Owen A Ross

Summary

Publications

  1. ncbi request reprint Global distribution and reduced penetrance: Lrrk2 R1441C in an Irish Parkinson's disease kindred
    David Gosal
    Mov Disord 22:291-2. 2007
  2. ncbi request reprint Common variants in Parkinson's disease
    Owen A Ross
    Mov Disord 22:899-900. 2007
  3. ncbi request reprint Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
    Owen A Ross
    Department of Geriatric Medicine, Belfast, Ireland
    Hum Immunol 65:340-6. 2004
  4. ncbi request reprint Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish
    Owen A Ross
    School of Biology and Biochemistry, Queens University of Belfast, Medical Biology Centre, and Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK
    Exp Gerontol 39:801-5. 2004
  5. ncbi request reprint Study of age-association with cytokine gene polymorphisms in an aged Irish population
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast BT9 7TS, UK
    Mech Ageing Dev 124:199-206. 2003
  6. ncbi request reprint mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast BT9 7TS, Northern Ireland, UK
    Exp Gerontol 38:397-405. 2003
  7. ncbi request reprint HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK
    Mech Ageing Dev 124:563-7. 2003
  8. ncbi request reprint Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Northern Ireland, Belfast, UK
    Exp Gerontol 38:561-5. 2003
  9. ncbi request reprint Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America
    Ashley Meenagh
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 63:1055-61. 2002
  10. ncbi request reprint Investigation of KIR diversity in immunosenescence and longevity within the Irish population
    Lynn D Maxwell
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland, UK
    Exp Gerontol 39:1223-32. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Global distribution and reduced penetrance: Lrrk2 R1441C in an Irish Parkinson's disease kindred
    David Gosal
    Mov Disord 22:291-2. 2007
  2. ncbi request reprint Common variants in Parkinson's disease
    Owen A Ross
    Mov Disord 22:899-900. 2007
  3. ncbi request reprint Functional promoter region polymorphism of the proinflammatory chemokine IL-8 gene associates with Parkinson's disease in the Irish
    Owen A Ross
    Department of Geriatric Medicine, Belfast, Ireland
    Hum Immunol 65:340-6. 2004
    ....
  4. ncbi request reprint Hypothetical soluble KIR2DS4 natural killer cell receptor molecule does not associate with successful ageing in the Irish
    Owen A Ross
    School of Biology and Biochemistry, Queens University of Belfast, Medical Biology Centre, and Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland, UK
    Exp Gerontol 39:801-5. 2004
    ....
  5. ncbi request reprint Study of age-association with cytokine gene polymorphisms in an aged Irish population
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast BT9 7TS, UK
    Mech Ageing Dev 124:199-206. 2003
    ..These findings would suggest that polymorphism of cytokine genes may not play as crucial a role in healthy ageing as previously believed...
  6. ncbi request reprint mt4216C variant in linkage with the mtDNA TJ cluster may confer a susceptibility to mitochondrial dysfunction resulting in an increased risk of Parkinson's disease in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast BT9 7TS, Northern Ireland, UK
    Exp Gerontol 38:397-405. 2003
    ..These findings lead one to postulate that the mt4216C variant, in linkage with the mtDNA TJ cluster, may influence mitochondrial dysfunction, resulting in an increased risk of PD...
  7. ncbi request reprint HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, BT9 7TS, Northern Ireland, Belfast, UK
    Mech Ageing Dev 124:563-7. 2003
    ..However, no age-related allele or genotype frequencies were observed for either polymorphic nucleotide...
  8. ncbi request reprint Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Northern Ireland, Belfast, UK
    Exp Gerontol 38:561-5. 2003
    ....
  9. ncbi request reprint Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America
    Ashley Meenagh
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast, Northern Ireland
    Hum Immunol 63:1055-61. 2002
    ..Five populations were investigated, Northern Ireland, South African Zulu, Omani, Singapore Chinese and Mexican Mestizos...
  10. ncbi request reprint Investigation of KIR diversity in immunosenescence and longevity within the Irish population
    Lynn D Maxwell
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland, UK
    Exp Gerontol 39:1223-32. 2004
    ..In view of the lack of studies to date, investigating the role of the KIR gene system in healthy ageing, further analysis of KIR diversity is required to fully elucidate it's role in respect to age-related disease and longevity...
  11. ncbi request reprint A novel polymorphic triplet repeat in intron five of the alpha-synuclein gene: no evidence of expansion or allelic association with idiopathic Parkinson's disease in the Irish
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, Belfast City Hospital, Belfast BT9 7TS, UK
    Neuroreport 13:1621-5. 2002
    ..These results would suggest that polymorphism of the alpha-synuclein gene may not play as significant a role in the pathogenesis of idiopathic PD as previously hypothesised...
