M A Aleksandrova

Summary

Country: Russia

Publications

  1. ncbi Small mammals disperse micromycete spores
    N A Shchipanov
    Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow State University, Moscow, Russia
    Dokl Biol Sci 390:225-30. 2003
  2. ncbi Characteristics of human bone marrow mesenchymal stem cells isolated by immunomagnetic selection
    M A Lagar'kova
    Institute of Gene Biology, Russian Academy of Sciences
    Bull Exp Biol Med 141:112-6. 2006
  3. ncbi [Transplantation of stem/progenitor cells of human brain into the brain of adult rats]
    M A Aleksandrova
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 34:167-73. 2003
  4. ncbi Transplantation of cultured neural cells from human fetuses into the brain of rats exposed to acute hypoxia
    M A Aleksandrova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:262-5. 2004
  5. ncbi Behavior of human neural progenitor cells transplanted to rat brain
    M A Aleksandrova
    Institute of Development Biology, Russian Academy of Sciences, Moscow, Russia
    Brain Res Dev Brain Res 134:143-8. 2002
  6. ncbi Human fetal neural stem cells in rat brain: effects of preculturing and transplantation
    A V Revishchin
    Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 139:213-6. 2005
  7. ncbi Characteristics of human neural stem cells in vitro and after transplantation into rat brain
    M A Aleksandrova
    Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 139:114-20. 2005
  8. ncbi Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo
    M A Aleksandrova
    Institute of Developmental Biology, Russian Academy of Sciences
    Bull Exp Biol Med 141:152-60. 2006
  9. ncbi Structure and cell composition of spheres cultured from human fetal retina
    M A Aleksandrova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 142:152-9. 2006
  10. ncbi Development of neural stem/progenitor cells from human brain by transplantation into the brains of adult rats
    M A Aleksandrova
    Laboratory of Experimental Neurobiology, Institute of Developmental Biology, Russian Academy of Sciences, Russia
    Neurosci Behav Physiol 34:659-62. 2004

