Mircea Grigorescu

Summary

Affiliation: Iuliu Hatieganu University of Medicine and Pharmacy
Country: Romania

Publications

  1. ncbi request reprint Noninvasive biochemical markers of liver fibrosis
    Mircea Grigorescu
    3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 15:149-59. 2006
  2. ncbi request reprint The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience
    Mircea Grigorescu
    3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 16:31-7. 2007
  3. ncbi request reprint Metabolic syndrome, insulin resistance and adiponectin level in patients with chronic hepatitis C
    Mircea Grigorescu
    3rd Medical Clinic, University of Medicine and Pharmacy, Croitorilor Street 19 21, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 17:147-54. 2008
  4. ncbi request reprint A novel pathophysiological-based panel of biomarkers for the diagnosis of nonalcoholic steatohepatitis
    M Grigorescu
    Regional Institute of Gastroenterology and Hepatology, 3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Physiol Pharmacol 63:347-53. 2012
  5. ncbi request reprint Performance of unidimensional transient elastography in staging non-alcoholic steatohepatitis
    Monica Lupsor
    Department of Medical Imaging, 3rd Medical Clinic, University of Medicine and Pharmacy, 19 21 Croitorilor Street, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 19:53-60. 2010
  6. ncbi request reprint Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy
    Corina Radu
    Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 3400 Cluj Napoca, Romania
    Rom J Gastroenterol 12:91-5. 2003
  7. ncbi request reprint A new and simple algorithm for the noninvasive assessment of esophageal varices in cirrhotic patients using serum fibrosis markers and transient elastography
    Horia Stefanescu
    Hepatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 20:57-64. 2011
  8. ncbi request reprint HCV genotype 1 is almost exclusively present in Romanian patients with chronic hepatitis C
    Mircea Grigorescu
    University of Medicine and Pharmacy Iuliu Hatieganu, Clinical Emergency Hospital Professor Dr Octavian Fodor, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 18:45-50. 2009
  9. doi request reprint Spleen stiffness measurement using Fibroscan for the noninvasive assessment of esophageal varices in liver cirrhosis patients
    Horia Stefanescu
    Department of Hepatology, 3rd Medical Clinic, University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Gastroenterol Hepatol 26:164-70. 2011
  10. ncbi request reprint Analysis of histopathological changes that influence liver stiffness in chronic hepatitis C. Results from a cohort of 324 patients
    Monica Lupsor
    Department of Ultrasonography, 3rd Medical Clinic, 19 21 Croitorilor Street, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 17:155-63. 2008

