In vitro comparison of hypericin and 5-aminolevulinic acid-derived protoporphyrin IX for photodynamic inactivation of medulloblastoma cellsRainer Ritz
Department of Neurosurgery, Eberhard Karls University Tubingen, Tubingen, Germany
PLoS ONE 7:e51974. 2012
....
Hypericin for visualization of high grade gliomas: first clinical experienceR Ritz
Klinik für Neurochirurgie, Eberhard Karls Universitat Tubingen, Germany
Eur J Surg Oncol 38:352-60. 2012
..We aimed to demonstrate that Hypericin, a component of St. Johns Wort, selectively visualizes malignant gliomas. Hypericin is known as one of the most powerful photosensitizers in nature with excellent fluorescent properties...
- Use of 5-ALA fluorescence guided endoscopic biopsy of a deep-seated primary malignant brain tumor
Rainer Ritz
Department of Neurosurgery, University of Tübingen Medical Center, Tubingen, Germany
J Neurosurg 114:1410-3. 2011
..The authors report that the lesion was easily detectable in the fluorescence mode and that biopsy led to histological diagnosis...
Photodynamic therapy of malignant glioma with hypericin: comprehensive in vitro study in human glioblastoma cell linesRainer Ritz
Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
Int J Oncol 30:659-67. 2007
..These results obtained in cell culture are encouraging and justify further evaluation HY-PDT for the treatment of malignant glioma in animal experiments...
- Resection of malignant brain tumors in eloquent cortical areas: a new multimodal approach combining 5-aminolevulinic acid and intraoperative monitoring
Guenther C Feigl
Department of Neurosurgery, University of Tuebingen Medical Center, Tuebingen, Germany
J Neurosurg 113:352-7. 2010
....
- Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro
Rainer Ritz
Department of Neurosurgery, Eberhard Karls University, University Hospital Tuebingen, 72076 Tuebingen, Germany
Int J Oncol 27:1543-9. 2005
..0001). Therefore, hypericin seems to be a promising substance for the photodynamic therapy of malignant brain tumors...
- An allograft glioma model reveals the dependence of aquaporin-4 expression on the brain microenvironment
Susan Noell
Department of Neurosurgery, University of Tubingen, Tubingen, Germany
PLoS ONE 7:e36555. 2012
..In contrast, primary rat or mouse astrocytes in culture did not lose their ability to express AQP4, and they were able to form few OAPs...
- Proliferation and progesterone receptor status in benign meningiomas are not age dependent
Florian Roser
Department of Neurosurgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
Cancer 104:598-601. 2005
..In the current study, proliferation activity with the Ki-67/MIB-1 antibody was evaluated by immunohistochemistry in meningioma tissue specimens from young and elderly patients...
- Evidence of ubiquitous in vivo and in vitro expression of pro-apoptotic Smac/DIABLO protein in meningioma cell lines
Christina Pfister
Department of Neurosurgery, University of Tubingen, D 72076 Tubingen, Germany
Oncol Rep 21:1181-8. 2009
..These findings indicate no pathological overexpression of survivin in meningiomas as is evident in several other cancer types impeding apoptosis...
- Subcellular colocalization of hypericin with respect to endoplasmic reticulum and Golgi apparatus in glioblastoma cells
Rainer Ritz
Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
Anticancer Res 28:2033-8. 2008
..Intracellular localization of HYP was investigated by quantitative colocalization analysis with respect to endoplasmic reticulum (ER) and Golgi apparatus (GA) by double staining experiments with fluorescence microscopy...
- Peduncular hallucinosis: insights from a neurosurgical point of view
Florian Roser
Department of Neurosurgery, University of Tuebingen, Tuebingen, Germany
Neurosurgery 57:E1068; discussion E1068. 2005
..It appears mainly in vascular lesions affecting the brainstem, and some recent reports describe the preoperative and postoperative appearance of peduncular hallucinosis in patients affected through tumor compression at the brainstem...
- Selective enrichment of hypericin in malignant glioma: pioneering in vivo results
Susan Noell
Department of Neurosurgery, Eberhard Karls Universitat Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
Int J Oncol 38:1343-8. 2011
..To the best of our knowledge, the present study demonstrates for the first time that hypericin accumulates selectively in intracerebral implanted C6 glioma in vivo after systemic (intravenous) administration...
- Predictive factors for beneficial application of high-frequency electromagnetics for tumour vaporization and coagulation in neurosurgery
Rainer Ritz
Department of Neurosurgery, Eberhard Karls University, Tubingen, Germany
World J Surg Oncol 6:45. 2008
..To identify preoperative and intraoperative factors and conditions that predicts the beneficial application of a high-frequency electromagnetic field (EMF) system for tumor vaporization and coagulation...
