Robert C Rickert

Summary

Publications

  1. pmc Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases
    Ana V Miletic
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Exp Med 207:2407-20. 2010
  2. doi New insights into pre-BCR and BCR signalling with relevance to B cell malignancies
    Robert C Rickert
    Program on Inflammatory Diseases, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 13:578-91. 2013
  3. pmc Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease
    Robert C Rickert
    Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 244:115-33. 2011
  4. ncbi Mousing around with caspases and IAPs
    Robert C Rickert
    Programs in Cell Death and Inflammation Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Biochem J 443:e1-2. 2012
  5. ncbi Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease
    Thomas Enzler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Immunity 25:403-15. 2006
  6. ncbi IKK beta is required for peripheral B cell survival and proliferation
    Zhi Wei Li
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 170:4630-7. 2003
  7. pmc Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals
    David M Mills
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:6359-64. 2007
  8. pmc SHEP1 partners with CasL to promote marginal zone B-cell maturation
    Cecille D Browne
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:18944-9. 2010
  9. pmc CD98hc facilitates B cell proliferation and adaptive humoral immunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, USA
    Nat Immunol 10:412-9. 2009
  10. ncbi Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
    Sidne A Omori
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Immunity 25:545-57. 2006

Collaborators

Detail Information

Publications33

  1. pmc Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases
    Ana V Miletic
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Cancer Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Exp Med 207:2407-20. 2010
    ..As such, assessment of both PTEN and SHIP function are relevant to understanding the etiology of human B cell malignancies that exhibit augmented activation of the PI3K pathway...
  2. doi New insights into pre-BCR and BCR signalling with relevance to B cell malignancies
    Robert C Rickert
    Program on Inflammatory Diseases, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Immunol 13:578-91. 2013
    ....
  3. pmc Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease
    Robert C Rickert
    Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Immunol Rev 244:115-33. 2011
    ..We also underscore how new findings and conceptual insights into TNFRSF signaling are facilitating the understanding of B-cell malignancies and autoimmune diseases...
  4. ncbi Mousing around with caspases and IAPs
    Robert C Rickert
    Programs in Cell Death and Inflammation Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Biochem J 443:e1-2. 2012
    ..This disturbing result implies that immune functions ascribed to c-IAP1 may be due to the caspase 11 mutation that is co-inherited with the locus...
  5. ncbi Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease
    Thomas Enzler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Immunity 25:403-15. 2006
    ..Thus, both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction. The same mechanisms may be involved in the pathogenesis of human SLE...
  6. ncbi IKK beta is required for peripheral B cell survival and proliferation
    Zhi Wei Li
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, Cancer Center, University of California San Diego, La Jolla, CA 92093, USA
    J Immunol 170:4630-7. 2003
    ..Thus, IKKbeta provides a requisite role in B cell activation and maintenance and thus is a key determinant of humoral immunity...
  7. pmc Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals
    David M Mills
    Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 104:6359-64. 2007
    ..Thus, the NIK-IKKalpha-p52 axis is not as linear and exclusive as previous studies suggest, and IKKalpha possesses critical NF-kappaB-independent functions in B cells...
  8. pmc SHEP1 partners with CasL to promote marginal zone B-cell maturation
    Cecille D Browne
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:18944-9. 2010
    ..Thus, SHEP1 orchestrates marginal zone B-cell movement and retention as a key downstream effector of the BCR and S1P receptors...
  9. pmc CD98hc facilitates B cell proliferation and adaptive humoral immunity
    Joseph Cantor
    Department of Medicine, University of California San Diego, La Jolla, USA
    Nat Immunol 10:412-9. 2009
    ..Thus, CD98hc supports integrin-dependent rapid proliferation of B cells. We propose that the advantage of adaptive immunity favored the appearance of CD98hc in vertebrates...
