R Rosmond

Summary

Publications

  1. ncbi request reprint The lean woman
    Fariba Baghaei
    Department of Heart and Lung Diseases, University of Goteborg, Goteborg, Sweden
    Obes Res 10:115-21. 2002
  2. pmc Association between serum levels of C-reactive protein and personality traits in women
    Susanne Henningsson
    Department of Neuroscience and Physiology, Section of Pharmacology, Goteborg University, P, O, Box 431, SE 405 30 Goteborg, Sweden
    Behav Brain Funct 4:16. 2008
  3. ncbi request reprint The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetes Metab Res Rev 19:159-63. 2003
  4. ncbi request reprint Role of stress in the pathogenesis of the metabolic syndrome
    Roland Rosmond
    Psychoneuroendocrinology 30:1-10. 2005
  5. ncbi request reprint [Contribution of stress to the development of the metabolic syndrome. In memory of Per Bjorntorp (1931-2003)]
    Roland Rosmond
    Lakartidningen 101:1371-5. 2004
  6. ncbi request reprint Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Biochim Biophys Acta 1588:103-5. 2002
  7. ncbi request reprint Obesity and depression: same disease, different names?
    Roland Rosmond
    Med Hypotheses 62:976-9. 2004
  8. ncbi request reprint The glucocorticoid receptor gene and its association to metabolic syndrome
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 10:1078-86. 2002
  9. doi request reprint A 5-year follow-up study of 3 polymorphisms in the human glucocorticoid receptor gene in relation to obesity, hypertension, and diabetes
    Roland Rosmond
    Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    J Cardiometab Syndr 3:132-5. 2008
  10. ncbi request reprint 5-HT2A receptor gene promoter polymorphism in relation to abdominal obesity and cortisol
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 10:585-9. 2002

Detail Information

Publications57

  1. ncbi request reprint The lean woman
    Fariba Baghaei
    Department of Heart and Lung Diseases, University of Goteborg, Goteborg, Sweden
    Obes Res 10:115-21. 2002
    ..In the current obesity epidemic, the ability to remain lean is beginning to be uncommon. Therefore, it was considered of interest to characterize such subjects...
  2. pmc Association between serum levels of C-reactive protein and personality traits in women
    Susanne Henningsson
    Department of Neuroscience and Physiology, Section of Pharmacology, Goteborg University, P, O, Box 431, SE 405 30 Goteborg, Sweden
    Behav Brain Funct 4:16. 2008
    ..abstract:..
  3. ncbi request reprint The Pro12Ala PPARgamma2 gene missense mutation is associated with obesity and insulin resistance in Swedish middle-aged men
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetes Metab Res Rev 19:159-63. 2003
    ..The Pro12Ala PPARgamma2 polymorphism has been variably associated with obesity, insulin sensitivity, and dyslipidemia...
  4. ncbi request reprint Role of stress in the pathogenesis of the metabolic syndrome
    Roland Rosmond
    Psychoneuroendocrinology 30:1-10. 2005
    ..In this review, we will discuss how such processes mediate a pathogenetic role in the Metabolic Syndrome...
  5. ncbi request reprint [Contribution of stress to the development of the metabolic syndrome. In memory of Per Bjorntorp (1931-2003)]
    Roland Rosmond
    Lakartidningen 101:1371-5. 2004
  6. ncbi request reprint Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Biochim Biophys Acta 1588:103-5. 2002
    ..From these data, we conclude that the C-->T substitution in exon 4 of the UCP2 gene does not contribute to the predisposition to be affected by the Metabolic Syndrome...
  7. ncbi request reprint Obesity and depression: same disease, different names?
    Roland Rosmond
    Med Hypotheses 62:976-9. 2004
    ..In this paper, we propose the notion that obesity and depression may represent different manifestations of the same disease process - Janus faces of the modern society...
  8. ncbi request reprint The glucocorticoid receptor gene and its association to metabolic syndrome
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 10:1078-86. 2002
    ..Further studies focusing on the most compelling GR mutations might offer a better understanding of metabolic syndrome pathogenesis and progression, aiding in the development of more effective treatments for this condition...
