David C S Roberts

Summary

Publications

  1. pmc Conflation of cocaine seeking and cocaine taking responses in IV self-administration experiments in rats: methodological and interpretational considerations
    David C S Roberts
    Department of Physiology and Pharmacology, Wake Forest Health Sciences, Winston Salem, NC 27101, USA Electronic address
    Neurosci Biobehav Rev 37:2026-36. 2013
  2. ncbi request reprint Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats
    Christopher M Lack
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 195:517-25. 2008
  3. ncbi request reprint Extended cocaine self-administration and deprivation produces region-specific and time-dependent changes in connexin36 expression in rat brain
    Clinton B McCracken
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 58:141-50. 2005
  4. ncbi request reprint Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation
    Yolanda Mateo
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 30:1455-63. 2005
  5. pmc Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals
    Mark J Ferris
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 38:2628-36. 2013
  6. pmc Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration
    Rodrigo A Espana
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 214:415-26. 2011
  7. ncbi request reprint Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats
    Yu Liu
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 195:369-75. 2007
  8. pmc Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter
    Erin S Calipari
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Neuropsychopharmacology 38:2385-92. 2013
  9. pmc Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration
    Mark J Ferris
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Biol Psychiatry 69:201-7. 2011
  10. pmc A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid
    Erik B Oleson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 214:567-77. 2011

