Michael Ristow

Summary

Publications

  1. ncbi request reprint Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
  2. ncbi request reprint Neurodegenerative disorders associated with diabetes mellitus
    Michael Ristow
    Department of Clinical Nutrition, German Institute for Human Nutrition, Potsdam Rehbrucke, 114 Arthur Scheunert Allee, 14558, Nuthetal Berlin, Germany
    J Mol Med (Berl) 82:510-29. 2004
  3. doi request reprint Extending life span by increasing oxidative stress
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Free Radic Biol Med 51:327-36. 2011
  4. doi request reprint Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
    Kim Zarse
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
    Cell Metab 15:451-65. 2012
  5. pmc Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension
    Sebastian Schmeisser
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743, Jena, Germany
    Aging Cell 12:508-17. 2013
  6. doi request reprint Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice
    Doreen Kuhlow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany
    Eur J Nutr 49:417-27. 2010
  7. pmc Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
    Gregor Beuster
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    J Biol Chem 286:22323-30. 2011
  8. doi request reprint Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
    Kathrin Schmeisser
    1 Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany 2
    Nat Chem Biol 9:693-700. 2013
  9. doi request reprint How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
    Michael Ristow
    Dept of Human Nutrition, Institute of Nutrition, University of Jena, Germany
    Exp Gerontol 45:410-8. 2010
  10. pmc Telomerase deficiency impairs glucose metabolism and insulin secretion
    Doreen Kuhlow
    Department of Human Nutrition, Inst of Nutrition, University of Jena, Germany
    Aging (Albany NY) 2:650-8. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
    ....
  2. ncbi request reprint Neurodegenerative disorders associated with diabetes mellitus
    Michael Ristow
    Department of Clinical Nutrition, German Institute for Human Nutrition, Potsdam Rehbrucke, 114 Arthur Scheunert Allee, 14558, Nuthetal Berlin, Germany
    J Mol Med (Berl) 82:510-29. 2004
    ....
  3. doi request reprint Extending life span by increasing oxidative stress
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Free Radic Biol Med 51:327-36. 2011
    ....
  4. doi request reprint Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
    Kim Zarse
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
    Cell Metab 15:451-65. 2012
    ..elegans life span. Taken together, iIIS promotes L-proline metabolism to generate a ROS signal for the adaptive induction of endogenous stress defense to extend life span...
  5. pmc Mitochondrial hormesis links low-dose arsenite exposure to lifespan extension
    Sebastian Schmeisser
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743, Jena, Germany
    Aging Cell 12:508-17. 2013
    ..1 to extend lifespan. Taken together, low-dose arsenite extends lifespan, providing evidence for nonlinear dose-response characteristics of toxin-mediated stress resistance and longevity in a multicellular organism...
  6. doi request reprint Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice
    Doreen Kuhlow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany
    Eur J Nutr 49:417-27. 2010
    ..Both dietary fat and dietary sucrose are major components of Western diets that may differentially affect the risk for body mass gain, diabetes mellitus, and cardiovascular disease...
  7. pmc Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growth
    Gregor Beuster
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    J Biol Chem 286:22323-30. 2011
    ....
  8. doi request reprint Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
    Kathrin Schmeisser
    1 Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany 2
    Nat Chem Biol 9:693-700. 2013
    ..elegans longevity. Taken together, sirtuin-mediated lifespan extension depends on methylation of NAM, providing an unexpected mechanistic role for sirtuins beyond histone deacetylation. ..
  9. doi request reprint How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
    Michael Ristow
    Dept of Human Nutrition, Institute of Nutrition, University of Jena, Germany
    Exp Gerontol 45:410-8. 2010
    ..Hence, the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of physical exercise, reduced calorie uptake, glucose restriction, and possibly beyond...
  10. pmc Telomerase deficiency impairs glucose metabolism and insulin secretion
    Doreen Kuhlow
    Department of Human Nutrition, Inst of Nutrition, University of Jena, Germany
    Aging (Albany NY) 2:650-8. 2010
    ....
  11. pmc Activation of mitochondrial energy metabolism protects against cardiac failure
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Germany
    Aging (Albany NY) 2:843-53. 2010
    ..Thus, induction of mitochondrial metabolism may be considered part of a generally protective mechanism to prevent cardiomyopathy and cardiac failure...
  12. pmc Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity
    Doreen Pomplun
    Department of Clinical Nutrition, German Institute of Human Nutrition, D 14558 Potsdam Rehbrücke, Germany
    Proc Natl Acad Sci U S A 104:6377-81. 2007
    ..Taken together, these findings indicate that a limited impairment in oxidative metabolism within the mitochondria directly predisposes mammals to excessive body weight gain...
