Andreas Reif

Summary

Publications

  1. ncbi request reprint MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia
    Sandra Selch
    Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 61:1211-4. 2007
  2. ncbi request reprint A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 9:13-20. 2006
  3. ncbi request reprint Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1162-8. 2005
  4. ncbi request reprint Neural stem cell proliferation is decreased in schizophrenia, but not in depression
    A Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:514-22. 2006
  5. ncbi request reprint Duplication 15q14 --> pter: a rare chromosomal abnormality underlying bipolar affective disorder
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Psychiatry 19:179-81. 2004
  6. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
  7. ncbi request reprint Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthase
    A Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, D 97078 Wurzburg, Germany
    Free Radic Biol Med 37:988-97. 2004
  8. ncbi request reprint Encephalopathy and myoclonus triggered by valproic acid
    Andreas Reif
    Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004
  9. ncbi request reprint Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndrome
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuechsleinstr 15, D 97080 Wuerzburg, Germany
    Psychiatry Res 132:273-8. 2004
  10. ncbi request reprint A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function
    A Reif
    Department of Psychiatry and Psychotherapy Section for Clinical and Molecular Psychobiology and Laboratory for Psychophysiology and Functional Imaging, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:286-300. 2006

Detail Information

Publications93

  1. ncbi request reprint MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia
    Sandra Selch
    Department of Psychiatry and Psychotherapy Molecular and Clinical Psychobiology, University of Wurzburg, Wurzburg, Germany
    Biol Psychiatry 61:1211-4. 2007
    ....
  2. ncbi request reprint A NOS-III haplotype that includes functional polymorphisms is associated with bipolar disorder
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Int J Neuropsychopharmacol 9:13-20. 2006
    ..Our results thus suggest that the NOS-III genotype may convey a modest genetic risk to develop bipolar disorder. This finding should be further clarified by the use of within-family designs and in samples of other ethnicity...
  3. ncbi request reprint Homocysteinemia as well as methylenetetrahydrofolate reductase polymorphism are associated with affective psychoses
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 29:1162-8. 2005
    ..In conclusion, we suggest that in females homocysteinemia is an unspecific risk factor for organic brain disorders like dementia, and possibly depression, but not for schizophrenia...
  4. ncbi request reprint Neural stem cell proliferation is decreased in schizophrenia, but not in depression
    A Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:514-22. 2006
    ....
  5. ncbi request reprint Duplication 15q14 --> pter: a rare chromosomal abnormality underlying bipolar affective disorder
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Psychiatry 19:179-81. 2004
    ..Possible implications of this rare chromosomal abnormality with regards to psychiatric disorders are discussed, with emphasis on recent evidence suggesting chromosome 15q13-15 as a susceptibility locus for psychosis...
  6. ncbi request reprint Differential effect of endothelial nitric oxide synthase (NOS-III) on the regulation of adult neurogenesis and behaviour
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Eur J Neurosci 20:885-95. 2004
    ..In conclusion, our results indicated that NOS-III is involved in the proliferation of neuronal progenitor cells, although behavioural analysis does not provide evidence for a pro-depressive effect of reduced neuroneogenesis...
  7. ncbi request reprint Superoxide dismutase and catalase are required to detect (.-)NO from both coupled and uncoupled neuronal no synthase
    A Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, D 97078 Wurzburg, Germany
    Free Radic Biol Med 37:988-97. 2004
    ..In conclusion, standard Clark-type ()NO electrodes are cross-sensitive to H(2)O(2) and therefore both SOD and catalase are absolutely required to specifically detect (.-)NO from NOS...
  8. ncbi request reprint Encephalopathy and myoclonus triggered by valproic acid
    Andreas Reif
    Department of Psychiatry, Julius Maximilians University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 28:1061-3. 2004
    ..On VPA discontinuation, all symptoms vanished and EEG normalized. We thus suggest that direct VPA-induced encephalopathy in the absence of ammonemia does exist, in this case probably facilitated by psychotropic polypharmacy...
