Georg Juckel

Summary

Affiliation: Ruhr-University Bochum

Publications

  1. ncbi request reprint [Inhalative loxapine: old tried and trusted medication with new indications]
    G Juckel
    Klinik fur Psychiatrie, Psychotherapie und Präventivmedizin, LWL Universitätsklinikum, Ruhr Universitat Bochum, Deutschland
    Nervenarzt 84:1113-4, 1116. 2013
  2. doi request reprint Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
    Neuropsychobiology 66:50-6. 2012
  3. ncbi request reprint Psychoeducation in subjects at elevated risk for psychosis--a critical review
    Marta Hauser
    The Zucker Hillside Hospital, North Shore Long Island Jewish Medical Center, NY, USA
    Curr Pharm Des 18:566-9. 2012
  4. ncbi request reprint Validation of the Personal and Social Performance (PSP) Scale in a German sample of acutely ill patients with schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL Hospital, Germany
    Schizophr Res 104:287-93. 2008
  5. doi request reprint The new approach: psychosocial functioning as a necessary outcome criterion for therapeutic success in schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
    Curr Opin Psychiatry 21:630-9. 2008
  6. doi request reprint Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany
    Schizophr Res 131:96-100. 2011
  7. doi request reprint Psychosurgery and deep brain stimulation as ultima ratio treatment for refractory depression
    Georg Juckel
    Department of Psychiatry Psychotherapy and Psychosomatic Medicine, Ruhr University, Alexandrinenstr 1, Bochum 44791, Germany
    Eur Arch Psychiatry Clin Neurosci 259:1-7. 2009
  8. ncbi request reprint Diagnostic usefulness of cognitive auditory event-related p300 subcomponents in patients with Alzheimers disease?
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    J Clin Neurophysiol 25:147-52. 2008
  9. ncbi request reprint Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity
    Georg Juckel
    Department of Psychiatry, University Hospital Charite, Berlin, Germany
    Schizophr Res 97:109-17. 2007
  10. ncbi request reprint Kinematic analysis of facial behaviour in patients with schizophrenia under emotional stimulation by films with "Mr. Bean"
    Georg Juckel
    Westphalian Center Bochum, Psychiatry, Psychotherapy, Psychosomatic Medicine Clinic of the Ruhr University Bochum, Bochum, Germany
    Eur Arch Psychiatry Clin Neurosci 258:186-91. 2008

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. ncbi request reprint [Inhalative loxapine: old tried and trusted medication with new indications]
    G Juckel
    Klinik fur Psychiatrie, Psychotherapie und Präventivmedizin, LWL Universitätsklinikum, Ruhr Universitat Bochum, Deutschland
    Nervenarzt 84:1113-4, 1116. 2013
    ..In view of the rapid onset antiagitation effect and the easy handling of inhaled loxapine, this might be a rather minor problem. ..
  2. doi request reprint Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
    Neuropsychobiology 66:50-6. 2012
    ....
  3. ncbi request reprint Psychoeducation in subjects at elevated risk for psychosis--a critical review
    Marta Hauser
    The Zucker Hillside Hospital, North Shore Long Island Jewish Medical Center, NY, USA
    Curr Pharm Des 18:566-9. 2012
    ..More research regarding the subjective psychoeducational needs of individuals at elevated risk for psychosis as well as more explicit provision and evaluation of psychoeducation in the elevated-risk state is strongly desirable...
  4. ncbi request reprint Validation of the Personal and Social Performance (PSP) Scale in a German sample of acutely ill patients with schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL Hospital, Germany
    Schizophr Res 104:287-93. 2008
    ..Thus, the findings prove the PSP scale to be a reliable and valid instrument for assessing social functioning of patients with schizophrenia during the course of treatment as well as in the acute state...
  5. doi request reprint The new approach: psychosocial functioning as a necessary outcome criterion for therapeutic success in schizophrenia
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
    Curr Opin Psychiatry 21:630-9. 2008
    ..Instead of only reducing the symptoms, therapy with antipsychotics must attain higher goals such as remission and recovery today...
  6. doi request reprint Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany
    Schizophr Res 131:96-100. 2011
    ....
  7. doi request reprint Psychosurgery and deep brain stimulation as ultima ratio treatment for refractory depression
    Georg Juckel
    Department of Psychiatry Psychotherapy and Psychosomatic Medicine, Ruhr University, Alexandrinenstr 1, Bochum 44791, Germany
    Eur Arch Psychiatry Clin Neurosci 259:1-7. 2009
    ..In this review, we suggest possible standard criteria for the application of deep brain stimulation on patients suffering from otherwise treatment-resistant depression...
  8. ncbi request reprint Diagnostic usefulness of cognitive auditory event-related p300 subcomponents in patients with Alzheimers disease?
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    J Clin Neurophysiol 25:147-52. 2008
    ....
  9. ncbi request reprint Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity
    Georg Juckel
    Department of Psychiatry, University Hospital Charite, Berlin, Germany
    Schizophr Res 97:109-17. 2007
    ..This effect may be relevant for auditory cortex activity in particular because only MMN amplitudes at the central, but not at the frontal electrodes were enhanced under cannabis...
