J Ruschoff

Summary

Publications

  1. doi request reprint [ErbB2 diagnostics in breast cancer--an update]
    J Ruschoff
    Pathologie Nordhessen, Kassel, Deutschland
    Pathologe 30:147-55. 2009
  2. doi request reprint Adenocarcinoma of the GEJ: gastric or oesophageal cancer?
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastraße 7, Kassel, Germany
    Recent Results Cancer Res 196:107-13. 2012
  3. doi request reprint Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test
    Josef Ruschoff
    Department of Pathology, Institute of Pathology Nordhessen, Kassel, Germany
    Arch Pathol Lab Med 137:1255-61. 2013
  4. doi request reprint [Translational research and diagnostics of melanoma]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119 Kassel
    Pathologe 33:291-5. 2012
  5. doi request reprint HER2 testing in gastric cancer: a practical approach
    Josef Ruschoff
    TARGOS Molecular Pathology GmbH, Kassel, Germany
    Mod Pathol 25:637-50. 2012
  6. doi request reprint [Anal cancer: diagnostic and differential diagnostic issues]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel, Deutschland
    Pathologe 32:336-44. 2011
  7. pmc HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
    Josef Ruschoff
    Targos Molecular Pathology GmbH und Pathologie Nordhessen, 34119 Kassel, Germany
    Virchows Arch 457:299-307. 2010
  8. doi request reprint [Her2 testing in gastric cancer. What is different in comparison to breast cancer?]
    J Ruschoff
    Pathologie Nordhessen u Targos GmbH, Germaniastr 7 9, 34119 Kassel
    Pathologe 31:208-17. 2010
  9. doi request reprint [Active surveillance of localized prostate cancer. Significance of prostate core needle biopsies]
    J Ruschoff
    Institut für Pathologie Nordhessen, Wilhelmshöher Allee 287, 34131, Kassel
    Pathologe 29:339-47. 2008
  10. doi request reprint [Differential diagnostics of hereditary colorectal cancer syndromes. The role of pathology]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel
    Pathologe 31:412-22. 2010

Detail Information

Publications14

  1. doi request reprint [ErbB2 diagnostics in breast cancer--an update]
    J Ruschoff
    Pathologie Nordhessen, Kassel, Deutschland
    Pathologe 30:147-55. 2009
    ..These cases need to be tested by IHC since over-expression is very exceptional and only these tumors have the potential to be trastuzumab responders...
  2. doi request reprint Adenocarcinoma of the GEJ: gastric or oesophageal cancer?
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastraße 7, Kassel, Germany
    Recent Results Cancer Res 196:107-13. 2012
    ....
  3. doi request reprint Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test
    Josef Ruschoff
    Department of Pathology, Institute of Pathology Nordhessen, Kassel, Germany
    Arch Pathol Lab Med 137:1255-61. 2013
    ....
  4. doi request reprint [Translational research and diagnostics of melanoma]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119 Kassel
    Pathologe 33:291-5. 2012
    ..Finally, the impact of molecular characteristics in different subtypes of MM (acral, mucosal, uveal) will be discussed with respect to their specific mutational spectrum (e.g. cKIT , NRAS , GNAQ)...
  5. doi request reprint HER2 testing in gastric cancer: a practical approach
    Josef Ruschoff
    TARGOS Molecular Pathology GmbH, Kassel, Germany
    Mod Pathol 25:637-50. 2012
    ..It is anticipated that these recommendations should ensure accurate and consistent HER2 testing, which will allow appropriate selection of patients eligible for treatment with trastuzumab...
  6. doi request reprint [Anal cancer: diagnostic and differential diagnostic issues]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel, Deutschland
    Pathologe 32:336-44. 2011
    ..Diagnosis of secondary malignancies, including pagetoid extension into the anogenital region, requires the application of specific immunohistochemical marker panels...
  7. pmc HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
    Josef Ruschoff
    Targos Molecular Pathology GmbH und Pathologie Nordhessen, 34119 Kassel, Germany
    Virchows Arch 457:299-307. 2010
    ..Specific issues relating to discordance were identified and recommendations formulated which proved to be effective to reliably determine HER2 status in a prospective test series of 447 diagnostic gastric cancer specimens...
  8. doi request reprint [Her2 testing in gastric cancer. What is different in comparison to breast cancer?]
    J Ruschoff
    Pathologie Nordhessen u Targos GmbH, Germaniastr 7 9, 34119 Kassel
    Pathologe 31:208-17. 2010
    ..In contrast to breast cancer, up to one-third of gastric cancers show a heterogeneous Her2 status both at IHC and ISH levels which favors bright field ISH over FISH...
  9. doi request reprint [Active surveillance of localized prostate cancer. Significance of prostate core needle biopsies]
    J Ruschoff
    Institut für Pathologie Nordhessen, Wilhelmshöher Allee 287, 34131, Kassel
    Pathologe 29:339-47. 2008
    ..Pathologists should concentrate on correct Gleason scoring in core needle biopsies and identification of lesions that exclude a patient from active surveillance...
  10. doi request reprint [Differential diagnostics of hereditary colorectal cancer syndromes. The role of pathology]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel
    Pathologe 31:412-22. 2010
    ..In the case of suspected familial cancer syndrome genetic counseling is warranted in order to decide ultimately whether there is an indication for genetic testing (evidence of a germ-line mutation)...
  11. doi request reprint Assessment of a HER2 scoring system for gastric cancer: results from a validation study
    M Hofmann
    Institute of Pathology, Klinikum Kassel, Kassel, Germany
    Histopathology 52:797-805. 2008
    ..The aim was to establish a HER2 scoring system for gastric cancer to identify suitable patients for enrollment in a trial of trastuzumab (Herceptin) in advanced metastatic gastric cancer...
  12. ncbi request reprint Transcriptional profiling of transurethral resection samples provides insight into molecular mechanisms of hormone refractory prostate cancer
    O Stoss
    TARGOS Molecular Pathology GmbH, Kassel, Germany
    Prostate Cancer Prostatic Dis 11:166-72. 2008
    ..Among the most significantly deregulated pathways in HRPC, we observed an induction of oxidative phosphorylation and a repression of cytoskeletal components...
  13. ncbi request reprint Central HER2 IHC and FISH analysis in a trastuzumab (Herceptin) phase II monotherapy study: assessment of test sensitivity and impact of chromosome 17 polysomy
    M Hofmann
    Institute of Pathology and Biomedical Research, Klinikum Kassel GmbH, Kassel, Germany
    J Clin Pathol 61:89-94. 2008
    ....
  14. doi request reprint [Angioinvasion by neuroendocrine jejunal tumor. Demonstration of a malignancy sign by acetone compression]
    A H Scheel
    Institut für Pathologie Nordhessen, Germaniastrasse 7, Kassel, Germany
    Pathologe 34:352-5. 2013
    ..In the case presented here, angioinvasion by a pT3 NET G1 was demonstrated after complete work-up of the mesenterial fat by acetone compression. The findings indicate an unfavorable course of disease requiring intensive surveillance. ..