  9. ncbi request reprint Altered functioning of the cingulate gyrus in two cases of chromosome 22q11 deletion syndrome
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuechsleinstr 15, D 97080 Wuerzburg, Germany
    Psychiatry Res 132:273-8. 2004
    ..We conclude that more extensive study of NoGo anteriorisation as a potential endophenotype of 22q11-DS patients at risk for 22q11-associated psychiatric conditions is warranted...
  10. ncbi request reprint A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function
    A Reif
    Department of Psychiatry and Psychotherapy Section for Clinical and Molecular Psychobiology and Laboratory for Psychophysiology and Functional Imaging, Julius Maximilians University Würzburg, Wurzburg, Germany
    Mol Psychiatry 11:286-300. 2006
    ..Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning...
  11. ncbi request reprint Carbohydrate-deficient transferrin parallels disease severity in anorexia nervosa
    Andreas Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Psychiatry Res 137:143-6. 2005
    ..In anorexia nervosa patients, CDT is unsuitable as a marker of alcohol abuse, but it might serve as a parameter indicating prognosis and disease severity. However, case-control studies with larger samples are warranted...
  12. ncbi request reprint Delusional paralysis: an unusual variant of Cotard's syndrome
    Andreas Reif
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, DE 97080 Würzburg, Germany
    Psychopathology 36:218-20. 2003
    ..Upon ECT, symptoms rapidly improved. Psychopathological implications and the nosological position of Cotard's syndrome are discussed...
  13. ncbi request reprint Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment
    Andreas Reif
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 32:2375-83. 2007
    ..These findings indicate complex interactions between genetic variation of the serotonergic circuitry and environmental factors arguing against simplistic, mono-causal explanations of violent behavior...
  14. doi request reprint The functional MAOA-uVNTR promoter polymorphism in patients with frontotemporal dementia
    A Reif
    Department of Psychiatry and Psychotherapy, Section of Clinical and Molecular Psychobiology, University of Wurzburg, Wurzburg, Germany
    Eur J Neurol 15:637-9. 2008
    ..However, no significant differences were observed between patients and controls. Bearing in mind the caveat of the small patient sample size, our data nevertheless argue against a major genetic role of MAO-A polymorphism in FTD...
  15. ncbi request reprint Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase
    A Reif
    Department of Pharmacology and Toxicology, Julius Maximilians University, Wurzburg, 97078 Germany
    J Biol Chem 274:24921-9. 1999
    ..In conclusion, we propose a role for H(4)Bip as a dimer-stabilizing factor of neuronal NOS during catalysis, possibly by interfering with enzyme destabilizing products...
  16. ncbi request reprint Toward a molecular architecture of personality
    Andreas Reif
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuchsleinstr 15, 97080, Wuerzburg, Germany
    Behav Brain Res 139:1-20. 2003
    ..The findings converge on the notion that a probabilistic rather than deterministic impact of genes on the expression of behavior will contribute to the demystification of behavioral disorders...
  17. pmc Neuroleptic malignant syndrome in Kufs' disease
    A Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Germany
    J Neurol Neurosurg Psychiatry 74:385-7. 2003
    ..Collectively the results argued for an involvement of the muscle in neuroleptic malignant syndrome at least in ANCL...
  18. ncbi request reprint Neurogenesis and schizophrenia: dividing neurons in a divided mind?
    Andreas Reif
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:290-9. 2007
    ..In conclusion, several lines of evidence suggest that reduced AN may contribute to the etiopathogenesis of schizophrenic disorders, whereas it does not seem to be a critical risk factor for affective disorders...
  19. ncbi request reprint Nitroxyl oxidizes NADPH in a superoxide dismutase inhibitable manner
    A Reif
    Clinical Neurochemistry, Department of Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    Free Radic Biol Med 30:803-8. 2001
    ..Thus, biologically formed NO(-) may function as an effective pro-oxidant unless scavenged by SOD and affect the apparent NADPH stoichiometry of the NOS reaction...
  20. doi request reprint COMT x DRD4 epistasis impacts prefrontal cortex function underlying response control
    Sebastian Heinzel
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, 97080 Wurzburg, Germany
    Cereb Cortex 23:1453-62. 2013
    ..Our findings might help to disentangle the genetic basis of dopaminergic mechanisms underlying prefrontal (dys)function...
