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..However, elderly renal patients receive less proper cardiovascular therapy compared to non-renal subjects of the same age. This review deals briefly with the most significant data published in the last decade on CVD in elderly with CKD...

..Finally, the authors provide recommendations on a more rigorous assessment of QoL in future trials in CKD patients...

..We aimed to describe in an East European cohort (i) the incidence of AKI and its risk factors; (ii) the 30-day mortality and its risk factors and (iii) the relationship between mortality, pre-existent renal function and subsequent AKI...

..Pegylated interferon (PEG-IFN) is better tolerated and has a more sustained antiviral effect in the general population. There have been no large trials to date with PEG-IFN in hemodialysis populations...

..There is, however, a lack of information on the comparative impact of different renal replacement therapies (RRTs) on PWV and Alx, and how these different methods might influence endothelial-dependent abnormal vasodilatation...

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..Finally, the most promising novel and/or potential therapies regarding reduction of arterial stiffness in renal patients are reviewed...

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..Very few data have been reported regarding arterial stiffness in paediatric renal populations...

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..We aimed to explore relationships between arterial stiffness and CAD in cohorts of patients with chronic kidney disease (CKD)...

..This report is the first review of histological data, over a period of 10 years (1995-2004), covering a population of over 6 million inhabitants and two distinct regions from an East European country - Romania...

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..In this cross-sectional study we examined the impact of illness representations on QoL of HD patients and the influence of HD duration on this relationship...

..Thus, a systematic review was conducted to assess methodological and clinical heterogeneity by comparing designs, analytical approaches and results of studies...

..This study primarily investigated the safety, and also the efficacy, of ferric carboxymaltose (FCM), a next-generation i.v. iron formulation, given as a bolus-push injection in patients with CKD undergoing maintenance haemodialysis (HD)...

..Few large series describe in detail clinical and laboratory features of cases with ARF and their outcome...

..It is not known how these parameters interfere with successful renal transplantation...

..However, most studies have included end-stage renal disease (ESRD) patients with significant heart pathology. We therefore aimed to study the impact of a single HD session in subjects without manifest cardiac disease...

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..Efficient dialysis, ACE-inhibitors and beta-blockers, statins, antiplatelet treatment and adequate control of calcium-phosphorus metabolism should be the mainstay of therapy in the ESRD patients with several CV risk factors...

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..MARS is a new, cell-free, extracorporeal liver assistance method utilizing an albumin dialysate for the removal of albumin-bound toxins...

..In addition, recent publications from large-scale epidemiological studies have highlighted the impact of anaemia on diabetic patients. The purpose of this review was to focus on the pathophysiology and impact of anaemia in DM...

..To evaluate BP control, white coat hypertension (WCH) and abnormal circadian variability in a significant outpatient sample of renal transplant (RTx) subjects, normotensive at the last regular visit...

..The potential therapeutic interventions - mainly the use of certain antihypertensive drugs and reduction of vascular calcification - are finally discussed...

..We advocate an estimated GFR threshold of <60 ml/min to trigger investigation for anaemia in diabetic subjects...

..It is not known whether the same is true for patients with renal disease...

..Our data show a low incidence of all-cause and cardiovascular mortality, confirming those from the Tassin unit in France, and make a medical case for extended haemodialysis treatment hours...

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..However, in the longer term, renal transplantation leads to a significant improvement of the circadian blood pressure profile, influenced by the renal function level and by the pretransplantation dipping profile...

..Use of ABP monitoring can go some way to overcoming these obstacles. In this review we critically examine the use of ABP monitoring in the understanding of blood pressure control in dialysis patients...

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..0001). CONCLUSION: We have demonstrated that PWV is strongly related to the degree of EBCT-derived coronary artery calcium score in chronic kidney disease patients...

..Only early kidney function was an independent predictor of later serum creatinine...

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..The mortality rate was 3.5%, compared to 21% for the overall ARF population treated during the same period (p < 0.05)...

..Renal hyperparathyroidism (RHPT) is a frequent complication of uremic patients on hemodialysis and despite various advances in medical therapy parathyroidectomy is necessary in a semnificative number of cases...

..Therefore, QoL needs to be regularly assessed in this setting. Our study describes QoL, as well as demographic and clinical variables associated with QoL in chronic haemodialysis (HD) patients in Romania...

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..Here, we review recent data on sleep disturbances in renal patients, focusing on the end-stage renal disease patient treated by dialysis...