  9. doi request reprint A 5-year follow-up study of 3 polymorphisms in the human glucocorticoid receptor gene in relation to obesity, hypertension, and diabetes
    Roland Rosmond
    Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    J Cardiometab Syndr 3:132-5. 2008
    ..It is concluded that the genetic information about GRL would be useful for further genetic study of obesity, diabetes, and related metabolic diseases...
  10. ncbi request reprint 5-HT2A receptor gene promoter polymorphism in relation to abdominal obesity and cortisol
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 10:585-9. 2002
    ....
  11. ncbi request reprint Association between a variant at the GABA(A)alpha6 receptor subunit gene, abdominal obesity, and cortisol secretion
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Ann N Y Acad Sci 967:566-70. 2002
    ..The pathophysiology may involve various environmental factors, particularly stress, that destabilize the GABA-hypothalamic-pituitary-adrenal systems in those with genetic vulnerability...
  12. ncbi request reprint Increased abdominal obesity in subjects with a mutation in the 5-HT(2A) receptor gene promoter
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Ann N Y Acad Sci 967:571-5. 2002
    ..The pathophysiology could involve stress factors that destabilize the serotonin-hypothalamic-pituitary-adrenal systems in those with genetic vulnerability in the serotonin receptor gene...
  13. ncbi request reprint Association studies of genetic polymorphisms in central obesity: a critical review
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes Relat Metab Disord 27:1141-51. 2003
    ..In this article, the current status of the literature of association studies for genetic dissection of central obesity is critically reviewed...
  14. ncbi request reprint Androgen excess in women--a health hazard?
    Roland Rosmond
    Bergsjön Primary Care Center, Rymdtorget 8B, S 415 19 Gothenburg, Sweden
    Med Hypotheses 67:229-34. 2006
    ..Furthermore, an attempt is made to appreciate what causes the androgens to initially rise from normal levels, allowing the onset of pathophysiological processes towards diseases...
  15. ncbi request reprint G-308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Clin Endocrinol Metab 86:2178-80. 2001
    ..However, to what extent this polymorphism is associated with these conditions is uncertain from the present data...
  16. ncbi request reprint Stress induced disturbances of the HPA axis: a pathway to Type 2 diabetes?
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Med Sci Monit 9:RA35-9. 2003
    ..The HPA axis perturbations associated with visceral obesity can be accounted for, in part, by increased environmental stress that destabilizes the hypothalamic-pituitary system in individuals with genetic susceptibility...
  17. ncbi request reprint Quality of life, overweight, and body fat distribution in middle-aged men
    R Rosmond
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgrenska University Hospital, Goteborg, Sweden
    Behav Med 26:90-4. 2000
    ..Impaired quality of life may be causally related to the development of abdominal obesity; the mechanism involved might be increased cortisol secretion, which can redistribute body fat to central adipose tissue depots...
  18. ncbi request reprint Aetiology of obesity: a striving after wind?
    R Rosmond
    Lundvägen, Sävedalen, Sweden
    Obes Rev 5:177-81. 2004
    ..Is the field of obesity research merely a striving after wind, and nothing more?..
  19. ncbi request reprint Occupational status, cortisol secretory pattern, and visceral obesity in middle-aged men
    R Rosmond
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgrenska University Hospital, Sweden
    Obes Res 8:445-50. 2000
    ..Despite several studies indicating that social gradients are predictive of cardiovascular mortality, the pathogenetic mechanisms remain incompletely understood...
  20. ncbi request reprint A brief update of glucocorticoid receptor variants and obesity risk
    Roland Rosmond
    The Cardiovascular Institute, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Ann N Y Acad Sci 1083:153-64. 2006
    ..In this article, we will estimate the risk by which such gene polymorphism mediates a role in obesity...
  21. ncbi request reprint Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
    J Intern Med 248:239-44. 2000
    ..To investigate the effect of polymorphisms in codon 16 (Arg16Gly) and codon 27 (Gln27Glu) of the beta2-adrenergic receptor gene (ADRB2) on anthropometric, endocrine, metabolic and haemodynamic variables...