  21. doi request reprint Influence of functional variant of neuronal nitric oxide synthase on impulsive behaviors in humans
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Arch Gen Psychiatry 66:41-50. 2009
    ..Although rodent data suggest that the neuronal isoform of nitric oxide synthase (NOS-I) modifies diverse behaviors including aggression, this has not been translated to human studies...
  22. ncbi request reprint Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department for Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080 Wurzburg, Germany
    Int J Neuropsychopharmacol 10:309-20. 2007
    ..These findings implicate alterations of 5-HT synthesis in emotion regulation and confirm TPH2 as a susceptibility and/or modifier gene of affective spectrum disorders...
  23. doi request reprint Influence of a latrophilin 3 (LPHN3) risk haplotype on event-related potential measures of cognitive response control in attention-deficit hyperactivity disorder (ADHD)
    Andreas J Fallgatter
    Department of Psychiatry and Psychotherapy, University of Tuebingen, Germany
    Eur Neuropsychopharmacol 23:458-68. 2013
    ..The results of our study further strengthen the concept of an LPHN3 risk haplotype for ADHD and support the usefulness of the endophenotype approach in psychiatric and psychological research...
  24. doi request reprint A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 260:317-26. 2010
    ..Further replication studies, however, are necessary to validate the apparent complexity of G x E interactions in disorders of human personality...
  25. doi request reprint Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety
    Agnieszka Gajewska
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, D 97080 Wuerzburg, Germany
    Prog Neuropsychopharmacol Biol Psychiatry 40:115-21. 2013
    ....
  26. doi request reprint KCNIP4 as a candidate gene for personality disorders and adult ADHD
    Lena Weißflog
    Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Eur Neuropsychopharmacol 23:436-47. 2013
    ..0079 to 0.049). Seven markers within the KCNIP4 gene showed an association with PD (p values from 0.0043 to 0.0437). The results of these studies suggest a role of KCNIP4 in the etiology of ADHD, PD and other co-morbid disorders...
  27. ncbi request reprint Neuronal nitric oxide synthase (NOS-I) knockout increases the survival rate of neural cells in the hippocampus independently of BDNF
    Sabrina Fritzen
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy Josef Schneider Str 11, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Mol Cell Neurosci 35:261-71. 2007
    ..Together, these results emphasize the important role of the different NOS isoforms with respect to adult neurogenesis...
  28. pmc DIRAS2 is associated with adult ADHD, related traits, and co-morbid disorders
    Andreas Reif
    Department of Psychiatry, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2318-27. 2011
    ..031). Additional SNPs showed association with personality scores (p=0.008-0.048). Converging lines of evidence implicate genetic variance in the promoter region of DIRAS2 in the etiology of ADHD and co-morbid impulsive disorders...
  29. doi request reprint Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life
    Claudia Kriegebaum
    Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:512-7. 2010
    ..The formation of the serotonergic system thus seems to be a preserved expressional pattern due to intrinsic cellular programs which occurs also in the absence of its key molecule, namely 5-HT...
  30. doi request reprint A functional promoter polymorphism of neuronal nitric oxide synthase moderates prefrontal functioning in schizophrenia
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, Julius Maximilians University Würzburg, Germany
    Int J Neuropsychopharmacol 14:887-97. 2011
    ..Our fNIRS data extend previous studies suggesting disturbed prefrontal functioning in schizophrenia and suggest that genetic variation of NOS1 has a role in cognitive dysfunction, probably by mediating glutamatergic tone...
  31. doi request reprint NOS1 ex1f-VNTR polymorphism affects prefrontal oxygenation during response inhibition tasks
    Juliane Kopf
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Clinical and Molecular Psychobiology, Wuerzburg, Germany
    Hum Brain Mapp 33:2561-71. 2012
    ..Impairment of prefrontal control with consecutive failure of inhibitory processes might underlie association findings reported previously...
  32. pmc Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 7:e37651. 2012
    ..In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females...
  33. doi request reprint Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation
    Katharina Domschke
    Department of Psychiatry and Psychotherapy, University of Muenster, Albert Schweitzer Campus 1, Gebaeude A9, 48149 Muenster, Germany
    Psychopharmacology (Berl) 222:533-41. 2012
    ..2006) and attenuating the stimulatory effects of NPS in rodents (Boeck et al., 2010)...
