Vladimir N Anisimov

Summary

Country: Russia

Publications

  1. ncbi Life span extension and cancer risk: myths and reality
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, 68 Leningradskaya Street, 197758 St Petersburg, Russian Federation
    Exp Gerontol 36:1101-36. 2001
  2. ncbi Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice
    Irina G Popovich
    Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg 197758, Russia
    Mech Ageing Dev 124:721-31. 2003
  3. ncbi Effect of melatonin and tetrapeptide on gene expression in mouse brain
    S V Anisimov
    Wallenberg Center of Neurology, Lund University, Sweden
    Bull Exp Biol Med 138:504-9. 2004
  4. ncbi Biological interactions of aging and carcinogenesis
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg, Russia
    Cancer Treat Res 124:17-50. 2005
  5. ncbi Rodent models for the preclinical evaluation of drugs suitable for pharmacological intervention in aging
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Department of Carcinogenesis and Oncogerontology, St Petersburg, Russia
    Expert Opin Drug Discov 7:85-95. 2012
  6. ncbi Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice
    T A Man'cheva
    N P Ogarev Mordovian State University, Saransk, Russia
    Bull Exp Biol Med 151:363-5. 2011
  7. ncbi Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 10:4230-6. 2011
  8. ncbi Carcinogenesis and aging 20 years after: escaping horizon
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Mech Ageing Dev 130:105-21. 2009
  9. ncbi Effects of phentermine and phenformin on biomarkers of aging in rats
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, D O Ott Research Institute of Obstetrics and Gynecology, St Petersburg, Russia
    Gerontology 51:19-28. 2005
  10. ncbi Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 40:685-93. 2005

Collaborators

Detail Information

Publications88

  1. ncbi Life span extension and cancer risk: myths and reality
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, 68 Leningradskaya Street, 197758 St Petersburg, Russian Federation
    Exp Gerontol 36:1101-36. 2001
    ..Recommendations of the available drugs and means of life span increase should be carefully reconsidered under the international scientific control...
  2. ncbi Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice
    Irina G Popovich
    Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg 197758, Russia
    Mech Ageing Dev 124:721-31. 2003
    ..6-fold), mainly mammary carcinomas and leukemias in mice as compared with the control group. This is the first report on geroprotector and anticarcinogenic effect of DSIP-containing preparation Deltaran...
  3. ncbi Effect of melatonin and tetrapeptide on gene expression in mouse brain
    S V Anisimov
    Wallenberg Center of Neurology, Lund University, Sweden
    Bull Exp Biol Med 138:504-9. 2004
    ..Comparative study of gene expression in the brain and heart of CBA mice receiving melatonin and Epithalon suggest that these preparations have a tissue-specific biological effect...
  4. ncbi Biological interactions of aging and carcinogenesis
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St. Petersburg, Russia
    Cancer Treat Res 124:17-50. 2005
  5. ncbi Rodent models for the preclinical evaluation of drugs suitable for pharmacological intervention in aging
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Department of Carcinogenesis and Oncogerontology, St Petersburg, Russia
    Expert Opin Drug Discov 7:85-95. 2012
    ..The authors also believe that the principles of international programs for the expert critical evaluation of pharmacological interventions should be created to improve the range of antiaging interventions available for human studies...
  6. ncbi Melatonin and metformin inhibit skin carcinogenesis and lipid peroxidation induced by benz(a)pyrene in female mice
    T A Man'cheva
    N P Ogarev Mordovian State University, Saransk, Russia
    Bull Exp Biol Med 151:363-5. 2011
    ..Melatonin, metformin, and their combination normalized LPO level...
  7. ncbi Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 10:4230-6. 2011
    ..Thus we demonstrated for the first time in normal inbred mice that lifespan can be extended by rapamycin. This opens an avenue to develop optimal doses and schedules of rapamycin as an anti-aging modality...
  8. ncbi Carcinogenesis and aging 20 years after: escaping horizon
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Mech Ageing Dev 130:105-21. 2009
    ..Aging is associated with number of events at molecular, cellular and physiological levels that influence carcinogenesis and subsequent cancer growth...