  10. ncbi request reprint Kinematic analysis of facial behaviour in patients with schizophrenia under emotional stimulation by films with "Mr. Bean"
    Georg Juckel
    Westphalian Center Bochum, Psychiatry, Psychotherapy, Psychosomatic Medicine Clinic of the Ruhr University Bochum, Bochum, Germany
    Eur Arch Psychiatry Clin Neurosci 258:186-91. 2008
    ..Kinematical analysis of facial movement using IV could help to distinguish subclinical Parkinsonian syndromes induced by typical neuroleptics from negative symptoms of schizophrenia...
  11. ncbi request reprint Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene
    Georg Juckel
    Department of Psychiatry, Ruhr University, 44791 Bochum, Germany
    J Psychiatr Res 44:541-6. 2010
    ..To evaluate the genetic basis of this relationship, we studied whether the LDAEP is correlated with genetic variants within the BDNF gene...
  12. ncbi request reprint Association of 5-HT1B receptor polymorphisms with the loudness dependence of auditory evoked potentials in a community-based sample of healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany
    Am J Med Genet B Neuropsychiatr Genet 147:454-8. 2008
    ....
  13. ncbi request reprint Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Psychiatry Res 153:183-7. 2007
    ..We speculate that the LD endophenotype depends more on genetic variations in components of the serotonergic system controlling release than on those controlling the uptake mechanism...
  14. doi request reprint Is evaluation of humorous stimuli associated with frontal cortex morphology? A pilot study using facial micro-movement analysis and MRI
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Cortex 47:569-74. 2011
    ....
  15. ncbi request reprint Reduction of auditory event-related P300 amplitude in subjects with at-risk mental state for schizophrenia
    Seza Ozgurdal
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Germany
    Schizophr Res 105:272-8. 2008
    ..e. before a manifestation of full-blown psychosis, and that these changes seem to have a progressive course from prodromal to chronic state of schizophrenia as assumed in this cross-sectional study...
  16. doi request reprint Switching schizophrenia patients from typical neuroleptics to aripiprazole: effects on working memory dependent functional activation
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Schizophr Res 118:189-200. 2010
    ..However, little is known about specific medication effects on the modulation of frontal activation during WM performance...
  17. ncbi request reprint Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charité Mitte CCM, Schumannstr 20 21, Berlin 10117, Germany
    Psychopharmacology (Berl) 187:222-8. 2006
    ..Dysfunction of the dopaminergic reward system may contribute to negative symptoms in schizophrenia...
  18. doi request reprint Switching schizophrenia patients from typical neuroleptics to olanzapine: effects on BOLD response during attention and working memory
    Florian Schlagenhauf
    Department of Psychiatry, Charite Universitaetsmedizin Berlin, Campus Mitte, Germany
    Eur Neuropsychopharmacol 18:589-99. 2008
    ..However, medication status had influences on the activation during attentional task (0-back), emphasizing the importance of baseline selection in pharmacological fMRI studies...
  19. doi request reprint Mentalizing in preclinical Huntington's disease: an fMRI study using cartoon picture stories
    Carsten Saft
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, 44791 Bochum, Germany
    Brain Imaging Behav 7:154-62. 2013
    ..This suggests that impaired mentalizing emerges with the clinical manifestation of the disease, but is not necessarily part of the pre-manifest stage...
  20. doi request reprint Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior
    Isabella Peruga
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Universitatsstr 150, Bochum, Germany
    Behav Brain Res 229:325-32. 2012
    ..These data imply that endogenous CNTF plays a pivotal role for the structural maintenance of hippocampal functions and thus has an important impact on the modulation of affective behavior in rodent models of anxiety and depression...
  21. ncbi request reprint Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    J Clin Psychiatry 68:1206-12. 2007
    ..The aim of the current randomized prospective study was to investigate whether or not LDAEP also allows the differential prediction of treatment response to serotonergic versus noradrenergic antidepressants...
  22. ncbi request reprint Serotonin and dopamine transporter availabilities correlate with the loudness dependence of auditory evoked potentials in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Neuropsychopharmacology 29:1910-7. 2004
    ....
  23. ncbi request reprint Association of catechol-O-methyltransferase variants with loudness dependence of auditory evoked potentials
    Georg Juckel
    Department of Psychiatry, Ruhr University Bochum, Germany
    Hum Psychopharmacol 23:115-20. 2008
    ..The aim of this study was to investigate the relationship between genetic variants of the COMT gene influencing synaptic dopamine levels and the LDAEP...
  24. doi request reprint Loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission: simultaneous electrophysiological recordings and in vivo microdialysis in the rat primary auditory cortex
    Alexander Wutzler
    Department of Psychiatry, Charite, Mitte, Berlin, Germany
    Neuropsychopharmacology 33:3176-81. 2008
    ..86, p=0.003). These data support the view that the LDAEP is closely modulated by cortical serotonergic activity. Thus, the LDAEP might serve as an inversely related marker of synaptically released serotonin in the CNS...