  34. doi request reprint The expression of the transcription factor FEV in adult human brain and its association with affective disorders
    Claudia B Kriegebaum
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    J Neural Transm 117:831-6. 2010
    ..FEV therefore might not account for the genetic risk towards depression or bipolar disorder. Furthermore, the specificity of FEV for the serotonergic system should be reconsidered...
  35. doi request reprint Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice
    Lise Gutknecht
    Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1127-32. 2008
    ..The findings confirm the exclusive specificity of Tph2 in brain 5-HT synthesis and suggest that Tph2-synthesized 5-HT is not required for serotonergic neuron formation...
  36. doi request reprint Meta-analysis argues for a female-specific role of MAOA-uVNTR in panic disorder in four European populations
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 159:786-93. 2012
    ..However, epigenetic mechanisms might obfuscate the genetic association, calling for ascertainment in larger samples as well as assessment of the MAOA promoter methylation status therein...
  37. pmc Affect-modulated startle: interactive influence of catechol-O-methyltransferase Val158Met genotype and childhood trauma
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    PLoS ONE 7:e39709. 2012
    ....
  38. pmc Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice
    Yong Chen
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Mol Pain 6:13. 2010
    ..Here we asked whether cytokines, which have well-described roles in inflammatory pain, are downstream targets of NO in inflammatory pain and which of the isoforms of NOS are involved in this process...
  39. ncbi request reprint Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity
    Christian P Jacob
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 30:1711-8. 2005
    ..Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper- (impulsive-aggressive) and hyporeactive (anxious-depressive) traits...
  40. ncbi request reprint Impact of catechol-O-methyltransferase on prefrontal brain functioning in schizophrenia spectrum disorders
    Ann Christine Ehlis
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 32:162-70. 2007
    ..These results indicate that COMT genotype exerts a strong impact on prefrontal functioning and executive control in schizophrenia spectrum disorders...
  41. doi request reprint Monoamine oxidase A gene DNA hypomethylation - a risk factor for panic disorder?
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany
    Int J Neuropsychopharmacol 15:1217-28. 2012
    ..Future studies are warranted to replicate the present finding in independent samples, preferably in a longitudinal design...
  42. doi request reprint Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivity
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany
    Depress Anxiety 28:1048-57. 2011
    ..Thus, a gene-environment interaction (G × E) study was conducted with respect to anxiety sensitivity (AS) as a promising intermediate phenotype of anxiety disorders...
  43. pmc Cross-disorder analysis of bipolar risk genes: further evidence of DGKH as a risk gene for bipolar disorder, but also unipolar depression and adult ADHD
    Heike Weber
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Wurzburg, Wurzburg, Germany
    Neuropsychopharmacology 36:2076-85. 2011
    ..We demonstrate an association of DGKH with BPD, UPD, and aADHD by applying a two-stage design. These disorders share the feature of mood instability, so that this phenotype might be associated with genetic variation in DGKH...
  44. doi request reprint Reduced prefrontal oxygenation during object and spatial visual working memory in unpolar and bipolar depression
    Martin Schecklmann
    University of Regensburg, Department of Psychiatry and Psychotherapy, Regensburg, Germany
    Psychiatry Res 194:378-84. 2011
    ..However, fNIRS can be considered as a valid, easy manageable, low cost and rapid tool for measuring (diminished) prefrontal cortex functions...
  45. pmc Impact of the AHI1 gene on the vulnerability to schizophrenia: a case-control association study
    Olga Rivero
    Unit of Molecular Psychiatry, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 5:e12254. 2010
    ..To further investigate the contribution of AHI1 to the susceptibility of schizophrenia, we evaluated the effect of AHI1 variation on the vulnerability to psychosis in two samples from Spain and Germany...
  46. doi request reprint NOS1 ex1f-VNTR polymorphism influences prefrontal brain oxygenation during a working memory task
    Juliane Kopf
    University of Wuerzburg, Department of Psychiatry, Psychosomatics and Psychotherapy, Wuerzburg, Germany
    Neuroimage 57:1617-23. 2011
    ..This suggests a potential compensatory mechanism, with task-related brain regions being more active in short allele carriers to compensate for reduced NOS1 expression...