Detail Information

Publications39

  1. pmc Conflation of cocaine seeking and cocaine taking responses in IV self-administration experiments in rats: methodological and interpretational considerations
    David C S Roberts
    Department of Physiology and Pharmacology, Wake Forest Health Sciences, Winston Salem, NC 27101, USA Electronic address
    Neurosci Biobehav Rev 37:2026-36. 2013
    ..e. drug seeking). The mechanisms that control drug intake should be considered distinct from appetitive and motivational processes and should be taken into consideration in future IV self-administration studies...
  2. ncbi request reprint Increased breakpoints on a progressive ratio schedule reinforced by IV cocaine are associated with reduced locomotor activation and reduced dopamine efflux in nucleus accumbens shell in rats
    Christopher M Lack
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 195:517-25. 2008
    ..This may reflect an increased motivation to self-administer cocaine, one hallmark of addiction...
  3. ncbi request reprint Extended cocaine self-administration and deprivation produces region-specific and time-dependent changes in connexin36 expression in rat brain
    Clinton B McCracken
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 58:141-50. 2005
    ..These results suggest that changes in neuronal gap junction expression may be one mechanism by which cocaine self-administration produces enduring changes in behavior...
  4. ncbi request reprint Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation
    Yolanda Mateo
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 30:1455-63. 2005
    ..Thus, the NAc was hypodopaminergic and DA terminals were less sensitive to cocaine following binge cocaine SA and deprivation...
  5. pmc Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals
    Mark J Ferris
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 38:2628-36. 2013
    ..Thus, we showed that tolerance to the cocaine-induced inhibition of DA uptake coexists with a behavioral phenotype that is defined by increased preoccupation with cocaine as measured by rapid acquisition and early high intake...
  6. pmc Hypocretin 1/orexin A in the ventral tegmental area enhances dopamine responses to cocaine and promotes cocaine self-administration
    Rodrigo A Espana
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 214:415-26. 2011
    ..For example, manipulations that decrease hypocretin neurotransmission result in disruptions of neurochemical and behavioral responses to cocaine...
  7. ncbi request reprint Cross-sensitization of the reinforcing effects of cocaine and amphetamine in rats
    Yu Liu
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 195:369-75. 2007
    ..There is a relative paucity of studies examining whether cross-sensitization occurs between amphetamine and cocaine when both are self-administered...
  8. pmc Temporal pattern of cocaine intake determines tolerance vs sensitization of cocaine effects at the dopamine transporter
    Erin S Calipari
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Neuropsychopharmacology 38:2385-92. 2013
    ..Thus, intake and pattern can both influence cocaine potency, and tolerance seems to be produced by high intake, while sensitization is produced by intermittent temporal patterns of intake...
  9. pmc Cocaine-insensitive dopamine transporters with intact substrate transport produced by self-administration
    Mark J Ferris
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Biol Psychiatry 69:201-7. 2011
    ..Amphetamine has the added mechanism of reverse transport of intracellular DA through the DAT...
  10. pmc A novel IV cocaine self-administration procedure in rats: differential effects of dopamine, serotonin, and GABA drug pre-treatments on cocaine consumption and maximal price paid
    Erik B Oleson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 214:567-77. 2011
    ..For example, appetitive behavior can be assessed with a progressive ratio schedule, whereas consummatory behavior is typically measured using a fixed ratio schedule...
  11. pmc Cocaine self-administration produces pharmacodynamic tolerance: differential effects on the potency of dopamine transporter blockers, releasers, and methylphenidate
    Mark J Ferris
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 37:1708-16. 2012
    ..Further, methylphenidate's interaction with the DAT is unique and concentration-dependent...
  12. pmc Decreased reinforcing effects of cocaine following 2 weeks of continuous D-amphetamine treatment in rats
    Keri A Chiodo
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 206:447-56. 2009
    ..In rats, a 14-day continuous infusion of D: -amphetamine via osmotic mini-pump has been shown to decrease cocaine-reinforced responding under a progressive ratio (PR) schedule of reinforcement...
  13. pmc Dopamine uptake changes associated with cocaine self-administration
    Erik B Oleson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 34:1174-84. 2009
    ..This model permits a computational interpretation of cocaine-induced dopamine uptake changes during cocaine self-administration...
  14. pmc Cocaine self-administration reinforced on a progressive ratio schedule decreases with continuous D-amphetamine treatment in rats
    Keri A Chiodo
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 200:465-73. 2008
    ..Agonist medications are used clinically in the treatment of other addictions, which suggests that this method of drug therapy could potentially be successful in treating cocaine addiction as well...
  15. pmc The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system
    Rodrigo A Espana
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Eur J Neurosci 31:336-48. 2010
    ..Additionally, the current observations suggest that the hypocretin system may provide a target for pharmacotherapies to treat cocaine addiction...
  16. ncbi request reprint Rapid and persistent sensitization to the reinforcing effects of cocaine
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 31:121-8. 2006
    ..These studies describe a form of sensitization that occurs rapidly to the reinforcing effects of cocaine, and provide a model to study the potential impact of initial experience on the development of drug dependence...
  17. doi request reprint Cocaine self-administration on a hold-down schedule of reinforcement in rats
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Psychopharmacology (Berl) 201:601-9. 2009
    ..g., a lever press) and reinforcers (e.g., 1.0 mg/kg/injection cocaine). Therefore, the present study provides an initial examination under experimental conditions with both responses and reinforcers measured along continuous dimensions...
  18. ncbi request reprint Lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine
    Mark A Smith
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pharmacol Biochem Behav 88:238-46. 2008
    ..These data suggest that lesions of the dorsomedial frontal cortex block sensitization to the positive-reinforcing effects of cocaine in rats with a history of binge-abstinence self-administration...
  19. ncbi request reprint Sensitization to the reinforcing effects of cocaine following binge-abstinent self-administration
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, USA
    Neurosci Biobehav Rev 27:803-12. 2004
    ..This model, in conjunction with recently developed tools to characterize neurochemical and epigenetic changes, will provide a better understanding of the neurobiological bases of the addiction process...
  20. ncbi request reprint Binge self-administration and deprivation produces sensitization to the reinforcing effects of cocaine in rats
    Drake Morgan
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 178:309-16. 2005