  22. ncbi request reprint A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Sweden
    Obes Res 8:211-8. 2000
    ....
  23. ncbi request reprint Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Int J Obes Relat Metab Disord 26:938-41. 2002
    ..At the level of the brain, cortisol secretion is partly controlled by gamma-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter in the vertebrate brain, and acts by binding to GABA(A) receptors...
  24. ncbi request reprint Phenotypic and genotypic characteristics of women in relation to personality traits
    F Baghaei
    Department of Heart and Lung Diseases, Sahlgren s Hospital University of Göteborg, Sweden
    Int J Behav Med 10:365-78. 2003
    ..It was concluded that a majority of women showed M type of personality traits, associated with normal hormones, somatic health, and a long microsatellite in the transactivating domain of the AR gene...
  25. ncbi request reprint Hypertension in obesity and the leptin receptor gene locus
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Endocrinol Metab 85:3126-31. 2000
    ..This might explain why not all obese men are hypertensive...
  26. ncbi request reprint A polymorphism in the regulatory region of the corticotropin-releasing hormone gene in relation to cortisol secretion, obesity, and gene-gene interaction
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Goteborg, Sweden
    Metabolism 50:1059-62. 2001
    ..From these results, we conclude that an abnormal production rate of the CRH gene product in the presence of an inadequate glucocorticoid receptor density might lead to elevated cortisol levels...
  27. ncbi request reprint Relationships between personality disorders and anthropometry, hormones and metabolism in women
    R Rosmond
    Department of Heart and Lung Diseases, , Sahlgrenska University Hospital, Sweden
    J Endocrinol Invest 24:159-65. 2001
    ..These results suggest that PD:s are involved in the development of obesity and abdominal fat accumulation in women, with different endocrine and metabolic profiles depending on the type of PD...
  28. ncbi request reprint A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol
    R Rosmond
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetologia 44:1335-8. 2001
    ....
  29. ncbi request reprint Serotonin transporter gene polymorphisms are associated with anxiety-related personality traits in women
    J Melke
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Am J Med Genet 105:458-63. 2001
    ..In addition, an association was found between the intron 2 polymorphism and one anxiety-related personality trait (somatic anxiety)...
  30. ncbi request reprint Serotonin transporter gene polymorphisms and platelet [3H] paroxetine binding in premenstrual dysphoria
    J Melke
    Department of Pharmacology, Goteborg University, Sweden
    Psychoneuroendocrinology 28:446-58. 2003
    ....
  31. ncbi request reprint Association between a dinucleotide repeat polymorphism of the estrogen receptor alpha gene and personality traits in women
    L Westberg
    Department of Pharmacology, Goteborg University, Sweden
    Mol Psychiatry 8:118-22. 2003
    ..The results suggest that the studied dinucleotide repeat polymorphism of the ER alpha gene may contribute to specific components of personality...
  32. ncbi request reprint Rise in morning saliva cortisol is associated with abdominal obesity in men: a preliminary report
    S Wallerius
    Department of Heart and Lung Diseases, University of Goteborg, Goteborg, Sweden
    J Endocrinol Invest 26:616-9. 2003
    ..The rise of cortisol immediately after awakening might be an indicator of an increased risk of developing serious, prevalent diseases via the metabolic syndrome...
  33. ncbi request reprint Polymorphisms in exon 3 of the proopiomelanocortin gene in relation to serum leptin, salivary cortisol, and obesity in Swedish men
    Roland Rosmond
    Department of Internal Medicine, Research Centre for Endocrinology and Metabolism, Goteborg University, Grona Straket 8, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Metabolism 51:642-4. 2002
    ..This association might reflect variations in melanocortin expression and/or activity, because exon 3 contains, among others, the coding sequences for melanocortins...
  34. ncbi request reprint A 5-year follow-up study of disease incidence in men with an abnormal hormone pattern
    R Rosmond
    Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 254:386-90. 2003
    ..Previous studies have suggested that abnormal levels of cortisol and testosterone might increase the risk of serious somatic diseases. To test this hypothesis, we conducted a 5-year follow-up study in middle-aged men...