  9. ncbi Effects of phentermine and phenformin on biomarkers of aging in rats
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, D O Ott Research Institute of Obstetrics and Gynecology, St Petersburg, Russia
    Gerontology 51:19-28. 2005
    ..Drugs which reduce appetite (anorexiants) represent one class of candidate treatments. Agents that reduce the glucose utilization by the organism could also represent another class of candidate CR mimetics...
  10. ncbi Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 40:685-93. 2005
    ..26 times. The metformin-treatment significantly decreased the incidence and size of mammary adenocarcinomas in mice and increased the mean latency of the tumors...
  11. ncbi Effect of host age on tumor growth rate in rodents
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Front Biosci 11:412-22. 2006
    ..Age-associated changes in both humoral and local host factors are critical to the behavior and progression of transplanted tumors in the old host...
  12. ncbi Cancer in rodents: does it tell us about cancer in humans?
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Nat Rev Cancer 5:807-19. 2005
    ..This review discusses the bio-epidemiological aspects of cancer manifestation in humans and rodents that have been underrepresented in the literature...
  13. ncbi Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Int J Cancer 111:475-9. 2004
    ..The data demonstrate, for the first time, that exposure to constant illumination was followed by increases in the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice...
  14. ncbi Is early life body weight a predictor of longevity and tumor risk in rats?
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 39:807-16. 2004
    ..BW at the age 3 months was not predictive of tumor growth but being heavier at the age of 1 year did confer an increased risk of tumor development for both male and female rats...
  15. ncbi Body weight is not always a good predictor of longevity in mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 39:305-19. 2004
    ..In general, the existence and direction of a significant correlation between body weight and life span depends upon the animals' age and genotype...
  16. ncbi [Priorities in fundamental research in gerontology: Russia contribution]
    V N Anisimov
    Gerontological Society of the Russian Academy of Sciences, Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, Leningradskaya str, 68, St Petersburg, 197758
    Adv Gerontol 12:9-27. 2003
    ..The prospects of the development of basic research on aging in Russia are reviewed as well...
  17. ncbi Insulin and longevity: antidiabetic biguanides as geroprotectors
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Biogerontology 4:297-307. 2003
    ..The results of our experiments provide evidence that antidiabetic biguanides are promising geroprotectors as well as drugs which can be used in the prevention of cancer...
  18. ncbi Effects of exogenous melatonin--a review
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, NN Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Toxicol Pathol 31:589-603. 2003
    ..Further studies and clinical trials are needed to verify that melatonin is both safe and has geroprotector efficacy for humans...
  19. ncbi Insulin/IGF-1 signaling pathway driving aging and cancer as a target for pharmacological intervention
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 38:1041-9. 2003
    ..Some old and new observations suggest that antidiabetic biguanides could be promising candidates for both the life span extension and the prevention of cancer...
  20. ncbi Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, NN Petrov Research Institute of Oncology, Pesochny 2, St Petersburg, 197758, Russia
    Biogerontology 4:193-202. 2003
    ..0-fold), as compared with the control group. The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice...
  21. ncbi Aging and cancer in transgenic and mutant mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Front Biosci 8:s883-902. 2003
    ..Thus, genetically modified animals are a valuable tool in unraveling mechanisms underlying aging and cancer...
  22. ncbi Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice
    V N Anisimov
    Prof N N Petrov Institute of Oncology, Ministry of Health of the Russian Federation, St Petersburg, Moscow
    Bull Exp Biol Med 139:721-3. 2005
    ..Hence, we first demonstrated a geroprotective effect of metformin and its suppressive effect towards the development of mammary tumors...
  23. ncbi Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Ann N Y Acad Sci 1057:220-34. 2005
    ..Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer...
  24. ncbi Expression of circadian Per1 and Per2 genes in the liver and breast tumor tissues of HER2/neu transgenic mice of different age
    S N Kolomeĭchuk
    Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia
    Bull Exp Biol Med 151:227-9. 2011
    ..The expression of Per1 and Per2 genes in breast tumor tissue decreased in comparison with their expression in the lever. The expression of these genes decreased with age in both the liver and tumor tissue...
  25. ncbi If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg, Russia
    Aging (Albany NY) 3:148-57. 2011
    ..Thus, in female SHR mice, metformin increased life span and postponed tumors when started at the young and middle but not at the old age. In contrast, metformin improves reproductive function when started at any age...
