Allen D Roses

Summary

Publications

  1. doi TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial
    Allen D Roses
    Duke University, Durham, NC, USA Zinfandel Pharmaceuticals, Durham, NC, USA
    Alzheimers Dement 9:132-6. 2013
  2. ncbi Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease
    Kristin K Nicodemus
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurogenetics 5:201-8. 2004
  3. pmc Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
    William K Scott
    Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 73:1041-51. 2003
  4. pmc Genetic variation at a single locus and age of onset for Alzheimer's disease
    Michael W Lutz
    Deane Drug Discovery Institute, Duke University, Durham, NC, USA
    Alzheimers Dement 6:125-31. 2010
  5. ncbi Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
  6. pmc A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
    Elizabeth R Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 75:436-47. 2004
  7. pmc A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA
    Alzheimers Dement 8:381-8. 2012
  8. ncbi Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
  9. pmc Characterization of the poly-T variant in the TOMM40 gene in diverse populations
    Colton Linnertz
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 7:e30994. 2012
  10. doi Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection
    Ornit Chiba-Falek
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genet 131:1911-20. 2012

Collaborators

Detail Information

Publications25

  1. doi TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial
    Allen D Roses
    Duke University, Durham, NC, USA Zinfandel Pharmaceuticals, Durham, NC, USA
    Alzheimers Dement 9:132-6. 2013
    ..This is true when assessing potential biomarkers for age of onset and when assessing the therapeutic potential of medicines that may delay the onset or progression of this disease...
  2. ncbi Comprehensive association analysis of APOE regulatory region polymorphisms in Alzheimer disease
    Kristin K Nicodemus
    Department of Medicine and Center for Human Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Neurogenetics 5:201-8. 2004
    ..In conclusion, SNPs +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small...
  3. pmc Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22
    William K Scott
    Department of Medicine, Duke University Medical Center, and Center for Human Genetics, Institute for Genome Sciences and Policy, Duke University, Durham, NC 27710, USA
    Am J Hum Genet 73:1041-51. 2003
    ..These results indicate that linkage to chromosome 9p is strongest in late-onset AD and that regions on chromosome 2q34 and 15q22 are linked to early-onset AD and very-late-onset AD, respectively...
  4. pmc Genetic variation at a single locus and age of onset for Alzheimer's disease
    Michael W Lutz
    Deane Drug Discovery Institute, Duke University, Durham, NC, USA
    Alzheimers Dement 6:125-31. 2010
    ....
  5. ncbi Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Institute for Genome Science and Policy, Duke University Medical Center, Box 3445, Durham, NC 27710, USA
    Hum Mol Genet 12:3259-67. 2003
    ..This is provocative given reports of the possible role of inflammation in these two neurodegenerative disorders...
  6. pmc A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study
    Elizabeth R Hauser
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 75:436-47. 2004
    ..These data provide initial areas of the human genome where further investigation may reveal susceptibility genes for early-onset CAD...
  7. pmc A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging
    Kathleen M Hayden
    Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA
    Alzheimers Dement 8:381-8. 2012
    ..A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset...
  8. ncbi Analysis of European mitochondrial haplogroups with Alzheimer disease risk
    Joelle M van der Walt
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 365:28-32. 2004
    ..We suggest that variations within haplogroup U may be involved in AD expression in combination with environmental exposures or nuclear proteins other than APOE...
  9. pmc Characterization of the poly-T variant in the TOMM40 gene in diverse populations
    Colton Linnertz
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
    PLoS ONE 7:e30994. 2012
    ..These data may be used as references for '523' allele and '523'-APOE haplotype frequencies in diverse populations for the design of research studies and clinical trials...
  10. doi Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection
    Ornit Chiba-Falek
    Division of Neurology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Hum Genet 131:1911-20. 2012
    ..In CHC patients, genetic heterogeneity in the APOE/TOMM40 genomic region is significantly associated with variation in serum ApoE and ApoB levels, and also with fibrosis suggesting a pleiotropic attribute of this genomic region...
  11. pmc Genome-wide scan of copy number variation in late-onset Alzheimer's disease
    Erin L Heinzen
    Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA
    J Alzheimers Dis 19:69-77. 2010
    ..In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation...