  47. pmc Dopamine transporter (SLC6A3) genotype impacts neurophysiological correlates of cognitive response control in an adult sample of patients with ADHD
    Thomas Dresler
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital Wuerzburg, Wuerzburg, Germany
    Neuropsychopharmacology 35:2193-202. 2010
    ....
  48. doi request reprint Catechol-O-methyltransferase Val158Met genotype affects neural correlates of aversive stimuli processing
    Martin J Herrmann
    Department of Psychiatry, Psychosomatics, and PsychotherapyUniversity of Würzburg, Wurzburg, Germany
    Cogn Affect Behav Neurosci 9:168-72. 2009
    ..Specifically, Met/Met carriers respond more sensitively to unpleasant stimuli, as compared with Val/Val carriers. We did not find evidence that life stress moderates the effect of the COMT genotype on emotional stimuli processing...
  49. doi request reprint Human IgG directed against amphiphysin induces anxiety behavior in a rat model after intrathecal passive transfer
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    J Neural Transm 119:981-5. 2012
    ..We propose that antibody-mediated amphiphysin deficiency may account for anxiety behavior in stiff person syndrome via presynaptic dysregulation of GABAergic pathways...
  50. pmc Human stiff-person syndrome IgG induces anxious behavior in rats
    Christian Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e16775. 2011
    ..Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear...
  51. doi request reprint The COGITAT holeboard system as a valuable tool to assess learning, memory and activity in mice
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Behav Brain Res 220:152-8. 2011
    ..Overall, our data indicate that this spatial learning task will be useful to characterize spatial memory in various genetic or pharmacological mouse models...
  52. ncbi request reprint The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Psychopharmacol 20:547-52. 2006
    ..The results of this first study of TPH2 in panic disorder argue against an importance of allelic variation of TPH2 in the pathogenesis of panic disorder with or without agoraphobia...
  53. doi request reprint Epigenetic signature of panic disorder: a role of glutamate decarboxylase 1 (GAD1) DNA hypomethylation?
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Germany Department of Psychiatry, University of Wuerzburg, Germany Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 46:189-96. 2013
    ..Future studies are warranted to replicate the present finding in independent samples, preferably in a longitudinal design. ..
  54. pmc A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity
    Annette Conzelmann
    Department of Psychology Biological Psychology, Clinical Psychology, and Psychotherapy, University of Wurzburg, Marcusstr 9 11, 97070 Wurzburg, Germany
    Psychopharmacology (Berl) 224:573-9. 2012
    ..However, the association of eCB system with emotional-motivational reactivity is complex and bidirectional due to upcoming compensatory processes...
  55. doi request reprint Gene-environment interaction influences anxiety-like behavior in ethologically based mouse models
    Antonia M Post
    Molecular Psychiatry, Laboratory of Translational Neuroscience, Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Behav Brain Res 218:99-105. 2011
    ..These results challenge the comparability of not sufficiently standardized tests of anxiety-like behavior and emphasize the need for controlling environmental variables in behavioral phenotyping...
  56. ncbi request reprint Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice
    Michael Karl Boettger
    Department of Neurology, Julius Maximilians University, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Eur J Pain 11:810-8. 2007
    ..These results support the proposed role of nNOS in sensitization of DRG neurones, and might indicate that CGRP is involved in this process...
  57. ncbi request reprint Co-morbidity of adult attention-deficit/hyperactivity disorder with focus on personality traits and related disorders in a tertiary referral center
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    Eur Arch Psychiatry Clin Neurosci 257:309-17. 2007
    ..The prevalence and consequences of co-morbid axis-I and axis-II disorders as well as personality traits were examined in a large cohort of adult attention-deficit/hyperactivity disorder (AADHD) at a tertiary referral center...
  58. doi request reprint A functional NOS1 promoter polymorphism interacts with adverse environment on functional and dysfunctional impulsivity
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Psychopharmacology (Berl) 214:239-48. 2011
    ..In line with this, we have previously shown that a functional promoter polymorphism of NOS1, termed NOS1 ex1f-VNTR, is associated with impulsivity-related traits and related disorders...
