5 Million Lives Campaign. Case study: an MRSA intervention at Evanston Northwestern HealthcareLance R Peterson
Northwestern University, Feinberg School of Medicine, Department of Medicine and Pathology, Evanston, Illinois, USA
Jt Comm J Qual Patient Saf 33:732-8. 2007
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- Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals
Ari Robicsek
Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
Ann Intern Med 148:409-18. 2008
..The effect of large-scale expanded surveillance for methicillin-resistant Staphylococcus aureus (MRSA) on health care-associated MRSA disease is not known...
Significant impact of terminal room cleaning with bleach on reducing nosocomial Clostridium difficileDonna M Hacek
NorthShore University Healthsystem, Department of Pathology and Laboratory Medicine, Division of Microbiology, Evanston, IL 60201, USA
Am J Infect Control 38:350-3. 2010
..In response, an intervention of terminal room cleaning with dilute bleach was instituted to decrease the amount of C difficile environmental spore contamination from patients with C difficile infection (CDI)...
Performance of the BD GeneOhm methicillin-resistant Staphylococcus aureus test before and during high-volume clinical useSuzanne M Paule
Department of Pathology and Laboratory Medicine, Evanston Northwestern Healthcare, 2650 Ridge Avenue, Evanston, IL 60201, USA
J Clin Microbiol 45:2993-8. 2007
..When one is dealing with large specimen numbers, the ACP lysis method offers easier processing without negatively affecting the sensitivity or specificity of the PCR assay...
- Implementation of a universal admission surveillance and decolonization program for methicillin-resistant staphylococcus aureus (MRSA) reduces the number of MRSA and total number of S. aureus isolates reported by the clinical laboratory
Donna M Hacek
NorthShore University Healthsystem, Department of Pathology and Laboratory Medicine, 2650 Ridge Avenue, Evanston, IL 60201, USA
J Clin Microbiol 47:3749-52. 2009
..The decreases in the numbers of MRSA and total S. aureus clinical isolates for each year after August 2005 were highly statistically significant compared to the numbers in each of the prior 3 years (P < 0.0001)...
- Laboratory testing for Clostridium difficile infection: light at the end of the tunnel
Lance R Peterson
Department of Medicine, NorthShore University Healthsystem, University of Chicago, Evanston, IL, USA
Am J Clin Pathol 136:372-80. 2011
..The common enzyme immunoassay tests all had sensitivity values less than 50%. Clinical laboratory professionals need to seriously consider their diagnostic testing and use the assays that perform best for the detection of CDI...
- Management of a multidrug-resistant Acinetobacter baumannii outbreak in an intensive care unit using novel environmental disinfection: a 38-month report
Carlo La Forgia
Department of Medicine, University of Chicago, Evanston, IL, USA
Am J Infect Control 38:259-63. 2010
..We describe the systematic investigation initiated to discover an environmental reservoir and a novel measure taken to terminate the outbreak...
- Detection of toxigenic Clostridium difficile in stool samples by real-time polymerase chain reaction for the diagnosis of C. difficile-associated diarrhea
Lance R Peterson
Department of Pathology and Laboratory Medicine, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
Clin Infect Dis 45:1152-60. 2007
..Current laboratory testing lacks a single assay that is sensitive, specific, and rapid. The purpose of this work was to design and validate a sensitive and specific real-time polymerase chain reaction (PCR) diagnostic test for CDAD...
- Does my patient have Clostridium difficile infection?
Lance R Peterson
Northwestern University and NorthShore University HealthSystem, Evanston, Illinois 60201, USA
Ann Intern Med 151:176-9. 2009
..Diagnoses of CDI will be more accurate if clinicians use tests with a higher sensitivity, reduce the frequency of testing for a single episode of diarrhea, and give more attention to key elements of the patient's history...
- Chromogenic media vs real-time PCR for nasal surveillance of methicillin-resistant Staphylococcus aureus: impact on detection of MRSA-positive persons
Suzanne M Paule
Department of Pathology and Laboratory Medicine, Division of Microbiology, NorthShore University Healthsystem, Walgreen SB525, 2650 Ridge Ave, Evanston, IL 60201, USA
Am J Clin Pathol 131:532-9. 2009
..There was no substantial difference in the labor required for any of the 3 approaches...
