Vladimir N Anisimov


Country: Russia


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    Anisimov V. Life span extension and cancer risk: myths and reality. Exp Gerontol. 2001;36:1101-36 pubmed
    ..Recommendations of the available drugs and means of life span increase should be carefully reconsidered under the international scientific control. ..
  2. Panchenko A, Popovich I, Trashkov A, Egormin P, Yurova M, Tyndyk M, et al. Biomarkers of aging, life span and spontaneous carcinogenesis in the wild type and HER-2 transgenic FVB/N female mice. Biogerontology. 2016;17:317-24 pubmed publisher
    ..It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis. ..
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    Anisimov V, Vinogradova I, Panchenko A, Popovich I, Zabezhinski M. Light-at-night-induced circadian disruption, cancer and aging. Curr Aging Sci. 2012;5:170-7 pubmed
    ..The data found in the literature and our observations suggest that the use of melatonin would be effective for cancer prevention in humans at risk as a result of light pollution. ..
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    Anisimov V. Effect of host age on tumor growth rate in rodents. Front Biosci. 2006;11:412-22 pubmed
    ..Age-associated changes in both humoral and local host factors are critical to the behavior and progression of transplanted tumors in the old host. ..
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    Anisimov V, Ukraintseva S, Yashin A. Cancer in rodents: does it tell us about cancer in humans?. Nat Rev Cancer. 2005;5:807-19 pubmed
    ..This review discusses the bio-epidemiological aspects of cancer manifestation in humans and rodents that have been underrepresented in the literature. ..
  6. Anisimov V, Khavinson V. Peptide bioregulation of aging: results and prospects. Biogerontology. 2010;11:139-49 pubmed publisher
    ..Possible mechanisms of the biological effects of small peptides are discussed in the paper. The results of clinical applications of peptide preparation during the period of 6-12 years are presented as well. ..
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    Anisimov V, Zabezhinski M, Popovich I, Zaripova E, Musatov S, Andre V, et al. Inhibitory effect of melatonin on 7, 12-dimethylbenz[a]anthracene-induced carcinogenesis of the uterine cervix and vagina in mice and mutagenesis in vitro. Cancer Lett. 2000;156:199-205 pubmed
    ..Thus, our data indicate that pineal indole hormone melatonin inhibits cervical and vaginal carcinogenesis induced by DMBA in mice and possess antimutagenic and anticlastogenic effect in vitro. ..
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    Anisimov V, Alimova I, Baturin D, Popovich I, Zabezhinski M, Manton K, et al. The effect of melatonin treatment regimen on mammary adenocarcinoma development in HER-2/neu transgenic mice. Int J Cancer. 2003;103:300-5 pubmed
    ..Adverse effect of melatonin on the life span in our study may be unique to the transgenic model used and may not be relevant to the suppressive effect of melatonin in delay of mammary cancer. ..
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    Anisimov V. Metformin for Prevention and Treatment of Colon Cancer: A Reappraisal of Experimental and Clinical Data. Curr Drug Targets. 2016;17:439-46 pubmed
    ..In this mini-review are presented the available data on the capacity of antidiabetic biguanide drugs to prevent colorectal carcinogenesis and growth in vitro and in vivo in experimental models and clinical observations. ..

More Information


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    Anisimov V, Berstein L, Egormin P, Piskunova T, Popovich I, Zabezhinski M, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7:2769-73 pubmed
    ..Thus, antidiabetic biguanide metformin dramatically extends life span, even without cancer prevention in this model. ..
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    Anisimov V, Serpov V, Finagentov A, Khavinson V. [A new stage of development of gerontology and geriatrics in Russia: problems of creation of a geriatric care system. Part 1. Relevance, regulatory infrastructure]. Adv Gerontol. 2017;30:158-166 pubmed
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    Zharinov G, Anisimov V. [Life span, longevity and incidence of violence death in writers and poets]. Adv Gerontol. 2016;29:210-217 pubmed
  4. Vinogradova I, Anisimov V, Bukalev A, Ilyukha V, Khizhkin E, Lotosh T, et al. Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats. Aging (Albany NY). 2010;2:82-92 pubmed
    ..We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months. ..
  5. Anisimov V. Metformin for aging and cancer prevention. Aging (Albany NY). 2010;2:760-74 pubmed
    ..Thus, antidiabetic drugs postpone spontaneous carcinogenesis in mice and rats, as well as chemical and radiation carcinogenesis in mice, rats and hamsters. Furthermore metformin seems to decrease cancer risk in diabetic patients. ..
  6. Anisimov V, Piskunova T, Popovich I, Zabezhinski M, Tyndyk M, Egormin P, et al. Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice. Aging (Albany NY). 2010;2:945-58 pubmed
    ..5 times the incidence of malignant neoplasms in female mice while somewhat stimulated formation of benign vascular tumors in the latter. ..
  7. Anisimov V, Berstein L, Popovich I, Zabezhinski M, Egormin P, Piskunova T, et al. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY). 2011;3:148-57 pubmed
    ..Thus, in female SHR mice, metformin increased life span and postponed tumors when started at the young and middle but not at the old age. In contrast, metformin improves reproductive function when started at any age. ..
  8. Anisimov V, Zabezhinski M, Popovich I, Piskunova T, Semenchenko A, Tyndyk M, et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle. 2011;10:4230-6 pubmed publisher
    ..Thus we demonstrated for the first time in normal inbred mice that lifespan can be extended by rapamycin. This opens an avenue to develop optimal doses and schedules of rapamycin as an anti-aging modality. ..
  9. Anisimov V, Zabezhinski M, Popovich I, Piskunova T, Semenchenko A, Tyndyk M, et al. Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol. 2010;176:2092-7 pubmed publisher
    ..Rapamycin dramatically delayed tumor onset as well as decreased the number of tumors per animal and tumor size. We suggest that, by slowing down organismal aging, rapamycin delays cancer. ..
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    Anisimov V, Egormin P, Piskunova T, Popovich I, Tyndyk M, Yurova M, et al. Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle. 2010;9:188-97 pubmed
    ..001). The combined treatment with metformin + melatonin significantly suppressed Ehrlich tumor growth (by 40%, p < 0.001). These results suggest that metformin may be useful in prevention and treatment of breast cancer. ..
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    Anisimov V, Ukraintseva S, Anikin I, Popovich I, Zabezhinski M, Bertsein L, et al. Effects of phentermine and phenformin on biomarkers of aging in rats. Gerontology. 2005;51:19-28 pubmed
    ..Drugs which reduce appetite (anorexiants) represent one class of candidate treatments. Agents that reduce the glucose utilization by the organism could also represent another class of candidate CR mimetics...
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    Anisimov V. Effects of exogenous melatonin--a review. Toxicol Pathol. 2003;31:589-603 pubmed
    ..Further studies and clinical trials are needed to verify that melatonin is both safe and has geroprotector efficacy for humans...
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    Anisimov V. [Editor-in-chief thoughts on the occasion of the 20th anniversary of the journal ┬źAdvances in Gerontology┬╗]. Adv Gerontol. 2017;30:479-485 pubmed
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    Anisimov V, Serpov V, Finagentov A, Khavinson V. [A new stage of development of gerontology and geriatrics in Russia: Problems o creation of a geriatric care system. Part 2. The structure of the system, scientific approach]. Adv Gerontol. 2017;30:486-497 pubmed