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Noninvasive biochemical markers of liver fibrosis
    Mircea Grigorescu
    3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 15:149-59. 2006
    ..Serum markers are of great value not only in patients at risk for liver biopsy, but also as a part of the assessment of patients with chronic liver disease avoiding the invasive methods...
  2. ncbi request reprint The FibroTest value in discriminating between insignificant and significant fibrosis in chronic hepatitis C patients. The Romanian experience
    Mircea Grigorescu
    3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 16:31-7. 2007
    ..To assess the diagnostic value of FibroTest to discriminate between insignificant and significant fibrosis in order to avoid the liver biopsy currently used for selection of chronic hepatitis C patients eligible for antiviral therapy...
  3. ncbi request reprint Metabolic syndrome, insulin resistance and adiponectin level in patients with chronic hepatitis C
    Mircea Grigorescu
    3rd Medical Clinic, University of Medicine and Pharmacy, Croitorilor Street 19 21, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 17:147-54. 2008
    ..To assess insulin resistance and adiponectin profile in patients with chronic hepatitis C (CHC), according to the presence or absence of metabolic syndrome (MS)...
  4. ncbi request reprint A novel pathophysiological-based panel of biomarkers for the diagnosis of nonalcoholic steatohepatitis
    M Grigorescu
    Regional Institute of Gastroenterology and Hepatology, 3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Physiol Pharmacol 63:347-53. 2012
    ..903, Sp=85.7% (PPV=94.2%) and Se=84.5% (NPV=66.7%). In conclusion, a novel pathophysiological - based panel of biomarkers combining total CK-18, IL-6 and adiponectin may be useful to predict NASH...
  5. ncbi request reprint Performance of unidimensional transient elastography in staging non-alcoholic steatohepatitis
    Monica Lupsor
    Department of Medical Imaging, 3rd Medical Clinic, University of Medicine and Pharmacy, 19 21 Croitorilor Street, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 19:53-60. 2010
    ..We aimed to assess the value of TE in the prediction of fibrosis stage in NASH as well as the factors determining the discordance between the TE-predicted and the biopsy-proven fibrosis stage in these patients...
  6. ncbi request reprint Correlation of sICAM-1 and sVCAM-1 level with biochemical, histological and viral findings in chronic hepatitis C after interferon-alpha + ribavirin therapy
    Corina Radu
    Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 3400 Cluj Napoca, Romania
    Rom J Gastroenterol 12:91-5. 2003
    ..The soluble forms of these molecules sICAM-1 and sVCAM-1 can be determined in the serum of patients through the immunoenzymatic technique (ELISA). The..
  7. ncbi request reprint A new and simple algorithm for the noninvasive assessment of esophageal varices in cirrhotic patients using serum fibrosis markers and transient elastography
    Horia Stefanescu
    Hepatology Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 20:57-64. 2011
    ..The aim of this study was to compare the performance of common serum fibrosis scores and transient elastography in diagnosing esophageal varices and to propose a new algorithm for predicting large varices...
  8. ncbi request reprint HCV genotype 1 is almost exclusively present in Romanian patients with chronic hepatitis C
    Mircea Grigorescu
    University of Medicine and Pharmacy Iuliu Hatieganu, Clinical Emergency Hospital Professor Dr Octavian Fodor, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 18:45-50. 2009
    ....
  9. doi request reprint Spleen stiffness measurement using Fibroscan for the noninvasive assessment of esophageal varices in liver cirrhosis patients
    Horia Stefanescu
    Department of Hepatology, 3rd Medical Clinic, University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Gastroenterol Hepatol 26:164-70. 2011
    ....
  10. ncbi request reprint Analysis of histopathological changes that influence liver stiffness in chronic hepatitis C. Results from a cohort of 324 patients
    Monica Lupsor
    Department of Ultrasonography, 3rd Medical Clinic, 19 21 Croitorilor Street, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 17:155-63. 2008
    ....
  11. ncbi request reprint Steatosis in hepatitis C virus infection. Response to anti-viral therapy
    Paula Szanto
    3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Str Croitorilor no 19 21, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 15:117-24. 2006
    ..Several studies suggested that steatosis induces resistance to interferon and ribavirin combination treatment...
  12. ncbi request reprint Prospective non-invasive follow-up of liver fibrosis in patients with chronic hepatitis C
    Dana Crisan
    Regional Institute of Gastroenterology and Hepatology Prof Dr Octavian Fodor, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 21:375-82. 2012
    ..Aim: To prospectively assess liver fibrosis in chronic hepatitis C (CHC) in patients treated vs untreated, using non-invasive methods...
  13. pmc Two or more synchronous combination of noninvasive tests to increase accuracy of liver fibrosis assessement in chronic hepatitis C; results from a cohort of 446 patients
    Dana Crisan
    Third Medical Clinic, Regional Institute of Gastroenterology and Hepatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Hepat Mon 12:177-84. 2012
    ..Non-invasive tests (NITs) have a number of advantages over the traditional standard of fibrosis assessment by liver biopsy, including safety, cost-effectiveness, and widespread accessibility...
