Physiogenomic analysis of localized FMRI brain activity in schizophreniaAndreas Windemuth
Genomas, Inc, Hartford, CT, 06106, USA
Ann Biomed Eng 36:877-88. 2008
..The results of this study support the physiogenomic analysis of neuroimaging data to discover associations between genotype and disease-related phenotypes...
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazoneGUALBERTO RUANO
Genomas, Inc, 67 Jefferson St, Hartford, CT, United States
Clin Chim Acta 400:48-55. 2009
..The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema...
- Implementing genotype-guided antithrombotic therapy
Richard L Seip
Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Future Cardiol 6:409-24. 2010
..The US FDA-mandated drug labeling recognizes the relevance of genotyping in the selection and dosing of both warfarin and clopidogrel...
- Physiogenomic analysis of the Puerto Rican population
GUALBERTO RUANO
Genomas Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Pharmacogenomics 10:565-77. 2009
..This research was aimed at determining the frequencies of SNPs in key physiological, pharmacological and biochemical genes to infer population structure and ancestry in the Puerto Rican population...
- Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
GUALBERTO RUANO
Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Pharmacogenomics 11:959-71. 2010
..We hypothesized novel genetic underpinnings for variation in LDLC levels in the context of statin therapy...
Physiogenomic association of statin-related myalgia to serotonin receptorsGUALBERTO RUANO
Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
Muscle Nerve 36:329-35. 2007
..Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients...
- Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis
GUALBERTO RUANO
Genomas, Inc, 67 Jefferson St, Hartford, CT 06106, USA
Pharmacogenomics 6:865-72. 2005
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- Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
GUALBERTO RUANO
Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Atherosclerosis 185:65-9. 2006
..3+/-6.6 mg/dL versus 4.7+/-1.2 mg/dL, p<0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training...
- Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patients
GUALBERTO RUANO
Genomas Inc, Hartford, CT 06106, USA
Biomark Med 5:439-49. 2011
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- Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
Andreas Windemuth
Genomas, Inc and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA
Prog Neuropsychopharmacol Biol Psychiatry 36:213-9. 2012
..We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population...
- CYP2C9 and VKORC1 genotypes in Puerto Ricans: A case for admixture-matching in clinical pharmacogenetic studies
David Villagra
Laboratory of Personalized Health, Genomas, Inc, Hartford, CT 06106, USA
Clin Chim Acta 411:1306-11. 2010
..Accordingly, this study is aimed at investigating whether a correlation between overall genetic similarity and CYP2C9 and/or VKORC1 genotypes could be established...
- Mechanisms of statin-induced myalgia assessed by physiogenomic associations
GUALBERTO RUANO
Genetics Research Center, Hartford Hospital, Hartford, CT, USA
Atherosclerosis 218:451-6. 2011
..We investigated genetic variants predictive of muscular side effects in patients treated with statins. We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia...
- Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genes
David Villagra
Genomas Inc, Hartford, CT, USA
Biomark Med 5:427-38. 2011
..Each index considers all three genes as complementary components of a liver enzyme drug metabolism system and uniquely benchmarks innate hepatic drug metabolism reserve or alteration through CYP450 combinatory genotype scores...
- CYP2C19 genotype-guided antiplatelet therapy in a patient with clopidogrel resistance
Mridula Rai
Hartford Hospital, Hartford, USA
Conn Med 76:267-72. 2012
..A medication switch to prasugrel,which does not rely on activation by the 2C19 enzyme, reduced platelet reactivity by 86%. The patient has suffered no cardiovascular events in the 18 months since initiation of prasugrel therapy...
- Guidance of pharmacotherapy in a complex psychiatric case by CYP450 DNA typing
Joan Landino
Integrated Psychiatric Services, Inc, North Haven, Connecticut, USA
J Am Acad Nurse Pract 23:459-63. 2011
..To illustrate the utility of CYP450 genotyping to guide clinical psychopharmacological treatment decisions and minimize or avoid harmful and costly adverse drug reactions (ADRs)...
- Genetic associations of brain structural networks in schizophrenia: a preliminary study
Kanchana Jagannathan
Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut 06106, USA
Biol Psychiatry 68:657-66. 2010
..We used structural parameters as potential intermediate illness markers to investigate genomic factors derived from single nucleotide polymorphism (SNP) arrays...
- Somatic complications of psychotropic medications in a patient with multiple CYP2 drug metabolism deficiencies
GUALBERTO RUANO
Genomas Inc, Hartford, USA
Conn Med 71:197-200. 2007
..DNA typing for multigene CYP2 deficiencies is diagnostically useful in individuals with histories of multiple ADRs, which could be avoided by DNA-guided individualized prescription...
- Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
Richard L Seip
Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
Nutr Metab (Lond) 5:4. 2008
..We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets...
- Pharmacogenomic data submissions to the FDA: clinical pharmacology case studies
GUALBERTO RUANO
Genomas LLC, New Haven, CT, USA
Pharmacogenomics 5:513-7. 2004
- DNA collage and personalized medicine
GUALBERTO RUANO
Genomas, USA
Conn Med 72:322. 2008
- The pharmacogenomics of warfarin (Coumadin) administration
GUALBERTO RUANO
Laboratory of Personalized Health, Genomas, USA
Conn Med 70:251-2. 2006
- Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction
Alan H B Wu
Department of Pathology and Laboratory Medicine, Hartford Hospital, 80 Seymour St, Hartford, CT 06102, USA
Clin Chim Acta 346:211-9. 2004
..With new rapid ED assessment protocols, there is increasing pressure to produce results with a short turnaround time (TAT), and point-of-care (POC) testing is one alternative for providing fast results...
