Tolerance to daytime sedative effects of H1 antihistaminesGary S Richardson
Sleep Disorders Clinic and Research Center, Henry Ford Hospital, Detroit, Michigan 48202, USA
J Clin Psychopharmacol 22:511-5. 2002
..While other antihistamines and dosing regimens may differ, these results suggest that tolerance to the sedation produced by these drugs develops with remarkable rapidity...
- Future directions in the management of insomnia
G S Richardson
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, Mich 48202, USA
J Clin Psychiatry 62:39-45. 2001
..It remains unclear, however, whether this activation is primary or secondary to the insomnia itself. If physiologic hyperarousal causes primary insomnia, it would provide new approaches to the management of this disorder...
- Safety and subjective sleep effects of ramelteon administration in adults and older adults with chronic primary insomnia: a 1-year, open-label study
Gary S Richardson
Henry Ford Hospital, Sleep Disorders Center, Detroit, MI 48202, USA
J Clin Psychiatry 70:467-76. 2009
..To evaluate the long-term safety and subjective sleep effects of ramelteon in adults with chronic insomnia...
Epidemiology of insomnia and the need for diagnosis and treatmentGary S Richardson
Sleep Disorders and Research Center, Henry Ford Hospital Sleep Center, Detroit, MI 48202, USA
Postgrad Med 116:14-8. 2004
..Several barriers exist to treatment, but incorporating simple questions may serve as step in guiding diagnosis and treatment...
Circadian phase-shifting effects of repeated ramelteon administration in healthy adultsGary S Richardson
Henry Ford Hospital, Sleep Center, 2799 West Grand Blvd, CFP 3, Detroit, MI 48202, USA
J Clin Sleep Med 4:456-61. 2008
..To assess the ability of repeated daily oral ramelteon to facilitate re-entrainment of human circadian rhythms after an imposed phase advance of the sleep-wake cycle...
- Human physiological models of insomnia
Gary S Richardson
Sleep Research Laboratory, Henry Ford Hospital, Detroit, MI, USA
Sleep Med 8:S9-14. 2007
....
- The human circadian system in normal and disordered sleep
Gary S Richardson
Division of Sleep Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
J Clin Psychiatry 66:3-9; quiz 42-3. 2005
..Taking into consideration the preeminence of the circadian clock in timing sleep, it is likely that other sleep disorders, such as insomnia, are also linked to circadian system abnormalities...
- Managing insomnia in the primary care setting: raising the issues
G S Richardson
Henry Ford Hospital, Detroit, MI 48202, USA
Sleep 23:S9-12; discussion S13-5. 2000
..In selecting research priorities, however, the practical application of this information in the clinical setting is important if the ultimate goal is to reduce the number of patients suffering from insomnia and its consequences...
- Management of insomnia--the role of zaleplon
Gary S Richardson
Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA
MedGenMed 4:9. 2002
..CONCLUSIONS: The characteristics of zaleplon may translate into distinct and significant clinical advances in the treatment of insomnia...
- Long-term use of sedative hypnotics in older patients with insomnia
Sonia Ancoli-Israel
Department of Psychiatry 116A, University of California San Diego and Veterans Affairs, San Diego Healthcare System, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
Sleep Med 6:107-13. 2005
..This paper reports the results of a 1-year open-label extension phases of two randomized, double-blind trials of zaleplon...