  59. doi request reprint Functional variants of TSPAN8 are associated with bipolar disorder and schizophrenia
    Claus Jürgen Scholz
    IZKF Laboratory for Microarray Applications, University of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 153:967-72. 2010
    ..Similar phenomena might also occur in other risk genes for both BPD and SCZ, providing a molecular basis for the genetic overlap of both entities...
  60. doi request reprint Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Alzheimers Dis 23:327-33. 2011
    ..As demonstrated, ex1f-VNTR interacted with the apolipoprotein E ε4 risk allele (OR in the presence of both risk alleles 3.63; 95% CI: 1.45-9.12). These findings provide further evidence for an association of NOS1 with AD...
  61. doi request reprint Genetic variation in MAOA modulates prefrontal cortical regulation of approach-avoidance reactions
    Lena H Ernst
    Psychophysiology and Optical Imaging, Department of Psychiatry and Psychotherapy, University of Tubingen, Tubingen, Germany
    Neuropsychobiology 67:168-80. 2013
    ..Regulation of automatic approach and avoidance behavior requires affective and cognitive control, which are both influenced by a genetic variation in the gene encoding Monoamine Oxidase A (termed MAOA-uVNTR)...
  62. ncbi request reprint Rare variants of the gene encoding the potassium chloride co-transporter 3 are associated with bipolar disorder
    Jobst Meyer
    Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Int J Neuropsychopharmacol 8:495-504. 2005
    ..Our data strongly suggest that rare variants of SLC12A6 may represent risk factors for bipolar disorder...
  63. pmc A novel approach to probabilistic biomarker-based classification using functional near-infrared spectroscopy
    Tim Hahn
    Department of Cognitive Psychology II, Johann Wolfgang Goethe University Frankfurt Main, Frankfurt am Main, Germany
    Hum Brain Mapp 34:1102-14. 2013
    ..In addition, our approach can easily compensate for variable class priors, which is highly advantageous in making predictions in a wide range of clinical neuroimaging applications...
  64. doi request reprint PPP2R2C as a candidate gene of a temperament and character trait-based endophenotype of ADHD
    Christian Jacob
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Atten Defic Hyperact Disord 4:145-52. 2012
    ..Nevertheless, as all those conditions are comorbid, PPP2R2C might reflect a common underlying neurobiological risk factor...
  65. pmc Dopamine transporter (DAT1) and dopamine receptor D4 (DRD4) genotypes differentially impact on electrophysiological correlates of error processing
    Stefanie C Biehl
    Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e28396. 2011
    ..They furthermore tie results from clinical investigations of disorders impacting on the dopamine system to genetic variations known to be at-risk genotypes...
  66. pmc ADORA2A Gene variation, caffeine, and emotional processing: a multi-level interaction on startle reflex
    Katharina Domschke
    Department of Psychiatry, University of Muenster, Muenster, Germany
    Neuropsychopharmacology 37:759-69. 2012
    ..The present findings may eventually aid in improving primary and secondary prevention by sharpening the risk profiles of anxiety-prone individuals...
  67. ncbi request reprint Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing
    Martin J Herrmann
    Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Cereb Cortex 17:1160-3. 2007
    ....
  68. doi request reprint Life events in panic disorder-an update on "candidate stressors"
    Benedikt Klauke
    Department of Psychiatry and Psychotherapy, University of Muenster, Germany
    Depress Anxiety 27:716-30. 2010
    ....
  69. doi request reprint Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
    Klaus Peter Lesch
    ADHD Clinical Research Program, Molecular and Clinical Psychobiology, Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstr 15, 97080, Wuerzburg, Germany
    J Neural Transm 115:1573-85. 2008
    ..g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability...
  70. ncbi request reprint Facial affect decoding in schizophrenic disorders: a study using event-related potentials
    Martin J Herrmann
    Department of Psychiatry and Psychotherapy at the University of Würzburg Füchsleinstr 15, 97080 Wurzburg, Germany
    Psychiatry Res 141:247-52. 2006
    ..Interestingly, schizophrenic patients had higher amplitudes in the neutral condition than did healthy controls. This effect was more pronounced in the paranoid subgroup of patients...
