate release...
  46. ncbi request reprint Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia
    L A Bokeriya
    A N Bakulev Institute of Cardiovascular Surgery, Russian Academy of Medical Sciences, Moscow
    Bull Exp Biol Med 145:323-7. 2008
    ..The use of natural dipeptides in cardioplegic solutions promoted an increase in the buffer capacity of myocardial cells and creation of an additional anti-ischemic effect under conditions of long ischemia and hypothermia...
  47. ncbi request reprint Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic Acid in rats
    A V Kulikov
    Research Center of Neurology, Russian Academy of Medical Sciences, Russia
    Bull Exp Biol Med 145:514-9. 2008
    ....
  48. pmc Oxygen-induced Regulation of Na/K ATPase in cerebellar granule cells
    Irina Yu Petrushanko
    Institute of Veterinary Physiology, Vetsuisse Faculty and Zurich Centre of Integrative Human Physiology, University of Zurich, Zurich CH 8057, Switzerland
    J Gen Physiol 130:389-98. 2007
    ..Taken together our observations suggest that NO and its derivatives are involved in maintenance of high Na/K ATPase activity under physiological conditions...
  49. ncbi request reprint Cerebellar granule cell death induced by aluminum
    Jelena Tuneva
    Institute for Health and the Environment, University at Albany, SUNY, Rensselaer, NY 12144, USA
    Neurotox Res 9:297-304. 2006
    ..These observations suggest that the cell death is subsequent to intracellular accumulation of Al (III) and subsequent perturbation of cellular metabolism...