Attention deficit hyperactivity disorder, tics and Tourette's syndrome: the relationship and treatment implications. A commentaryMary M Robertson
Dept of Mental Health Sciences, University College London, 2nd Floor, Wolfson Building, 48 Riding House Street, London W1W 7EY, UK
Eur Child Adolesc Psychiatry 15:1-11. 2006
..This commentary briefly discusses the comorbidity between TS and ADHD and offers treatment suggestions...
The Gilles de la Tourette syndrome: the current statusMary May Robertson
Department of Mental Health Sciences, University College, London, UK
Arch Dis Child Educ Pract Ed 97:166-75. 2012
..Other treatments which may be needed for loud and severe phonic tics include botulinum toxin. In severe adult GTS patients who are refractory to medication and other therapies, deep brain stimulation looks promising...
- The disaster was my fault!
Mary M Robertson
Department of Mental Health Sciences, Royal Free and University College Medical School, University College London, London, UK
Neurocase 13:446-51. 2007
..Prognostic and treatment implications are also presented, along with a review of the literature on the clinical and psychosocial impact of terrorist attacks and natural disasters on children suffering from neuropsychiatric disorders...
- The Gilles de la Tourette syndrome: a principal component factor analytic study of a large pedigree
Mary M Robertson
Department of Mental Health Sciences, University College London, UK
Psychiatr Genet 17:143-52. 2007
..Factor analytic studies suggest that there are more than one Gilles de la Tourette syndrome phenotype and it is not a unitary condition...
- The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies
Mary M Robertson
University College, London, United Kingdom
J Psychosom Res 65:461-72. 2008
..GTS is found in all other cultures, although to possibly differing degrees. In all cultures where GTS has been reported, the phenomenology is similar, highlighting the biological underpinnings of the disorder...
- The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes
Mary M Robertson
University College, London, United Kingdom
J Psychosom Res 65:473-86. 2008
..It is suggested that a new nomenclature be adopted for GTS in future, pending further genetic and phenomenological studies. To what extent the aetiology affects the phenotype and, thus, the prevalence is still unclear...
- Tourette's syndrome (TS): inhibitory performance in adults with uncomplicated TS
Shelley Channon
Department of Cognitive, Perceptual, and Brain Sciences, University College London, London, UK
Neuropsychology 23:359-66. 2009
..A range of different types of inhibitory tasks may be sensitive to TS-alone, and this may depend on both the type of inhibition and the strength of the inhibitory manipulation...
- Judgements of social inappropriateness in adults with Tourette's syndrome
Shelley Channon
Department of Cognitive, Perceptual and Brain Sciences, University College London, and Department of Neurology, St George s Hospital and Medical School, London, UK
Cogn Neuropsychiatry 17:246-61. 2012
..The current study was designed to examine the appropriateness of self-disclosures in TS using an emotional self-disclosure task...
- Tourette's syndrome (TS): cognitive performance in adults with uncomplicated TS
Shelley Channon
Department of Psychology, University College London, London, United Kingdom
Neuropsychology 20:58-65. 2006
..The findings provide further evidence that uncomplicated TS is associated with only mild, circumscribed impairment. The nature of any impairment is discussed...
- Tourette's syndrome: performance on tests of behavioural inhibition, working memory and gambling
Sarah Crawford
Department of Psychology, University College London, UK
J Child Psychol Psychiatry 46:1327-36. 2005
..The present study was designed to examine this issue using carefully screened participants with TS and experimental measures thought to involve different areas of the frontal lobes...
- Diagnosing Tourette syndrome: is it a common disorder?
Mary M Robertson
Department of Psychiatry and Behavioural Sciences, Royal Free and University College Medical School, University College London, 2nd Floor Wolfson Building, 48 Riding House Street, London W1N 8AA, UK
J Psychosom Res 55:3-6. 2003
..The evaluate the prevalence of Tourette syndrome (TS)...
- Fragile X syndrome associated with tic disorders
Susanne A Schneider
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 23:1108-12. 2008
..We suggest considering fragile X syndrome in GTS complicated by co-morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present...