  71. doi request reprint Decreased anxiety in mice lacking the organic cation transporter 3
    Thomas Wultsch
    Section of Clinical and Molecular Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 116:689-97. 2009
    ....
  72. pmc Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity
    P Kotsonis
    Department of Pharmacology and Toxicology, Julius Maximilians University, Versbacher Strasse 9, D 97078 Wurzburg, Germany
    Biochem J 340:745-52. 1999
    ..Consistent with this, exogenous H2O2 also inhibited NOS activity during phase I. Thus during catalysis NOS is subject to complex autoinhibition by both enzyme-derived RNS and H2O2, differentially affecting enzyme activity...
  73. pmc Pterin interactions with distinct reductase activities of NO synthase
    M M Pantke
    Department of Pharmacology and Toxicology, , Versbacher Str. 9, , Germany
    Biochem J 356:43-51. 2001
    ....
  74. ncbi request reprint Morphological abnormalities in nitric-oxide-synthase-positive striatal interneurons of schizophrenic patients
    Martin Lauer
    Department of Psychiatry, Julius Maximilian University Würzburg, Fuchsleinstrasse 15, DE 97080 Würzburg, Germany
    Neuropsychobiology 52:111-7. 2005
    ..0001). Striatal nitrinergic interneurons might thus be involved in the pathogenesis of at least some forms of schizophrenia. Studies on larger samples are however needed to further corroborate this finding...
  75. ncbi request reprint NO synthase-positive striatal interneurons are decreased in schizophrenia
    S Fritzen
    Department of Psychiatry, Julius Maximilians University Würzburg, Germany
    Eur Neuropsychopharmacol 17:595-9. 2007
    ..Our results suggest that striatal nitrinergic interneurons are involved in the pathophysiology of at least some forms of schizophrenia, such as e.g. catatonic schizophrenia...
  76. ncbi request reprint Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patients
    A Reif
    Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Germany
    J Neural Transm 110:1401-11. 2003
    ..9+/-3.8 micromol/l), especially in elderly subjects. We thus suggest that homocysteinemia, at least in females, is an unspecific risk factor for organic brain disorders, but not endogenous psychoses...
  77. doi request reprint Stiff person syndrome-associated autoantibodies to amphiphysin mediate reduced GABAergic inhibition
    Christian Geis
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Brain 133:3166-80. 2010
    ....
  78. doi request reprint Neurovascular coupling in the human visual cortex is modulated by cyclooxygenase-1 (COX-1) gene variant
    Tim Hahn
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wuerzburg, Fuechsleinstrasse 15, 97080 Wuerzburg, Germany
    Cereb Cortex 21:1659-66. 2011
    ..Additionally, our results may have important implications for functional brain imaging in which HRs are commonly used as a surrogate for neural activation...
  79. pmc Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes
    Sarah Kittel-Schneider
    Department of Psychiatry, Psychosomatics and Psychotherapy, Psychiatric Neurobiology and Bipolar Disorder Program, University of Würzburg Würzburg, Germany
    Front Psychiatry 3:33. 2012
    ..Finally, neither Dat nor Nos3 RNA expression was detected in cultured astrocytes. Conclusion: These data provide further evidence for a role of astroglial cells in the molecular mechanisms of action of antidepressants...
  80. ncbi request reprint Anxiety-related traits in mice with modified genes of the serotonergic pathway
    Klaus Peter Lesch
    Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080, Wurzburg, Germany
    Eur J Pharmacol 480:185-204. 2003
    ..Finally, we attempt to identify future directions of genetic manipulation in animal models to advance our understanding of brain dysregulation characteristic of anxiety disorders...
  81. ncbi request reprint Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders
    Christian P Jacob
    Department of Psychiatry and Psychotherapy, University of Wuerzburg, Germany
    Am J Psychiatry 161:569-72. 2004
    ..The authors analyzed the influence of 5-HTTLPR variants on personality disorders...
  82. doi request reprint DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in schizophrenic patients--support for the glutamate hypothesis of schizophrenias
    A J Fallgatter
    Department of Psychiatry, University of Wuerzburg, Wuerzburg, Germany Fallgatter
    Genes Brain Behav 9:489-97. 2010
    ..An impact on fundamental processes of cognitive response control may be one mechanism by which DTNBP1 gene variants via glutamatergic transmission contribute to the pathophysiology underlying schizophrenic illnesses...