  10. ncbi Regulation of class-switch recombination and plasma cell differentiation by phosphatidylinositol 3-kinase signaling
    Sidne A Omori
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Immunity 25:545-57. 2006
    ..However, ectopic expression of AID could not fully overcome inhibition of CSR by PI3K, suggesting that PI3K regulates both the expression and function of AID...
  11. ncbi CD19 function in early and late B cell development. II. CD19 facilitates the pro-B/pre-B transition
    Dennis C Otero
    Division of Biology and University of California San Diego Cancer Center, La Jolla, CA 92093, USA
    J Immunol 171:5921-30. 2003
    ..Thus, in addition to promoting mature B cell homeostasis and Ag-induced responses, the early onset of CD19 expression acts to enhance B cell generation...
  12. pmc Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy
    Cecille D Browne
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center and Program of Signal Transduction, Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Immunity 31:749-60. 2009
    ..These findings establish repression of the PI3K signaling pathway as a necessary condition to avert the generation, activation, and persistence of self-reactive B cells...
  13. pmc Onco-miR-155 targets SHIP1 to promote TNFalpha-dependent growth of B cell lymphomas
    Irene M Pedersen
    Section of Molecular Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA, USA
    EMBO Mol Med 1:288-95. 2009
    ....
  14. ncbi Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
    Amy N Anzelon
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, MC 0322, La Jolla, CA 92093, USA
    Nat Immunol 4:287-94. 2003
    ..These findings establish the central role of PI-3,4,5-P3 regulation in the differentiation of peripheral B cell subsets...
  15. ncbi A critical role for complement C3d and the B cell coreceptor (CD19/CD21) complex in the initiation of inflammatory arthritis
    Christopher J Del Nagro
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, CA 92037, USA
    J Immunol 175:5379-89. 2005
    ..These findings indicate that binding of C3d to self-Ags can promote autoimmunity through enhanced Ag retention and presentation by follicular dendritic cells and B cells, respectively...
  16. pmc Censoring of self-reactive B cells by follicular dendritic cell-displayed self-antigen
    Irene W Yau
    Program on Inflammatory Diseases, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Immunol 191:1082-90. 2013
    ..These results implicate FDCs as an important component of peripheral B cell tolerance that prevents the emergence of naive B cells capable of responding to sequestered self-antigens. ..
  17. ncbi Phosphatidylinositol 3-kinase (PI3K) signaling and regulation of the antibody response
    Sidne A Omori
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Cell Cycle 6:397-402. 2007
    ..How PI3K activity may be regulating CSR during antigen-driven B cell differentiation and its potential contribution to humoral immunodeficiencies will be discussed...
  18. pmc Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    Hart S Dengler
    Program of Inflammatory Disease Research, Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Nat Immunol 9:1388-98. 2008
    ..Thus, Foxo1 regulates a transcriptional program that is essential for early B cell development and peripheral B cell function...
  19. pmc Cyclin D3 is selectively required for proliferative expansion of germinal center B cells
    Matthew H Cato
    Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Mol Cell Biol 31:127-37. 2011
    ....
  20. pmc Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers
    Giuseppina Bonizzi
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    EMBO J 23:4202-10. 2004
    ..This site links induction of organogenic chemokines and other important regulatory molecules to activation of the alternative pathway...
  21. ncbi CD19 function in central and peripheral B-cell development
    Christopher J Del Nagro
    Program of Inflammatory Disease Research, Infection and Inflammatory Disease Center, Program of Signal Transduction, Cancer Center, The Burnham Institute, CA, USA
    Immunol Res 31:119-31. 2005
    ..In this article, we focus on recent progress in the understanding of CD19 function through the characterization of mouse models that relate in vivo function to biochemical properties of CD19...
  22. pmc Context-specific BAFF-R signaling by the NF-κB and PI3K pathways
    Julia Jellusova
    Program on Inflammatory Diseases, Infectious and Inflammatory Diseases Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Rep 5:1022-35. 2013