  25. ncbi request reprint Electrophysiological evidence for cortical abnormalities in obsessive-compulsive disorder - a replication study using auditory event-related P300 subcomponents
    Doris Gohle
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    J Psychiatr Res 42:297-303. 2008
    ..Once again, our findings point to a hyperactivated cortical state also of temporo-parietal and hippocampal regions in OCD...
  26. ncbi request reprint Differential reward processing in subtypes of adult attention deficit hyperactivity disorder
    Marc Andreas Edel
    Dept of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
    J Psychiatr Res 47:350-6. 2013
    ..This study sought to compare neural activations in the ventral striatum (VS) and prefrontal regions during reward processing in homogenous ADHD subtype groups and healthy adults, using the MID task...
  27. ncbi request reprint Serotonergic dysfunction in schizophrenia assessed by the loudness dependence measure of primary auditory cortex evoked activity
    Georg Juckel
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Schizophr Res 64:115-24. 2003
    ..These results suggest that the loudness dependence of primary auditory cortex evoked activity is well suitable to assess serotonergic dysfunction in schizophrenia...
  28. ncbi request reprint Auditory cortex and anterior cingulate cortex sources of the early evoked gamma-band response: relationship to task difficulty and mental effort
    Christoph Mulert
    Department of Psychiatry, LMU, Nussbaumstrasse 7, D 80336 Munich, Germany
    Neuropsychologia 45:2294-306. 2007
    ..These findings are in line with a top-down influence of dACC-activity to the auditory association area 22 during the early evoked GBR...
  29. doi request reprint Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects
    Patrik Roser
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Eur Arch Psychiatry Clin Neurosci 259:284-92. 2009
    ..This result may be due to functional changes involving GABAergic and glutamatergic neurotransmission within the corpus callosum...
  30. doi request reprint Auditory mismatch negativity deficits in long-term heavy cannabis users
    Patrik Roser
    Department of Psychiatry, Ruhr University Bochum, Alexandrinenstr 1, 44791, Bochum, Germany
    Eur Arch Psychiatry Clin Neurosci 260:491-8. 2010
    ..The results indicate that chronic cannabis use may cause a specific impairment of auditory information processing. In particular, duration and quantity of cannabis use could be identified as important factors of deficient MMN generation...
  31. ncbi request reprint Symptom-specific EEG power correlations in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Division of Clinical Neurophysiology, Ludwig Maximilians University of Munich, Germany
    Int J Psychophysiol 62:87-92. 2006
    ..The opposite correlations of neurophysiological data and clinical features, i.e. obsessions and compulsions, are suggestive of pathophysiological differences based on the presence of the respective cardinal symptoms of OCD...
  32. ncbi request reprint Prediction of treatment response in major depression: integration of concepts
    Christoph Mulert
    Department of Psychiatry, LMU, Munich, Germany
    J Affect Disord 98:215-25. 2007
    ..Here, a high LDAEP is supposed to reflect low central serotonergic activity. We present the first study comparing both approaches in the same group of patients...
  33. doi request reprint Association between wind-up ratio and central serotonergic function in healthy subjects and depressed patients
    Idun Uhl
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany
    Neurosci Lett 504:176-80. 2011
    ..340, p=0.043), indicating that WUR may be modulated by serotonergic activity. It can be concluded that inhibitory control to noxious stimuli is partly associated with the central serotonergic function as indicated by LDAEP...
  34. ncbi request reprint Proverb comprehension impairments in schizophrenia are related to executive dysfunction
    Patrizia Thoma
    Dept of Neuropsychology, Ruhr University of Bochum, 44780 Bochum, Germany
    Psychiatry Res 170:132-9. 2009
    ....
  35. ncbi request reprint Hand-motor dysfunction in depression: characteristics and pharmacological effects
    Roland Mergl
    Dept of Psychiatry, University Leipzig, Germany
    Clin EEG Neurosci 38:82-8. 2007
    ..II: Computer-aided analysis of hand movements is a sensitive tool for the registration of differential pharmaceutical effects on hand-motor function in depression...
  36. doi request reprint Serotonergic dysfunction in the prodromal, first-episode and chronic course of schizophrenia as assessed by the loudness dependence of auditory evoked activity
    Yehonala Gudlowski
    Department of Psychiatry and Psychotherapy, Charite, University Medicine of Berlin, Campus Mitte, Berlin, Germany
    Schizophr Res 109:141-7. 2009
    ..A weak LDAEP may therefore represent a vulnerability marker rather than an expression of illness progression...
  37. pmc Hippocampal subdivision and amygdalar volumes in patients in an at-risk mental state for schizophrenia
    Henning Witthaus
    Early Recognition and Therapy Centre for Beginning Psychoses Bochum, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, Bochum, Germany
    J Psychiatry Neurosci 35:33-40. 2010
    ..Furthermore, no subregions of the hippocampus have been investigated in people at UHR...
