Ruan L, Liu H, Shi H. Characterization and function of GSK3? from Litopenaeus vannamei in WSSV infection. Fish Shellfish Immunol. 2018;82:220-228 pubmed publisher
..The study will be helpful for understanding the molecular mechanism of host-virus interaction. ..
Ruan L, Sun J, Zhou C, Shi H, Lei K. Cloning, identification and function analysis of a Chibby homolog from Litopenaeus vannamei. Fish Shellfish Immunol. 2018;78:114-120 pubmed publisher
..In sum, these results implied that Wnt/?-catenin signal pathway plays an important role in the defense against virus, and Chibby could be modulated by WSSV to regulate the signal pathway. ..
Shi H, Guo G, Liu R, Wang C, Xu X, Ruan L. Membrane associated protein flotillin-2 in Litopenaeus vannamei plays a role in WSSV infection. Fish Shellfish Immunol. 2016;54:247-53 pubmed publisher
..These observations indicated that Lvflotillin-2 was involved in WSSV infection, and presented here should be useful for gaining insight into shrimp immunity and WSSV pathogenesis. ..
Wang C, Ruan L, Shi H, Xu X. Wnt5b regulates apoptosis in Litopenaeus vannamei against white spot syndrome virus. Fish Shellfish Immunol. 2018;74:318-324 pubmed publisher
..It will be helpful for understanding the function of Wnt signaling pathway in virus invasion and host defense. ..
Yao D, Ruan L, Lu H, Shi H, Xu X. Shrimp STAT was hijacked by white spot syndrome virus immediate-early protein IE1 involved in modulation of viral genes. Fish Shellfish Immunol. 2016;59:268-275 pubmed publisher
..In conclusion, our findings revealed a novel linkage between WSSV IE1 and shrimp STAT, which was a clue to well understand how WSSV adopted the active strategies to modulate the shrimp signaling pathway. ..
Yao D, Ruan L, Xu J, Shi H, Xu X. Characterization of a novel non-receptor tyrosine kinase Src from Litopenaeus vannamei and its response to white spot syndrome virus infection. Fish Shellfish Immunol. 2017;68:377-385 pubmed publisher
..In sum, our studies suggested that LvSrc might act in the FAK-regulated signaling pathway during WSSV infection, which would give us a better insight in understanding the role of SKFs in host-virus interactions in crustaceans. ..
Dong Q, Ruan L, Shi H. A ?-agarase with high pH stability from Flammeovirga sp. SJP92. Carbohydr Res. 2016;432:1-8 pubmed publisher
..It can hydrolyze the ?-1, 4-glycosidic linkages of agarose, yielding neoagarotetraose and neoagarohexaose as the main products. These properties could make AgaB has a potential application in the food, cosmetic and medical industries. ..
Sun J, Ruan L, Zhou C, Shi H, Xu X. Characterization and function of a Î²-catenin homolog from Litopenaeus vannamei in WSSV infection. Dev Comp Immunol. 2017;76:412-419 pubmed publisher
..Conclusively, our study provided evidences that Î²-catenin may participate in the WSSV infection, and Wnt/Î²-catenin signal pathway may play an important role in immune regulation. ..