  14. ncbi request reprint Prevalence and associated risk factors of non-alcoholic fatty liver disease in hospitalized patients
    Corina Radu
    Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 17:255-60. 2008
    ..There is increasing interest in ultrasound-diagnosed NAFLD. The aim of the study was to evaluate the prevalence of NAFLD in hospitalized patients and to determine the metabolic features of ultrasound-diagnosed patients...
  15. ncbi request reprint Serum levels of soluble intercellular-1 and vascular cell-1 adhesion molecules in chronic hepatitis C and the influence of interferon-alpha + ribavirin therapy
    Doru Dejica
    3rd Medical Clinic, University of Medicine and Pharmacy, Str Croitorilor no 19 21, 3400 Cluj Napoca, Romania
    Rom J Gastroenterol 11:277-83. 2002
    ..In conclusion, the normalization of serum sICAM-1 at 6 months of treatment may be useful prognostic parameter of response to the end of the administration period (1 year)...
  16. ncbi request reprint What is the real prevalence of the D virus infection in chronic hepatitis and liver cirrhosis in Romania?
    Mircea Grigorescu
    3rd Medical Clinic, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania
    Rom J Gastroenterol 12:179-82. 2003
    ..These findings situate Romania among countries with a high prevalence of the hepatitis D virus infection, but which is decreasing as compared to the data communicated by previous reports...
  17. doi request reprint Tolerance of liver biopsy in a tertiary care center: comparison of the percutaneous and the transvenous route in 143 prospectively followed patients
    Bogdan Procopet
    Department of Hepato Gastroenterology, Purpan Hospital, CHU Toulouse, Toulouse, France
    Eur J Gastroenterol Hepatol 24:1209-13. 2012
    ..Transjugular liver biopsy (TJLB) is usually performed when a percutaneous liver biopsy (PLB) is contraindicated. TJLB is an invasive procedure and the patient's tolerance may be variable...
  18. ncbi request reprint Mortality risk factors in chronic pancreatitis
    Andrada Seicean
    3rd Medical Clinic, University of Medicine and Pharmacy, Str Croitorilor no 19 21, 400162 Cluj Napoca, Romania
    J Gastrointestin Liver Dis 15:21-6. 2006
    ..Mortality in chronic pancreatitis is higher than in the general population, the 10-year survival after diagnosis is estimated between 69-80%...
  19. ncbi request reprint Genetic factors in pancreatitis
    Mircea Grigorescu
    3rd Medical Clinic, University of Medicine and Pharmacy, Str Croitorilor 19 21, 400162 Cluj Napoca, Romania
    Rom J Gastroenterol 14:53-61. 2005
    ..Acute pancreatitis is viewed as an event and chronic pancreatitis as a process, sequentially linked, reflecting a complex interaction between genetic and environmental factors...
  20. ncbi request reprint Efficacy, tolerability and predictive factors for early and sustained virologic response in patients treated with weight-based dosing regimen of PegIFN alpha-2b ribavirin in real-life healthcare setting
    Liana Gheorghe
    Department of Hepatology, Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Str Fundeni no 258, 72437 Bucharest, Romania
    J Gastrointestin Liver Dis 16:23-9. 2007
    ....
  21. ncbi request reprint National Romanian consensus conference--treatment of chronic hepatitis
    Mircea Grigorescu
    Rom J Gastroenterol 11:237-54. 2002
  22. ncbi request reprint Impaired health-related quality of life in Romanian patients with chronic viral hepatitis before antiviral therapy
    Cristina Pojoga
    3rd Medical Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    Eur J Gastroenterol Hepatol 16:27-31. 2004
    ..We investigated the impact of chronic viral hepatitis on health-related quality of life. The relationship between transaminase level and score in the quality-of-life questionnaire was also investigated...
  23. doi request reprint Albinterferon alfa-2b dosed every two or four weeks in interferon-naïve patients with genotype 1 chronic hepatitis C
    Stefan Zeuzem
    JW Goethe University Hospital, Frankfurt, Germany
    Hepatology 48:407-17. 2008
    ..1 versus 4.3 days; P = 0.006). CONCLUSION: Alb-IFN administered q2wk or q4wk may offer comparable efficacy, with an improved dosing schedule, compared with PEG-IFNalpha-2a...
  24. ncbi request reprint Effectiveness and tolerability of pegylated Interferon alpha-2a and ribavirin combination therapy in Romanian patients with chronic hepatitis C: from clinical trials to clinical practice
    Liana Gheorghe
    Department of Hepatology, Center of Gastroenterology and Hepatology, Fundeni Clinical Institute, Str Fundeni no 258, 72437 Bucharest, Romania
    Rom J Gastroenterol 14:109-15. 2005
    ....
  25. ncbi request reprint The effect of interferon alpha plus ribavirin on health-related quality of life in chronic C hepatitis. The Romanian experience
    Cristina Pojoga
    3rd Medical Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj Napoca, Romania
    J Gastrointestin Liver Dis 15:31-5. 2006
    ..We looked for the effect of this treatment on health-related quality of life in chronic hepatitis C when measured immediately after the antiviral therapy...
  26. ncbi request reprint Antiendomysial and antitissue transglutaminase antibodies in gluten-induced enteropathy
    Simina Tărmure
    4th Medical Clinic, University of Medicine and Pharmacie Iuliu Haţieganu, Str Republicii 18, 3400 Cluj Napoca, Romania
    Rom J Gastroenterol 11:91-5. 2002
    ..We also found that serum EMA levels correlated perfectly with the degree of histological alterations. A very good correlation was found between the serum concentrations of the two antibodies studied..