- Randomized controlled trials in perianal Crohn's disease
Villa Sofia Cervello Hospital, Palermo, Italy
Rev Recent Clin Trials 7:297-302. 2012
..Their use is recommended as a second line medical treatment. The use of tacrolimus and thalidomide is limited by its side effects. A few evidences support the use of methotrexate and cyclosporine but they are insufficient...
- Adalimumab in steroid-dependent Crohn's disease patients: prognostic factors for clinical benefit
DI BI MIS, Division of Internal Medicine Villa Sofia V Cervello Hospital, University of Palermo, Palermo, Italy
Inflamm Bowel Dis 18:826-31. 2012
..Corticosteroids are effective in the treatment of Crohn's disease but some patients relapse during tapering or after discontinuation. We report data on efficacy and prognostic factors of response of adalimumab in steroid-dependent patients...
- Is splenectomy a treatment option for aseptic abscesses in patients with Crohn's disease?
Department of Medicine, Pneumology and Nutrition Clinic, Internal Medicine I, V Cervello Hospital, Palermo University, Via Trabucco 180, Palermo, Italy
Eur J Gastroenterol Hepatol 21:1314-6. 2009
..We report a case of a young woman with splenic aseptic abscesses as complication of Crohn's disease. After steroid sparing and antibiotic failure the patient underwent successful splenectomy...
- Cyclosporine or infliximab as rescue therapy in severe refractory ulcerative colitis: early and long-term data from a retrospective observational study
DI BI MIS, Division of Internal Medicine Villa Sofia Cervello Hospital, University of Palermo, Via Trabucco 180, 90146, Palermo, Italy
J Crohns Colitis 6:681-6. 2012
..Iv cyclosporine and infliximab are an effective rescue therapy in steroid-refractory UC patients but up to now it is still unclear which is the best therapeutic choice...
- Placebo therapy in Crohn's disease
Department of Medicine, Pneumology and Nutrition Clinic, V Cervello Hospital, Palermo University, Palermo, Italy
Eur J Intern Med 20:572-8. 2009
..Better selection of patients and more precise definition of outcome measures are warranted to reduce the heterogeneity among placebo response in clinical trials...
- Medical management of Crohn's disease
University of Palermo, Villa Sofia V Cervello Hospital, Division of Internal Medicine, DI BI MIS, Via Trabucco 180, 90146, Palermo, Italy
Expert Opin Pharmacother 12:2505-25. 2011
..Anti-TNF therapy is indicated in patients intolerant or not responding to steroids and immunosuppressors and in fistulizing Crohn's disease. Early therapy with biologics may be considered in patients with severe disease...
- Meta-analysis of the placebo rates of clinical relapse and severe endoscopic recurrence in postoperative Crohn's disease
Dipartimento di Medicina, Pneumologia e Fisiologia della Nutrizione Umana, Universita di Palermo, Palermo, Italy
Gastroenterology 135:1500-9. 2008
..The aim of this meta-analysis was to focus on knowledge of the placebo rates of relapse and recurrence in postoperative CD and to identify factors influencing these rates...
- Is 5-ASA still the treatment of choice for ulcerative colitis?
Dipartimento Biomedico di Medicina Interna e Specialistica, AO Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy
Curr Drug Targets 12:1396-405. 2011
..The possible chemopreventive role of long term treatment with 5-ASA strengthens the indication to the long term use of 5-ASA...
- Gastrointestinal lesions associated with spondyloarthropathies
Department of General Medicine, Pneumology and Nutrition Clinic, V Cervello Hospital, Palermo University, Palermo, Italy
World J Gastroenterol 15:2443-8. 2009
..This topic reviews the major gastrointestinal manifestations that can occur in patients with SpA and in nonsteroidal anti-inflammatory drugs users...