  26. ncbi Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Aging (Albany NY) 2:945-58. 2010
    ..5 times the incidence of malignant neoplasms in female mice while somewhat stimulated formation of benign vascular tumors in the latter...
  27. ncbi Metformin for aging and cancer prevention
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg 197758, Russia
    Aging (Albany NY) 2:760-74. 2010
    ..Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore metformin seems to decrease cancer risk in diabetic patients...
  28. ncbi Biogerontology in Russia: from past to future
    Vladimir N Anisimov
    Gerontological Society of the Russian Academy of Sciences, St Petersburg, Russia
    Biogerontology 12:47-60. 2011
    ..Some results of Russian researchers obtained during 2005-2010 have been summarized as well. Special attention is given to the prospects of gerontology in Russia...
  29. ncbi Rapamycin extends maximal lifespan in cancer-prone mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Am J Pathol 176:2092-7. 2010
    ..Rapamycin dramatically delayed tumor onset as well as decreased the number of tumors per animal and tumor size. We suggest that, by slowing down organismal aging, rapamycin delays cancer...
  30. ncbi Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 9:188-97. 2010
    ..001). The combined treatment with metformin + melatonin significantly suppressed Ehrlich tumor growth (by 40%, p < 0.001). These results suggest that metformin may be useful in prevention and treatment of breast cancer...
  31. ncbi Peptide bioregulation of aging: results and prospects
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Leningradskaya Str 68, Pesochny 2, St Petersburg, Russia
    Biogerontology 11:139-49. 2010
    ..Possible mechanisms of the biological effects of small peptides are discussed in the paper. The results of clinical applications of peptide preparation during the period of 6-12 years are presented as well...
  32. ncbi Relationships between cancer and aging: a multilevel approach
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Biogerontology 10:323-38. 2009
    ..An improved understanding of age-associated variables impacting on the tumor microenvironment, as well as the cancer cells themselves, will result in improved treatment modalities in geriatric oncology...
  33. ncbi Metformin slows down aging and extends life span of female SHR mice
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 7:2769-73. 2008
    ..Thus, antidiabetic biguanide metformin dramatically extends life span, even without cancer prevention in this model...
  34. ncbi Biology of aging and cancer
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology at N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Cancer Control 14:23-31. 2007
    ..The incidence of cancer increases with age in both humans and laboratory animals. A clear understanding of the causes of the age-related increase in cancer incidence is needed to develop a strategy for primary cancer prevention...
  35. ncbi Premature ageing prevention: limitations and perspectives of pharmacological interventions
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Curr Drug Targets 7:1485-503. 2006
    ..The program may assist national and international authorities in devising programs of health promotion and premature ageing prevention...
  36. ncbi Melatonin as antioxidant, geroprotector and anticarcinogen
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Biochim Biophys Acta 1757:573-89. 2006
    ..Thus, we believe that melatonin may be used for the prevention of premature aging and carcinogenesis...
  37. ncbi Light pollution, reproductive function and cancer risk
    Vladimir N Anisimov
    Saint Petersburg Institute of Bioregulation and Gerontology, RAMS, St Petersburg, Russia
    Neuro Endocrinol Lett 27:35-52. 2006
    ..These observations might lead to use melatonin for cancer prevention in groups of humans at risk of light pollution...
  38. ncbi The role of pineal gland in breast cancer development
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, 197758, St Petersburg, Russia
    Crit Rev Oncol Hematol 46:221-34. 2003
    ..Pineal peptide preparation Epithalamin and synthetic tetrapeptide Epitalon (Ala-Glu-Asp-Gly) are potent inhibitors of mammary carcinogenesis in rodents and might be useful in the prevention of breast cancer in women at risk...
  39. ncbi Games with glass-beads for biologists or science for the day after tomorrow?
    V N Anisimov
    Petrov Research Institute for Oncology, Ministry of Public Health, Pesochnyi 2, St Petersburg, 197758 Russia
    Biochemistry (Mosc) 68:242-6. 2003
  40. ncbi [Ten steps on the ladder of knowledge]
    V N Anisimov
    Gerontological Society of the Russian Academy of Sciences, N N Petrov Research Instittue of Oncology, Pescochny 2, St Petersburg 197758
    Adv Gerontol 10:7-10. 2002
    ..There is an analysis of the topics and directions of published papers and their geographic and department distributions...
