Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaquesJohn A Ronald
Robarts Research Institute, London, Ontario, Canada
Circulation 120:592-9. 2009
..We report here that a unique functional in vivo magnetic resonance agent can visualize myeloperoxidase activity in atherosclerotic plaques in a rabbit model...
Comparison of gadofluorine-M and Gd-DTPA for noninvasive staging of atherosclerotic plaque stability using MRIJohn A Ronald
Robarts Research Institute, Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
Circ Cardiovasc Imaging 2:226-34. 2009
..In this report, we determined the utility of the MR contrast agent gadofluorine-M (GdF) for staging plaque stability and compared this to the conventional agent Gd-DTPA...
The in vivo diagnosis of early-stage aortic valve sclerosis using magnetic resonance imaging in a rabbit modelAmanda M Hamilton
Department of Anatomy and Cell Biology, The University of Western Ontario, London, ON, Canada
J Magn Reson Imaging 29:825-31. 2009
..A major obstacle to early stage medical management of AVS has been the lack of an objective noninvasive technique to identify its presence and monitor its progress...
Early identification of aortic valve sclerosis using iron oxide enhanced MRIAmanda M Hamilton
Department of Anatomy, The University of Western Ontario, London, ON, Canada
J Magn Reson Imaging 31:110-6. 2010
..To test the ability of MION-47 enhanced MRI to identify tissue macrophage infiltration in a rabbit model of aortic valve sclerosis (AVS)...
Clinical field-strength MRI of amyloid plaques induced by low-level cholesterol feeding in rabbitsJohn A Ronald
Robarts Research Institute, University of Western Ontario, 100 Perth Drive, 1st Floor, London, ON, Canada N6A 5K8
Brain 132:1346-54. 2009
..We believe extension of these technologies to an in vivo setting in rabbits is feasible and that our results support future work exploring the role of MRI as a leading imaging tool for this debilitating and life-threatening disease...
MRI of early- and late-stage arterial remodeling in a low-level cholesterol-fed rabbit model of atherosclerosisJohn A Ronald
Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
J Magn Reson Imaging 26:1010-9. 2007
..To monitor early- and late-stage arterial remodeling following low-level cholesterol (CH) feeding in rabbits using a standardized MRI protocol...
In vivo magnetic resonance imaging of single cells in mouse brain with optical validationChris Heyn
Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
Magn Reson Med 55:23-9. 2006
..This work demonstrates the sensitivity of MRI for detecting single cells in small animals for a wide range of application from stem cell to cancer cell tracking...
In vivo MRI of cancer cell fate at the single-cell level in a mouse model of breast cancer metastasis to the brainChris Heyn
Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
Magn Reson Med 56:1001-10. 2006
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