  35. ncbi request reprint A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels
    R Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    J Intern Med 251:252-7. 2002
    ....
  36. ncbi request reprint The metabolic syndrome--a neuroendocrine disorder?
    P Bjorntorp
    Department of Heart and Lung Diseases, University of Goteborg, Sahlgren s Hospital, Sweden
    Br J Nutr 83:S49-57. 2000
    ..These results suggest a complex neuroendocrine background to the metabolic syndrome, where the kinetics of the regulation of the HPA axis play a central role...
  37. ncbi request reprint Hypothalamic arousal, insulin resistance and Type 2 diabetes mellitus
    P Bjorntorp
    Department of Heart and Lung Diseases, University of Gothenburg, Sahlgren s Hospital, Sweden
    Diabet Med 16:373-83. 1999
    ..Insulin resistance may be induced via psychoneuroendocrine pathways, a possibility which has received little previous attention...
  38. ncbi request reprint Polymorphism in exon 6 of the dopamine D(2) receptor gene (DRD2) is associated with elevated blood pressure and personality disorders in men
    R Rosmond
    Department of Heart and Lung Diseases, Sahlgrenska University Hospital, Goteborg University, S 413 45 Goteborg, Sweden
    J Hum Hypertens 15:553-8. 2001
    ..Paranoid or schizoid personality disorders is also associated with a polymorphism of the DRD2, which might be associated with a previously demonstrated low density of this receptor...
  39. ncbi request reprint The CYP19 gene and associations with androgens and abdominal obesity in premenopausal women
    Fariba Baghaei
    The Cardiovascular Institute, Sahlgrenska University Hospital, Goteborg, Sweden
    Obes Res 11:578-85. 2003
    ..Polymorphisms of a tetranucleotide repeat [TTTA](n) in the fourth intron of the CYP19 gene are associated with endocrine-dependent diseases and were examined in relation to hormone levels and disease risk factors in premenopausal women...
  40. ncbi request reprint Increased abdominal obesity, insulin and glucose levels in nondiabetic subjects with a T29C polymorphism of the transforming growth factor-beta1 gene
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg, Sweden
    Horm Res 59:191-4. 2003
    ....
  41. ncbi request reprint Depression and anxiety symptoms in relation to anthropometry and metabolism in men
    Ann Charlotte Ahlberg
    Department of Psychiatry, Sahlgrenska University Hospital, University of Goteborg, Sweden
    Psychiatry Res 112:101-10. 2002
    ..We conclude that men with abdominal obesity have symptoms of depression and anxiety...
  42. ncbi request reprint Obesity and cortisol
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Goteborg, Sweden
    Nutrition 16:924-36. 2000
    ..The mechanism involved is not known, but available information suggests that programming of the hypothalamic-pituitary-adrenal axis may be responsible...
  43. ncbi request reprint Angiotensin-related genes in patients with panic disorder
    Marie Olsson
    Department of Pharmacology, Goteborg University, Gothenburg, Sweden
    Am J Med Genet B Neuropsychiatr Genet 127:81-4. 2004
    ..005), but not female, panic disorder patients than in controls. The results of this investigation provide preliminary evidence for the suggestion that angiotensin-related genes may be associated with panic disorder in men...
  44. ncbi request reprint Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Biochem Biophys Res Commun 293:629-32. 2002
    ..The pathogenic mechanism underlying this association is, however, uncertain from the present data and further studies are warranted...
  45. ncbi request reprint Sex steroid-related genes and male-to-female transsexualism
    Susanne Henningsson
    Department of Pharmacology, Institute of Physiology and Pharmacology, Goteborg University, Goteborg, Sweden
    Psychoneuroendocrinology 30:657-64. 2005
    ..Further study of the putative role of these and other sex steroid-related genes for the development of transsexualism may, however, be worthwhile...
