J Ruschoff

Summary

Publications

  1. doi request reprint [ErbB2 diagnostics in breast cancer--an update]
    J Ruschoff
    Pathologie Nordhessen, Kassel, Deutschland
    Pathologe 30:147-55. 2009
  2. doi request reprint Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test
    Josef Ruschoff
    Department of Pathology, Institute of Pathology Nordhessen, Kassel, Germany
    Arch Pathol Lab Med 137:1255-61. 2013
  3. doi request reprint [Translational research and diagnostics of melanoma]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119 Kassel
    Pathologe 33:291-5. 2012
  4. doi request reprint Adenocarcinoma of the GEJ: gastric or oesophageal cancer?
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastraße 7, Kassel, Germany
    Recent Results Cancer Res 196:107-13. 2012
  5. doi request reprint HER2 testing in gastric cancer: a practical approach
    Josef Ruschoff
    TARGOS Molecular Pathology GmbH, Kassel, Germany
    Mod Pathol 25:637-50. 2012
  6. doi request reprint [Anal cancer: diagnostic and differential diagnostic issues]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel, Deutschland
    Pathologe 32:336-44. 2011
  7. pmc HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
    Josef Ruschoff
    Targos Molecular Pathology GmbH und Pathologie Nordhessen, 34119 Kassel, Germany
    Virchows Arch 457:299-307. 2010
  8. doi request reprint [Her2 testing in gastric cancer. What is different in comparison to breast cancer?]
    J Ruschoff
    Pathologie Nordhessen u Targos GmbH, Germaniastr 7 9, 34119 Kassel
    Pathologe 31:208-17. 2010
  9. doi request reprint [Active surveillance of localized prostate cancer. Significance of prostate core needle biopsies]
    J Ruschoff
    Institut für Pathologie Nordhessen, Wilhelmshöher Allee 287, 34131, Kassel
    Pathologe 29:339-47. 2008
  10. doi request reprint [Differential diagnostics of hereditary colorectal cancer syndromes. The role of pathology]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel
    Pathologe 31:412-22. 2010

Detail Information

Publications14

  1. doi request reprint [ErbB2 diagnostics in breast cancer--an update]
    J Ruschoff
    Pathologie Nordhessen, Kassel, Deutschland
    Pathologe 30:147-55. 2009
    ..These cases need to be tested by IHC since over-expression is very exceptional and only these tumors have the potential to be trastuzumab responders...
  2. doi request reprint Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test
    Josef Ruschoff
    Department of Pathology, Institute of Pathology Nordhessen, Kassel, Germany
    Arch Pathol Lab Med 137:1255-61. 2013
    ....
  3. doi request reprint [Translational research and diagnostics of melanoma]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119 Kassel
    Pathologe 33:291-5. 2012
    ..Finally, the impact of molecular characteristics in different subtypes of MM (acral, mucosal, uveal) will be discussed with respect to their specific mutational spectrum (e.g. cKIT , NRAS , GNAQ)...
  4. doi request reprint Adenocarcinoma of the GEJ: gastric or oesophageal cancer?
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastraße 7, Kassel, Germany
    Recent Results Cancer Res 196:107-13. 2012
    ....
  5. doi request reprint HER2 testing in gastric cancer: a practical approach
    Josef Ruschoff
    TARGOS Molecular Pathology GmbH, Kassel, Germany
    Mod Pathol 25:637-50. 2012
    ..It is anticipated that these recommendations should ensure accurate and consistent HER2 testing, which will allow appropriate selection of patients eligible for treatment with trastuzumab...
  6. doi request reprint [Anal cancer: diagnostic and differential diagnostic issues]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel, Deutschland
    Pathologe 32:336-44. 2011
    ..Diagnosis of secondary malignancies, including pagetoid extension into the anogenital region, requires the application of specific immunohistochemical marker panels...
  7. pmc HER2 diagnostics in gastric cancer-guideline validation and development of standardized immunohistochemical testing
    Josef Ruschoff
    Targos Molecular Pathology GmbH und Pathologie Nordhessen, 34119 Kassel, Germany
    Virchows Arch 457:299-307. 2010
    ..Specific issues relating to discordance were identified and recommendations formulated which proved to be effective to reliably determine HER2 status in a prospective test series of 447 diagnostic gastric cancer specimens...
  8. doi request reprint [Her2 testing in gastric cancer. What is different in comparison to breast cancer?]
    J Ruschoff
    Pathologie Nordhessen u Targos GmbH, Germaniastr 7 9, 34119 Kassel
    Pathologe 31:208-17. 2010
    ..In contrast to breast cancer, up to one-third of gastric cancers show a heterogeneous Her2 status both at IHC and ISH levels which favors bright field ISH over FISH...
  9. doi request reprint [Active surveillance of localized prostate cancer. Significance of prostate core needle biopsies]
    J Ruschoff
    Institut für Pathologie Nordhessen, Wilhelmshöher Allee 287, 34131, Kassel
    Pathologe 29:339-47. 2008
    ..Pathologists should concentrate on correct Gleason scoring in core needle biopsies and identification of lesions that exclude a patient from active surveillance...
  10. doi request reprint [Differential diagnostics of hereditary colorectal cancer syndromes. The role of pathology]
    J Ruschoff
    Institut für Pathologie Nordhessen, Germaniastr 7, 34119, Kassel
    Pathologe 31:412-22. 2010
    ..In the case of suspected familial cancer syndrome genetic counseling is warranted in order to decide ultimately whether there is an indication for genetic testing (evidence of a germ-line mutation)...
  11. doi request reprint Assessment of a HER2 scoring system for gastric cancer: results from a validation study
    M Hofmann
    Institute of Pathology, Klinikum Kassel, Kassel, Germany
    Histopathology 52:797-805. 2008
    ..The aim was to establish a HER2 scoring system for gastric cancer to identify suitable patients for enrollment in a trial of trastuzumab (Herceptin) in advanced metastatic gastric cancer...
  12. ncbi request reprint Transcriptional profiling of transurethral resection samples provides insight into molecular mechanisms of hormone refractory prostate cancer
    O Stoss
    TARGOS Molecular Pathology GmbH, Kassel, Germany
    Prostate Cancer Prostatic Dis 11:166-72. 2008
    ..Among the most significantly deregulated pathways in HRPC, we observed an induction of oxidative phosphorylation and a repression of cytoskeletal components...
  13. ncbi request reprint Central HER2 IHC and FISH analysis in a trastuzumab (Herceptin) phase II monotherapy study: assessment of test sensitivity and impact of chromosome 17 polysomy
    M Hofmann
    Institute of Pathology and Biomedical Research, Klinikum Kassel GmbH, Kassel, Germany
    J Clin Pathol 61:89-94. 2008
    ....
  14. doi request reprint [Angioinvasion by neuroendocrine jejunal tumor. Demonstration of a malignancy sign by acetone compression]
    A H Scheel
    Institut für Pathologie Nordhessen, Germaniastrasse 7, Kassel, Germany
    Pathologe 34:352-5. 2013
    ..In the case presented here, angioinvasion by a pT3 NET G1 was demonstrated after complete work-up of the mesenterial fat by acetone compression. The findings indicate an unfavorable course of disease requiring intensive surveillance. ..