  38. doi request reprint Effects of acute oral Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory P300 event-related potential in healthy volunteers
    Patrik Roser
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Eur Neuropsychopharmacol 18:569-77. 2008
    ..It can be speculated whether the lack of effect of CBD may be due to an insufficient dose used or to an involvement of neurotransmitter systems in P300 generation which are not influenced by CBD...
  39. doi request reprint Neurocognitive performances in participants of at-risk mental state for schizophrenia and in first-episode patients
    Seza Ozgurdal
    Early Recognition and Therapy Centre for Beginning Psychoses Bochum BoFit, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, Bochum, Germany
    J Clin Exp Neuropsychol 31:392-401. 2009
    ..Results suggest that high-risk participants do perform at average neurocognitive performance levels at all tested domains compared with normative data. Compared to norm values first-episode patients showed decreased attention abilities...
  40. ncbi request reprint Can a subgroup of OCD patients with motor abnormalities and poor therapeutic response be identified?
    Roland Mergl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336 Munich, Bavaria, Germany
    Psychopharmacology (Berl) 179:826-37. 2005
    ..In a subgroup of patients with obsessive-compulsive disorder (OCD), motor soft signs, tics and other movement disorders can be observed, indicating a special pathogenetic involvement of basal ganglia...
  41. doi request reprint Theory of mind in schizophrenia: the role of clinical symptomatology and neurocognition in understanding other people's thoughts and intentions
    Mona Abdel-Hamid
    Department of Psychiatry, Psychotherapy, Psychosomatics and Preventative Medicine, University of Bochum, LWL Hospital, Germany
    Psychiatry Res 165:19-26. 2009
    ..This study lends further support to the assumption of differential associations of ToM deficits with individual symptoms and symptom clusters in schizophrenia...
  42. ncbi request reprint Prediction of clinical response to antidepressants in patients with depression: neurophysiology in clinical practice
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:74-7. 2007
    ..This review focuses on recent studies providing evidence for the validity of LD as an indirect serotonergic marker and highlights data on the clinical application in terms of prediction of treatment response in patients with depression...
  43. ncbi request reprint Is the loudness dependence of auditory evoked potentials modulated by the selective serotonin reuptake inhibitor citalopram in healthy subjects?
    Idun Uhl
    Department of Psychiatry and Psychotherapy, Charite, Campus Mitte, Berlin, Germany
    Hum Psychopharmacol 21:463-71. 2006
    ..The result underlines that the acceptance of LDAEP as a marker of central serotonergic function still needs further discussion...
  44. ncbi request reprint Sound level dependence of the primary auditory cortex: Simultaneous measurement with 61-channel EEG and fMRI
    Christoph Mulert
    Department of Psychiatry, LMU, Munich, Germany
    Neuroimage 28:49-58. 2005
    ..In addition, the correspondence of the ERP-based data and the fMRI results further supports the validity of the ERP localization approach...
  45. doi request reprint Alterations of theory of mind network activation in chronic cannabis users
    Patrik Roser
    Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Germany
    Schizophr Res 139:19-26. 2012
    ..These activation patterns resemble those found in at-risk populations, suggesting that cannabis use can affect the processing of social information similar to other risk factor constellations for psychosis...
  46. ncbi request reprint Altered ventral striatal activation during reward and punishment processing in premanifest Huntington's disease: a functional magnetic resonance study
    Björn Enzi
    Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
    Exp Neurol 235:256-64. 2012
    ..Altered reward and punishment processing could therefore reflect a motivational deficit that may contribute to the pathogenesis of Huntington's disease...
  47. doi request reprint Social skills and behavioral problems in schizophrenia: the role of mental state attribution, neurocognition and clinical symptomatology
    Martin Brune
    Research Department for Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Germany
    Psychiatry Res 190:9-17. 2011
    ..As such, training to target social cognitive skills, including mental state attribution, may be particularly beneficial for patients' social functioning...
  48. ncbi request reprint A Ser9Gly polymorphism in the dopamine D3 receptor gene (DRD3) and event-related P300 potentials
    Christoph Mulert
    Department of Psychiatry, University of Munich, LMU, Munich, Germany
    Neuropsychopharmacology 31:1335-44. 2006
    ..Further studies should address the direct role of the DRD3 Ser9Gly polymorphism in attenuated P300 amplitudes in psychiatric disorders like schizophrenia or alcoholism...
  49. pmc Cooperation and deception recruit different subsets of the theory-of-mind network
    Silke Lissek
    Department of Neurology, Ruhr University Bochum, BG Kliniken Bergmannsheil, Bochum, Germany
    PLoS ONE 3:e2023. 2008
    ..These results indicate an important role for prefrontal cortex in processing a mismatch between a character's intention and another's expectations as required in complex social interactions...
  50. ncbi request reprint Gray matter abnormalities in subjects at ultra-high risk for schizophrenia and first-episode schizophrenic patients compared to healthy controls
    Henning Witthaus
    Early Recognition and Therapy Centre for Psychoses Bochum BoFit, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, Alexandrinenstrasse 1, 44791, Germany
    Psychiatry Res 173:163-9. 2009
    ..This study provides further evidence that gray matter brain volume, especially in the anterior cingulate cortex, is already reduced in the prodromal state of schizophrenia...
