Darren M Roberts

Summary

Publications

  1. pmc Intentional self-poisoning with the chlorophenoxy herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA)
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Medical School, Australian National University, Acton, Australian Capital Territory, Australia
    Ann Emerg Med 46:275-84. 2005
  2. pmc Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    BMC Clin Pharmacol 9:3. 2009
  3. pmc Acute human self-poisoning with bispyribac-containing herbicide Nominee: a prospective observational study
    Indika Bandara Gawarammana
    Faculty of Medicine, Department of Medicine and South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    Clin Toxicol (Phila) 48:198-202. 2010
  4. pmc Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    Toxicol Lett 201:270-6. 2011
  5. doi request reprint Enhanced elimination in acute barbiturate poisoning - a systematic review
    Darren M Roberts
    Burns, Trauma and Critical Care Research Unit, Royal Brisbane and Women s Hospital, School of Medicine, University of Queensland, Australia
    Clin Toxicol (Phila) 49:2-12. 2011
  6. doi request reprint The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review
    Darren M Roberts
    Statewide Renal Services, Royal Prince Alfred and Concord Repatriation General Hospitals, New South Wales, Australia
    Transplantation 94:775-83. 2012
  7. ncbi request reprint Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales
    Darren M Roberts
    New South Wales Poisons Information Centre, Children s Hospital at Westmead, Sydney, NSW, Australia
    Med J Aust 198:43-7. 2013
  8. doi request reprint Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study
    Darren M Roberts
    Burns, Trauma, and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Crit Care Med 40:1523-8. 2012
  9. ncbi request reprint The relevance of drug clearance to antibiotic dosing in critically ill patients
    Darren M Roberts
    Department of Clinical Pharmacology, St Vincent s Hospital, Darlinghurst, NSW, Australia, 2010
    Curr Pharm Biotechnol 12:2002-14. 2011
  10. doi request reprint Extreme γ-butyrolactone overdose with severe metabolic acidosis requiring hemodialysis
    Darren M Roberts
    Clinical Pharmacology and Toxicology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Ann Emerg Med 58:83-5. 2011

