Robert Rude

Summary

Publications

  1. pmc Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton
    Helen E Gruber
    Department of Orthopaedic Surgery, Cannon Bldg, 3rd Floor, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28203, USA
    BMC Musculoskelet Disord 4:7. 2003
  2. ncbi Magnesium deficiency and osteoporosis: animal and human observations
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
    J Nutr Biochem 15:710-6. 2004
  3. ncbi Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption
    R K Rude
    University of Southern California, Los Angeles, USA
    Magnes Res 12:257-67. 1999
  4. doi TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone
    Robert K Rude
    Keck School of Medicine and Orthopaedic Hospital, University of Sourthern California, Los Angeles, CA, 90033, USA
    Growth Factors 27:370-6. 2009
  5. ncbi Skeletal and hormonal effects of magnesium deficiency
    Robert K Rude
    USC Keck School of Medicine, Los Angeles, CA, USA
    J Am Coll Nutr 28:131-41. 2009
  6. ncbi Magnesium deficiency: effect on bone and mineral metabolism in the mouse
    R K Rude
    University of Southern California and the Orthopaedic Hospital, 2025 Zonal Ave, Los Angeles, CA 90033, USA
    Calcif Tissue Int 72:32-41. 2003
  7. ncbi Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
    J Nutr 134:79-85. 2004
  8. ncbi Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism
    R K Rude
    University of Southern California and the Orthopaedic Hospital, 1975 Zonal Ave, GNH 6602, Los Angeles, CA 90089 9317, USA
    Osteoporos Int 17:1022-32. 2006
  9. ncbi Dietary magnesium reduction to 25% of nutrient requirement disrupts bone and mineral metabolism in the rat
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, 1975 Zonal Avenue, GNH 6602, Los Angeles, CA 90089 9317, USA
    Bone 37:211-9. 2005
  10. doi Variation of trabecular architecture in proximal femur of postmenopausal women
    Maria Grazia Ascenzi
    UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, Biomechanics Research, University of California at Los Angeles, CA, USA
    J Biomech 44:248-56. 2011