    ..Behavioral procedures that incorporate dynamic changes in drug-maintained behavior are needed to model the development of cocaine addiction in humans...
  21. pmc How to make a rat addicted to cocaine
    David C S Roberts
    Wake Forest University Health Sciences, Department of Physiology and Pharmacology, Winston Salem, NC 27157, United States
    Prog Neuropsychopharmacol Biol Psychiatry 31:1614-24. 2007
    ..Finally, we suggest that specific parameters (dose, price and availability) can be used to examine the transition from recreational use to binge-like intake...
  22. pmc Examination of behavioral strategies regulating cocaine intake in rats
    Benjamin A Zimmer
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 225:935-44. 2013
    ..Most studies examining this phenomenon have used fixed, unit doses in which case the only titration strategy available to the animal is to adjust inter-infusion intervals...
  23. pmc Methylphenidate and cocaine self-administration produce distinct dopamine terminal alterations
    Erin S Calipari
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston Salem, NC, USA Department of Pharmacology, University of Toronto, Toronto, Canada
    Addict Biol 19:145-55. 2014
    ..These findings suggest that the factors governing DA system adaptations are more complicated than simple DA uptake blockade. ..
  24. ncbi request reprint Effect of HD-23, a potent long acting cocaine-analog, on cocaine self-administration in rats
    David C S Roberts
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 167:386-92. 2003
    ..HD-23 is a very long acting tropane analog that displays a neurochemical profile similar to cocaine...
  25. pmc Behavioral economic assessment of price and cocaine consumption following self-administration histories that produce escalation of either final ratios or intake
    Erik B Oleson
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 34:796-804. 2009
    ..These results suggest that distinct aspects of the addiction process can be parsed using self-administration models, thereby facilitating the investigation of specific neurobiological adaptations that occur through the addiction process...
  26. ncbi request reprint A single evoked afterdischarge produces rapid time-dependent changes in connexin36 protein expression in adult rat dorsal hippocampus
    Clinton B McCracken
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neurosci Lett 405:84-8. 2006
    ..These data suggest that a relatively brief hypersynchronous neuronal discharge can produce rapid and specific changes in Cx36 expression, which may have implications for both normal brain function and the pathophysiology of epilepsy...
  27. ncbi request reprint Fast onset of dopamine uptake inhibition by intravenous cocaine
    Yolanda Mateo
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Eur J Neurosci 20:2838-42. 2004
    ..This is at least 10-fold faster than previous neurochemical estimates. The present findings may contribute to the understanding of the neurobiological mechanisms underlying the early behavioral responses to cocaine...
  28. ncbi request reprint Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats
    Mark A Smith
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 173:105-11. 2004
    ..Previous studies have strongly implicated a role for GABA(B) receptors in modulating the reinforcing effects of cocaine...
  29. pmc Free-running rhythms of cocaine self-administration in rats held under constant lighting conditions
    Caroline E Bass
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27101, USA
    Chronobiol Int 27:535-48. 2010
    ..The DT procedure is therefore a useful model to examine the substrates underlying the relationship between circadian rhythms and cocaine intake...
  30. pmc Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems
    Lawrence C Blume
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Neurochem 124:808-20. 2013
    ....
  31. ncbi request reprint Synchronous oscillations and phase reorganization in the basal ganglia during akinesia induced by high-dose haloperidol
    John M Burkhardt
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Eur J Neurosci 26:1912-24. 2007
    ..Our results demonstrate that acute DA blockade is sufficient to produce synchronous oscillatory activity across basal ganglia neuron populations, and that prolonged DA blockade results in phase lag changes in pallidostriatal synchrony...
  32. ncbi request reprint Reduction of the reinforcing effectiveness of cocaine by continuous D-amphetamine treatment in rats: importance of active self-administration during treatment period
    Benjamin A Zimmer
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC, 27157, USA
    Psychopharmacology (Berl) 231:949-54. 2014
    ..In rodent studies, constant infusion of D-amphetamine (5 mg/kg/day) has been shown to reduce cocaine-reinforced responding in the dose range of 0.19-0.75 mg/kg/inf...
  33. pmc Nipping cue reactivity in the bud: baclofen prevents limbic activation elicited by subliminal drug cues
    Kimberly A Young
    Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, Department of Physiology and Pharmacology, School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, and Philadelphia VA Medical Center, Philadelphia, Pennsylvania 19104
    J Neurosci 34:5038-43. 2014
    ..005; cluster corrected at p < 0.05). These results suggest that baclofen may inhibit the earliest type of drug cue-induced motivational processing-that which occurs outside of awareness-before it evolves into a less manageable state. ..
  34. ncbi request reprint Neuronal gap junctions: expression, function, and implications for behavior
    Clinton B McCracken
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Int Rev Neurobiol 73:125-51. 2006
  35. ncbi request reprint Repetitive vibrissae-elicited forelimb placing before and immediately after unilateral 6-hydroxydopamine improves outcome in a model of Parkinson's disease
    Kristin K Anstrom
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Behav Brain Res 179:183-91. 2007
    ..Only the PRE+123 group showed significant sparing of TH-ir compared to the HANDLE group. These data suggest that extensive repetitive exposure to a sensorimotor task may provide therapeutic effects in an animal model of PD...
  36. ncbi request reprint Preclinical evidence for GABAB agonists as a pharmacotherapy for cocaine addiction
    David C S Roberts
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    Physiol Behav 86:18-20. 2005
    ..Preliminary clinical data with baclofen have also been encouraging. The obstacles and issues related to the use of GABA drugs in addiction therapy are briefly addressed...
  37. pmc The group II metabotropic glutamate receptor agonist, LY379268, decreases methamphetamine self-administration in rats
    Jordan T Crawford
    Department of Physiology and Pharmacology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, United States
    Drug Alcohol Depend 132:414-9. 2013
    ..We sought to test the ability of the selective group II mGluR agonist LY379268 to reduce METH self-administration in rats...
  38. ncbi request reprint Amphetamine withdrawal produces region-specific and time-dependent changes in connexin36 expression in rat brain
    Clinton B McCracken
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 56:39-44. 2005
    ..This is, to our knowledge, the first demonstration of pharmacological manipulation of connexin36 in vivo...
  39. ncbi request reprint Patterns of cocaine self-administration in rats produced by various access conditions under a discrete trials procedure
    David C S Roberts
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27101, USA
    Drug Alcohol Depend 67:291-9. 2002
    ..This DT procedure provides a method to examine the behavioral and neurochemical effects of high cocaine intake over extended periods without toxicity...