  41. ncbi Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice
    V N Anisimov
    Saint Petersburg Institute of Bioregulation and Gerontology, 3, pr Dynamo, 197110, St Petersburg, Russia
    Mech Ageing Dev 122:41-68. 2001
    ..These data suggest the geroprotector potential of the pineal peptide...
  42. ncbi Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals
    V N Anisimov
    Saint Petersburg Institute of Bioregulation and Gerontology, St Petersburg, Russia
    Neuro Endocrinol Lett 22:9-18. 2001
    ..The review on our own data on the effect of the pineal peptide preparation Epithalamin on free radical processes in rodents and humans is presented in this paper...
  43. ncbi The light-dark regimen and cancer development
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Neuro Endocrinol Lett 23:28-36. 2002
    ..Treatment with pineal indole hormone melatonin inhibits carcinogenesis in pinealectomized rats or animals kept at the standard light/dark regimen (LD) or at the constant illumination (LL) regimen...
  44. ncbi Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats
    Irina A Vinogradova
    Petrozavodsk State University, Petrozavodsk 185910, Russia
    Aging (Albany NY) 2:82-92. 2010
    ..We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months...
  45. ncbi Experimental research on ageing in Russia
    V N Anisimov
    Gerontological Society of the Russian Academy of Sciences, Laboratory of Carcinogenesis and Ageing, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 189646, Russia
    Exp Gerontol 36:935-45. 2001
    ..In Russia, the most basic problem facing researchers in biogerontology and other relevant areas is an almost complete absence of support from the State and other decision makers...
  46. ncbi Mutant and genetically modified mice as models for studying the relationship between aging and carcinogenesis
    V N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, 197758, St Petersburg, Russia
    Mech Ageing Dev 122:1221-55. 2001
    ..Thus, genetically modified animals are a valuable tool in unravelling mechanisms underlying aging and cancer. Systemic evaluation of newly generated models should include onco-gerontological studies...
  47. ncbi Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats
    Vladimir N Anisimov
    Laboratory of Carcinogenesis and Aging, N N Petrov Research Institute of Oncology, 68 Leningradskaya Street, Pesochny 2, 197758, St Petersburg, Russia
    Cancer Lett 183:1-8. 2002
    ..Epitalon inhibited also the development of tumors in jejunum and ileum. Thus, our results demonstrated an inhibitory effect of Epitalon on chemically induced bowel carcinogenesis in rats...
  48. ncbi Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, N N Petrov Research Institute of Oncology, Pescony 2, St Petersburg 189646, Russia
    Biogerontology 1:55-9. 2000
    ..4 times lower (P < 0.02) in rats exposed to the dipeptide in comparison with controls. Thus, treatment with L-Glu-L-Trp delayed aging rate and decreased spontaneous tumor incidence in rats...
  49. ncbi Inhibitory effect of melatonin on 7, 12-dimethylbenz[a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, N N Petrov Research Institute of Oncology, Pesochny 2, 189646, St Petersburg, Russia
    Cancer Lett 156:199-205. 2000
    ..Thus, our data indicate that pineal indole hormone melatonin inhibits cervical and vaginal carcinogenesis induced by DMBA in mice and possess antimutagenic and anticlastogenic effect in vitro...
  50. ncbi Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Int J Cancer 101:7-10. 2002
    ....
  51. ncbi Number of pregnancies and ovariectomy modify mammary carcinoma development in transgenic HER-2/neu female mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russia
    Cancer Lett 193:49-55. 2003
    ..Our results indicate that pregnancy accelerated the development of mammary adenocarcinomas in transgenic HER-2/neu mice whereas ovariectomy inhibits their development...
  52. ncbi Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice
    Vladimir N Anisimov
    N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758, Russian Federation
    Exp Gerontol 38:449-61. 2003
    ..For this reason, we conclude that the effect of melatonin as a geroprotector is dose-dependent...
