CLIFFORD JAMES ROSEN

Summary

Publications

  1. ncbi request reprint Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, 360 Broadway, Bangor, ME 04401, USA
    Clin Chem 45:1384-90. 1999
  2. ncbi request reprint A rational approach to evidence gaps in the management of osteoporosis
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Am J Med 118:1183-9. 2005
  3. ncbi request reprint The role of parathyroid hormone in the management of osteoporosis
    Clifford J Rosen
    The Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME, USA
    Horm Res 64:81-5. 2005
  4. ncbi request reprint Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, ME, USA
    Bone 35:1046-58. 2004
  5. ncbi request reprint Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies
    Clifford J Rosen
    St Joseph Hospital, The Jackson Laboratory, 900 Broadway, Bldg No 2, Bangor, ME 04401, USA
    Best Pract Res Clin Endocrinol Metab 18:423-35. 2004
  6. ncbi request reprint What's new with PTH in osteoporosis: where are we and where are we headed?
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, 900 Broadway, Bldg 2, Bangor, ME 04401, USA
    Trends Endocrinol Metab 15:229-33. 2004
  7. ncbi request reprint Vignettes in osteoporosis: a road map to successful therapeutics
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, Maine 04401, USA
    J Bone Miner Res 19:3-10. 2004
  8. ncbi request reprint Insulin-like growth factor I and calcium balance: evolving concepts of an evolutionary process
    Clifford J Rosen
    Jackson Laboratory and St Joseph Hospital, Bangor, Maine 04401, USA
    Endocrinology 144:4679-81. 2003
  9. ncbi request reprint The cellular and clinical parameters of anabolic therapy for osteoporosis
    Clifford J Rosen
    The Jackson Laboratory and St Joseph Hospital, Bangor, ME 04401, USA
    Crit Rev Eukaryot Gene Expr 13:25-38. 2003
  10. ncbi request reprint Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006