  83. doi request reprint Behavioral genetics of affective and anxiety disorders
    Katharina Domschke
    Department of Psychiatry, University of Wurzburg, Fuchsleinstrasse 15, D 97080, Wurzburg, Germany
    Curr Top Behav Neurosci 12:463-502. 2012
    ..Finally, there is some evidence for genetic factors potentially shared between affective and anxiety disorders pointing to a possible overlapping phenotype between anxiety disorders and depression...
  84. ncbi request reprint Folie a deux versus genetically driven delusional disorder: case reports and nosological considerations
    Andreas Reif
    Department of Psychiatry and Psychotherapy, University of Würzberg, Fuchsleinstrasse 15, 97080 Würzberg, Germany
    Compr Psychiatry 45:155-60. 2004
    ..Thus, thorough psychopathological examination in suspected folie a deux settings can help to obtain valid diagnoses...
  85. doi request reprint A functional dopamine-beta-hydroxylase gene promoter polymorphism is associated with impulsive personality styles, but not with affective disorders
    C Hess
    Department of Psychiatry and Psychotherapy, Clinical and Molecular Psychobiology, University of Wuerzburg, Wuerzburg, Germany
    J Neural Transm 116:121-30. 2009
    ....
  86. ncbi request reprint NADPH-diaphorase staining reveals new types of interneurons in human putamen
    Silvia Johannes
    Laboratory of Neurobiology, Department of Psychiatry and Psychotherapy, Julius Maximilians University Würzburg, Fuchsleinstr 15, D 97080, Wurzburg, Germany
    Brain Res 980:92-9. 2003
    ..Thus, we suggest at least three novel types of neostriatal interneurons. Furthermore, a special class of large neurons thought to be efferent in nature, stained NOS-positive...
  87. doi request reprint Genome-wide linkage analysis of ADHD using high-density SNP arrays: novel loci at 5q13.1 and 14q12
    M Romanos
    ADHD Clinical Research Program, Department of Child and Adolescent Psychiatry and Psychotherapy, University of Wuerzburg, Wuerzburg, Germany
    Mol Psychiatry 13:522-30. 2008
    ..Our study provides further evidence for common gene effects throughout different populations despite the complex multifactorial etiology of ADHD...
  88. ncbi request reprint Carbohydrate-deficient transferrin is elevated in catabolic female patients
    A Reif
    Department of Psychiatry and Psychotherapy, , , , Germany
    Alcohol Alcohol 36:603-7. 2001
    ..Possible biochemical mechanisms of this phenomenon are discussed. As a consequence of these findings, the measurement of CDT alone is not suitable to screen for alcohol misuse in catabolic subjects...
  89. ncbi request reprint Association of a NOS1 promoter repeat with Alzheimer's disease
    Daniela Galimberti
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, Fondazione Ospedale Maggiore Policlinico IRCCS, Milan, Italy
    Neurobiol Aging 29:1359-65. 2008
    ..83). Therefore, short alleles of the NOS1 exon 1f-VNTR are likely to be susceptibility factors for AD, and interact with the epsilon 4 allele to markedly increase the AD risk...
  90. ncbi request reprint Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases
    Hans Matter
    Sanofi Aventis, Chemical Sciences, Drug Design, Building G 878, D 65926 Frankfurt am Main, Germany
    J Med Chem 48:4783-92. 2005
    ....
  91. ncbi request reprint Acute akinetic crisis with marked cognitive impairment due to Valproate treatment
    Andreas Reif
    Int J Geriatr Psychiatry 18:356-7. 2003
  92. ncbi request reprint Venlafaxine and reversible blepharoedema
    Andreas Reif
    Int J Neuropsychopharmacol 5:413-4. 2002
  93. ncbi request reprint In vitro detection of nitric oxide and nitroxyl by electron paramagnetic resonance
    Andrei M Komarov
    Department of Physiology and Experimental Medicine, George Washington University Medical Center, Washington, DC 20037, USA
    Methods Enzymol 359:18-27. 2002