Anca V Sima

Summary

Affiliation: Institute of Cellular Biology and Pathology Nicolae Simionescu
Country: Romania

Publications

  1. ncbi Apolipoprotein E polymorphism--a risk factor for metabolic syndrome
    Anca Sima
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Clin Chem Lab Med 45:1149-53. 2007
  2. pmc Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass
    Marius R Robciuc
    National Institute for Health and Welfare, Public Health Genomics Research Unit and FIMM, Institute for Molecular Medicine Finland, Helsinki, Finland
    Lipids Health Dis 9:59. 2010
  3. doi Vascular endothelium in atherosclerosis
    Anca V Sima
    Institute of Cellular Biology and Pathology Nicolae Simionescu, 8 B P Hasdeu Street, 050568 Bucharest, Romania
    Cell Tissue Res 335:191-203. 2009
  4. doi Effect of irreversibly glycated LDL in human vascular smooth muscle cells: lipid loading, oxidative and inflammatory stress
    Anca V Sima
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    J Cell Mol Med 14:2790-802. 2010
  5. doi Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose
    Laura Toma
    Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 390:877-82. 2009
  6. doi HDL inhibits endoplasmic reticulum stress by stimulating apoE and CETP secretion from lipid-loaded macrophages
    Loredan S Niculescu
    Institute of Cellular Biology and Pathology N Simionescu of the Romanian Academy, Bucharest, Romania
    Biochem Biophys Res Commun 434:173-8. 2013
  7. doi Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
    Camelia S Stancu
    Institute of Cellular Biology and Pathology Nicolae Simionescu of the Romanian Academy, 8, B P Hasdeu Street, 050568 Bucharest, Romania
    Cell Tissue Res 349:433-46. 2012
  8. doi Apolipoprotein A-I stimulates cholesteryl ester transfer protein and apolipoprotein E secretion from lipid-loaded macrophages; the role of NF-κB and PKA signaling pathways
    Loredan S Niculescu
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 415:497-502. 2011
  9. doi Anti-oxidant and anti-inflammatory mechanisms of amlodipine action to improve endothelial cell dysfunction induced by irreversibly glycated LDL
    Laura Toma
    Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 411:202-7. 2011
  10. doi Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects
    Alina Constantin
    Department of Vascular Dysfunctions in Diabetes and Obesity, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 391:282-6. 2010