Research Grants

  1. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    Clifford Rosen; Fiscal Year: 2007
  2. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    Clifford Rosen; Fiscal Year: 2007
  3. Seasonal Bone Loss in Mice
    Clifford Rosen; Fiscal Year: 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, 360 Broadway, Bangor, ME 04401, USA
    Clin Chem 45:1384-90. 1999
    ..The IGFs remain a major area for basic and clinical investigations; future studies may define both diagnostic and therapeutic roles for these peptides or their related proteins in several disease states...
  2. ncbi request reprint A rational approach to evidence gaps in the management of osteoporosis
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Am J Med 118:1183-9. 2005
    ..Evidence gaps in each treatment scenario are presented, and rational approaches to management are suggested...
  3. ncbi request reprint The role of parathyroid hormone in the management of osteoporosis
    Clifford J Rosen
    The Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME, USA
    Horm Res 64:81-5. 2005
    ....
  4. ncbi request reprint Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, ME, USA
    Bone 35:1046-58. 2004
    ..Congenic mice are useful models not only for mapping genes related to bone mass but also for elucidating the biology underlying various skeletal phenotypes associated with more subtle manipulation of the mouse genome...
  5. ncbi request reprint Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies
    Clifford J Rosen
    St Joseph Hospital, The Jackson Laboratory, 900 Broadway, Bldg No 2, Bangor, ME 04401, USA
    Best Pract Res Clin Endocrinol Metab 18:423-35. 2004
    ..The implications from these animal models are far-reaching and suggest that newer approaches for manipulating the IGF regulatory system may one day be useful as therapeutic adjuncts for the treatment of osteoporosis...
  6. ncbi request reprint What's new with PTH in osteoporosis: where are we and where are we headed?
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, 900 Broadway, Bldg 2, Bangor, ME 04401, USA
    Trends Endocrinol Metab 15:229-33. 2004
    ..This review presents recent findings on PTH signaling in bone and discusses how they could be used to design randomized trials and establish clinical practice guidelines for this novel anabolic peptide...
  7. ncbi request reprint Vignettes in osteoporosis: a road map to successful therapeutics
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, Maine 04401, USA
    J Bone Miner Res 19:3-10. 2004
    ..We describe five common clinical scenarios encountered in the practice of osteoporosis medicine and various road maps that could lead to successful therapy...
  8. ncbi request reprint Insulin-like growth factor I and calcium balance: evolving concepts of an evolutionary process
    Clifford J Rosen
    Jackson Laboratory and St Joseph Hospital, Bangor, Maine 04401, USA
    Endocrinology 144:4679-81. 2003
  9. ncbi request reprint The cellular and clinical parameters of anabolic therapy for osteoporosis
    Clifford J Rosen
    The Jackson Laboratory and St Joseph Hospital, Bangor, ME 04401, USA
    Crit Rev Eukaryot Gene Expr 13:25-38. 2003
    ..Novel in vivo strategies, including temporal and conditional mutagenesis, will almost certainly lead to newer therapeutic paradigms for the treatment of postmenopausal osteoporosis...
  10. ncbi request reprint Mechanisms of disease: is osteoporosis the obesity of bone?
    Clifford J Rosen
    The Jackson Laboratory in Bar Harbor, ME 04401, USA
    Nat Clin Pract Rheumatol 2:35-43. 2006
    ....
  11. ncbi request reprint Clinical practice. Postmenopausal osteoporosis
    Clifford J Rosen
    St Joseph Hospital, Maine Center for Osteoporosis Research and Education, Bangor, ME 04401, USA
    N Engl J Med 353:595-603. 2005
  12. ncbi request reprint Growth hormone and aging
    C J Rosen
    The Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor 04401, USA
    Endocrine 12:197-201. 2000
    ..Hence, there is less enthusiasm for reversing the changes of the "somatopause" with recombinant growth factors. An overview of these issues and the prospects for the future will be discussed in this article...
  13. ncbi request reprint Mapping quantitative trait loci for serum insulin-like growth factor-1 levels in mice
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Bone 27:521-8. 2000
    ..C3H-6 congenic mice demonstrated effects on both the IGF-1 and BMD phenotypes. The genetic determinants of these Igf1sl QTLs will provide much insight into the regulation of IGF-1 and the subsequent acquisition of peak bone mass...
  14. ncbi request reprint Clinical review 123: Anabolic therapy for osteoporosis
    C J Rosen
    St Joseph Hospital, Bangor, Maine 04401, USA
    J Clin Endocrinol Metab 86:957-64. 2001
    ..Fluoride, GH, insulin-like growth factor I, the statins, and PTH will be reviewed. Although still in development, approaches to combination therapy with antiresorptives and anabolic agents are also promising...
  15. ncbi request reprint Emerging anabolic treatments for osteoporosis
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, USA
    Rheum Dis Clin North Am 27:215-33, viii. 2001
    ..The two most promising agents, parathyroid hormone (PTH) and GH/IGF-I, act to increase osteoblast mediated bone formation. A review of the potential usefulness of PTH and GH/IGF-I is presented...
  16. ncbi request reprint Treatment of postmenopausal osteoporosis: an evidence-based approach
    C J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME, USA
    Rev Endocr Metab Disord 2:35-43. 2001
    ..What is certain, is that there are now cost effective treatments for this disease. It remains up to the practicing physician to select, based on the existing evidence, treatments most appropriate for the individual patient...
  17. pmc Marrow fat and the bone microenvironment: developmental, functional, and pathological implications
    Clifford J Rosen