  12. pmc An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease
    Allen D Roses
    Department of Neurobiology and Neurology and the Deane Drug Discovery Institute, Duke University, Durham, North Carolina 27708, USA
    Arch Neurol 67:536-41. 2010
    ..Additional data will further refine the relationship between the length of the poly-T alleles and age at disease onset and determine if the relationship is linear...
  13. ncbi The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease
    Sofia A Oliveira
    Department of Medicine and Center for Human Genetics, Institute for Genome Sciences and Policy, Box 3445, Duke University Medical Center, Durham, NC 27710, USA
    Neurosci Lett 347:143-6. 2003
    ..We found no evidence of significant association of this polymorphism with risk of AD using family-based and case-control tests of association...
  14. doi African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles
    Allen D Roses
    Duke University Bryan Alzheimer s Disease Research Center, Duke University, Durham, NC, USA Zinfandel Pharmaceuticals Inc, Chapel Hill, NC, USA Cabernet Pharmaceuticals, Inc, Chapel Hill, NC, USA Electronic address
    Alzheimers Dement 10:592-601.e2. 2014
    ..An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523-APOE haplotypes...
  15. pmc The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes
    Colton Linnertz
    Division of Neurology at the Department of Medicine, Duke University Medical Center, Durham, NC, USA
    Alzheimers Dement 10:541-51. 2014
    ..Alleles of this locus are classified as S, short; L, long; and VL, very long based on the number of T residues...
  16. pmc The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease
    Colton Linnertz
    Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 23:4814-21. 2014
    ....
  17. doi New applications of disease genetics and pharmacogenetics to drug development
    Allen D Roses
    Zinfandel Pharmaceuticals, Inc, Durham, NC, United States Duke University Medical Center, Department of Neurology, Durham, NC, United States Electronic address
    Curr Opin Pharmacol 14:81-9. 2014
    ..The trial is made practical by the use of a pharmacogenetic algorithm based on TOMM40 and APOE genotypes and age to identify normal subjects at high risk of MCI-AD between the ages of 65-83 years within a five year follow-up period. ..
  18. doi The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety
    Allen D Roses
    Deane Drug Discovery Institute, Institute for Genomic Sciences and Policy, Duke University, Durham, NC 27708, USA
    Neuropsychopharmacology 34:6-17. 2009
    ..Targeting of medicines during drug development is now possible, practical, and profitable...
  19. ncbi Use of whole-genome association scans in disease gene identification, drug discovery and development
    Allen D Roses
    Duke University, R David Thomas Center, 1 Towerview Drive, Suite 343, Box 90120, Durham, NC 27708, USA
    IDrugs 10:797-804. 2007
    ..This feature article discusses the use of whole-genome association scans in disease gene identification, drug discovery and development...
  20. doi Pharmacogenetics in drug discovery and development: a translational perspective
    Allen D Roses
    Deane Drug Discovery Institute, Duke University Medical Center and Fuqua School of Business, Durham, North Carolina 27708, USA
    Nat Rev Drug Discov 7:807-17. 2008
    ....
  21. ncbi Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study
    Elizabeth R Hauser
    Duke University Medical Center, Durham, NC 27710, USA
    Am Heart J 145:602-13. 2003
    ..Early onset (premature) coronary artery disease (EOCAD) is known to have a particularly strong genetic component. However, the actual genes leading to this increased risk of CAD remain obscure...
  22. pmc Age at onset in two common neurodegenerative diseases is genetically controlled
    Yi Ju Li
    Department of Medicine, Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 70:985-93. 2002
    ..62. These data suggest that a common gene affects AAO in these two common complex neurodegenerative diseases...
  23. doi Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." An impending prevention clinical trial for Alzheimer's disease: roadmaps and realities
    Allen D Roses
    Duke University Medical Center and the Fuqua School of Business, Durham, NC, USA
    Alzheimers Dement 4:164-6. 2008
  24. pmc A comparison of neuropsychological performance between US and Russia: preparing for a global clinical trial
    Kathleen M Hayden
    Department of Psychiatry, Joseph and Kathleen Bryan ADRC, Duke University Medical Center, Durham, NC, USA Electronic address
    Alzheimers Dement 10:760-768.e1. 2014
    ..Understanding regional differences in cognitive performance is important for interpretation of data from large multinational clinical trials...
  25. pmc A genome-wide investigation of SNPs and CNVs in schizophrenia
    Anna C Need
    Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, USA
    PLoS Genet 5:e1000373. 2009
    ..On balance, these data suggest that very few schizophrenia patients share identical genomic causation, potentially complicating efforts to personalize treatment regimens...