  51. ncbi request reprint Rostral anterior cingulate cortex activity in the theta band predicts response to antidepressive medication
    Christoph Mulert
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Clin EEG Neurosci 38:78-81. 2007
    ..In addition to major differences between responders and nonresponders in the rostral ACC, we have identified a nearby region in the midline orbito-frontal region...
  52. ncbi request reprint The loudness dependence of auditory evoked potentials and effects of psychopathology and psychopharmacotherapy in psychiatric inpatients
    Julia Ostermann
    Department of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr University Bochum, LWL University Hospital Bochum, Bochum, Germany
    Hum Psychopharmacol 27:595-604. 2012
    ..Many studies have provided evidence for the loudness dependence of auditory evoked potentials (LDAEP) as a marker for central serotonergic activity but remained inconclusive for its suitability in clinical use...
  53. pmc Neuroanatomical correlates of suicide in psychosis: the possible role of von Economo neurons
    Martin Brune
    Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, University Hospital Bochum, Bochum, Germany
    PLoS ONE 6:e20936. 2011
    ..VEN density in the ACC seems to be increased in suicide victims with psychosis. This finding may support the assumption that VEN have a special role in emotion processing and self-evaluation, including negative self-appraisal...
  54. doi request reprint Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology
    Nadine Schaaff
    Department of Psychiatry, Ludwig Maximilian University of Munich, Germany
    Psychiatry Res 199:181-7. 2012
    ..The significant clinical correlations suggest monoaminergic modulations of psychopathology on the symptom level...
  55. ncbi request reprint White matter abnormalities in subjects at ultra high-risk for schizophrenia and first-episode schizophrenic patients
    Henning Witthaus
    Early Recognition and Therapy Centre for beginning psychosis Bochum BoFit, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr University of Bochum, 44791 Bochum, Germany
    Schizophr Res 102:141-9. 2008
    ..Furthermore, white matter abnormalities seem to progress after transition into schizophrenia...
  56. doi request reprint Face and body perception in schizophrenia: a configural processing deficit?
    Denise Soria Bauser
    Institute of Cognitive Neuroscience, Dept of Neuropsychology, Faculty of Psychology, Universitatsstrase 150, Ruhr University Bochum, Germany
    Psychiatry Res 195:9-17. 2012
    ..The magnitude of the inversion effects was not related to clinical symptoms. Overall, the data point towards reduced configural processing, not only for faces but also for bodies and cars in individuals with schizophrenia...
  57. ncbi request reprint [123I] ADAM brainstem binding correlates with the loudness dependence of auditory evoked potentials
    Oliver Pogarell
    Dept of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-7. 2008
    ..01). Associations between LD and SERT availability contribute to the understanding of the central serotonergic system and further validate the use of neurophysiological approaches as indirect measures of neurochemical brain activity...
  58. doi request reprint Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia
    Christine Winter
    Department of Psychiatry and Psychotherapy, University Medicine Berlin, Berlin, Germany
    Int J Neuropsychopharmacol 12:513-24. 2009
    ....
  59. ncbi request reprint Differential effects of reboxetine and citalopram on hand-motor function in patients suffering from major depression
    Ulrich Hegerl
    Laboratory of Clinical Neurophysiology, Department of Psychiatry, Ludwig Maximilians Universitat Munchen, Nussbaumstr 7, 80336, Munich, Germany
    Psychopharmacology (Berl) 178:58-66. 2005
    ..However, the effects of antidepressants on motor function in depression have rarely been analyzed systematically. Computerized methods allow the objective registration of drug-induced motor dysfunction and were applied in this study...
  60. ncbi request reprint Elevated brain serotonin transporter availability in patients with obsessive-compulsive disorder
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
    Biol Psychiatry 54:1406-13. 2003
    ..The aim of this study was to investigate the serotonin transporter availability in patients with OCD as an in vivo marker of the central serotonergic system...
  61. doi request reprint High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats
    Adrian Mundt
    Department of Psychiatry and Psychotherapy, Charite Campus Mitte, Charite University Medicine, Berlin, Germany
    Eur J Neurosci 29:2401-12. 2009
    ..We therefore conclude that both, the NAc core and shell constitute potential target structures in the treatment of OCD...
  62. doi request reprint No association between chronic cannabis use and loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmission
    Patrik Roser
    Department of Psychiatry, Ruhr University, Alexandrinenstr 1, 44791 Bochum, Germany
    Neurosci Lett 465:113-7. 2009
    ..It can be suggested that significant alterations in serotonergic systems may rather be related to acute activation of the endogenous cannabinoid system or to cannabis dependence accompanied by manifest depressive symptoms...