  53. ncbi The relationship between aging and carcinogenesis: a critical appraisal
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, 68 Leningradskaya St, St Petersburg 197758, Russia
    Crit Rev Oncol Hematol 45:277-304. 2003
    ..At least some geroprotectors may increase the survival of a short-living individuals in populations but increase the incidence of malignancy...
  54. ncbi Current status and perspectives of gerontology in Russia
    V N Anisimov
    Gerontological Society of the Russian Academy of Sciences, Laboratory of Carcinogenesis and Aging, N N Petrov Research Institute of Oncology, St Petersburg
    Aging (Milano) 12:53-8. 2000
    ....
  55. ncbi Melatonin increases both life span and tumor incidence in female CBA mice
    V N Anisimov
    N N Petrov Research Institute of Oncology, St Petersburg, Russia
    J Gerontol A Biol Sci Med Sci 56:B311-23. 2001
    ..However, we also found that treatment with the used dose of melatonin increased spontaneous tumor incidence in mice. For this reason, we concluded that it would be premature to recommend melatonin as a geroprotector for long-term use...
  56. ncbi The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Int J Cancer 103:300-5. 2003
    ..Adverse effect of melatonin on the life span in our study may be unique to the transgenic model used and may not be relevant to the suppressive effect of melatonin in delay of mammary cancer...
  57. ncbi Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging
    V N Anisimov
    St Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St Petersburg
    Bull Exp Biol Med 133:167-70. 2002
    ..7 times lower than in control animals. These results indicate that Epithalon inhibits breast tumor development in transgenic mice, which is probably related to suppression of HER-2/neu expression...
  58. ncbi Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology
    S V Anisimov
    St Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, St Petersburg
    Bull Exp Biol Med 133:293-9. 2002
    ..61 times) and inhibited expression of 48 clones (maximally by 2.71 times). Our results demonstrate the specific effects of Epithalon and Vilon on gene expression...
  59. ncbi [The use of mutagenic and transgenic mice for the study of aging mechanisms and age pathology]
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, N N Petrov Research Institute of Oncology, St Petersburg, Pesochny 2, Leningradskaya, 68, 197758, Russia
    Adv Gerontol 7:72-94. 2001
    ..These observations are in agreement with the data on the positive correlation between tumor incidence and the rate of its age-related increase, and the aging rate in a population...
  60. ncbi Insulin in aging and cancer: antidiabetic drug Diabenol as geroprotector and anticarcinogen
    Irina G Popovich
    Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, St. Petersburg 197758, Russia
    Int J Biochem Cell Biol 37:1117-29. 2005
    ..3% and 50%, and 47.4% and 14.7%, respectively). Thus, the drug increases survival and inhibits spontaneous carcinogenesis in mice and inhibits colon carcinogenesis in rats...
  61. ncbi Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats
    Irina A Vinogradova
    Petrozavodsk State University, Pr Lenina, 33, Petrozavodsk 185910, Russia
    Aging (Albany NY) 1:855-65. 2009
    ..This observation supports the conclusion of the International Agency Research on Cancer that shift-work that involves circadian disruption is probably carcinogenic to humans...
  62. ncbi Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray
    Sergey V Anisimov
    Saint-Petersburg Institute of Bioregulation and Gerontology, RAMS, St.-Petersburg, Russia
    Neuro Endocrinol Lett 25:87-93. 2004
    ....
  63. ncbi [Effect of pineal peptide on parameters of the biological age and life span in mice]
    V N Anisimov
    Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia
    Ross Fiziol Zh Im I M Sechenova 87:125-36. 2001
    ..However, it slowed down the age-related switching off of the estrus function, decreased body temperature, decelerated free redical processes, prolonged the mice life span with an accompanying drop in spontaneous tumour incidence...
  64. ncbi Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster
    V N Anisimov
    Laboratory of Experimental Tumors, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Mech Ageing Dev 97:81-91. 1997
    ..melanogaster and slowed down their aging rate by 2.12 times. This effect is in good agreement with the inhibiting effect of epithalamin in lipid peroxidation processes in fly tissues...
  65. ncbi Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents
    Vladimir N Anisimov
    Petrov Institute of Oncology, St Petersburg 197758, Russia
    Aging (Albany NY) 3:1110-9. 2011
    ..For males under LP or SPF conditions, SkQ1 increased the lifespan, affecting also some other system(s) responsible for aging...