- Metabolic Mapping of Gliomas Using Hybrid MR-PET Imaging: Feasibility of the Method and Spatial Distribution of Metabolic Changes
Sotirios Bisdas
From the Departments of Neuroradiology, Neurosurgery, Radiology, Neurology, and Nuclear Medicine, Eberhard Karls University, Tubingen, Germany
Invest Radiol 48:295-301. 2013
....
- Are there attacking points in the eicosanoid cascade for chemotherapeutic options in benign meningiomas?
Christina Pfister
Department of Neurosurgery, University of Tubingen, Germany
Neurosurg Focus 23:E8. 2007
..To find possible targets for chemotherapeutic intervention, the authors evaluated the expression of AA derivatives at different molecular levels in meningiomas...
- Do antibiotic-impregnated shunts in hydrocephalus therapy reduce the risk of infection? An observational study in 258 patients
Rainer Ritz
Department of Neurosurgery, University Hospital Tubingen, Tubingen, Germany
BMC Infect Dis 7:38. 2007
..The study was performed to analyze if AIS can diminish the rate of shunt infection. The pathogenic nature of shunt infection in patients with AIS systems and those without antibiotic impregnated shunts (non-AIS) was compared...
- Distinguishing recurrent high-grade gliomas from radiation injury: a pilot study using dynamic contrast-enhanced MR imaging
Sotirios Bisdas
Department of Diagnostic and Interventional Neuroradiology, Eberhard Karls University, Tubingen, Germany
Acad Radiol 18:575-83. 2011
..The aim of this study was to investigate whether hemodynamic parameters derived from dynamic contrast-enhanced (DCE) T1-weighted magnetic resonance imaging (MRI) can be used to distinguish recurrent gliomas from radiation necrosis...
- Dynamics of expression patterns of AQP4, dystroglycan, agrin and matrix metalloproteinases in human glioblastoma
Susan Noell
Department of Neurosurgery, University of Tubingen, Tubingen, Germany
Cell Tissue Res 347:429-41. 2012
..The results underline our concept of the loss of glioma cell polarity as one of the factors responsible for the disturbance of the neurovascular unit and as an explanation for the formation of edemas in the glioblastoma...
- Three-dimensional constructive interference in steady-state magnetic resonance imaging in syringomyelia: advantages over conventional imaging
Florian Roser
Department of Neurosurgery, University of Tubingen, Germany
J Neurosurg Spine 8:429-35. 2008
..As this region is critical in preoperative evaluation, the authors hypothesized that CISS imaging would provide superior assessment of syrinx pathology and surgical planning...
- Comparison of prognosis and complications after warning leaks in subarachnoidal hemorrhage--experience with 214 patients following aneurysm clipping
Rainer Ritz
Department of Neurosurgery, Eberhard Karls University Tuebingen, 72076 Tuebingen, Germany
Neurol Res 27:620-4. 2005
..The present study was performed to compare the complications and prognosis for 214 patients with and without a warning leak; aneurysm clipping had been performed in all...
- Spinal nerve root ganglionitis as a cause of disc herniation: case report
Florian Roser
Department of Neurosurgery, University of Tubingen, Germany
J Neurosurg Spine 2:472-5. 2005
..Because all of these differential diagnoses were negative in the treated patient, chronic nerve root compression due to disc herniation was suspected as the causative factor for the spinal ganglionitis...
- Specific intensity imaging for glioblastoma and neural cell cultures with 5-aminolevulinic acid-derived protoporphyrin IX
Frank Duffner
Department of Neurosurgery, Eberhard-Karls University of Tuebingen, Germany
J Neurooncol 71:107-11. 2005
..The glioma cell lines showed significant variation in this possibly limiting clinical use of fluorescence as a guide for resection...
- Long-standing intraspinal glass fragments causing subsequent radiculopathy after dorsal stabilization
Florian Roser
Department of Neurosurgery, University of Tubingen, Tubingen, Germany
Neurol Med Chir (Tokyo) 46:459-61. 2006
..Microsurgical removal of the extra- and intradural glass fragments led to complete relief of the radicular pain. Foreign bodies can become symptomatic due to changes in the status of the spine, especially during growth in young patients...
- Proliferation potential of spinal meningiomas
Florian Roser
Department of Neurosurgery, University of Tubingen, Hoppe Seyler Strasse 3, 72076 Tuebingen, Germany
Eur Spine J 15:211-5. 2006
..This information could provide the spinal surgeon with important additional information concerning surgical management and follow-up recommendations for the individual patient...
- Aortic dissection mimicking subarachnoidal hemorrhage
Boris Nohé
Department of Anaesthesiology and Intensive Care Medicine, Eberhard Karls University Tubingen, Germany
Anesth Analg 101:233-4, table of contents. 2005
....