Collaborators

Detail Information

Publications36

  1. ncbi Small mammals disperse micromycete spores
    N A Shchipanov
    Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow State University, Moscow, Russia
    Dokl Biol Sci 390:225-30. 2003
  2. ncbi Characteristics of human bone marrow mesenchymal stem cells isolated by immunomagnetic selection
    M A Lagar'kova
    Institute of Gene Biology, Russian Academy of Sciences
    Bull Exp Biol Med 141:112-6. 2006
    ..Immunocytochemical analysis showed that bone marrow mesenchymal stem cells acquired homogeneity during in vitro culturing, but initially contained heterogeneous populations...
  3. ncbi [Transplantation of stem/progenitor cells of human brain into the brain of adult rats]
    M A Aleksandrova
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 34:167-73. 2003
    ..Some growing nerve cells had long processes with growth cones. At the same time, some transplanted cells retained the undifferentiated state within one month after the implantation, as shown by the vimentin expression...
  4. ncbi Transplantation of cultured neural cells from human fetuses into the brain of rats exposed to acute hypoxia
    M A Aleksandrova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:262-5. 2004
    ..The transplants and brain tissue were not separated with a glial barrier. Human neuroblasts widely migrated into regions of neuronal degeneration in the host brain...
  5. ncbi Behavior of human neural progenitor cells transplanted to rat brain
    M A Aleksandrova
    Institute of Development Biology, Russian Academy of Sciences, Moscow, Russia
    Brain Res Dev Brain Res 134:143-8. 2002
    ..Our results demonstrate that cultured human neural stem/progenitor cells migrate and differentiate into both neurons and astrocytes after transplantation to the rat forebrain or cerebellum of young and adult rats...
  6. ncbi Human fetal neural stem cells in rat brain: effects of preculturing and transplantation
    A V Revishchin
    Institute of Problems of Ecology and Evolution, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 139:213-6. 2005
    ..After transplantation of long-cultured cells into the brain mainly committed neuroblasts and solitary nestin-positive cells migrated from the site of transplantation into the brain...
  7. ncbi Characteristics of human neural stem cells in vitro and after transplantation into rat brain
    M A Aleksandrova
    Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 139:114-20. 2005
    ..Neural stem cells cultured with LIF migrated, apart from the above mentioned pathways, in the cortex and hippocampus, well survived; proliferating cells were retained 30 days after transplantation...
  8. ncbi Comparative analysis of differentiation and behavior of human neural and mesenchymal stem cells in vitro and in vivo
    M A Aleksandrova
    Institute of Developmental Biology, Russian Academy of Sciences
    Bull Exp Biol Med 141:152-60. 2006
    ..Recipient filaments grew into mesenchymal stem cell transplants containing no neural cells due to local changes in the extracellular matrix at the site of transplantation...
  9. ncbi Structure and cell composition of spheres cultured from human fetal retina
    M A Aleksandrova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 142:152-9. 2006
    ..All spheres, irrespective of age and duration of culturing, consisted of numerous cell rosettes, each histotypically similar to the neuroblastic layer of the developing retina...
  10. ncbi Development of neural stem/progenitor cells from human brain by transplantation into the brains of adult rats
    M A Aleksandrova
    Laboratory of Experimental Neurobiology, Institute of Developmental Biology, Russian Academy of Sciences, Russia
    Neurosci Behav Physiol 34:659-62. 2004
    ..Cells from suspension transplants migrated intensely and differentiated into neurons and gliocytes. At the same time, transplants of whole neurospheres showed limited or no migration because of the development of a glial barrier...
  11. ncbi [Effect of the foreign gene GDNF on development of homo- and xenografts in the rat brain]
    M A Aleksandrova
    Kol tsov Institute of Developmental Biology, Russian Academy of Science, Moscow, Russia
    Genetika 36:1553-60. 2000
    ....
  12. ncbi Structure of cell clusters formed in cultures of dissociated human embryonic brain
    A V Revishchin
    Institute of Gene Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 132:856-60. 2001
    ..Stem cells were localized on the surface of clusters. The percentage of stem cells in large clusters was lower than in small clusters...
  13. ncbi Transplantation of cultured human neural progenitor cells into rat brain: migration and differentiation
    M A Aleksandrova
    N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 132:1000-3. 2001
    ..Immunohistochemical assay demonstrated that some cells differentiated into astrocytes and neurons, while others retained the embryonic phenotype...
  14. ncbi Immunohistochemical study of fetal stem/progenitor cells from human brain transplanted into traumatized spinal cord of adult rats
    O V Podgornyi
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:415-8. 2004
    ..Human neural stem/progenitor cells were viable for not less than 3 months. They migrated and differentiated into neurons and glia in the traumatized spinal cord of adult rats...
  15. ncbi Evaluation of progenitor cell cultures from human embryos for neurotransplantation
    R A Poltavtseva
    Institute of Biological Medicine, Moscow, Russia
    Brain Res Dev Brain Res 134:149-54. 2002
    ..Our results demonstrate that the flow cytometry phenotyping allows the screening and standardization of HNSC samples for further expansion and transplantation...
  16. ncbi Comparative analysis of the expression of neural stem cell-associated genes during neocortex and retina development in human
    B I Verdiev
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 154:529-36. 2013
    ..Our experiments showed that genetically determined cell potencies typical of native cells are realized in primary cultures without specific stimulation...
  17. ncbi Human neural stem cells normalize rat behavior after hypoxia
    O V Podgornyi
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 137:348-51. 2004
    ..They normalized animal behavior and improved conditioning in two-way avoidance response paradigm in a shuttle box...
  18. ncbi [Neural stem and progenitor cells of human embryos and fetuses as a basis of biomedical new technologies]
    R A Poltavtseva
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 34:211-5. 2003
    ..In most neurospheres, the nestin-immunopositive cells were located near the surface while the cells stained for beta-tubulin III and glial fibrillar acid protein, as compact groups inside the neurospheres...