- Social cognition in Tourette's syndrome: intact theory of mind and impaired inhibitory functioning
Shelley Channon
Department of Psychology, University College London, UK
J Autism Dev Disord 34:669-77. 2004
..The implications of the findings for our understanding of TS and of the relationship between social cognition and executive skills are discussed...
- Depressive symptomatology in young people with Gilles de la Tourette Syndrome-- a comparison of self-report scales
Mary M Robertson
UCLMS Department of Mental Health Sciences, 2nd Floor, Wolfson Building, 48 Riding House Street, London W1W 7EY, United Kingdom
J Affect Disord 91:265-8. 2006
..Few studies have examined depressive symptomatology in children and adolescents with Tourette Syndrome (TS) using standardised measures and none have compared different self-report scales in the context of TS...
- Air swallowing as a tic
Rimona S Weil
Institute of Neurology, Queen Square, London, UK
J Psychosom Res 65:497-500. 2008
..The authors present a patient with Gilles de la Tourette syndrome who developed abdominal distension and bloating due to air swallowing. We suggest that this air swallowing may have been due to a tic...
- Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome
Davide Martino
Neuroscience and Trauma Centre, Barts and The London School Medicine and Dentistry, Queen Mary University of London, London, UK
J Neurol 259:2137-40. 2012
..Eye tic phenomenology was similar in patients with or without co-morbidity. Eye tics are therefore likely to be a core feature of GTS and should be routinely evaluated in order to strengthen the clinician's confidence in diagnosing GTS...
- A patient with both Gilles de la Tourette's syndrome and chromosome 22q11 deletion syndrome: clue to the genetics of Gilles de la Tourette's syndrome?
Mary M Robertson
St Georges Hospital and Medical School, UK
J Psychosom Res 61:365-8. 2006
....
- Antineuronal antibody status and phenotype analysis in Tourette's syndrome
Davide Martino
Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 22:1424-9. 2007
..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS...
- Adult-onset tic disorders
Valsamma Eapen
Department of Psychiatry and Behavioural Sciences, Royal Free and University College, London Medical School, London, United Kingdom
Mov Disord 17:735-40. 2002
....
- Obsessive compulsive behaviour and depressive symptoms in young people with Tourette syndrome. A controlled study
Mary M Robertson
Royal Free and University College London Medical School, Department of Psychiatry and Behavioural Sciences, 2nd Floor, Wolfson Building, 48 Riding House Street, London W1N 8AA, UK
Eur Child Adolesc Psychiatry 11:261-5. 2002
..The findings illustrate the potentially complex, challenging combination of difficulties encountered by children with TS and those who care for them...
- Behavioral and affective disorders in Tourette syndrome
Mary M Robertson
Department of Mental Health Sciences, St. Georges Hospital, London, United Kingdom
Adv Neurol 99:39-60. 2006
- Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndrome
Andrea E Cavanna
Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, United Kingdom
Eur J Paediatr Neurol 16:605-12. 2012
..The diagnosis of GTS is usually established in childhood but little is known about factors that predict the long-term well-being of patients, especially in the presence of co-morbid behavioural problems...
- Gilles de la Tourette syndrome: the complexities of phenotype and treatment
Mary M Robertson
University College London, London, UK
Br J Hosp Med (Lond) 72:100-7. 2011
..Management includes reassurance, education, behavioural treatments and medications for tics and psychopathology...
- Real-life-type problem solving in Tourette syndrome
Shelley Channon
Department of Psychology, University College London, School of Medicine, London, UK
Cogn Behav Neurol 16:3-15. 2003
..The main objective of the study was to examine social problem solving in real-life-type situations in Tourette syndrome (TS)...
- Grip force behavior in Gilles de la Tourette syndrome
Dennis A Nowak
Sobell Department of Motor Neuroscience and Movements Disorders, Institute of Neurology, University of London, London, United Kingdom
Mov Disord 20:217-23. 2005
..We found no significant effect of medication on the performance of GTS patients, regardless of the task performed. These results are consistent with deficient sensory-motor processing in Gilles de la Tourette syndrome...
