Acute tryptophan depletion evokes negative mood in healthy females who have previously experienced concurrent negative mood and tryptophan depletionOliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge CB22QQ, UK
Psychopharmacology (Berl) 205:227-35. 2009
..Such associations would mean that subsequent reductions in serotonin are more likely to provoke depressed mood and hence trigger an episode of depression...
- Dissociable responses to punishment in distinct striatal regions during reversal learning
Oliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Neuroimage 51:1459-67. 2010
..These data help to reconcile conflicting findings from previous studies by showing that distinct regions of the striatum exhibit dissociable responses to punishment during reversal learning...
- Dopamine precursor depletion improves punishment prediction during reversal learning in healthy females but not males
Oliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 211:187-95. 2010
..Here, we extend these prior findings by examining the effects of artificially reducing DA synthesis in healthy individuals performing this previously employed task...
- Tryptophan depletion disinhibits punishment but not reward prediction: implications for resilience
Oliver J Robinson
Department of Psychiatry and MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, Addenbrooke s Hospital, P O Box 189, Level E4, Hills Road, Cambridge, CB2 2QQ, UK
Psychopharmacology (Berl) 219:599-605. 2012
..in J Neurosci 29:11993-11999, 2009) approaches have, however, further specified this role by showing that serotonin is critical for punishment-induced inhibition...
- Reliance on habits at the expense of goal-directed control following dopamine precursor depletion
Sanne de Wit
Behavioral and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Psychopharmacology (Berl) 219:621-31. 2012
..Recent animal studies have implicated dopamine in the reinforcement of stimulus-response habits, as well as in flexible, goal-directed action. However, the role of dopamine in human action control is still not well understood...
Acute tryptophan depletion in healthy volunteers enhances punishment prediction but does not affect reward predictionRoshan Cools
Department of Experimental Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK
Neuropsychopharmacology 33:2291-9. 2008
..Furthermore, the finding highlights the importance of central 5-HT in resilience to adversity and may have implications for a variety of neuropsychiatric disorders including depression and anxiety...
- A double dissociation in the roles of serotonin and mood in healthy subjects
Oliver J Robinson
Department of Psychiatry and Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
Biol Psychiatry 65:89-92. 2009
..We attempted to disentangle the influence of affect on cognition by examining the effect of manipulating both serotonin (via acute tryptophan depletion [ATD]) and mood on established hot and cold cognitive tasks...
