Extending life span by increasing oxidative stressMichael Ristow
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Free Radic Biol Med 51:327-36. 2011
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Neurodegenerative disorders associated with diabetes mellitusMichael Ristow
Department of Clinical Nutrition, German Institute for Human Nutrition, Potsdam Rehbrucke, 114 Arthur Scheunert Allee, 14558, Nuthetal Berlin, Germany
J Mol Med (Berl) 82:510-29. 2004
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- Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal
Kim Zarse
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
Cell Metab 15:451-65. 2012
..elegans life span. Taken together, iIIS promotes L-proline metabolism to generate a ROS signal for the adaptive induction of endogenous stress defense to extend life span...
- Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
Tim J Schulz
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Cell Metab 6:280-93. 2007
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- Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice
Doreen Kuhlow
Department of Human Nutrition, Institute of Nutrition, University of Jena, 07743 Jena, Germany
Eur J Nutr 49:417-27. 2010
..Both dietary fat and dietary sucrose are major components of Western diets that may differentially affect the risk for body mass gain, diabetes mellitus, and cardiovascular disease...
Inhibition of alanine aminotransferase in silico and in vivo promotes mitochondrial metabolism to impair malignant growthGregor Beuster
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
J Biol Chem 286:22323-30. 2011
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- Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity
Doreen Pomplun
Department of Clinical Nutrition, German Institute of Human Nutrition, D 14558 Potsdam Rehbrücke, Germany
Proc Natl Acad Sci U S A 104:6377-81. 2007
..Taken together, these findings indicate that a limited impairment in oxidative metabolism within the mitochondria directly predisposes mammals to excessive body weight gain...
- How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
Michael Ristow
Dept of Human Nutrition, Institute of Nutrition, University of Jena, Germany
Exp Gerontol 45:410-8. 2010
..Hence, the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of physical exercise, reduced calorie uptake, glucose restriction, and possibly beyond...
- Telomerase deficiency impairs glucose metabolism and insulin secretion
Doreen Kuhlow
Department of Human Nutrition, Inst of Nutrition, University of Jena, Germany
Aging (Albany NY) 2:650-8. 2010
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- Activation of mitochondrial energy metabolism protects against cardiac failure
Tim J Schulz
Department of Human Nutrition, Institute of Nutrition, University of Jena, Germany
Aging (Albany NY) 2:843-53. 2010
..Thus, induction of mitochondrial metabolism may be considered part of a generally protective mechanism to prevent cardiomyopathy and cardiac failure...
- Improved glucose metabolism in mice lacking alpha-tocopherol transfer protein
Marc Birringer
Dept of Human Nutrition, Inst of Nutrition, University of Jena, Dornburger Strasse 29, 07743, Jena, Germany
Eur J Nutr 46:397-405. 2007
..The alpha-tocopherol transfer protein (alpha-TTP) mediates the transfer of alpha-tocopherol (alpha-TOH) from hepatocytes to very-low-density lipoproteins, thereby controlling plasma levels of alpha-TOH...
Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotypingTim J Schulz
University of Jena, Institute of Nutrition, Jena, Germany
PLoS ONE 2:e1013. 2007
..This indicates that sustained post hoc analyses in regards to efficacy of disruption for every single study group member may be required...
- Antidepressants of the serotonin-antagonist type increase body fat and decrease lifespan of adult Caenorhabditis elegans
Kim Zarse
Institute of Nutrition, University of Jena, Jena, Germany
PLoS ONE 3:e4062. 2008
..elegans reflecting the mammalian phenotype. Taken together and in conflict with previously published findings, we find that antidepressants of the serotonin-antagonist type not only promote obesity, but also decrease nematode lifespan...
- Antioxidants prevent health-promoting effects of physical exercise in humans
Michael Ristow
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena D 07743, Germany
Proc Natl Acad Sci U S A 106:8665-70. 2009
..Supplementation with antioxidants may preclude these health-promoting effects of exercise in humans...
- L: -Theanine extends lifespan of adult Caenorhabditis elegans
Kim Zarse
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
Eur J Nutr 51:765-8. 2012
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- Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress
Marc Birringer
Department of Human Nutrition, Institute of Nutrition, Friedrich Schiller University of Jena, Jena, Germany
Free Radic Biol Med 49:1315-22. 2010
..Taken together, these results indicate that long-chain metabolites may be responsible for antiproliferative properties of vitamin E vitamers...
- Low-dose lithium uptake promotes longevity in humans and metazoans
Kim Zarse
Department of Human Nutrition, Institute of Nutrition, University of Jena, Germany
Eur J Nutr 50:387-9. 2011
..Environmental lithium exposure and concurrent nutritional intake vary considerably in different regions. We here have analyzed the possibility that low-dose lithium exposure may affect mortality in both metazoans and mammals...
- Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag
Jens Ripcke
Department of Human Nutrition, Friedrich Schiller University Jena, Dornburger Strasse 29, Jena, Germany
Chembiochem 10:1689-96. 2009
..Overall, reversible tagging combines decreased tag-related cytotoxicity with increased bioactivity, and this potentially provides a novel concept in mitochondrial pharmacology...
- Impaired respiration is positively correlated with decreased life span in Caenorhabditis elegans models of Friedreich Ataxia
Kim Zarse
Department of Human Nutrition, Inst of Nutrition, University of Jena, 29 Dornburger St, Jena D 07743, Germany
FASEB J 21:1271-5. 2007
..Taken together, impaired mitochondrial metabolism due to RNAi-mediated inhibition of the frataxin homologue frh-1 causes both impaired respiration as well as decreased life span in the multicellular eukaryote C. elegans...
- Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass
Michael Ristow
German Institute of Human Nutrition, Department Klinische Ernährung, 114 Arthur Scheunert Strasse, D 14558 Bergholz Rehbrücke, Germany
J Clin Invest 112:527-34. 2003
..These observations might provide insight into the deterioration of beta cell function observed in different subtypes of diabetes in humans...
- Oxidative metabolism in cancer growth
Michael Ristow
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
Curr Opin Clin Nutr Metab Care 9:339-45. 2006
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- Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice
Rene Thierbach
German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal Berlin, and Charité University Medicine, Berlin, Germany
Hum Mol Genet 14:3857-64. 2005
..Taken together, these findings indicate that frataxin may act as a mitochondrial tumor suppressor protein in mammals...
- Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome
Matthias Mohlig
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
Eur J Endocrinol 154:295-301. 2006
..This procedure is time-consuming and inconvenient, limiting its general use. Therefore, an easy method is wanted to separate PCOS women with normal from those with potentially abnormal glucose metabolism...
- The polycystic ovary syndrome per se is not associated with increased chronic inflammation
Matthias Mohlig
Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam Rehbruecke, Germany
Eur J Endocrinol 150:525-32. 2004
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- Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
Joachim Spranger
Department of Clinical Nutrition, German Institute of Human Nutrition, , Campus Benjamin Franklin, Berlin, Germany
Clin Endocrinol (Oxf) 61:738-46. 2004
..However, circulating adiponectin is independently associated with the degree of insulin resistance in PCOS women and may contribute to the development and/or maintenance of insulin resistance independent from adiposity...
- Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes
Matthias Mohlig
Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
J Clin Endocrinol Metab 89:1885-90. 2004
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- Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men
Matthias Mohlig
German Institute of Human Nutrition Potsdam Rehbruecke, Department of Clinical Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
J Clin Endocrinol Metab 91:964-7. 2006
..We therefore investigated whether salicylates reduce lipid-induced insulin resistance in humans by affecting inflammatory pathways as reflected by serum adipocytokines...
- Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice
Frank Isken
Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin, Germany
Am J Physiol Endocrinol Metab 295:E350-5. 2008
..GIP receptors thus interact with estrogens in the hypothalamic regulation of food intake in mice, and their blockade may carry promising potential for the prevention of obesity in gonadal steroid deficiency...
- Frataxin deficiency alters heme pathway transcripts and decreases mitochondrial heme metabolites in mammalian cells
Robert A Schoenfeld
Department of Molecular Biosciences, University of California, Davis 95616, USA
Hum Mol Genet 14:3787-99. 2005
..As ataxic symptoms occur in other diseases of heme deficiency, the heme defect we observe in frataxin-deficient cells could be primary to the pathophysiological process...
- The yeast frataxin homolog Yfh1p plays a specific role in the maturation of cellular Fe/S proteins
Ulrich Muhlenhoff
Institut für Zytobiologie und Zytopathologie, Philipps Universitat Marburg, Robert Koch Str 5, 35033 Marburg, Germany
Hum Mol Genet 11:2025-36. 2002
..Friedreich's ataxia may therefore represent a disorder caused by defects in Fe/S protein maturation...
- Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
Andrew W Norris
Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA
J Clin Invest 112:608-18. 2003
..The tissue crosstalk mediating these effects is perhaps due to altered lipid metabolism in muscle...
- Rat insulin promoter 2-Cre recombinase mice bred onto a pure C57BL/6J background exhibit unaltered glucose tolerance
Malin Fex
Department of Experimental Medical Science, Lund University, SE 22184 Lund, Sweden
J Endocrinol 194:551-5. 2007
..As our RIP2-Cre mice are on a near 100% pure genetic background (C57BL/6J), we suggest that the perturbations in glucose homeostasis previously reported in RIP2-Cre mouse lines can be accounted for by differences in genetic background...
- Induction of oxidative metabolism by mitochondrial frataxin inhibits cancer growth: Otto Warburg revisited
Tim J Schulz
German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal
J Biol Chem 281:977-81. 2006
..Taken together, these results support the view that an increase in oxidative metabolism induced by mitochondrial frataxin may inhibit cancer growth in mammals...
- Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
Joachim Spranger
Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
Diabetes 52:812-7. 2003
..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
- Impaired mitochondrial activity and insulin-resistant offspring of patients with type 2 diabetes
Matthias Mohlig
N Engl J Med 350:2419-21; author reply 2419-21. 2004
- Modulation of Cyp3a11 mRNA expression by alpha-tocopherol but not gamma-tocotrienol in mice
Dirk Kluth
Department of Biochemistry of Micronutrients, German Institute of Human Nutrition, , Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany
Free Radic Biol Med 38:507-14. 2005
..If fed in supranutritional dosages, especially for longer times, alpha-tocopherol induces Cyp3a11 to levels which might interfere with drug metabolism...
- Consuming fructose-sweetened beverages increases body adiposity in mice
Hella Jürgens
Department of Pharmacology, German Institute of Human Nutrition, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
Obes Res 13:1146-56. 2005
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- RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function
Ji-Yeon Lee
Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:2649-53. 2006
..In addition, we review the use of RIP-Cre mice and discuss possible molecular underpinnings and ramifications of our findings...
- Frataxin promotes antioxidant defense in a thiol-dependent manner resulting in diminished malignant transformation in vitro
Sarah A Shoichet
Center for Molecular Medicine, Clinic III for Internal Medicine and Center for Physiology and Pathophysiology, University of Cologne, Germany
Hum Mol Genet 11:815-21. 2002
..These findings expand the understanding of antioxidant properties of frataxin, and tentatively suggest a role in the early induction of cancer...