  13. pmc Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping
    Tim J Schulz
    University of Jena, Institute of Nutrition, Jena, Germany
    PLoS ONE 2:e1013. 2007
    ..This indicates that sustained post hoc analyses in regards to efficacy of disruption for every single study group member may be required...
  14. ncbi request reprint Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein
    Marc Birringer
    Dept of Human Nutrition, Inst of Nutrition, University of Jena, Dornburger Strasse 29, 07743, Jena, Germany
    Eur J Nutr 46:397-405. 2007
    ..The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH...
  15. pmc Antioxidants prevent health-promoting effects of physical exercise in humans
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Proc Natl Acad Sci U S A 106:8665-70. 2009
    ..Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans...
  16. pmc In silico evidence for gluconeogenesis from fatty acids in humans
    Christoph Kaleta
    Department of Bioinformatics, School of Biology and Pharmaceutics, Friedrich Schiller University of Jena, Jena, Germany
    PLoS Comput Biol 7:e1002116. 2011
    ..Moreover, the energetic loss associated to the usage of gluconeogenesis from fatty acids can help explain the efficiency of carbohydrate reduced and ketogenic diets such as the Atkins diet...
  17. pmc Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans
    Kim Zarse
    Institute of Nutrition, University of Jena, Jena, Germany
    PLoS ONE 3:e4062. 2008
    ..elegans reflecting the mammalian phenotype. Taken together and in conflict with previously published findings, we find that antidepressants of the serotonin-antagonist type not only promote obesity, but also decrease nematode lifespan...
  18. pmc Lipid-lowering fibrates extend C. elegans lifespan in a NHR-49/PPARalpha-dependent manner
    Sven Brandstädt
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
    Aging (Albany NY) 5:270-5. 2013
    ..Taken together, fibrates promote C. elegans longevity in an NHR-49-dependent manner possibly by promoting mitohormesis and suggesting that these compounds may promote lifespan also in mammals...
  19. pmc L-Theanine extends lifespan of adult Caenorhabditis elegans
    Kim Zarse
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
    Eur J Nutr 51:765-8. 2012
    ....
  20. doi request reprint Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress
    Marc Birringer
    Department of Human Nutrition, Institute of Nutrition, Friedrich Schiller University of Jena, Jena, Germany
    Free Radic Biol Med 49:1315-22. 2010
    ..Taken together, these results indicate that long-chain metabolites may be responsible for antiproliferative properties of vitamin E vitamers...
  21. ncbi request reprint Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia
    Kim Zarse
    Department of Human Nutrition, Inst of Nutrition, University of Jena, 29 Dornburger St, Jena D 07743, Germany
    FASEB J 21:1271-5. 2007
    ..Taken together, impaired mitochondrial metabolism due to RNAi-mediated inhibition of the frataxin homologue frh-1 causes both impaired respiration as well as decreased life span in the multicellular eukaryote C. elegans...
  22. doi request reprint Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri
    Nils Hartmann
    Department of Molecular Genetics, Leibniz Institute for Age Research Fritz Lipmann Institute FLI, Beutenbergstrasse 11, Jena, Germany
    Aging Cell 10:824-31. 2011
    ..These findings suggest that despite the short lifespan, aging in N. furzeri is associated with a decline in mtDNA copy number, the downregulation of mtDNA-associated genes and an impairment of mitochondrial function...
  23. pmc Low-dose lithium uptake promotes longevity in humans and metazoans
    Kim Zarse
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Germany
    Eur J Nutr 50:387-9. 2011
    ..Environmental lithium exposure and concurrent nutritional intake vary considerably in different regions. We here have analyzed the possibility that low-dose lithium exposure may affect mortality in both metazoans and mammals...
  24. doi request reprint Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag
    Jens Ripcke
    Department of Human Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 29, Jena, Germany
    Chembiochem 10:1689-96. 2009
    ..Overall, reversible tagging combines decreased tag-related cytotoxicity with increased bioactivity, and this potentially provides a novel concept in mitochondrial pharmacology...
  25. pmc Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass
    Michael Ristow
    German Institute of Human Nutrition, Department Klinische Ernährung, 114 Arthur Scheunert Strasse, D 14558 Bergholz Rehbrücke, Germany
    J Clin Invest 112:527-34. 2003
    ..These observations might provide insight into the deterioration of beta cell function observed in different subtypes of diabetes in humans...