  12. ncbi request reprint Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants
    Irene M Rea
    Department of Geriatric Medicine, Queens University of Belfast, Whitla Medical Building, 97, Lisburn Road, Belfast, UK
    Mech Ageing Dev 124:555-61. 2003
    ....
  13. ncbi request reprint Mitochondrial DNA damage in lymphocytes: a role in immunosenescence?
    Owen A Ross
    Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, Blood Transfusion Building, City Hospital, Belfast, Northern Ireland BT9 7TS, UK
    Exp Gerontol 37:329-40. 2002
    ..A similar explanation may also apply to the in vitro model of T cell ageing if the vast majority of the cells are replicating rather than entering senescence...
  14. ncbi request reprint Clinical traits of LRRK2-associated Parkinson's disease in Ireland: a link between familial and idiopathic PD
    David Gosal
    Department of Neurology, Mater Misericordiae Hospital, Eccles St, Dublin 7, Ireland
    Parkinsonism Relat Disord 11:349-52. 2005
    ..The influence of the G2019S substitution on protein function and disease phenotype has yet to be fully resolved, but its elucidation will undoubtedly further our understanding of the mechanisms underlying Parkinson's disease...
  15. pmc Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study
    Irene Maeve Rea
    School of Medicine, Dentistry and Biomedical Science, Whitla Medical Building, Queen s University Belfast, BT9 7BL, Belfast, Northern Ireland, UK
    Age (Dordr) 35:1445-56. 2013
    ..These findings are of interest in view of mtDNA J haplogroup's association with increased age in some previous studies. ..
  16. ncbi request reprint ELAVL4, PARK10, and the Celts
    Kristoffer Haugarvoll
    Department of Neuroscience and Neurology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Mov Disord 22:585-7. 2007
    ..Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect...
  17. ncbi request reprint Variants in the LRRK1 gene and susceptibility to Parkinson's disease in Norway
    Kristoffer Haugarvoll
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA, and Department of Neurology, St Olav s Hospital, Trondheim, Norway
    Neurosci Lett 416:299-301. 2007
    ..Two rare coding variants ss65713826 and ss65713830 were more frequent in patients than controls. However, their identification in healthy controls and lack of co-segregation with disease suggests they may represent benign polymorphisms...
  18. ncbi request reprint Frequency of cytokine gene promoter polymorphisms in the Northern Ireland cystic fibrosis population
    Alison P Watt
    Respiratory Research Group, The Queen s University of Belfast, United Kingdom
    J Cyst Fibros 6:363-5. 2007
    ..This study observed no differences in the frequency of cytokine promoter polymorphisms associated with variant levels of expression in patients with CF and a non-CF population of Northern Ireland...
  19. pmc Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Mech Ageing Dev 128:378-82. 2007
    ..It is now crucial to identify the susceptibility allele and elucidate its functionality which may generate a therapeutic target for PD...
  20. ncbi request reprint Lrrk2-associated parkinsonism is a major cause of disease in Northern Spain
    María C González-Fernández
    Servicio General de Investigación Genómica, Banco de ADN and Departamento de Z y Biología Celular A, Universidad del Pais Vasco, Vitoria Gasteiz, Spain
    Parkinsonism Relat Disord 13:509-15. 2007
    ..Our findings highlight the importance of Lrrk2 parkinsonism in this population and may have important consequences for its extended Diaspora in North, Central and South Americas...
  21. doi request reprint Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Ann Neurol 64:88-92. 2008
    ..20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LRRK2 variants in sporadic Parkinson's disease. Ann Neurol 2008...
  22. doi request reprint Genomic investigation of alpha-synuclein multiplication and parkinsonism
    Owen A Ross
    Division of Neurogenetics, Department of Neuroscience, College of Medicine, Mayo Clinic, Jacksonville, FL 32224, USA
    Ann Neurol 63:743-50. 2008
    ..Herein we characterize five families with parkinsonism that have been identified to harbor multiplication of the chromosomal 4q21 locus containing the alpha-synuclein gene (SNCA)...
  23. doi request reprint Corticobasal syndrome and primary progressive aphasia as manifestations of lrrk2 gene mutations
    Owen A Ross
    Neurology 71:303; author reply 303-4. 2008
  24. ncbi request reprint Lack of evidence for association of Parkin promoter polymorphism (PRKN-258) with increased risk of Parkinson's disease
    Owen A Ross
    Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 13:386-8. 2007
    ..These data do not support a role for this common variant in PD etiology...
  25. ncbi request reprint Lrrk2 G2385R is an ancestral risk factor for Parkinson's disease in Asia
    Matthew J Farrer
    Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 13:89-92. 2007
    ..Moreover, our findings demonstrate that common genetic coding variants contribute to Parkinson's disease in a population specific manner which may have important implications for future genome-wide association studies...