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..The quality of RRT appears to be good and survival was similar to that in other registries. Further evolution implies strategies of prevention, based on national surveys, supported by the Romanian Renal Registry...

..The measurement of sialic acid as a risk factor may be superior to that of CRP in this group as its concentration is independent of renal function...

..ABPM offers some clear solutions to these problems and thus should be routinely used in appropriately defined clinical settings, but is not a panacea...

..Improvement in predialysis nephrologic care and in transplantation rates is required to further ensure the ultimate success of the Romanian PD program...

..There is a real need for additional and complementary markers of coronary disease in these patients. We discuss some novel ideas for screening and for intervention in this most challenging clinical setting...

..Regarding mineral metabolism, the percent of patients achieving all four parameters (Ca, P, CaxP and PTH) was also higher in Western Europe. The adherence to EBPG (European Best Practice Guidelines) was also higher in these countries...

..Thus, a systematic review was conducted to assess method or clinical heterogeneity by comparing the design, analytical techniques, and results of studies...

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..However, the optimal stroke prevention strategy in these patients is unclear, because controlled studies are scarce...

..Therefore, current strategy in dialysis patients should use these tests instead of TST for LTBI screening and as an aid for the diagnosis of active TB...

..The effect is not explained by the UFV depletion but is highly correlated with the decrease in SBP and PP. Further work is now needed to explore a potential role for endothelin and nitric oxide metabolism...

..Leptospirosis is a re-emerging infectious disease, which may lead to multiple organ failure (MOF)and death...

..A brief description of the current knowledge of sirolimus therapeutic drug monitoring, methods of analysis, pharmacokinetics and drug interactions with calcineurin inhibitors is also included...

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..Blocking either the binding of cell-surface molecules or intracellular signal transduction, these mAbs could become an effective method to promote the holy grail of solid-organ transplantation, antigen-specific tolerance...

..Therefore, a combined biomarker and bedside investigational approach could be a starting point for developing optimal therapeutic tools...

..SUMMARY: Ambulatory blood pressure monitoring remains an important adjunct to the comprehensive cardiovascular evaluation of patients with chronic, end-stage renal failure or after renal transplantation...

..It is the purpose of this article to briefly review the contribution from transplant immunosuppression to PTA and to assess its likely effects on and treatment options for patients...

..Unfortunately, this issue still remains a major challenge for nephrologists...

..This may contribute to a better understanding of the RPGN evolution and, implicitly, to the refinement of the diagnosis...

..This review takes a look at how biosimilars are fundamentally different from their originator products by examining the biopharmaceutical production process and how it can influence the structure and function of the final drug product...

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..A large interventional prospective study with valid control groups is now needed to assess the long-term contributions of clinical and biochemical factors of renal function and to elucidate the effects of therapy on outcome...

..Iron deficiency did not seem to be a causative factor for anaemia in this population...

..Much more work is needed to dissect out the causes for abnormal diurnal blood pressure rhythm and attempt to modulate this parameter. Obstructive sleep apnea may be a promising target for intervention...

..Hypertension in patients affected by chronic renal insufficiency (CRI) has been recognized as one of the major classical CV risk factors in CRI from the very beginning of the dialysis era. However, its treatment is still unsatisfactory...

..The Optimal Renal Anaemia Management Assessment (ORAMA) is the first European study investigating the impact of adherence to the 2004 revised European Best Practice Guidelines (EBPG) and its impact on patient outcomes...

..We therefore conducted a prospective study to investigate the benefits of allopurinol treatment in hyperuricemic patients with normal renal function...

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..Further studies are warranted to confirm this relationship and to elucidate the pathogenetic mechanisms of this relationship...

..In addition, the authors showed that ABPM is a more sensitive method for diagnosing hypertension than is sole reliance on office BP in renal transplant recipients...

..Anemia management in patients with chronic kidney disease shows considerable regional differences across Europe, and target attainment remains suboptimal in many European nephrology centers after the revised 2004 guidelines...

..The present publication reviews the arguments based on which this decision was taken...

..Second, to evaluate the additional value of albumin and hemoglobin levels in conjunction with bone mineral markers in the prediction of mortality and clinical events...

..Introduction. From the beginning of the dialysis era, the most appropriate composition of the dialysate has been one of the central topics in the delivery of dialysis treatment...

..50% of our patients have 2 to 4 risk factors for sudden death, which increase incidence of sudden death in patients on HD...