  26. ncbi request reprint Oxidative metabolism in cancer growth
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
    Curr Opin Clin Nutr Metab Care 9:339-45. 2006
    ....
  27. ncbi request reprint Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice
    Rene Thierbach
    German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal Berlin, and Charité University Medicine, Berlin, Germany
    Hum Mol Genet 14:3857-64. 2005
    ..Taken together, these findings indicate that frataxin may act as a mitochondrial tumor suppressor protein in mammals...
  28. ncbi request reprint Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Eur J Endocrinol 154:295-301. 2006
    ..This procedure is time-consuming and inconvenient, limiting its general use. Therefore, an easy method is wanted to separate PCOS women with normal from those with potentially abnormal glucose metabolism...
  29. ncbi request reprint The polycystic ovary syndrome per se is not associated with increased chronic inflammation
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam Rehbruecke, Germany
    Eur J Endocrinol 150:525-32. 2004
    ....
  30. ncbi request reprint Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 89:1885-90. 2004
    ....
  31. ncbi request reprint Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
    Joachim Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 61:738-46. 2004
    ..The aim of the study was to elucidate determinants of circulating adiponectin levels and to investigate the potential role of adiponectin in insulin resistance in PCOS women...
  32. ncbi request reprint Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men
    Matthias Mohlig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Clinical Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 91:964-7. 2006
    ..We therefore investigated whether salicylates reduce lipid-induced insulin resistance in humans by affecting inflammatory pathways as reflected by serum adipocytokines...
  33. ncbi request reprint Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells
    Robert A Schoenfeld
    Department of Molecular Biosciences, University of California, Davis 95616, USA
    Hum Mol Genet 14:3787-99. 2005
    ..As ataxic symptoms occur in other diseases of heme deficiency, the heme defect we observe in frataxin-deficient cells could be primary to the pathophysiological process...
  34. pmc Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice
    Frank Isken
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
    Am J Physiol Endocrinol Metab 295:E350-5. 2008
    ..GIP receptors thus interact with estrogens in the hypothalamic regulation of food intake in mice, and their blockade may carry promising potential for the prevention of obesity in gonadal steroid deficiency...
  35. pmc Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    Andrew W Norris
    Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
    J Clin Invest 112:608-18. 2003
    ..The tissue crosstalk mediating these effects is perhaps due to altered lipid metabolism in muscle...
  36. ncbi request reprint Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited
    Tim J Schulz
    German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal
    J Biol Chem 281:977-81. 2006
    ..Taken together, these results support the view that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals...
  37. ncbi request reprint The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins
    Ulrich Muhlenhoff
    Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Robert Koch Str 5, 35033 Marburg, Germany
    Hum Mol Genet 11:2025-36. 2002
    ..Friedreich's ataxia may therefore represent a disorder caused by defects in Fe/S protein maturation...
  38. ncbi request reprint Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance
    Malin Fex
    Department of Experimental Medical Science, Lund University, SE 22184 Lund, Sweden
    J Endocrinol 194:551-5. 2007
    ..As our RIP2-Cre mice are on a near 100% pure genetic background (C57BL/6J), we suggest that the perturbations in glucose homeostasis previously reported in RIP2-Cre mouse lines can be accounted for by differences in genetic background...
  39. ncbi request reprint Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro
    Sarah A Shoichet
    Center for Molecular Medicine, Clinic III for Internal Medicine and Center for Physiology and Pathophysiology, University of Cologne, Germany
    Hum Mol Genet 11:815-21. 2002
    ..These findings expand the understanding of antioxidant properties of frataxin, and tentatively suggest a role in the early induction of cancer...
  40. ncbi request reprint Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes
    Matthias Mohlig
    N Engl J Med 350:2419-21; author reply 2419-21. 2004
  41. ncbi request reprint Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  42. ncbi request reprint Consuming fructose-sweetened beverages increases body adiposity in mice
    Hella Jürgens
    Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Obes Res 13:1146-56. 2005
    ....
  43. ncbi request reprint Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice
    Dirk Kluth
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Free Radic Biol Med 38:507-14. 2005
    ..If fed in supranutritional dosages, especially for longer times, alpha-tocopherol induces Cyp3a11 to levels which might interfere with drug metabolism...
  44. ncbi request reprint RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function
    Ji Yeon Lee
    Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:2649-53. 2006
    ..In addition, we review the use of RIP-Cre mice and discuss possible molecular underpinnings and ramifications of our findings...