  63. ncbi request reprint Serotonergic neurotransmission in early Parkinson's disease: a pilot study to assess implications for depression in this disorder
    Jan C Beucke
    Department of Clinical Psychology, Humboldt University, Berlin, Germany
    World J Biol Psychiatry 11:781-7. 2010
    ..We hypothesized a serotonergic as well as a dopaminergic deficit in PD patients. We also assumed a correlation between these neurotransmitters indicating a relationship between dopaminergic and serotonergic function in PD...
  64. doi request reprint The illness and everyday living: close interplay of psychopathological syndromes and psychosocial functioning in chronic schizophrenia
    Daniela Schaub
    LWL University Hospital, Department of Psychiatry, Psychotherapy, Psychosomatics and Preventive Medicine, Ruhr University Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
    Eur Arch Psychiatry Clin Neurosci 261:85-93. 2011
    ..Findings prove the close interplay between social functioning and psychopathology in the chronic course of schizophrenia...
  65. doi request reprint An fMRI study of "theory of mind" in at-risk states of psychosis: comparison with manifest schizophrenia and healthy controls
    Martin Brune
    Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Ruhr University Bochum, LWL University Hospital, Germany
    Neuroimage 55:329-37. 2011
    ..We therefore examined ToM in subjects at risk of developing psychosis using an fMRI paradigm and compared brain activations with those of patients with manifest schizophrenia and healthy controls...
  66. doi request reprint Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilian University of Munich, Germany
    Psychiatry Res 194:212-8. 2011
    ..This association might be of relevance for the interpretation of P300 studies in psychiatric disorders...
  67. doi request reprint Von Economo neuron density in the anterior cingulate cortex is reduced in early onset schizophrenia
    Martin Brune
    Research Department for Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, LWL University Hospital Bochum, Ruhr University Bochum, Bochum, Germany
    Acta Neuropathol 119:771-8. 2010
    ..These findings suggest that VENs in the ACC are involved in neurodevelopmental and perhaps neurodegenerative processes specific to schizophrenia...
  68. ncbi request reprint Early mood swings as symptoms of the bipolar prodrome: preliminary results of a retrospective analysis
    Seza Ozgurdal
    Department of Psychiatry, Ruhr University Bochum, LWL University Hospital Bochum, Bochum, Germany
    Psychopathology 42:337-42. 2009
    ..The aim of this study was to investigate the relationship between affective temperament and mood swings in bipolar disorder. We explored these clinical features retrospectively...
  69. doi request reprint Evaluation of basal ganglia, brainstem raphe and ventricles in bipolar disorder by transcranial sonography
    Christos Krogias
    Dept of Neurology, Ruhr University Bochum, St Josef Hospital, Gudrunstr 56, Bochum, Germany
    Psychiatry Res 194:190-7. 2011
    ..If bipolar disorder coexists with hypoechogenic raphe structure, depressive symptoms are more severe...
  70. ncbi request reprint 1 H-MR spectroscopy in ultra-high risk and first episode stages of schizophrenia
    Idun Uhl
    Dept of Psychiatry, Ruhr University Bochum, LWL University Hospital Bochum, Alexandrinenstrasse 1, 44791 Bochum, Germany
    J Psychiatr Res 45:1135-9. 2011
    ..Careful LCModel analyses revealed no differences between the patient groups and 31 healthy controls, casting doubt upon the idea of metabolic changes in early stages of psychosis...
  71. doi request reprint Nonverbal behavior during standardized interviews in patients with schizophrenia spectrum disorders
    Martin Brune
    Centre for Psychiatry, Psychotherapy, Psychosomatics and Preventative Medicine, University of Bochum, Germany
    J Nerv Ment Dis 196:282-8. 2008
    ..Culture-specific nonverbal expressivity seems to play an additional (minor) role in distinguishing patients from healthy controls...
  72. doi request reprint Cognitive and affective empathy in depression linked to executive control
    Patrizia Thoma
    Institute of Cognitive Neuroscience, Dept of Neuropsychology, Ruhr University Bochum, Germany
    Psychiatry Res 189:373-8. 2011
    ..Impairments in this regard could contribute to the interpersonal difficulties depressed patients are frequently faced with which might have important implications for treatment...
  73. ncbi request reprint An fMRI study of theory of mind in schizophrenic patients with "passivity" symptoms
    Martin Brune
    Department of Psychiatry, Ruhr University Bochum, LWL Hospital, Alexandrinenstr 1, 44791 Bochum, Germany
    Neuropsychologia 46:1992-2001. 2008
    ..These findings suggest abnormal activation of those brain areas involved in the evaluation of self-reference during mental state attribution...
  74. doi request reprint Comparison of self- and clinician's ratings of Personal and Social Performance in patients with schizophrenia: the role of insight
    Daniela Schaub
    Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Bochum, Germany
    Psychopathology 45:109-16. 2012
    ....
  75. ncbi request reprint Integration of fMRI and simultaneous EEG: towards a comprehensive understanding of localization and time-course of brain activity in target detection
    Christoph Mulert
    Department of Psychiatry, LMU, Nussbaumstrasse 7, 80336 Munich, Germany
    Neuroimage 22:83-94. 2004
    ..The results suggest that the combination of EEG and fMRI permits an improved understanding of the spatiotemporal dynamics of brain activity...