- A case series of patients with Tourette's syndrome in the United Kingdom treated with aripiprazole
Lisa Davies
St George's Hospital, Department of Neurology, Atkinson Morley Wing, Blackshaw Rd, London, SW17-0QT, UK
Hum Psychopharmacol 21:447-53. 2006
..CONCLUSION: We suggest that aripiprazole may well be useful for individuals with TS as response to it is often quick, dramatic, sustained and with few generally mild and transient side effects...
- Principal components analysis of a large cohort with Tourette syndrome
Mary M Robertson
Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Br J Psychiatry 193:31-6. 2008
..Tourette syndrome is a heterogeneous familial disorder for which the genetic mechanisms are unknown. A better characterisation of the phenotype may help identify susceptibility genes...
- The successful use of ondansetron in a boy with both leukemia and Tourette syndrome
Renata Rizzo
Section of Child Neuropsychiatry, Department of Pediatrics University of Catania, Azienda Policlinico, Catania, Italy
J Child Neurol 23:108-11. 2008
..This not only relieved the target symptoms, but also those of his Gilles de la Tourette syndrome. Following a reduction of the ondansetron dosage, his Gilles de la Tourette syndrome symptoms reemerged...
- Executive function, memory, and learning in Tourette's syndrome
Shelley Channon
Subdepartment of Clinical Health Psychology, University College London, England
Neuropsychology 17:247-54. 2003
..There was no evidence of impairment in implicit aspects of memory and learning for any of the TS groups. The findings are discussed in terms of the frontostriatal hypothesis of TS and the contribution of comorbid symptomatology...
- Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
James F Leckman
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003
..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental...
- Psychological morbidity and caregiver burden in parents of children with Tourette's disorder and psychiatric comorbidity
Claudia Cooper
Camden and Islington Mental Health and Social Care Trust, UK
J Am Acad Child Adolesc Psychiatry 42:1370-5. 2003
..CONCLUSIONS: Parents of children with TD are at risk of psychiatric morbidity; an intervention targeting caregiver burden might be helpful in reducing this...
- Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome
Erwin Petek
Institute of Medical Biology and Human Genetics, Medical University of Graz, Harrachgasse 21 8, 8010, Graz, Austria
Mol Genet Genomics 277:71-81. 2007
..Despite the fact that no deleterious mutations in IMMPL2 (other than the inverted duplication identified previously) were identified in either GTS or AD, this gene cannot be excluded as a possible rare cause of either disorder...
- Phenomenology of obsessive compulsive disorder in patients with temporal lobe epilepsy or tourette syndrome
Marco Mula
The Neuropsychiatry Research Group, Department of Clinical and Experimental Medicine, Section of Neurology, Amedeo Avogadro University, C so Mazzini, 18, Novara 28100, Italy
J Neuropsychiatry Clin Neurosci 20:223-6. 2008
..Content of obsessive-compulsive themes focuses on sexuality and impulsiveness in Tourette syndrome and existential thoughts in temporal lobe epilepsy...
- Increased antistreptococcal antibody titers and anti-basal ganglia antibodies in patients with Tourette syndrome: controlled cross-sectional study
Renata Rizzo
Section of Child Neuropsychiatry, Department of Pediatrics, Catrania University, Via S Sofia 78, 95125 Catania, Italy
J Child Neurol 21:747-53. 2006
..01). These results support the reported association between streptococcal infection and anti-basal ganglia antibodies and some patients with Tourette syndrome...
- Catatonic signs in Gilles de la Tourette syndrome
Andrea E Cavanna
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N3BG, UK
Cogn Behav Neurol 21:34-7. 2008
..Originally described in association with schizophrenia, catatonic signs have been reported in a wide range of neuropsychiatric conditions...
- Disentangling the effects of Tourette syndrome and attention deficit hyperactivity disorder on cognitive and behavioral phenotypes
Renata Rizzo
Section of Child Neuropsychiatry, Department of Pediatrics, University of Catania, Italy
Brain Dev 29:413-20. 2007
..The "additive effect" hypothesis is discussed in detail in the light of our results and recent literature...
