Injectable therapies for localized fat loss: state of the artDiane Duncan
Clin Plast Surg 38:489-501, vii. 2011
..Several medications with novel detergent and lipolytic activity are in development and have demonstrated potential as minimally invasive fat reducing treatments...
Poly-L-lactic acid: a new dimension in soft tissue augmentationAdam M Rotunda
Department of Dermatology, Mohs Micrographic Surgery and Cutaneous Oncology, Bennett Surgery Center, University of Southern California Keck School of Medicine, USA
Dermatol Ther 19:151-8. 2006
..The present authors reviewed the background and clinical applications of PLLA as treatment for HIV-associated facial lipoatrophy and age-related facial volume loss...
- Mesotherapy and phosphatidylcholine injections: historical clarification and review
Adam M Rotunda
Department of Dermatology, University of Southern California School of Medicine, Los Angeles, California, USA
Dermatol Surg 32:465-80. 2006
..Despite their attraction as purported "fat-dissolving" injections, the safety and efficacy of these novel cosmetic treatments remain ambiguous to most patients and physicians...
- Cellulite: Is there a role for injectables?
Adam M Rotunda
Department of Dermatology, University of Southern California Keck School of Medicine, Bennett Surgery Center, Santa Monica, CA 90404, USA
J Cosmet Laser Ther 7:147-54. 2005
..Mesotherapy, a method of delivering medication locally with the use of numerous cutaneous injections, has recently become a popular method to purportedly treat the condition...
- Lipomas treated with subcutaneous deoxycholate injections
Adam M Rotunda
Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
J Am Acad Dermatol 53:973-8. 2005
..Injections of phosphatidylcholine solubilized with deoxycholate, a bile salt, have been used to reduce unwanted accumulations of fat. Recent in vitro and ex vivo investigations indicate that deoxycholate alone causes adipocyte lysis...
- Injectable treatments for adipose tissue: terminology, mechanism, and tissue interaction
Adam M Rotunda
Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, CA 92660, USA
Lasers Surg Med 41:714-20. 2009
..Just as injectable fillers have addressed the need for non-surgical methods to restore desired volume, a number of injectable therapies purpor to play a comparable role to reduce undesired volume...
- Randomized double-blind clinical trial of subcutaneously injected deoxycholate versus a phosphatidylcholine-deoxycholate combination for the reduction of submental fat
Adam M Rotunda
David Geffen School of Medicine, University of California at Los Angeles, 90095, USA
Dermatol Surg 35:792-803. 2009
..Subcutaneous injections consisting of the detergent, sodium deoxycholate, alone or in combination with the phospholipid, phosphatidylcholine, have been reported to reduce adipose tissue. The role of phosphatidylcholine remains unclear...
- Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution
Adam M Rotunda
Division of Dermatology, University of California Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
Dermatol Surg 30:1001-8. 2004
..Detergent substances may have a role in eliminating unwanted adipose tissue. It is advised that physicians use caution until adequate safety data are available...
- The new age of acne therapy: light, lasers, and radiofrequency
Adam M Rotunda
Division of Dermatology, David Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA, USA
J Cosmet Laser Ther 6:191-200. 2004
..CONCLUSION: Research emphasizing long-term follow-up and comparative, randomized trials is necessary to determine whether these emerging technologies will become a viable alternative to standard therapies such as antibiotics...
- Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review
Glynis Ablon
West Los Angeles Veteran Administration Medical Center, Los Angeles, CA, USA
Dermatol Surg 30:422-7; discussion 428. 2004
..Current use internationally has led to a significant interest in this novel substance...
- Nasal tip wound repair using a rhombic transposition flap with a double Z-plasty at its base
Adam M Rotunda
Department of Dermatology, University of Southern California, School of Medicine, Los Angeles, CA, USA
Dermatol Surg 32:945-7. 2006
- Pemphigus foliaceus masquerading as postoperative wound infection: report of a case and review of the Koebner and related phenomenon following surgical procedures
Adam M Rotunda
Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Dermatol Surg 31:226-31. 2005
..Skin biopsies for histopathology and immunologic studies may be necessary for definitive diagnosis and optimal management...
- Injectable lipolysis: speculation vs. science
Adam M Rotunda
J Cosmet Dermatol 5:302. 2006
- Simultaneous subungual melanoma in situ of both thumbs
Adam M Rotunda
J Am Acad Dermatol 58:S42-4. 2008
- Unilateral Darier's disease associated with migraine headache responsive to isotretinoin
Adam M Rotunda
J Am Acad Dermatol 52:175-6. 2005