  76. pmc An rTMS study into self-face recognition using video-morphing technique
    Christine Heinisch
    Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, University of Bochum, LWL University Hospital, Alexandrinenstr 1, D 44791 Bochum, Germany
    Soc Cogn Affect Neurosci 6:442-9. 2011
    ..The transition from an unfamiliar face to one's own face indicated a left frontal lateralization...
  77. doi request reprint Association between a cannabinoid receptor gene (CNR1) polymorphism and cannabinoid-induced alterations of the auditory event-related P300 potential
    Andreas M Stadelmann
    Department of Psychiatry and Psychotherapy, Charite University Hospital Berlin, Berlin, Germany
    Neurosci Lett 496:60-4. 2011
    ..Moreover, it appears that variations within CNR1 may differentially alter the sensitivity to the acute effects of cannabinoids on P300 generation in healthy subjects...
  78. doi request reprint COMT Val108/158Met genotype modulates human sensory gating
    Tomislav Majic
    Clinic for Psychiatry and Psychotherapy, Charite University Medicine, Campus Mitte, Berlin, Germany
    Neuroimage 55:818-24. 2011
    ..It is however unclear if COMT genotype as a predictor of prefrontal efficiency modulates sensory gating on the level of the auditory cortex, i.e. the gating of the auditory evoked P50 and N100 components...
  79. pmc Dopamine and serotonin levels following prenatal viral infection in mouse--implications for psychiatric disorders such as schizophrenia and autism
    Christine Winter
    Department of Psychiatry, Charite, Campus Mitte, Berlin, Germany
    Eur Neuropsychopharmacol 18:712-6. 2008
    ..The present study shows that the serotonergic system is disrupted following prenatal viral infection, potentially modelling disruptions that occur in patients with schizophrenia and autism...
  80. ncbi request reprint EEG abnormalities associated with antipsychotics: a comparison of quetiapine, olanzapine, haloperidol and healthy subjects
    Benedikt L Amann
    Department of Psychiatry, Section of Clinical Neurophysiology, University of Munich, Germany
    Hum Psychopharmacol 18:641-6. 2003
    ..To our knowledge, this is the first electrophysiological investigation comparing the new atypical antipsychotics quetiapine, haloperidol, olanzapine with healthy subjects...
  81. ncbi request reprint Facial expressions and personality: a kinematical investigation during an emotion induction experiment
    Roland Mergl
    Department of Psychiatry, Ludwig Maximilians University Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
    Neuropsychobiology 54:114-9. 2006
    ....
  82. ncbi request reprint Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing
    Jurgen Gallinat
    Department of Psychiatry, Free University of Berlin, Eschenallee 3, 14050 Berlin, Germany
    Neuropsychopharmacology 28:530-2. 2003
    ..The LD may serve as endophenotype in human serotonin research...
  83. ncbi request reprint Trauma exposure and post-traumatic stress disorder in bipolar disorder
    Hans Jörg Assion
    Department of Psychiatry and Psychotherapy, LWL Hospital, Ruhr University Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
    Soc Psychiatry Psychiatr Epidemiol 44:1041-9. 2009
    ..There is a lack of data about post-traumatic stress disorder (PTSD) in European bipolar patients compared to the US-population. This study was conducted to ascertain the rates and types of traumatic events and PTSD in bipolar-I disorder...
  84. ncbi request reprint P300 subcomponents in obsessive-compulsive disorder
    Paraskevi Mavrogiorgou
    Department of Psychiatry, Section of Clinical Neurophysiology and Outpatient Clinic for Obsessive Compulsive Disorder, Ludwig Maximilians University Munich, Germany
    J Psychiatr Res 36:399-406. 2002
    ....
  85. doi request reprint Psychoeducation with patients at-risk for schizophrenia--an exploratory pilot study
    Marta Hauser
    Early Recognition and Therapy Centre for Beginning Psychoses Berlin Brandenburg FETZ, Department of Psychiatry and Psychotherapy, Charité University Medicine Campus Mitte, Berlin, Germany
    Patient Educ Couns 76:138-42. 2009
    ..To introduce a psychoeducational program for patients of at-risk mental state and its preliminary evaluation...
  86. ncbi request reprint Impairment of probabilistic reward-based learning in schizophrenia
    Julia A Weiler
    Institute of Cognitive Neuroscience, Department of Neuropsychology, Ruhr University Bochum, Bochum, Germany
    Neuropsychology 23:571-80. 2009
    ..In summary, although there was evidence of intact basic processing of reward magnitudes, individuals with schizophrenia were impaired at using this feedback for the adaptive guidance of behavior...
  87. ncbi request reprint "Theory of mind" and executive functioning in forensic patients with schizophrenia
    Karina Majorek
    Department of Psychiatry, University of Bochum, LWL University Hospital, Germany
    J Forensic Sci 54:469-73. 2009
    ....
