Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selectionBrigit E Riley
Department of Biology, Stanford University, Stanford, CA 94305, USA
J Cell Biol 191:537-52. 2010
....
Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's diseaseMark S Hipp
Department of Biology, Stanford University, Stanford, CA 94305, USA
J Cell Biol 196:573-87. 2012
..Our data confirm that proteasomes are not directly impaired by aggregated N-terminal fragments of htt; instead, our data suggest that Ub accumulation is linked to impaired function of the cellular proteostasis network...
Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin poolsStephen E Kaiser
Department of Biology, Stanford University, Stanford, California, USA
Nat Methods 8:691-6. 2011
..Our method is convenient, adaptable and should be a valuable tool to facilitate our understanding of this important signaling molecule...
Cellular mechanisms of protein quality controlEric J Bennett
Department of Biological Sciences, Stanford University, USA
Rinsho Shinkeigaku 46:805. 2006
HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtinAtsushi Iwata
Department of Biological Sciences, Bio X Program, Stanford University, Stanford, California 94305 5430, USA
J Biol Chem 280:40282-92. 2005
..These data suggest that HDAC6-dependent retrograde transport on microtubules is used by cells to increase the efficiency and selectivity of autophagic degradation...