  19. ncbi [Development of human brain neural/progenitor cells after transplantation into the brain of adult rats]
    M A Aleksandrova
    Laboratory of Experimental Neurobiology, Institute of Developmental Biology, RAS, Moscow
    Morfologiia 123:17-20. 2003
    ..Cells from suspension transplants actively migrated and differentiated into neurons and glial cells. Meanwhile, cell migration from the transplanted whole neurospheres was limited or absent due to the formation of glial barrier...
  20. ncbi Molecular genetic and immunophenotypical analysis of Pax6 transcription factor and neural differentiation markers in human fetal neocortex and retina in vivo and in vitro
    B I Verdiev
    N K Koltsov Institute of Developmental Biology, The Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 148:697-704. 2009
    ..It can be hypothesized that heterotransplantation of the cerebral progenitor cells into the retina of experimental animals can lead to realization of their neurotrophic effect, but not to their functional integration...
  21. ncbi In vivo and in vitro proliferative and differentiation activity of human embryonic retinal cells
    I G Panova
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Russia
    Bull Exp Biol Med 139:517-22. 2005
    ..Culturing was accompanied by the formation of aggregates and neurospheres, where mitoses and progenitor or differentiated cells expressing markers of photoreceptors, neurons, and glia were found...
  22. ncbi Expression of multipotent and retinal markers in pigment epithelium of adult human in vitro
    L A Milyushina
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 153:157-62. 2012
    ..These findings attest to the capacity of retinal pigment epithelium from adult human eye to transdifferentiation into neural lineage cells, which makes them an interesting object for cell therapy in neurodegeneration...
  23. ncbi In vitro development of neural progenitor cells from human embryos
    R A Poltavtseva
    Institute of Biological Medicine, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 132:861-3. 2001
    ..In a serum-containing medium some cells underwent differentiation by the neuronal pathway, while others remained in the stem state...
  24. ncbi Formation of neuroepithelial structures in culture of neural stem cells from human brain
    O V Podgornyi
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 140:113-7. 2005
    ..These cells express nestin, a marker of neural stem cells. The cells in "rosettes" found after transplantation have similar characteristics...
  25. ncbi Transplantation of cultured human neural stem cells in rabbits with experimental laser-induced damage to the retina
    N V Pak
    Ghelmgolts Moscow Research Institute of Eye Diseases, Russian Ministry of Health, Moscow, Russia
    Bull Exp Biol Med 138:525-8. 2004
    ..Transplanted cells survived, retained multipotent activity, migrated into the zone of injury, and stimulated reparation and regeneration in the traumatized retina...
  26. ncbi In vitro phenotypic modification of pigmented epithelium cells from human eye at early stages of development
    L A Milyushina
    N K Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 148:113-9. 2009
    ....
  27. ncbi Xenografts of embryonic nerve tissue from Drosophila neuromutants stimulate development of neural homografts in rat brain and block glial scar formation
    L I Korochkin
    Institute of Gene Biology RAS, Moscow, Russia
    Tsitologiia 44:1181-5. 2002
    ....
  28. ncbi Analysis of differentiation of stem/progenitor cells in tissue culture of neocortical primordium of mouse brain
    A M Samarina
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Bull Exp Biol Med 144:602-7. 2007
    ..It was found that cells of mouse embryonic neocortex lose the capacity for spontaneous multipotent differentiation during culturing...
  29. ncbi BLBP-immunoreactive cells in the primary culture of neural precursors from embryonic mouse brain
    O V Podgornyi
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 147:125-31. 2009
    ..Otherwise, some heterogeneous cells of the radial glia include a previously unknown linear population that differentiates into S-100b-positive astrocytes...
  30. ncbi Phenotypic plasticity of retinal pigment epithelial cells from adult human eye in vitro
    L A Milyushina
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 151:506-11. 2011
    ..However, irrespective of initial morphological features differentiation of retinal pigment cells can be modulated by varying culturing conditions...
  31. ncbi [Biological foundations for neurotransplantation]
    M A Aleksandrova
    Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119991 GSP-1, Russia
    Ontogenez 32:106-13. 2001
    ....
  32. ncbi [Appearance and differentiation of NADPH-D-neurons in ontogeny of the cerebral cortex in rats]
    I N Saburina
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, ul Vavilova 26, Moscow, 119991 Russia
    Ontogenez 33:36-42. 2002
    ..Most NADPH-D-positive neurons reach their structural-functional maturity already by the end of the first week of postnatal development, while their complete maturation takes place by the end of the second week of postnatal development...
  33. ncbi Effect of transplants of retinal pigment epithelial cells from adult human eye on degenerative processes in the brain of rats with experimental acute hypoxia
    M A Aleksandrova
    N K Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia
    Bull Exp Biol Med 157:125-31. 2014
    ..The cells transplanted into rat brain survive for at least 20 days. During this period, they stimulate compensatory and reparative processes that protected cortical neurons in the recipients from hypoxia-induced degeneration. ..
  34. ncbi Functional activity of mitochondria in cultured neural precursor cells
    E Yu Plotnikov
    A N Belozvorskii Institute of Physico Chemical Biology, M V Lomonosov Moscow State University
    Bull Exp Biol Med 141:142-6. 2006
    ..These data will help to create optimum conditions for culturing of neural stem cells for the maintenance of their maximum functional and proliferative activity...
  35. ncbi Xenotransplantation of stem/progenitor cells from human fetal brain to adult rats with spinal trauma
    G A Stepanov
    Central Institute of Traumatology and Orthopedics, Moscow
    Bull Exp Biol Med 135:397-400. 2003
    ..Human neural stem/progenitor cells were viable, migrated, and differentiated into neurons and glia in the traumatized spinal cord in adult rats...
  36. ncbi Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy
    V N Yarygin
    Russian State Medical University, Moscow
    Bull Exp Biol Med 136:88-92. 2003
    ..Our results indicate that xenogeneic transplantation of embryonic myogenic precursors compensates the genetic defect in dystrophin-deficient mice...