Wim Robberecht

Summary

Publications

  1. doi request reprint The changing scene of amyotrophic lateral sclerosis
    Wim Robberecht
    Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium
    Nat Rev Neurosci 14:248-64. 2013
  2. doi request reprint The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding
    Louis De Muynck
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Neurobiol Aging 34:2541-7. 2013
  3. doi request reprint Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
    Sarah Herdewyn
    Laboratory of Neurobiology, Experimental Neurology and Leuven Institute for Neurodegenerative Disorders LIND University of Leuven, Leuven, Belgium
    Neurobiol Aging 34:2302-3. 2013
  4. doi request reprint Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:2214-20. 2013
  5. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
  6. doi request reprint Clinical implications of recent breakthroughs in amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, Vesalius Research Center, VIB, University of Leuven, Leuven, Belgium
    Curr Opin Neurol 26:466-72. 2013
  7. pmc Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
    Thomas Philips
    Laboratory of Neurobiology, Vesalius Research Centre, VIB, 3000 Leuven, Belgium
    Brain 136:471-82. 2013
  8. pmc Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:391-7. 2013
  9. ncbi request reprint EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
  10. doi request reprint Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
    Thomas Philips
    VIB Vesalius Research Center, Leuven, Belgium
    Lancet Neurol 10:253-63. 2011

Collaborators

Detail Information

Publications10

  1. doi request reprint The changing scene of amyotrophic lateral sclerosis
    Wim Robberecht
    Laboratory of Neurobiology, VIB Vesalius Research Center, 3000 Leuven, Belgium
    Nat Rev Neurosci 14:248-64. 2013
    ..Here, we summarize the new findings in ALS research, discuss what they have taught us about this disease and examine issues that are still outstanding...
  2. doi request reprint The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding
    Louis De Muynck
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Neurobiol Aging 34:2541-7. 2013
    ..These results suggest that GRN E mediates the neurotrophic properties of PGRN and that binding to SORT1 is not required for this effect...
  3. doi request reprint Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats
    Sarah Herdewyn
    Laboratory of Neurobiology, Experimental Neurology and Leuven Institute for Neurodegenerative Disorders LIND University of Leuven, Leuven, Belgium
    Neurobiol Aging 34:2302-3. 2013
    ..Overexpression of PGRN in mice and intracerebroventricular delivery of PGRN in rats did not affect onset or progression of motor neuron degeneration. ..
  4. doi request reprint Modifying expression of EphA4 and its downstream targets improves functional recovery after stroke
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:2214-20. 2013
    ..Our findings show that reduction of EphA4 improves motor function after experimental stroke and demonstrate that ROCK inhibition is a promising therapeutic strategy to enhance recovery after ischemic stroke...
  5. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
    ..Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated...
  6. doi request reprint Clinical implications of recent breakthroughs in amyotrophic lateral sclerosis
    Philip Van Damme
    Laboratory of Neurobiology, Vesalius Research Center, VIB, University of Leuven, Leuven, Belgium
    Curr Opin Neurol 26:466-72. 2013
    ..This review examines the clinical implications of recent breakthroughs in amyotrophic lateral sclerosis (ALS)...
  7. pmc Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
    Thomas Philips
    Laboratory of Neurobiology, Vesalius Research Centre, VIB, 3000 Leuven, Belgium
    Brain 136:471-82. 2013
    ..Our data suggest that oligodendroglial dysfunction may be a contributor to motor neuron degeneration in amyotrophic lateral sclerosis...
  8. pmc Novel COL4A1 mutations cause cerebral small vessel disease by haploinsufficiency
    Robin Lemmens
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Hum Mol Genet 22:391-7. 2013
    ..These findings suggest haploinsufficiency, a different mechanism from the commonly assumed dominant-negative effect, for COL4A1 mutations as a cause of (antenatal) intracerebral hemorrhage and white matter disease...
  9. ncbi request reprint EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans
    Annelies Van Hoecke
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Nat Med 18:1418-22. 2012
    ..This suggests that Epha4 generically modulates the vulnerability of (motor) neurons to axonal degeneration and may represent a new target for therapeutic intervention...
  10. doi request reprint Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
    Thomas Philips
    VIB Vesalius Research Center, Leuven, Belgium
    Lancet Neurol 10:253-63. 2011
    ..An improved understanding of the biological processes that cause neuroinflammation will help to define its medical importance and to identify the therapeutic potential of interfering with this reaction...