  66. ncbi Microarray technology in studying the effect of melatonin on gene expression in the mouse heart
    S V Anisimov
    Petrov Research Institute of Oncology, Russian Academy of Medical Science, Pesochnyi-2, St. Petersburg, 197758 Russia
    Dokl Biol Sci 383:90-5. 2002
  67. ncbi The effect of light regimen and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression
    D A Baturin
    Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology, Pesochny-2, St.Petersburg 197758, Russia
    Neuro Endocrinol Lett 22:441-7. 2001
    ....
  68. ncbi Antioxidant system and energy provision of the rat heart during aging depend on illumination regimen and are resistant to exogenous melatonin
    E A Khizhkin
    Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia
    Bull Exp Biol Med 149:354-8. 2010
    ..Melatonin treatment did not modify activities of antioxidant enzymes and negligibly modified the level of tocopherol and isoenzyme spectrum of lactate dehydrogenase in rat heart...
  69. ncbi Long-live euthymic BALB/c-nu mice. II: spontaneous tumors and other pathologies
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 189646, Russia
    Mech Ageing Dev 122:477-89. 2001
    ..This subdivision will be helpful in interpreting inter-individual variability of the biological parameters checked in these animals...
  70. ncbi Methods of evaluating the effect of pharmacological drugs on aging and life span in mice
    Vladimir N Anisimov
    Department of Carcinogenis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Methods Mol Biol 371:227-36. 2007
    ..It includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment, pathology examination, and statistical treatment of the results...
  71. ncbi An attempt to prevent senescence: a mitochondrial approach
    Vladimir P Skulachev
    A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Vorobyevy Gory 1, Moscow, Russia
    Biochim Biophys Acta 1787:437-61. 2009
    ..Thus, SkQs look promising as potential tools for treatment of senescence and age-related diseases...
  72. ncbi Prevention of spontaneous and chemically-induced carcinogenesis using activated carbon fiber adsorbent. I. Effect of the activated carbon fiber adsorbent 'Aqualen' on spontaneous carcinogenesis and life-span in mice
    V N Anisimov
    Laboratory of Experimental Tumors, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cancer Lett 126:23-8. 1998
    ..05). No carcinogenic effect of Aqualen was found. It could be supposed that Aqualen has some geroprotective and anticarcinogenic properties...
  73. ncbi Disturbances of diurnal rhythms of biogenic amines contents in hypothalamic nuclei as an evidence of neurotropic effects of enterotropic carcinogen 1,2-dimethylhydrazine
    A V Arutjunyan
    D O Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, Russia
    Neuro Endocrinol Lett 22:229-37. 2001
    ....
  74. ncbi Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence
    V N Anisimov
    Petrov Institute of Oncology, St Petersburg, 197758, Russia
    Biochemistry (Mosc) 73:1329-42. 2008
    ..Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence...
  75. ncbi Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens
    I A Vinogradova
    Petrozavodsk State University N N Petrov Institute of Oncology, Rosmedtekhnologies, St Petersburg, Russia
    Bull Exp Biol Med 145:472-7. 2008
    ..Epithalone injected to rats exposed to any photoregimen significantly inhibited the development of spontaneous tumors, primarily testicular leydigomas and leukemias...
  76. ncbi Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes
    I A Vinogradova
    Petrozavodsk State University, St Petersburg
    Bull Exp Biol Med 144:825-30. 2007
    ..This peptide exhibited virtually no effect on the development of spontaneous tumors in rats exposed to standard and constant illumination, but significantly inhibited their development in rats exposed to natural light...
  77. ncbi The effect of delta-sleep-inducing peptide on the lifespan and incidence of spontaneous tumors in mice
    I G Popovich
    Petrov Research Institute of Oncology, ul. Leningradskaya 68, pos. Pesochnyi-2, St. Petersburg, 197758 Russia
    Dokl Biol Sci 388:28-30. 2003
  78. ncbi Melatonin and colon carcinogenesis. III. Effect of melatonin on proliferative activity and apoptosis in colon mucosa and colon tumors induced by 1,2-dimethylhydrazine in rats
    V N Anisimov
    Laboratory of Carcinogenesis and Aging, NN Petrov Research Institute of Oncology, St Petersburg, Russia
    Exp Toxicol Pathol 52:71-6. 2000
    ..Long-term treatment with melatonin was followed also by the decrease in the area of lymphoid infiltrates in the colon mucosa of tumor-bearing rats...