    ..These findings indicate that the combined activities of PI3K and IKK1 drive peripheral B cell differentiation and survival in a context-dependent manner. ..
  23. pmc Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3
    Dennis C Otero
    Division of Biological Sciences and University of California San Diego Moore s Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    J Immunol 177:6593-7. 2006
    ..Importantly, STAT3(-/-) B-1 cells become susceptible to irradiation, indicating that STAT3 activation by the BCR in the presence of IL costimuli account for the inherent radioresistance of peritoneal B-1 B cells...
  24. ncbi CD19 function in early and late B cell development: I. Maintenance of follicular and marginal zone B cells requires CD19-dependent survival signals
    Dennis C Otero
    Division of Biology and University of California, San Diego Cancer Center, University of California, San Diego, La Jolla, CA 92093 0322, USA
    J Immunol 170:73-83. 2003
    ..Together these findings suggest that maintenance of the follicular and MZ B cell compartments require CD19-dependent survival signals...
  25. pmc Magnetic-based purification of untouched mouse germinal center B cells for ex vivo manipulation and biochemical analysis
    Matthew H Cato
    Program on Inflammatory Disease Research, Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Nat Protoc 6:953-60. 2011
    ..The sorting process can be carried out in ∼1 h and provides a population of GC B cells of sufficient purity and quantity to allow ex vivo manipulation, including biochemical and genetic analysis as well as cell culture...
  26. pmc LYP inhibits T-cell activation when dissociated from CSK
    Torkel Vang
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, La Jolla, California, USA
    Nat Chem Biol 8:437-46. 2012
    ..Our compound also represents a starting point for the development of a LYP-based treatment of autoimmunity...
  27. pmc Complement C3d conjugation to anthrax protective antigen promotes a rapid, sustained, and protective antibody response
    Ravi V Kolla
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, La Jolla, California, United States of America
    PLoS ONE 2:e1044. 2007
    ..These data suggest that incorporation of C3d as an adjuvant may overcome shortcomings of the currently licensed aluminum-based vaccine, and may confer protection in the early days following acute anthrax exposure...
  28. pmc In silico screening for PTPN22 inhibitors: active hits from an inactive phosphatase conformation
    ShuangDing Wu
    Infectious and Inflammatory Disease Center, Burnham Institute for Medical Research, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA
    ChemMedChem 4:440-4. 2009
    ..Tryptophan fluorescence measurements further support a binding mode in which these compounds seem to stabilize the phosphatase in its inactive conformation...
  29. ncbi Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex
    Robert C Rickert
    Program of Inflammatory Disease Research, Infectious and Inflammatory Disease Center, The Burnham Institute, La Jolla, California 92037, USA
    Curr Opin Immunol 17:237-43. 2005
    ....
  30. ncbi Cell-type specific and cytoplasmic targeting of PEGylated carbon nanotube-based nanoassemblies
    Matthew H Cato
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Nanosci Nanotechnol 8:2259-69. 2008
    ..The present manuscript is the first report about the cytoplasmic delivery of carbon nanotubes in a specific cell type in intact animals and paves the way for their use as in vivo intracellular delivery systems...
  31. ncbi PDK1 regulates B cell differentiation and homeostasis
    Gisele V Baracho
    Program on Immunity and Pathogenesis, Sanford Burnham Medical Research Institute, La Jolla, CA 92037 and
    Proc Natl Acad Sci U S A 111:9573-8. 2014
    ..In summary, our results demonstrate that PDK1 is indispensable for B cell survival, proliferation, and growth regulation. ..
  32. doi Protein tyrosine phosphatases in autoimmunity
    Torkel Vang
    Burnham Institute for Medical Research, La Jolla, California 92037, USA
    Annu Rev Immunol 26:29-55. 2008
    ..We also find it likely that additional PTPs are involved in susceptibility to autoimmune and inflammatory diseases. Finally, we discuss the possibility that PTPs regulating the immune system may serve as therapeutic targets...
  33. pmc Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids
    Torkel Vang
    Infectious and Inflammatory Disease Center, Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, United States
    J Med Chem 54:562-71. 2011
    ..Selectivity profiling against closely related tyrosine phosphatases and in silico docking studies with the crystal structure of Lyp yielded valuable information for the design of Lyp-specific compounds...