- Reporting catheter-associated urinary tract infections: denominator matters
Marc Oliver Wright
Department of Infection Control, NorthShore University Healthsystem, Evanston, Illinois 60201, USA
Infect Control Hosp Epidemiol 32:635-40. 2011
..To evaluate two different methods of measuring catheter-associated urinary tract infection (CAUTI) rates in the setting of a quality improvement initiative aimed at reducing device utilization...
- The electronic medical record as a tool for infection surveillance: successful automation of device-days
Marc Oliver Wright
Department of Infection Control, NorthShore University Healthsystem, 2650 Ridge Ave, Burch 124, Evanston, IL 60201, USA
Am J Infect Control 37:364-70. 2009
..Manual collection of central venous catheter, ventilator, and indwelling urinary catheter device-days is time-consuming, often restricted to intensive care units (ICU) and prone to error...
- Duration of colonization with methicillin-resistant Staphylococcus aureus
Ari Robicsek
Department of Medicine, Northwestern University s Feinberg School of Medicine, Evanston, Illinois 60201, USA
Clin Infect Dis 48:910-3. 2009
..8% of the patients (95% confidence interval, 45.8%-51.7%) remained colonized; at 4 years, 21.2% of the patients (95% confidence interval, 13.1%-31.4%) remained colonized...
- Impact of laboratory-reported urine culture colony counts on the diagnosis and treatment of urinary tract infection for hospitalized patients
Jennie H Kwon
Department of Internal Medicine, NorthShore University Healthsystem, Evanston, IL 60201, USA
Am J Clin Pathol 137:778-84. 2012
..These data suggest that reporting colony counts less than 100,000 CFU/mL encourages treatment of non-clinically significant UTIs in hospitalized patients, causing inappropriate antibiotic use...
- Electronic surveillance for infectious disease trend analysis following a quality improvement intervention
Kari E Peterson
Department of Laboratory Medicine and Pathology, Division of Microbiology, NorthShore University Healthsystem, Evanston, Illinois 60201, USA
Infect Control Hosp Epidemiol 33:790-5. 2012
..The purpose of this study was to validate electronic tools for MRSA healthcare-associated infection (HAI) trending that can replace manual medical record review...
- Prediction of methicillin-resistant Staphylococcus aureus involvement in disease sites by concomitant nasal sampling
Ari Robicsek
Department of Medicine, Northwestern University s Feinberg School of Medicine, Chicago, Illinois, USA
J Clin Microbiol 46:588-92. 2008
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- Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005
Jacob Strahilevitz
Department of Clinical Microbiology and Infectious Diseases, Hadassah Ein Kerem, Jerusalem, Israel
Antimicrob Agents Chemother 51:3001-3. 2007
..Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints...
- The worldwide emergence of plasmid-mediated quinolone resistance
Ari Robicsek
Massachusetts General Hospital, Boston, MA 02114-2696, USA
Lancet Infect Dis 6:629-40. 2006
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- Prevalence in the United States of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme
Chi Hye Park
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696, USA
Antimicrob Agents Chemother 50:3953-5. 2006
..aac(6')-Ib-cr was geographically widespread, stable over time, most common in Escherichia coli, equally prevalent in ciprofloxacin-susceptible and -resistant strains, and not associated with qnr genes...
- Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica
Kathryn Gay
Atlanta Research and Education Foundation, Atlanta, GA, USA
Clin Infect Dis 43:297-304. 2006
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- Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones
Jacob Strahilevitz
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114-2696, USA
Antimicrob Agents Chemother 50:600-6. 2006
..Our findings suggest that the extended alpha4 domain of S. aureus GyrA is responsible, at least in part, for the increased resistance of S. aureus gyrase to quinolones and that this effect is modulated by K+-glutamate...
- Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase
Ari Robicsek
Harvard Medical School, Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 512, Boston, Massachusetts 02114, USA
Nat Med 12:83-8. 2006
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