Dudek J, Hartmann M, Rehling P. The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease. Biochim Biophys Acta Mol Basis Dis. 2019;1865:810-821 pubmed publisher
Richter F, Dennerlein S, Nikolov M, Jans D, Naumenko N, Aich A, et al
. ROMO1 is a constituent of the human presequence translocase required for YME1L protease import. J Cell Biol. 2019;218:598-614 pubmed publisher
..Our analyses establish an unexpected link between mitochondrial protein import and inner membrane protein quality control. ..
Chowdhury A, Aich A, Jain G, Wozny K, Lüchtenborg C, Hartmann M, et al
. Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia. Cell Rep. 2018;25:561-570.e6 pubmed publisher
..We conclude that defective mitochondrial cardiolipin remodeling dampens HIF-1α signaling due to a lack of NF-κB activation through reduced mitochondrial ROS production, decreasing HIF-1α transcription. ..
Schendzielorz A, Bragoszewski P, Naumenko N, Gomkale R, Schulz C, Guiard B, et al
. Motor recruitment to the TIM23 channel's lateral gate restricts polypeptide release into the inner membrane. Nat Commun. 2018;9:4028 pubmed publisher
..This finding explains why a motor-free form of the translocase facilitates the lateral movement of precursors with a stop-transfer signal. ..
Dennerlein S, Rehling P. Human mitochondrial COX1 assembly into cytochrome c oxidase at a glance. J Cell Sci. 2015;128:833-7 pubmed publisher
..Furthermore, these findings will be discussed in the context of human COX-related disorders. ..
Lorenzi I, Oeljeklaus S, Ronsör C, Bareth B, Warscheid B, Rehling P, et al
. Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates. Mol Cell Biol. 2016;36:2782-2793 pubmed publisher
..We suggest that Mba1 stabilizes the Cox20-ribosome complex and supports the handover of Cox2 to the Cox18 tail export machinery. ..
Dudek J, Cheng I, Chowdhury A, Wozny K, Balleininger M, Reinhold R, et al
. Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome. EMBO Mol Med. 2016;8:139-54 pubmed publisher
..As a similar defect of SDH is apparent in patient cell-derived cardiomyocytes, we conclude that these defects represent a molecular basis for the cardiac pathology in Barth syndrome. ..
Bareth B, Nikolov M, Lorenzi I, Hildenbeutel M, Mick D, Helbig C, et al
. Oms1 associates with cytochrome c oxidase assembly intermediates to stabilize newly synthesized Cox1. Mol Biol Cell. 2016;27:1570-80 pubmed publisher
..Our analyses show that Oms1 participates in cytochrome c oxidase assembly by stabilizing newly synthesized Cox1. ..
Levchenko M, Wuttke J, Römpler K, Schmidt B, Neifer K, Juris L, et al
. Cox26 is a novel stoichiometric subunit of the yeast cytochrome c oxidase. Biochim Biophys Acta. 2016;1863:1624-32 pubmed publisher
..Our analyses reveal Cox26 as a novel stoichiometric structural subunit of the cytochrome c oxidase. A loss of Cox26 affects cytochrome c oxidase activity and respirasome organization. ..