Brian Ross

Summary

Publications

  1. doi request reprint High-field MRS in clinical drug development
    Brian D Ross
    Huntington Medical Research Institutes, Magnetic Resonance Spectroscopy Unit, 10 Pico Street, Pasadena 91105, USA
    Expert Opin Drug Discov 8:849-63. 2013
  2. pmc Cardiovascular magnetics resonance diagnosis of cystic tumor of the atrioventricular node
    Thao T Tran
    Huntington Medical Research Institutes, Pasadena, CA, USA
    J Cardiovasc Magn Reson 11:13. 2009
  3. ncbi request reprint Application of NMR spectroscopy in medicinal chemistry and drug discovery
    Brian Ross
    Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Curr Top Med Chem 11:93-114. 2011
  4. doi request reprint Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism
    B D Ross
    Huntington Medical Research Institutes, Pasadena, California, USA
    AJNR Am J Neuroradiol 31:24-33. 2010
  5. ncbi request reprint Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia
    Kent Harris
    Magnetic Resonance Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Adv Exp Med Biol 576:263-73; discussion 361-3. 2006
  6. pmc Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study
    Napapon Sailasuta
    Clinical MR Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Neuropsychiatr Dis Treat 7:495-9. 2011
  7. doi request reprint Magnetic resonance spectroscopy in neurological diagnosis
    Thao Tran
    Clinical MRS Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
    Neurol Clin 27:21-60, xiii. 2009
  8. doi request reprint Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, USA
    NMR Biomed 22:326-31. 2009
  9. ncbi request reprint Clinical experience with 13C MRS in vivo
    Brian Ross
    Huntington Medical Research Institutes, 660 S Fair Oaks Avenue, Pasadena, CA 91105, USA
    NMR Biomed 16:358-69. 2003
  10. ncbi request reprint Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo
    P Bhattacharya
    MR Spectroscopy Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
    MAGMA 18:245-56. 2005

Collaborators

Detail Information

Publications11

  1. doi request reprint High-field MRS in clinical drug development
    Brian D Ross
    Huntington Medical Research Institutes, Magnetic Resonance Spectroscopy Unit, 10 Pico Street, Pasadena 91105, USA
    Expert Opin Drug Discov 8:849-63. 2013
    ..Published evidence based medicine (EBM) surveys, which generally conclude the opposite, are seriously flawed and do a disservice to the field of drug discovery...
  2. pmc Cardiovascular magnetics resonance diagnosis of cystic tumor of the atrioventricular node
    Thao T Tran
    Huntington Medical Research Institutes, Pasadena, CA, USA
    J Cardiovasc Magn Reson 11:13. 2009
    ..LGE CMR is also useful for identifying the nature of cardiac masses or lesions. We report a case of a rare primary cystic tumor of the atrioventricular node, in which CMR proved to be valuable...
  3. ncbi request reprint Application of NMR spectroscopy in medicinal chemistry and drug discovery
    Brian Ross
    Clinical Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Curr Top Med Chem 11:93-114. 2011
    ..Finally, recognizing that a known feature of MR is the lack of sensitivity, we describe new efforts to harness hyperpolarization, with its 50,000 signal amplification, to conventional MRS...
  4. doi request reprint Hyperpolarized MR imaging: neurologic applications of hyperpolarized metabolism
    B D Ross
    Huntington Medical Research Institutes, Pasadena, California, USA
    AJNR Am J Neuroradiol 31:24-33. 2010
    ..Recent developments in clinical (13)C neurospectroscopy encourage us to overcome the remaining barriers to clinical HD-MR imaging...
  5. ncbi request reprint Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia
    Kent Harris
    Magnetic Resonance Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Adv Exp Med Biol 576:263-73; discussion 361-3. 2006
  6. pmc Minimally invasive biomarker confirms glial activation present in Alzheimer's disease: a preliminary study
    Napapon Sailasuta
    Clinical MR Unit, Huntington Medical Research Institutes, Pasadena, CA, USA
    Neuropsychiatr Dis Treat 7:495-9. 2011
    ..The value of (13)C MRS as an early, noninvasive biomarker may lie in the conduct of cost-effective clinical trials...
  7. doi request reprint Magnetic resonance spectroscopy in neurological diagnosis
    Thao Tran
    Clinical MRS Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
    Neurol Clin 27:21-60, xiii. 2009
    ..Finally, we muse about the still-underappreciated role of MRS as a molecular neuroimaging technique and predict steady growth of this application as hyperpolarization MR technology approaches the clinic...
  8. doi request reprint Evidence of reduced glutamate in the frontal lobe of HIV-seropositive patients
    Napapon Sailasuta
    Huntington Medical Research Institutes, Pasadena, CA, USA
    NMR Biomed 22:326-31. 2009
    ..Our findings suggest that Glu neurotransmission is abnormal and may be a key target for early interventions to reduce the later incidence of neurocognitive impairment and dementia among HIV-seropositive patients...
  9. ncbi request reprint Clinical experience with 13C MRS in vivo
    Brian Ross
    Huntington Medical Research Institutes, 660 S Fair Oaks Avenue, Pasadena, CA 91105, USA
    NMR Biomed 16:358-69. 2003
    ..Despite low inherent signal-to-noise, natural abundance (13)C MRS showed diagnostic promise. (13)C MRS is feasible in a clinical setting, at reasonable cost in neonates, children, adults and elderly patients...
  10. ncbi request reprint Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo
    P Bhattacharya
    MR Spectroscopy Unit, Huntington Medical Research Institutes, 10 Pico Street, Pasadena, CA 91105, USA
    MAGMA 18:245-56. 2005
    ..The extreme brevity of signal enhancement obtained by hyperpolarization requires improved 13C MR in vivo imaging techniques for their optimum utility...
  11. ncbi request reprint Short-echo time proton MR spectroscopy in the presence of gadolinium
    A P Lin
    Magnetic Resonance Spectroscopy Unit, Huntington Medical Research Institutes, Pasadena, CA 91105, USA
    J Comput Assist Tomogr 25:705-12. 2001
    ..02). CONCLUSION: Proton MRS with TE of 30 ms may safely be used in combined contrast-enhanced MRI/MRS protocols. Further study is required with long-TE MRS because of the prolonged T2 of Cho...