Patricia Rojas

Summary

Publications

  1. doi request reprint Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: therapeutic perspectives
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, Mexico, D F, Mexico
    Nutrition 28:1081-8. 2012
  2. doi request reprint Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice
    P Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269 México, D F, Mexico
    Neuroscience 223:246-57. 2012
  3. ncbi request reprint EGb761 pretreatment reduces monoamine oxidase activity in mouse corpus striatum during 1-methyl-4-phenylpyridinium neurotoxicity
    Patricia Rojas
    Laboratory of Neurotoxicology, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, Mexico, DF, Mexico
    Neurochem Res 29:1417-23. 2004
  4. ncbi request reprint Reduction of zinc-positive terminal fields in striatum of mouse after 1-methyl-4-phenylpyridinium neurotoxicity
    Patricia Rojas
    Laboratory of Neurotoxicology, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269 México D F, Mexico
    Neurotoxicology 26:959-68. 2005
  5. doi request reprint EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice: role of oxidative stress
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, Col La Fama C P 14269, Mexico, D F, Mexico
    Eur J Neurosci 28:41-50. 2008
  6. doi request reprint Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, Mexico, D F, Mexico
    Nutrition 25:482-5. 2009
  7. doi request reprint S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Mexico City, D F, Mexico
    J Nutr Biochem 22:937-44. 2011
  8. doi request reprint Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269, Mexico D F, Mexico
    Neurochem Int 59:628-36. 2011
  9. ncbi request reprint Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    Germán Chamorro
    Laboratorio de Toxicologia Preclinica, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Apartado Postal 314, C P, 11520 México, D F, Mexico
    Nutr Neurosci 9:207-12. 2006

Collaborators

Detail Information

Publications9

  1. doi request reprint Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: therapeutic perspectives
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, Mexico, D F, Mexico
    Nutrition 28:1081-8. 2012
    ..These studies suggest it as an alternative in the future treatment of PD...
  2. doi request reprint Ginkgo biloba extract (EGb 761) modulates the expression of dopamine-related genes in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice
    P Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269 México, D F, Mexico
    Neuroscience 223:246-57. 2012
    ..Moreover, this neuroprotection also involves the regulation of transcription factors such as Nurr1 that are important for the functional maintenance of dopaminergic neurons...
  3. ncbi request reprint EGb761 pretreatment reduces monoamine oxidase activity in mouse corpus striatum during 1-methyl-4-phenylpyridinium neurotoxicity
    Patricia Rojas
    Laboratory of Neurotoxicology, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, Mexico, DF, Mexico
    Neurochem Res 29:1417-23. 2004
    ..Results suggest that EGb761 supplements may be effective in reducing MAO activity as well as enhancement in dopamine metabolism, thereby preventing MPP+-neurotoxicity...
  4. ncbi request reprint Reduction of zinc-positive terminal fields in striatum of mouse after 1-methyl-4-phenylpyridinium neurotoxicity
    Patricia Rojas
    Laboratory of Neurotoxicology, Instituto Nacional de Neurologia y Neurocirugia, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269 México D F, Mexico
    Neurotoxicology 26:959-68. 2005
    ..The decrease of zinc-positive neuronal terminal fields in the striatum after MPP+ administration is most likely due to a neuronal release of vesicular zinc in response to its dopaminergic neurotoxicity...
  5. doi request reprint EGb761 protects against nigrostriatal dopaminergic neurotoxicity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice: role of oxidative stress
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, Col La Fama C P 14269, Mexico, D F, Mexico
    Eur J Neurosci 28:41-50. 2008
    ....
  6. doi request reprint Effect of EGb761 supplementation on the content of copper in mouse brain in an animal model of Parkinson's disease
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, Mexico, D F, Mexico
    Nutrition 25:482-5. 2009
    ..Because copper has been implicated in Parkinson's disease, we investigated whether the protective effect of EGb761 in MPP(+) neurotoxicity is related to the regulation of copper in the brain...
  7. doi request reprint S-Allylcysteine, a garlic compound, protects against oxidative stress in 1-methyl-4-phenylpyridinium-induced parkinsonism in mice
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Mexico City, D F, Mexico
    J Nutr Biochem 22:937-44. 2011
    ..These findings suggest that in mice, SAC attenuates MPP(+)-induced neurotoxicity in the striatum and that an antioxidant effect against oxidative stress may be partly responsible for its observed neuroprotective effects...
  8. doi request reprint Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: role of oxidative stress
    Patricia Rojas
    Laboratory of Neurotoxicology, National Institute of Neurology and Neurosurgery, Manuel Velasco Suarez, SS, Av Insurgentes Sur No 3877, C P 14269, Mexico D F, Mexico
    Neurochem Int 59:628-36. 2011
    ..It is suggested that EGb761 produces an antidepressant-like effect, and that an antioxidant effect against oxidative stress may be partly responsible for its observed neuroprotective effects...
  9. ncbi request reprint Spirulina maxima pretreatment partially protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    Germán Chamorro
    Laboratorio de Toxicologia Preclinica, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Apartado Postal 314, C P, 11520 México, D F, Mexico
    Nutr Neurosci 9:207-12. 2006
    ..Spirulina partially prevents MPTP neurotoxicity and oxidative stress, suggesting it could be a possible alternative in experimental therapy...