Rare HLA drive additional HIV evolution compared to more frequent allelesChristine M Rousseau
Department of Microbiology, University of Washington, Seattle, Washington 98103, USA
AIDS Res Hum Retroviruses 25:297-303. 2009
..05), suggesting that rare HLA alleles provide a disproportionate force driving viral evolution compared to common alleles, likely due to the loss of preexisting escape variants during early stages postinfection...
- Association of levels of HIV-1-infected breast milk cells and risk of mother-to-child transmission
Christine M Rousseau
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA
J Infect Dis 190:1880-8. 2004
..09; P=.03) and breast milk (HR, 1.01; P=1.00). This suggests that infected BMCs may play a more important role in transmission of HIV via breast-feeding than does cell-free virus...
- Subtype C Is associated with increased vaginal shedding of HIV-1
Grace C John-Stewart
Department of Medicine, University of Washington, Seattle, 98104, USA
J Infect Dis 192:492-6. 2005
..4-8.8]; P = .006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [95% CI, 1.1-8.6]; P = .03). These observations suggest that HIV-1 subtype influences mucosal shedding of HIV-1...
- Extensive intrasubtype recombination in South African human immunodeficiency virus type 1 subtype C infections
Christine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 81:4492-500. 2007
..Thus, intrasubtype recombinants are common within the subtype C epidemic and these impact analyses of HIV-1 evolution...
- Broad and Gag-biased HIV-1 epitope repertoires are associated with lower viral loads
Morgane Rolland
Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 3:e1424. 2008
..e., the intrinsic ability to present fewer, more or specific viral epitopes, could affect clinical markers of disease progression...
- HLA class I-driven evolution of human immunodeficiency virus type 1 subtype c proteome: immune escape and viral load
Christine M Rousseau
Department of Microbiology, University of Washington, 1959 NE Pacific Street, Box 358070, Seattle, WA 98195 8070, USA
J Virol 82:6434-46. 2008
....
Large-scale amplification, cloning and sequencing of near full-length HIV-1 subtype C genomesChristine M Rousseau
Department of Microbiology, University of Washington, Seattle, WA 98195 8070, USA
J Virol Methods 136:118-25. 2006
..The methods are readily adaptable to other HIV-1 subtypes, and provide materials for viral functional analyses and population-based molecular epidemiology studies that include analysis of viral genome chimerization...
- Longitudinal analysis of human immunodeficiency virus type 1 RNA in breast milk and of its relationship to infant infection and maternal disease
Christine M Rousseau
Department of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, Seattle, WA 98109 1024, USA
J Infect Dis 187:741-7. 2003
..3-3.0; P<.001). These results indicate that the risk of infant infection from breast-feeding is influenced by breast-milk virus load, which is highest early after delivery...
