- Transplant vasculopathy is associated with increased AlloMap gene expression score
Mohamad H Yamani
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Kaufman Center for Heart Failure, Cleveland, Ohio 44195, USA
J Heart Lung Transplant 26:403-6. 2007
..2 +/- 3.9 vs 26.1 +/- 6.5, p < 0.001). There was a correlation of AlloMap score with time after transplantation (r = 0.31, p = 0.01). We found transplant vasculopathy to be associated with increased AlloMap score...
- Update on cardiac transplantation pathology
Carmela D Tan
Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, OH 44195, USA
Arch Pathol Lab Med 131:1169-91. 2007
..The grading system for evaluation of heart transplant biopsies published in 1990 was revised in 2004 after more than a decade of implementation...
- The pathology of heart transplant biopsy specimens: revisiting the 1990 ISHLT working formulation
E Rene Rodriguez
Cardiovascular Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Heart Lung Transplant 22:3-15. 2003
- Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load
Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
J Clin Invest 115:1221-31. 2005
..Reversal of this process by BH4 suggests a potential treatment to ameliorate the pathophysiology of chronic pressure-induced hypertrophy...
- Noninvasive detection of myocardial fibrosis in arrhythmogenic right ventricular cardiomyopathy using delayed-enhancement magnetic resonance imaging
Division of Cardiology, The Johns Hopkins University, Baltimore, MD 21287, USA
J Am Coll Cardiol 45:98-103. 2005
..We evaluated the role of myocardial delayed-enhancement (MDE) magnetic resonance imaging (MRI) for noninvasive detection of fibrosis in Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C)...
- Evaluation and course of an unusual case of arrhythmogenic right ventricular dysplasia
Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Int J Cardiovasc Imaging 22:269-73. 2006
..In this report, we describe accurate evaluation by MR imaging confirmed by histopathologic findings as well as imaging progression of this unusual case of arrhythmogenic right ventricular dysplasia...
- Reversible cardiomyopathy caused by administration of interferon alpha
Aarif Y Khakoo
Division of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA
Nat Clin Pract Cardiovasc Med 2:53-7. 2005
..Physical examination findings were consistent with congestive heart failure. Laboratory studies were notable for hypothyroidism. Echocardiography revealed severe, global left-ventricular dysfunction...
- Immunological challenges of cardiac transplantation: the need for better animal models to answer current clinical questions
Jennifer R Wehner
Department of Pathology, Johns Hopkins Medical Institutes, Baltimore, MD, USA
J Clin Immunol 29:722-9. 2009
..First, more sensitive diagnostic tests for detection of AMR have been developed. Second, improvements in immunosuppression have made severe acute cellular rejection uncommon, but have had less effect on AMR...
- Antithymocyte globulin is associated with complement deposition in cardiac transplant biopsies
William M Baldwin
Department of Pathology, The Johns Hopkins University, Baltimore, MD 21205 2196, USA
Hum Immunol 65:1273-80. 2004
..Thus prophylactic treatment with ATGAM is associated with the deposition of horse IgG and activation of complement in the transplant...
- Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Division of Cardiology, Department of Medicine, Johns Hopkins Medical Institutions, Ross 835, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
Nat Med 11:214-22. 2005
..PDE5A inhibition may provide a new treatment strategy for cardiac hypertrophy and remodeling...
- Antibody and complement in transplant vasculopathy
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
Circ Res 100:191-203. 2007
..The effect of these treatment modalities on the development of coronary vasculopathy is unknown...
- High-resolution three-dimensional aortic magnetic resonance angiography and quantitative vessel wall characterization of different atherosclerotic stages in a rabbit model
Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Invest Radiol 42:614-21. 2007
..We sought to evaluate novel magnetic resonance imaging (MRI) angiography and vessel wall sequences to visualize and quantify different morphologic stages of atherosclerosis in a Watanabe hereditary hyperlipidemic (WHHL) rabbit model...
- Arrhythmogenic right ventricular dysplasia: ex vivo and in vivo fat detection with black-blood MR imaging
Russell H Morgan Dept of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, MRI 143 Nelson Basement, Baltimore, MD 21287, USA
Radiology 232:38-48. 2004
- Impaired up-regulation of CD25 on CD4+ T cells in IFN-gamma knockout mice is associated with progression of myocarditis to heart failure
Department of Pathology, The Johns Hopkins Medical Institutions, 720 Rutland Avenue, Baltimore, MD 21205, USA
Proc Natl Acad Sci U S A 102:180-5. 2005
..An exaggerated inflammatory response in IFN-gamma KO mice causes cardiac dysfunction, leading to dilated cardiomyopathy and heart failure...
- Noninvasive diagnosis of biopsy-proven cardiac amyloidosis
Joseph E Rahman
Division of Cardiology, Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Avenue, Baltimore, MD 21224 2780, USA
J Am Coll Cardiol 43:410-5. 2004
..This study analyzed the utility of electrocardiographic (ECG) and echocardiographic findings in the diagnosis of amyloidosis proven by endomyocardial biopsy...
- Endovascular model of rabbit hindlimb ischemia: a platform to evaluate therapeutic angiogenesis
Robert P Liddell
Russell H Morgan Department of Radiology and Radiological Science, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
J Vasc Interv Radiol 16:991-8. 2005
- Increased expression of angiotensin II type 1 receptor (AGTR1) in heart transplant recipients with recurrent rejection
Mohamad H Yamani
Department of Cardiovascular Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
J Heart Lung Transplant 25:1283-9. 2006
..We hypothesized that recurrent acute rejection is associated with increased gene expression of AGTR1 in human heart transplantation...
- Acute antibody-mediated rejection of cardiac transplants
Elaine F Reed
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, 1000 Veteran Avenue, Room 1335, Los Angeles, CA 90095, USA
J Heart Lung Transplant 25:153-9. 2006
- Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection
International Society for Heart and Lung Transplantation, Addison, Texas, USA
J Heart Lung Transplant 24:1710-20. 2005
..Technical considerations in biopsy processing are also addressed. This consensus revision of the Working Formulation was approved by the ISHLT Board of Directors in December 2004...
- Molecular testing in the management of cardiac transplant recipients: initial clinical experience
Randall C Starling
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
J Heart Lung Transplant 25:1389-95. 2006
- Cardiac chimerism as a mechanism for self-repair: does it happen and if so to what degree?
Doris A Taylor
Circulation 106:2-4. 2002
- Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
McKusick Nathans Institute of Genetic Medicine, Baltimore, MD, USA
Circulation 108:79-85. 2003
..Hypoxia-inducible factor 1 (HIF-1) mediates adaptive transcriptional responses to hypoxia/ischemia...
- Complement in transplant rejection: diagnostic and mechanistic considerations
William M Baldwin
Department of Pathology, Ross Research Bldg, Room 659, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Springer Semin Immunopathol 25:181-97. 2003
..Therefore, the complement cascade can be activated by multiple mechanisms and various components of complement can modulate the response to transplants in different directions...
- Beyond C4d: other complement-related diagnostic approaches to antibody-mediated rejection
William M Baldwin
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 4:311-8. 2004
..Understanding the mechanisms by which complement integrates the interactions of leukocytes, platelets and parenchymal cells offers opportunities to further refine the diagnosis of rejection...
- Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms
Lili A Barouch
Department of Medicine Cardiology Division, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA
Nature 416:337-9. 2002
..Thus, NOS1 and NOS3 mediate independent, and in some cases opposite, effects on cardiac structure and function...