  88. ncbi request reprint Effects of sertraline on kinematic aspects of hand movements in patients with obsessive-compulsive disorder
    Roland Mergl
    Department of Psychiatry, Laboratory of Clinical Neurophysiology, Ludwig Maximilians Universitat Munchen, Nussbaumstrasse 7, 80336, Munchen, Germany
    Psychopharmacology (Berl) 171:179-85. 2004
    ..Movement disorders such as disturbances of fine motor co-ordination are a frequent phenomenon in patients with obsessive-compulsive disorder (OCD)...
  89. ncbi request reprint Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study
    Georg Juckel
    Department of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Germany
    Psychiatry Res 158:79-82. 2008
    ..Thus, we were able again to demonstrate electrophysiological evidence for an upregulated serotonergic system in schizophrenia...
  90. doi request reprint Rules of social exchange: game theory, individual differences and psychopathology
    Julia Wischniewski
    Department of Psychiatry, University of Bochum, LWL University Hospital, Alexandrinenstr 1, D 44791 Bochum, Germany
    Neurosci Biobehav Rev 33:305-13. 2009
    ....
  91. ncbi request reprint Dysfunction of ventral striatal reward prediction in schizophrenia
    Georg Juckel
    Department of Psychiatry, Charite University Medical Center, Campus Charite Mitte, CCM, Schumannstr 20 21, 10117 Berlin, Germany
    Neuroimage 29:409-16. 2006
    ..We used functional magnetic resonance imaging (fMRI) to assess the BOLD response in the ventral striatum of unmedicated schizophrenics during presentation of reward-indicating and loss-indicating stimuli...
  92. ncbi request reprint Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease
    Thomas Frodl
    Department of Psychiatry, Ludwig Maximilians University Munich, Germany
    Psychophysiology 39:175-81. 2002
    ..Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD...
  93. ncbi request reprint Quetiapine indication shift in the elderly: diagnosis and dosage in 208 psychogeriatric patients from 2000 to 2006
    Lorenz Hilwerling
    Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
    Int J Geriatr Psychiatry 22:401-4. 2007
    ..The approval of quetiapine for treatment of bipolar depression is expected. We hypothesized that the psychogeriatric prescription pattern for quetiapine shifts from the psychotic to the affective spectrum...
  94. ncbi request reprint High frequency stimulation of the subthalamic nucleus modulates neurotransmission in limbic brain regions of the rat
    Christine Winter
    Department of Neurology, Charite Campus Virchow, Berlin, Germany
    Exp Brain Res 185:497-507. 2008
    ..preceding lesion of the VTA seems to prohibit further detection of DA in the NAc. We conclude that STN-HFS significantly affects neurotransmission in the limbic system, which might contribute to explain the non-motor effects of STN-HFS...
  95. ncbi request reprint A single application of MK801 causes symptoms of acute psychosis, deficits in spatial memory, and impairment of synaptic plasticity in rats
    Denise Manahan-Vaughan
    Learning and Memory Research, Medical Faculty, Ruhr University Bochum, Germany
    Hippocampus 18:125-34. 2008
    ..These data suggest that treatment with MK801 to generate an acute psychotic episode in rats, gives rise to grave disturbances in synaptic plasticity and is associated with lasting impairments with the ability to form spatial memory...
  96. ncbi request reprint [Genetic and pharmacological effects on prefrontal cortical function in schizophrenia]
    Andreas Heinz
    Klinik fur Psychiatrie und Psychotherapie, Charite Campus Mitte, Charite Universitatsmedizin Berlin, Berlin
    Nervenarzt 75:845-56. 2004
    ..Molecular brain imaging combines imaging techniques with the assessment of genotype effects and represents a powerful tool for the understanding of neuropsychiatric disorders...
  97. ncbi request reprint Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression
    Peter Zill
    Psychiatric Hospital of the Ludwig Maximilians University Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Neuropsychopharmacology 26:489-93. 2002
    ..Our results suggest that the investigated polymorphisms are not major susceptibility factors in the etiology of major depression...
  98. ncbi request reprint Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 196:673-84. 2008
    ..This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor...
  99. ncbi request reprint An African patient with ziprasidone intolerance
    Jakob Hein
    J Clin Psychiatry 66:800. 2005
  100. doi request reprint Association of functional polymorphisms in NOS1 and NOS3 with loudness dependence of auditory evoked potentials
    Wolfram Kawohl
    Research Group Clinical and Experimental Psychopathology, Psychiatric University Hospital Zurich, Zurich, Switzerland
    Int J Neuropsychopharmacol 11:477-83. 2008
    ..Further studies are needed to fully clarify the relationship between nitrinergic transmission, LDAEP and complex disorders such as schizophrenia and affective disorders...
  101. ncbi request reprint [Kinematic movement analyses and their application in psychiatry]
    Georg Juckel
    Klinik fur Psychiatrie und Psychotherapie, Charite, Campus Mitte Berlin
    Psychiatr Prax 32:S31-7. 2005
    ..Thus, these methods are well suitable for relating them to other neurobiological parameters in order to contribute to the pathophysiological understanding of psycho-motor symptoms in psychiatric patients...