    Maine Medical Center Research Institute, Scarborough, ME 04041, USA
    Crit Rev Eukaryot Gene Expr 19:109-24. 2009
    ..However, more studies are needed to understand the interrelationship among hematopoietic, osteoblastic, and adipogenic cells within the marrow niche...
  18. pmc Fat targets for skeletal health
    Masanobu Kawai
    Maine Medical Center Research Institute, Scarborough, ME 04074 7205, USA
    Nat Rev Rheumatol 5:365-72. 2009
    ..Hence, a more complete picture of energy utilization and skeletal remodeling will be required to bring any potential agents into the future clinical armamentarium...
  19. pmc Nocturnin: a circadian target of Pparg-induced adipogenesis
    Masanobu Kawai
    Maine Medical Center Research Institute, Scarborough, Maine, USA
    Ann N Y Acad Sci 1192:131-8. 2010
    ..Defining the function of nocturnin in peripheral tissues should provide new insights into lineage allocation and the intimate relationship between nuclear receptors and physiologic timekeeping...
  20. pmc PPARG by dietary fat interaction influences bone mass in mice and humans
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1398-408. 2008
    ..These findings suggest that dietary fat has a significant influence on BMD that is dependent on the alleles present for the PPARG gene...
  21. pmc PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells
    Keith R Shockley
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    J Cell Biochem 106:232-46. 2009
    ....
  22. ncbi request reprint Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo
    Mary L Bouxsein
    The The Jackson Laboratory, Bar Harbor, Maine, USA
    J Bone Miner Res 17:570-9. 2002
    ..This locus also influences bone density and morphology, with more dramatic effects in cancellous bone than in cortical bone...
  23. pmc Strain-specific effects of rosiglitazone on bone mass, body composition, and serum insulin-like growth factor-I
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Endocrinology 150:1330-40. 2009
    ..The divergent skeletal responses to rosiglitazone in this study suggest the existence of a strong genetic background effect...
  24. pmc Nocturnin suppresses igf1 expression in bone by targeting the 3' untranslated region of igf1 mRNA
    Masanobu Kawai
    Center for Translational Research, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074 7205, USA
    Endocrinology 151:4861-70. 2010
    ..Posttranscriptional regulation of Igf1 may be critically important during skeletal acquisition and maintenance...
  25. doi request reprint Mouse models for understanding the growth hormone insulin-like growth factor-I axis
    Clifford J Rosen
    Maine Center for Osteoporosis Research and Education, St Joseph Hospital, Bangor, ME 04401, USA
    Horm Res 68:2-4. 2007
    ..The role of peroxisome proliferator-activated receptor gamma, a nuclear receptor and key differentiation factor for adipogenesis, has provided new insights into the relationship of marrow fat to skeletal mass...
  26. ncbi request reprint Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density
    Kathryn L Shultz
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 18:175-85. 2003
    ....
  27. doi request reprint Bone, fat, and body composition: evolving concepts in the pathogenesis of osteoporosis
    Clifford J Rosen
    Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Am J Med 122:409-14. 2009
    ..This article explores these relationships in the context of a new paradigm with implications for obesity and osteoporosis...
  28. pmc A novel spontaneous mutation of Irs1 in mice results in hyperinsulinemia, reduced growth, low bone mass and impaired adipogenesis
    Victoria E DeMambro
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Endocrinol 204:241-53. 2010
    ..Changes in the heterozygous Irs1(+)(/sml) mice raise the possibility that similar mutations in humans are associated with short stature or osteoporosis...
  29. ncbi request reprint A chromosomal inversion within a quantitative trait locus has a major effect on adipogenesis and osteoblastogenesis
    Cheryl L Ackert-Bicknell
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Ann N Y Acad Sci 1116:291-305. 2007
    ..Rather, 6T demonstrates that disordered regulation of gene expression by genomic rearrangement can have a profound effect on a complex trait, such as BMD, and that genomic rearrangement can supersede the effects of various alleles...
  30. pmc A circadian-regulated gene, Nocturnin, promotes adipogenesis by stimulating PPAR-gamma nuclear translocation
    Masanobu Kawai
    The Musculoskeletal Laboratory, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Proc Natl Acad Sci U S A 107:10508-13. 2010
    ..These data illustrate a unique mechanism whereby a nutrient-responsive gene influences BMSCs differentiation, adipogenesis, and ultimately body composition...
  31. pmc Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation
    Sumithra Urs
    Maine Medical Center Research Institute, 81 Research Dr, Scarborough, ME 04074, USA
    FASEB J 24:3264-73. 2010
    ..Spry1 is a critical regulator of adipocyte differentiation and mesenchymal stem cell (MSC) lineage allocation, potentially acting through regulation of CEBP-beta and TAZ...
  32. pmc The many facets of PPARgamma: novel insights for the skeleton
    Masanobu Kawai
    Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Am J Physiol Endocrinol Metab 299:E3-9. 2010
    ....
  33. ncbi request reprint Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition
    Clifford J Rosen
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Pediatr Nephrol 20:255-60. 2005
    ..Lifelong changes in circulating and skeletal IGF-I may be relevant for the pathophysiology of several diseases, including chronic renal failure...
  34. doi request reprint Leptin's RIGHT turn to the brain stem
    Clifford J Rosen
    Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Cell Metab 10:243-4. 2009
    ..The data from those studies strengthen the tenet that skeletal remodeling is intimately connected to central regulation of metabolism...