Research Grants

Collaborators

Detail Information

Publications15

  1. pmc Magnesium deficiency: effect on bone mineral density in the mouse appendicular skeleton
    Helen E Gruber
    Department of Orthopaedic Surgery, Cannon Bldg, 3rd Floor, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28203, USA
    BMC Musculoskelet Disord 4:7. 2003
    ..Dietary magnesium (Mg) deficiency in the mouse perturbs bone and mineral homeostasis. The objective of the present study was to evaluate bone mineral density of the femur in control and Mg-deficient mice...
  2. ncbi Magnesium deficiency and osteoporosis: animal and human observations
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
    J Nutr Biochem 15:710-6. 2004
    ..In this paper, we will review animal and human evidence of the association of Mg deficiency with osteoporosis and explore possible mechanisms by which this may occur...
  3. ncbi Magnesium deficiency-induced osteoporosis in the rat: uncoupling of bone formation and bone resorption
    R K Rude
    University of Southern California, Los Angeles, USA
    Magnes Res 12:257-67. 1999
    ..While the fall in PTH and/or 1.25(OH)2-D may explain a decrease in osteoblast activity, the mechanism for increased osteoclast activity is unclear. These data suggest that Mg deficiency may be a risk factor for osteoporosis...
  4. doi TNFalpha receptor knockout in mice reduces adverse effects of magnesium deficiency on bone
    Robert K Rude
    Keck School of Medicine and Orthopaedic Hospital, University of Sourthern California, Los Angeles, CA, 90033, USA
    Growth Factors 27:370-6. 2009
    ..No/B.Pm in the WT mice, with a trend toward greater eroded bone perimeter, as compared to TNF-r-KO. These findings suggest that TNFalpha may play a role in Mg deficiency-induced bone loss...
  5. ncbi Skeletal and hormonal effects of magnesium deficiency
    Robert K Rude
    USC Keck School of Medicine, Los Angeles, CA, USA
    J Am Coll Nutr 28:131-41. 2009
    ..These data support the notion at dietary Mg intake at levels not uncommon in humans may perturb bone and mineral metabolism and be a risk factor for osteoporosis...
  6. ncbi Magnesium deficiency: effect on bone and mineral metabolism in the mouse
    R K Rude
    University of Southern California and the Orthopaedic Hospital, 2025 Zonal Ave, Los Angeles, CA 90033, USA
    Calcif Tissue Int 72:32-41. 2003
    ....
  7. ncbi Bone loss induced by dietary magnesium reduction to 10% of the nutrient requirement in rats is associated with increased release of substance P and tumor necrosis factor-alpha
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, Los Angeles, CA 90089 9317, USA
    J Nutr 134:79-85. 2004
    ..These data demonstrated that a Mg intake of 10% of NR in rats causes bone loss that may be secondary to the increased release of substance P and TNF-alpha...
  8. ncbi Reduction of dietary magnesium by only 50% in the rat disrupts bone and mineral metabolism
    R K Rude
    University of Southern California and the Orthopaedic Hospital, 1975 Zonal Ave, GNH 6602, Los Angeles, CA 90089 9317, USA
    Osteoporos Int 17:1022-32. 2006
    ....
  9. ncbi Dietary magnesium reduction to 25% of nutrient requirement disrupts bone and mineral metabolism in the rat
    Robert K Rude
    University of Southern California and the Orthopaedic Hospital, 1975 Zonal Avenue, GNH 6602, Los Angeles, CA 90089 9317, USA
    Bone 37:211-9. 2005
    ..These data demonstrate that Mg intake of 25% NR in the rat causes lower bone mass which may be related to increased release of substance P and TNFalpha...
  10. doi Variation of trabecular architecture in proximal femur of postmenopausal women
    Maria Grazia Ascenzi
    UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, Biomechanics Research, University of California at Los Angeles, CA, USA
    J Biomech 44:248-56. 2011
    ..This phenomenon may render the local tissue less able to carry out the expected mechanical function...
  11. ncbi Preservation of bone mineral density of the proximal femur following hemisurface arthroplasty
    Harlan C Amstutz
    Joint Replacement Institute, J Vernon Luck, Sr Center for Orthopaedic Research, Los Angeles Orthopaedic Hospital, UCLA, 2400 S Flower St, Los Angeles, CA 90007 2697, USA
    Orthopedics 27:1266-71. 2004
    ..012 to -0.0300 g/cm2 in operated hips. These results support bone conservation and preservation with hemiresurfacing arthroplasty in young patients with osteonecrosis of the femoral head...
  12. ncbi Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease
    M Shechter
    Preventive and Rehabilitative Cardiac Center, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Cardiol 84:152-6. 1999
    ..These findings suggest a potential mechanism whereby magnesium may beneficially alter outcomes in patients with CAD...
  13. ncbi Genetic heterogeneity in familial renal magnesium wasting
    Vitaly Kantorovich
    Burns and Allen Research Institute, University of Southern California, School of Medicine, Los Angeles, California 90033, USA
    J Clin Endocrinol Metab 87:612-7. 2002
    ..In conclusion, our data demonstrate locus heterogeneity for the phenotype of isolated renal Mg wasting with hypomagnesemia and suggest that hypomagnesemia, at least in this pedigree, may be associated with low bone mass...
  14. ncbi Magnesium deficiency in critical illness
    Garrison M Tong
    University of Southern California, School of Medicine, Los Angeles, CA 90089 9317, USA
    J Intensive Care Med 20:3-17. 2005
    ....
  15. ncbi Bone mineral density screening: assessment of influence on prevention and treatment of osteoporosis
    Catherine Anastasopoulou
    University of Southern California, Keck School of Medicine and Orthopaedic Hospital, Los Angeles, California 90089 9317, USA
    Endocr Pract 8:199-201. 2002
    ..To assess the effect of bone mineral density (BMD) screening on the decision to initiate preventive or therapeutic measures for osteoporosis...

Research Grants3

  1. Magnesium Deficiency: Effect on Bone and Mineral
    Robert Rude; Fiscal Year: 2004
    ..These studies should substantiate our hypothesis that Mg depletion contributes to osteoporosis and provide mechanistic explanations. ..