Collaborators

Detail Information

Publications26

  1. pmc Intentional self-poisoning with the chlorophenoxy herbicide 4-chloro-2-methylphenoxyacetic acid (MCPA)
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Medical School, Australian National University, Acton, Australian Capital Territory, Australia
    Ann Emerg Med 46:275-84. 2005
    ..Our objective is to describe outcomes from intentional self-poisoning with MCPA in a prospective case series of 181 patients presenting to hospitals in Sri Lanka...
  2. pmc Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    BMC Clin Pharmacol 9:3. 2009
    ..However, there is limited information about the clinical toxicity and kinetics. The objective of this study is to describe the clinical outcomes and kinetics of propanil following acute intentional self-poisoning...
  3. pmc Acute human self-poisoning with bispyribac-containing herbicide Nominee: a prospective observational study
    Indika Bandara Gawarammana
    Faculty of Medicine, Department of Medicine and South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    Clin Toxicol (Phila) 48:198-202. 2010
    ..We present the first case series of acute human self-poisoning with an herbicide product containing bispyribac...
  4. pmc Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    Toxicol Lett 201:270-6. 2011
    ..5h (95%CI 15.0-83.0h; n=16 patients) compared to 16.8h (95%CI 13.6-22.2h; n=10 patients) at lower concentrations. MCPA is subject to saturable protein binding but the influence on half-life appears marginal...
  5. doi request reprint Enhanced elimination in acute barbiturate poisoning - a systematic review
    Darren M Roberts
    Burns, Trauma and Critical Care Research Unit, Royal Brisbane and Women s Hospital, School of Medicine, University of Queensland, Australia
    Clin Toxicol (Phila) 49:2-12. 2011
    ..Information regarding the efficacy of these techniques for individual barbiturates is not available in standard textbooks...
  6. doi request reprint The treatment of acute antibody-mediated rejection in kidney transplant recipients-a systematic review
    Darren M Roberts
    Statewide Renal Services, Royal Prince Alfred and Concord Repatriation General Hospitals, New South Wales, Australia
    Transplantation 94:775-83. 2012
    ..A range of therapies targeting removal of circulating donor-specific antibodies (DSAs), blocking their effect or reducing production have been reported...
  7. ncbi request reprint Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales
    Darren M Roberts
    New South Wales Poisons Information Centre, Children s Hospital at Westmead, Sydney, NSW, Australia
    Med J Aust 198:43-7. 2013
    ..To report the frequency and clinical outcomes of Amanita phalloides poisoning in the Australian Capital Territory and New South Wales, and the treatments used (including silibinin)...
  8. doi request reprint Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study
    Darren M Roberts
    Burns, Trauma, and Critical Care Research Centre, University of Queensland, Brisbane, Queensland, Australia
    Crit Care Med 40:1523-8. 2012
    ....
  9. ncbi request reprint The relevance of drug clearance to antibiotic dosing in critically ill patients
    Darren M Roberts
    Department of Clinical Pharmacology, St Vincent s Hospital, Darlinghurst, NSW, Australia, 2010
    Curr Pharm Biotechnol 12:2002-14. 2011
    ..Strategies for dose modification of antibiotics in critically ill patients will be discussed...
  10. doi request reprint Extreme γ-butyrolactone overdose with severe metabolic acidosis requiring hemodialysis
    Darren M Roberts
    Clinical Pharmacology and Toxicology, St Vincent s Hospital, Darlinghurst, New South Wales, Australia
    Ann Emerg Med 58:83-5. 2011
    ..Plasma GHB concentrations were the highest reported to date. The acidosis was attributed to rapid systemic absorption of GBL, followed by rapid metabolism to GHB...
  11. doi request reprint Antibiotic stability in commercial peritoneal dialysis solutions: influence of formulation, storage and duration
    Darren M Roberts
    Department of Renal Medicine, The Canberra Hospital, Woden, ACT, Australia
    Nephrol Dial Transplant 26:3344-9. 2011
    ..Data on antibiotic stability for solutions in current use are limited. The aim of this study was to determine the stability of cefepime, cephazolin and ampicillin in three commercial PD solutions...
  12. pmc A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Clin Toxicol (Phila) 48:129-36. 2010
    ..Furthermore, the clinical utility of the glyphosate plasma concentration for predicting clinical outcomes and guiding treatment has not been determined...
  13. ncbi request reprint Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation
    Darren M Roberts
    Medical School, Australian National University, Canberra, ACT, Australia
    Med J Aust 188:310-1. 2008
    ..Current treatment recommendations, based on experience with a different formulation in the United States, may not be appropriate for the Australian formulation...
  14. doi request reprint Lessons learnt in the pharmacokinetic analysis of the effect of haemoperfusion for acute overdose with sustained-release diltiazem
    D M Roberts
    Burns, Trauma and Critical Care Research Centre, University of Queensland, Butterfield Street, Herston, Australia
    Anaesthesia 63:714-8. 2008
    ..5 mg diltiazem during 4 h of haemoperfusion. Haemoperfusion did not appear to remove sufficient diltiazem to recommend its routine use in the treatment of patients with acute diltiazem overdose...
  15. pmc Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    Toxicol Lett 202:69-74. 2011
    ..Death due to acute paraquat poisoning is associated with changes in creatinine and cystatin concentrations. Further validation of these measurements is needed before they can be adopted in guiding intensive treatments...
  16. pmc Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study
    Shukry Zawahir
    South Asian Clinical Toxicology Research Collaboration, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
    Clin Toxicol (Phila) 47:792-7. 2009
    ....
  17. pmc Acute human self-poisoning with imidacloprid compound: a neonicotinoid insecticide
    Fahim Mohamed
    Department of Clinical Medicine, South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Peradeniya, Sri Lanka
    PLoS ONE 4:e5127. 2009
    ..This study reports the clinical outcomes and toxicokinetics of the neonicotinoid insecticide imidacloprid following acute self-poisoning in humans...
  18. pmc Pharmacokinetics of digoxin cross-reacting substances in patients with acute yellow Oleander (Thevetia peruviana) poisoning, including the effect of activated charcoal
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Australian National University, Acton, ACT, Australia
    Ther Drug Monit 28:784-92. 2006
    ....
  19. doi request reprint Simultaneous quantification of carbamate insecticides in human plasma by liquid chromatography/tandem mass spectrometry
    Ahmed Mostafa
    Therapeutics Research Centre, School of Medicine, University of Queensland, Brisbane, QLD, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 879:2234-8. 2011
    ..The method was effectively applied to 270 clinical samples from patients with a history of acute intentional carbamate self-poisoning...
  20. pmc Mycobacterium fortuitum as a cause of peritoneal dialysis-associated peritonitis: case report and review of the literature
    Simon H Jiang
    Department of Renal Medicine, Concord Repatriation and General Hospital, Concord, New South Wales, Australia
    BMC Nephrol 13:35. 2012
    ..We describe the first reported case of multiresistant Mycobacterium fortuitum PD-peritonitis in an Australian patient...
  21. pmc Management of acute organophosphorus pesticide poisoning
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Australian National University
    BMJ 334:629-34. 2007
  22. pmc Influence of pesticide regulation on acute poisoning deaths in Sri Lanka
    Darren M Roberts
    Division of Medicine, Royal Brisbane Hospital, Queensland, Australia
    Bull World Health Organ 81:789-98. 2003
    ..These regulations, which were implemented in Sri Lanka from the 1970s, aimed to reduce the number of deaths - the majority from self-poisoning - by limiting the availability and use of highly toxic pesticides...
  23. doi request reprint Non-tuberculous mycobacterial PD peritonitis in Australia
    Simon H Jiang
    Department of Renal Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW, 2050, Australia
    Int Urol Nephrol 45:1423-8. 2013
    ..The incidence, culprit NTM species, and outcomes associated with PD peritonitis have not been described in many countries, including Australia...
  24. doi request reprint Allopurinol hypersensitivity: a systematic review of all published cases, 1950-2012
    Sheena N Ramasamy
    Department of Clinical Pharmacology and Toxicology, St Vincent s Hospital, 390 Victoria Street, Darlinghurst, NSW, 2010, Australia
    Drug Saf 36:953-80. 2013
    ..Severe forms of AH have been associated with high mortality. The pathophysiology underlying this reaction remains unknown, but several risk factors have been proposed...
  25. doi request reprint Availability of antidotes for the treatment of acute poisoning in Queensland public hospitals
    Lisa M Nissen
    University of Queensland, Brisbane, Australia
    Aust J Rural Health 18:78-84. 2010
    ..To determine the sufficiency of stock levels of 13 antidotes in Queensland hospitals...
  26. ncbi request reprint Pharmacokinetic considerations in clinical toxicology: clinical applications
    Darren M Roberts
    South Asian Clinical Toxicology Research Collaboration, Medical School, Australian National University, Canberra, Australia
    Clin Pharmacokinet 46:897-939. 2007
    ..A firm grounding in pharmacokinetics/toxicokinetics should be regarded as a core competency for all professionals involved in clinical care or undertaking research in clinical toxicology...