  46. ncbi request reprint Neuroendocrine abnormalities in visceral obesity
    P Bjorntorp
    Department of Heart and Lung Diseases, Sahlgren s Hospital, University of Goteborg, Sweden
    Int J Obes Relat Metab Disord 24:S80-5. 2000
    ..The gene for this receptor has shown polymorphisms which are associated with poorly regulated cortisol secretion, central obesity, insulin resistance and hypertension...
  47. ncbi request reprint Polymorphisms of the androgen receptor gene and the estrogen receptor beta gene are associated with androgen levels in women
    L Westberg
    Department of Pharmacology, Goteborg University, SE 405 30 Goteborg, Sweden
    J Clin Endocrinol Metab 86:2562-8. 2001
    ..Our results suggest that the serum levels of androgens in premenopausal women may be influenced by variants of the AR gene and the ER beta gene, respectively...
  48. doi request reprint Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men
    Kristina Annerbrink
    Institute of Neuroscience and Physiology, Goteborg University, and Institute of Medicine, Department of Molecular and Clinical Medicine, Sahlgrenska University Hospital, S 405 30 Goteborg, Sweden
    Metabolism 57:708-11. 2008
    ....
  49. ncbi request reprint Dyslipidemia and high waist-hip ratio in women with self-reported social anxiety
    Mikael Landen
    Department of Psychiatry, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Goteborg University, SE 431 80 Molndal, Sweden
    Psychoneuroendocrinology 29:1037-46. 2004
    ..83+/-0.06 vs. 0.80+/-0.07, P=0.016), BMI did not differ between the groups. Our data suggest that self-reported social anxiety is associated with two established risk factors for cardiovascular disease: dyslipidemia and increased WHR...
  50. ncbi request reprint A polymorphism in the serotonin receptor 3A (HTR3A) gene and its association with harm avoidance in women
    Jonas Melke
    Departments of Pharmacology, Goteborg University, Goteborg, Sweden
    Arch Gen Psychiatry 60:1017-23. 2003
    ..A polymorphism (C178T) in the 5' region of the HTR3A gene has recently been identified and suggested to be of functional importance...
  51. ncbi request reprint Polymorphisms in oestrogen and progesterone receptor genes: possible influence on prolactin levels in women
    Lars Westberg
    Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Clin Endocrinol (Oxf) 61:216-23. 2004
    ....
  52. ncbi request reprint Association between a functional polymorphism in the progesterone receptor gene and panic disorder in women
    Hoi Por Ho
    Department of Pharmacology, Goteborg University, P O B 431, SE 405 30 Goteborg, Sweden
    Psychoneuroendocrinology 29:1138-41. 2004
    ..5. No differences between groups were observed for the PROGINS polymorphism. In conclusion, these data suggest that the G331A polymorphism in the progesterone receptor gene may influence the risk for panic disorder in women...
  53. ncbi request reprint Interleukin-6 gene polymorphism -174G/C influences plasma lipid levels in women
    Susanne Henningsson
    Department of Pharmacology, The Sahlgrenska Academy at Goteborg University, Box 431, SE 405 30 Goteborg, Sweden
    Obesity (Silver Spring) 14:1868-73. 2006
    ..None of the associations between IL-6 genotype and lipid pattern seemed to result from an effect of the polymorphism on IL-6 plasma levels...
  54. ncbi request reprint Pleiotropic relationships between cortisol levels and adiposity: The HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Obes Res 10:1222-31. 2002
    ..To investigate familial basis for the relationship between cortisol adiposity at baseline and their training responses...
  55. ncbi request reprint Glucocorticoid receptor gene and coronary artery disease: right idea, wrong gene variant?
    Roland Rosmond
    Hypertension 42:e3-4; author reply e3-4. 2003
  56. ncbi request reprint Letter: Glucocorticoid receptor N363S variant in obesity: comes into vanity and goes into darkness
    Roland Rosmond
    Obes Res 11:1606-7; author reply 1607-9. 2003
  57. ncbi request reprint A genetic study of cortisol measured before and after endurance training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, and Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Metabolism 51:360-5. 2002
    ..The putative major gene effects appear to explain most of the observed familial resemblance, this will motivate further linkage and association studies...