Detail Information

Publications15

  1. ncbi Apolipoprotein E polymorphism--a risk factor for metabolic syndrome
    Anca Sima
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Clin Chem Lab Med 45:1149-53. 2007
    ..The aim of this study was to determine the association between apolipoprotein E (apoE) genotypes and the risk of metabolic syndrome and/or coronary heart disease complications...
  2. pmc Human apoA-I increases macrophage foam cell derived PLTP activity without affecting the PLTP mass
    Marius R Robciuc
    National Institute for Health and Welfare, Public Health Genomics Research Unit and FIMM, Institute for Molecular Medicine Finland, Helsinki, Finland
    Lipids Health Dis 9:59. 2010
    ..The aim of the present study was to determine whether the major protein from HDL, apoA-I, affects PLTP derived from MFCs...
  3. doi Vascular endothelium in atherosclerosis
    Anca V Sima
    Institute of Cellular Biology and Pathology Nicolae Simionescu, 8 B P Hasdeu Street, 050568 Bucharest, Romania
    Cell Tissue Res 335:191-203. 2009
    ..As a consequence, EC may progress to senescence, lose their integrity and detach into the circulation...
  4. doi Effect of irreversibly glycated LDL in human vascular smooth muscle cells: lipid loading, oxidative and inflammatory stress
    Anca V Sima
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    J Cell Mol Med 14:2790-802. 2010
    ..These results may partly explain the contribution of AGE-LDL and hSMC to the accelerated atherosclerosis in diabetes...
  5. doi Irreversibly glycated LDL induce oxidative and inflammatory state in human endothelial cells; added effect of high glucose
    Laura Toma
    Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 390:877-82. 2009
    ..Both AGE-LDL and nLDL in the presence of high glucose amplify their effect, revealing a link between hyperlipidemia, diabetes, and endothelial cell dysfunction...
  6. doi HDL inhibits endoplasmic reticulum stress by stimulating apoE and CETP secretion from lipid-loaded macrophages
    Loredan S Niculescu
    Institute of Cellular Biology and Pathology N Simionescu of the Romanian Academy, Bucharest, Romania
    Biochem Biophys Res Commun 434:173-8. 2013
    ..These data suggest a new mechanism by which HDL3 diminish ER stress and stimulate cholesterol efflux from lipid-loaded macrophages...
  7. doi Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
    Camelia S Stancu
    Institute of Cellular Biology and Pathology Nicolae Simionescu of the Romanian Academy, 8, B P Hasdeu Street, 050568 Bucharest, Romania
    Cell Tissue Res 349:433-46. 2012
    ..Its main focus is the antagonistic role of atherogenic Lp (LDL, VLDL, dysfunctional HDL) versus anti-atherogenic Lp (HDL), also pointing out the potential targets for arresting or reversing this process...
  8. doi Apolipoprotein A-I stimulates cholesteryl ester transfer protein and apolipoprotein E secretion from lipid-loaded macrophages; the role of NF-κB and PKA signaling pathways
    Loredan S Niculescu
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 415:497-502. 2011
    ..In conclusion, our data suggest a new mechanism by which apoA-I stimulates CETP secretion, in addition to apoE, from lipid loaded macrophages, a process involving NF-κB inhibition and/or PKA pathway activation...
  9. doi Anti-oxidant and anti-inflammatory mechanisms of amlodipine action to improve endothelial cell dysfunction induced by irreversibly glycated LDL
    Laura Toma
    Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 411:202-7. 2011
    ..In conclusion, the reported data demonstrate that amlodipine may improve endothelial dysfunction in diabetes through anti-oxidant and anti-inflammatory mechanisms...
  10. doi Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects
    Alina Constantin
    Department of Vascular Dysfunctions in Diabetes and Obesity, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 391:282-6. 2010
    ..However, LEP -2548GG genotype appear to be important in regulating leptin levels, whereas the LEPR 223R allele might predispose healthy subjects to develop metabolic disturbances...
  11. doi Endothelial transcytosis in health and disease
    Maya Simionescu
    Institute of Cellular Biology and Pathology, Nicolae Simionescu, Bucharest, Romania
    Cell Tissue Res 335:27-40. 2009
    ....
  12. ncbi Apolipoprotein A-V gene polymorphisms in subjects with metabolic syndrome
    Loredan Stefan Niculescu
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Clin Chem Lab Med 45:1133-9. 2007
    ..Genetic variation at the apolipoprotein A-V locus, recently discovered proximal to the APOA1/C3/A4 gene cluster, is associated with elevated triglyceride concentrations, a risk factor for atherosclerosis...
  13. doi Modified low density lipoproteins decrease the activity and expression of lysosomal acid lipase in human endothelial and smooth muscle cells
    Constantina Heltianu
    Institute of Cellular Biology and Pathology N Simionescu, 8, B P Hasdeu Street, PO Box 14 35, 050568 Bucharest, Romania
    Cell Biochem Biophys 61:209-16. 2011
    ..In conclusion, modified LDL down regulates LAL expression in human EC and SMC by a process involving the LXR signaling pathway. This is the first demonstration that modified LDL modulate LAL expression, in a cell specific manner...
  14. doi Association of APOA5 and APOC3 gene polymorphisms with plasma apolipoprotein A5 level in patients with metabolic syndrome
    Loredan S Niculescu
    Department of Lipoproteins and Atherosclerosis, Institute of Cellular Biology and Pathology Nicolae Simionescu, Bucharest, Romania
    Biochem Biophys Res Commun 391:587-91. 2010
    ..56G allele in MS patients. We propose APOA5c.56C>G as a functional polymorphism, whereas APOA5 -1131T>C is not an independent risk factor, being effective only when associated with APOC3 -482T or -455C alleles...
  15. ncbi Homozygous familial hypercholesterolemia: specific indication for domino liver transplantation
    Irinel Popescu
    Center of General Surgery and Liver Transplantation, Fundeni Clinical Institute, Bucharest, Romania
    Transplantation 76:1345-50. 2003
    ..We report a case of a patient with FHC whose liver was used for domino transplantation in a patient with cirrhosis and hepatocellular carcinoma...