  35. doi request reprint Bone: adiposity and bone accrual-still an established paradigm?
    Masanobu Kawai
    Skeletal Research Laboratory, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074 7205, USA
    Nat Rev Endocrinol 6:63-4. 2010
    ..A new study published in the Journal of Bone and Mineral Research challenges the basic framework of that tenet...
  36. ncbi request reprint Treatment with once-weekly alendronate 70 mg compared with once-weekly risedronate 35 mg in women with postmenopausal osteoporosis: a randomized double-blind study
    Clifford J Rosen
    Maine Center of Osteoporosis Research and Education and St Joseph Hospital, Bangor, Maine 04401, USA
    J Bone Miner Res 20:141-51. 2005
    ..These two agents were compared in a 12-month head-to-head trial. Greater gains in BMD and greater reductions in markers of bone turnover were seen with alendronate compared with risedronate with similar tolerability...
  37. doi request reprint Insulin-like growth factor-I and bone: lessons from mice and men
    Masanobu Kawai
    Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074 7205, USA
    Pediatr Nephrol 24:1277-85. 2009
    ..This review highlights recent findings that shed new light on the interaction of the IGF-I signaling pathway with other skeletal networks, and the role of IGF-I in the bone marrow milieu...
  38. ncbi request reprint Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes
    Wesley G Beamer
    The Jackson Laboratory, Bar Harbor, Maine, USA
    J Bone Miner Res 22:1187-96. 2007
    ..The homologous relationship between distal mouse Chr 1 and human 1q21-24 offers the possibility of finding common regulatory genes for cortical and trabecular bone...
  39. doi request reprint Bone remodeling, energy metabolism, and the molecular clock
    Clifford J Rosen
    Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Cell Metab 7:7-10. 2008
    ..These findings support a new paradigm concerning the regulation of bone remodeling and provide a foundation for novel approaches to preventing osteoporosis...
  40. ncbi request reprint From mouse to man: redefining the role of insulin-like growth factor-I in the acquisition of bone mass
    Shoshana Yakar
    The National Institutes of Health and The Jackson Laboratory and St Joseph Hospital, Bangor, Maine 04401, USA
    Exp Biol Med (Maywood) 228:245-52. 2003
    ..The implications are far reaching and suggest that newer approaches for manipulating the IGF regulatory system may one day be useful as therapeutic adjuncts for the treatment of osteoporosis...
  41. pmc A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis
    Leah Rae Donahue
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 18:1612-21. 2003
    ..In addition, SED patients have been identified with a similar molecular mutation in human COL2A1. This mouse model offers a useful tool for molecular and biological studies of bone development and pathology...
  42. pmc Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels
    Rong Yuan
    The Jackson Aging Center at The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Aging Cell 8:277-87. 2009
    ..53, P < 0.01). These results support the hypothesis that the IGF1 pathway plays a key role in regulating longevity in mice and indicates that common genetic mechanisms may exist for regulating IGF1 levels and lifespan...
  43. pmc Quantitative trait loci for BMD in an SM/J by NZB/BlNJ intercross population and identification of Trps1 as a probable candidate gene
    Naoki Ishimori
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 23:1529-37. 2008
    ..This study shows the power of statistical modeling to resolve linked QTLs and the use of haplotype analysis in narrowing the list of candidates...
  44. ncbi request reprint Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvImJ inbred mice
    Naoki Ishimori
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Bone Miner Res 21:105-12. 2006
    ..To identify loci controlling BMD, we conducted a QTL analysis in a (B6 x 129) F2 population of mice. We report on additional QTLs and also narrow one QTL by combining the data from multiple crosses and through haplotype analysis...
  45. ncbi request reprint Bone density in ambulatory and immobile children
    Krystyna Tuckerman
    Eastern Maine Medical Center, Bangor, USA
    J Clin Densitom 5:327-34. 2002
    ..When bone measurements were corrected for bone volume, there was no difference in bone density between healthy control subjects and immobile children with neuromuscular disease an unexpected result...
  46. pmc Minireview: A skeleton in serotonin's closet?
    Masanobu Kawai
    Center for Translational Research, Maine Medical Center Research Institute, Scarborough, Maine 04074, USA
    Endocrinology 151:4103-8. 2010
    ..In this brief review, we will summarize recent findings linking serotonin to the skeleton and discuss future directions for this new but challenging aspect of this multidimensional molecule...
  47. ncbi request reprint Chromosomal inversion discovered in C3H/HeJ mice
    Ellen C Akeson
    The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Genomics 87:311-3. 2006
    ..The inversion has been named In(6)1J (inversion Chr 6, Jackson 1)...

Research Grants6

  1. MOUSE MODELS TO DELINEATE A UNIQUE METABOLIC AND SKELETAL NETWORK
    Clifford Rosen; Fiscal Year: 2007
    ..More importantly, this work could lead to a sea change in our general approach to identifying osteoporosis genes in mice and humans. ..
  2. A Chromosome 10 QTL Associated with IGF-1 and Bone Mass
    Clifford Rosen; Fiscal Year: 2007
    ..These studies will also determine how specific alleles in the Igfl gene affect critical post-transcriptional events that ultimately determine circulating levels of IGF-I. ..
  3. Seasonal Bone Loss in Mice
    Clifford Rosen; Fiscal Year: 2007
    ..Understanding the impact of circadian and circannual rhythms on the skeleton will afford greater insight into homeostatic mechanisms controlling bone maintenance. ..