  79. ncbi Peptide regulation of aging: 35-year research experience
    V Kh Khavinson
    St Petersburg Institute of Bioregulation and Gerontology, North Western Division of the Russian Academy of Medical Sciences, St Petersburg, Russia
    Bull Exp Biol Med 148:94-8. 2009
    ..A molecular model of complementary interactions between short peptides and gene promotor sites, underlying the initiation of protein synthesis, is proposed. Prospects of peptide bioregulators in prevention of early aging are discussed...
  80. ncbi [Aging and carcinogenesis]
    V N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758
    Adv Gerontol 10:99-125. 2002
    ..At least some geroprotectors and modifications may increase the survival of a short-living individuals in populations but increase the incidence of malignancy...
  81. ncbi [Effect of the enterosorbent Aqualen on intestinal carcinogenesis induced by 1,2-dimethylhydrazine in rats]
    V N Anisimov
    N N Petrov Research Institute of Oncology, Ministry of Health of the RF Corp Aquaphor, St Petersburg
    Vopr Onkol 44:74-8. 1998
    ..In both runs, tumor size in enterosorbent-fed animals was smaller than in controls. All intestinal tumors were adenocarcinomas. No pathology was observed in Aqualen-fed rats untreated with the carcinogenic agent...
  82. ncbi [Basic directions and prospects for international collaboration in gerontology. Role of the International Association of Gerontology]
    O N Mikhailova
    St Petersburg Institute of Bioregulation and Gerontology, 3, Dynamo Prospect, 197110 St Petersburg, Russia
    Adv Gerontol 9:7-16. 2002
    ..Role of the International Association of Gerontology and other international organizations in the promotion of gerontology and geriatrics in each of these spheres is shown by the example of Russia...
  83. ncbi Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. II. Inhibitory effect of the activated carbon fiber adsorbent 'Aqualen' on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats
    V N Anisimov
    Laboratory of Experimental Tumors, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cancer Lett 138:23-6. 1999
    ..No lesions were observed in rats exposed to Aqualen without MNNG. Thus, our results demonstrate the inhibitory effect of the activated carbon fiber adsorbent Aqualen on stomach carcinogenesis in rats...
  84. ncbi Prevention of spontaneous and chemically induced carcinogenesis using activated carbon fiber adsorbent. III. Inhibitory effect of the activated carbon fiber adsorbent 'Aqualen' on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats
    V N Anisimov
    Laboratory of Experimental Tumors, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cancer Lett 138:27-35. 1999
    ..Thus, our results demonstrate the inhibitory effect of activated carbon fiber adsorbent Aqualen on intestinal carcinogenesis in rats...
  85. ncbi Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?
    Ganna V Semenchenko
    Max Planck Institute for Demographic Research, Konrad Zuse Strasse 1, Rostock D 18057, Germany
    Exp Gerontol 39:1499-511. 2004
    ..The proposed model helps to advance our understanding of the effects--such as debilitation, longevity hormesis and incomplete hormesis--which occur in the population as a result of different treatments...
  86. ncbi Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice
    George Kossoy
    Koret School of Veterinary Medicine, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    In Vivo 20:253-7. 2006
    ..These data highlight the antimetastatic effect of Epitalon as part of its oncostatic properties...
  87. ncbi A model of accelerated aging induced by 5-bromodeoxyuridine
    Alexander A Butov
    Department of Applied Mathematics, Faculty of Mechanics and Mathematics, Ulyanovsk State University, Leo Tolstoi 42, 432700 Ulyanovsk, Russian Federation
    Biogerontology 3:175-82. 2002
    ..The methods of stochastic modeling and computer simulation of the processes of aging and carcinogenesis have been used for the verification of the biological suggestions...
  88. ncbi Light, endocrine systems and cancer--a meeting report
    Vladimir N Anisimov
    Neuro Endocrinol Lett 23:84-7. 2002
    ..The symposium covered also the mechanisms and epidemiology of skin cancer which, however, are not included in the present summary...