  26. ncbi request reprint Pathogenicity of the Lrrk2 R1514Q substitution in Parkinson's disease
    Mathias Toft
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    Mov Disord 22:389-92. 2007
    ..3; 95% CI: 0.6-2.8; P = 0.45). These findings highlight the importance of using family-based studies and multiple population screenings when examining the association of these polymorphic LRRK2 gene variants with Parkinson's disease...
  27. ncbi request reprint Phenotypic associations of tau and ApoE in Parkinson's disease
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, United States
    Neurosci Lett 414:141-4. 2007
    ..Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies...
  28. pmc Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations
    Jennifer Kachergus
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Am J Hum Genet 76:672-80. 2005
    ..Our work highlights the fact that a proportion of clinically typical, late-onset PD cases have a genetic basis...
  29. ncbi request reprint LRRK2 mutations and Parkinsonism
    Mathias Toft
    Lancet 365:1229-30. 2005
  30. ncbi request reprint LRRK2 mutations are not common in Alzheimer's disease
    Mathias Toft
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL, USA
    Mech Ageing Dev 126:1201-5. 2005
    ..However, these results do not exclude a possible role of other genetic variants within the LRRK2 gene in AD or other forms of dementia...
  31. ncbi request reprint Leucine-rich repeat kinase 1: a paralog of LRRK2 and a candidate gene for Parkinson's disease
    Julie P Taylor
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Neurogenetics 8:95-102. 2007
    ..Comparison of evolutionary interspecies sequences of LRRK1 and LRRK2 suggests they diverged from a common founder gene...
  32. pmc Genomewide association, Parkinson disease, and PARK10
    Matthew J Farrer
    Am J Hum Genet 78:1084-8; author reply 1092-4. 2006
  33. pmc Linkage disequilibrium and association of MAPT H1 in Parkinson disease
    Lisa Skipper
    Laboratories of Neurogenetics, Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Am J Hum Genet 75:669-77. 2004
    ..Using a sliding scale of MAPT H1-specific haplotypes--in age/sex-matched PD cases and controls from central Norway--we have refined the disease association to within an approximately 90-kb interval of the 5' end of the MAPT locus...
  34. pmc Lrrk2 mutations in South America: A study of Chilean Parkinson's disease
    Carolina Perez-Pastene
    Molecular and Clinical Pharmacology, ICBM, Faculty of Medicine, University of Chile, Casilla 70000, Santiago 7, Chile
    Neurosci Lett 422:193-7. 2007
    ..These findings suggest Lrrk2 G2019S may play an important role in Parkinson's disease on the South American Continent and further studies are now warranted...
  35. ncbi request reprint Clinical heterogeneity of the LRRK2 G2019S mutation
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
    Arch Neurol 63:1242-6. 2006
    ..The "common" LRRK2 G2019S kinase domain substitution has been reported to account for approximately 5% of familial and 1% of sporadic Parkinson disease...
  36. ncbi request reprint Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions
    Justus C Dachsel
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Acta Neuropathol 113:601-6. 2007
    ..These findings may be coincidental; however, there is a small nucleus of LRRK2-positive patients displaying atypical features suggesting a role for this protein in other neurodegenerative disorders...
  37. ncbi request reprint Lrrk2 and Lewy body disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 59:388-93. 2006
    ..The Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. Patients harboring the G2019S substitution usually present with clinical Parkinson's disease...
  38. ncbi request reprint Heterogeneity of Moyamoya disease: after a decade of linkage, is there new hope for a gene?
    James F Meschia
    Neurology 70:2353-4. 2008
  39. pmc Identification of potential protein interactors of Lrrk2
    Justus C Dachsel
    Department of Neuroscience and Neurology, Mayo Clinic College of Medicine, Birdsall Building, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 13:382-5. 2007
    ..Future investigation of these candidates is now warranted and may help resolve the pathomechanism behind Lrrk2 neurodegeneration...
  40. ncbi request reprint Digenic parkinsonism: investigation of the synergistic effects of PRKN and LRRK2
    Justus C Dachsel
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida, USA
    Neurosci Lett 410:80-4. 2006
    ..However, in vivo studies are required to assess whether there is an indirect link between Lrrk2 and parkin in disease pathogenesis...
  41. ncbi request reprint The ups and downs of alpha-synuclein mRNA expression
    Justus C Dachsel
    Mov Disord 22:293-5. 2007
  42. ncbi request reprint Lrrking in the background: common pathways of neurodegeneration
    Owen A Ross
    J Am Geriatr Soc 55:804-5. 2007