Thomas C Register

Summary

Publications

  1. pmc Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:1916-22. 2013
  2. ncbi request reprint Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Psychoneuroendocrinology 32:981-90. 2007
  3. pmc Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 24:1719-27. 2009
  4. pmc Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study
    Thomas C Register
    Departments of Pathology T C R, Public Health Sciences J D, L E W, C D L, Radiology T C R, J J C, R C H, and Internal Medicine Nephrology B I F and Center for Genomics and Personalized Medicine Research D W B, N D P, J X, S C S, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 and Department of Pediatric Nephrology K A H, D J D, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Endocrinol Metab 99:315-21. 2014
  5. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
  6. doi request reprint Transcriptional profiles of progestogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 114:233-42. 2009
  7. ncbi request reprint Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 14:639-47. 2007
  8. ncbi request reprint Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Carcinogenesis 28:801-8. 2007
  9. ncbi request reprint Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 66:1241-9. 2006
  10. pmc Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model
    Kelly F Ethun
    Wake Forest University Primate Center, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Menopause 20:777-84. 2013

Detail Information

Publications58

  1. pmc Relationships between serum adiponectin and bone density, adiposity and calcified atherosclerotic plaque in the African American-Diabetes Heart Study
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:1916-22. 2013
    ..Adipokines vary in relation to changes in body composition and may play roles in regulation of BMD and risk of cardiovascular disease...
  2. ncbi request reprint Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Psychoneuroendocrinology 32:981-90. 2007
    ..Further research is needed to explore social context as an important feature of behavioral response to steroid hormone regimens and to verify and extend knowledge of systemic effects of vaginal ring-delivered progestogens...
  3. pmc Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 24:1719-27. 2009
    ..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans...
  4. pmc Sclerostin is positively associated with bone mineral density in men and women and negatively associated with carotid calcified atherosclerotic plaque in men from the African American-Diabetes Heart Study
    Thomas C Register
    Departments of Pathology T C R, Public Health Sciences J D, L E W, C D L, Radiology T C R, J J C, R C H, and Internal Medicine Nephrology B I F and Center for Genomics and Personalized Medicine Research D W B, N D P, J X, S C S, Wake Forest School of Medicine, Winston Salem, North Carolina 27157 and Department of Pediatric Nephrology K A H, D J D, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Endocrinol Metab 99:315-21. 2014
    ..Sclerostin, an endogenous regulator of the Wnt pathway and bone formation, has been associated with impaired osteoblast activation and may play a role in vascular calcification...
  5. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
    ..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
  6. doi request reprint Transcriptional profiles of progestogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 114:233-42. 2009
    ....
  7. ncbi request reprint Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 14:639-47. 2007
    ..To evaluate the effects of oral estradiol given with either oral or intravaginal micronized progesterone (P4) on risk biomarkers for breast cancer in a postmenopausal monkey model...
  8. ncbi request reprint Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Carcinogenesis 28:801-8. 2007
    ..01 for all). These findings suggest that long-term exposure to soy isoflavonoids, equol in particular, may facilitate endogenous estrogen clearance and catabolism to more benign 2-hydroxylated metabolites...
  9. ncbi request reprint Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 66:1241-9. 2006
    ..These findings show that in the presence of estrogen higher doses of dietary soy isoflavones may alter ER signaling and induce selective antagonistic effects in the breast...
  10. pmc Endometrial profile of bazedoxifene acetate alone and in combination with conjugated equine estrogens in a primate model
    Kelly F Ethun
    Wake Forest University Primate Center, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Menopause 20:777-84. 2013
    ..The primary aim of this study was to evaluate the endometrial profile of bazedoxifene acetate (BZA), a third-generation SERM, alone and in combination with conjugated equine estrogens (CEE) in a postmenopausal primate model...
  11. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
    ..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model...
  12. pmc Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis)
    Latanya M Scott
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2594-602. 2008
    ..Premenopausal OCs may have long-term systemic effects on response to estrogen and its metabolism whereas postmenopausal dietary isoflavones may alter endogenous estrogen metabolism in a modest but selective manner...
  13. doi request reprint Variants in adiponectin signaling pathway genes show little association with subclinical CVD in the diabetes heart study
    Amanda J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, North Carolina, USA Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, North Carolina, USA Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 21:E456-62. 2013
    ....
  14. pmc Dietary soy effects on mammary gland development during the pubertal transition in nonhuman primates
    Fitriya N Dewi
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Cancer Prev Res (Phila) 6:832-42. 2013
    ..05). Our findings suggest that consumption of soy starting before menarche may result in modest effects consistent with a more differentiated breast phenotype in adulthood...
  15. doi request reprint Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes
    Jasmin Divers
    Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 26:1554-60. 2011
    ..This relationship was independent of conventional CVD risk factors and supports the hypothesis that bone metabolism and atherosclerotic plaque mineralization are related processes...
  16. pmc Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
    Jasmin Divers
    Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:5382-9. 2010
    ..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
  17. pmc Effects of bazedoxifene acetate with and without conjugated equine estrogens on the breast of postmenopausal monkeys
    Kelly F Ethun
    Wake Forest University Primate Center and the Department of Pathology Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 19:1242-52. 2012
    ....
  18. ncbi request reprint Bone mass and soy isoflavones in socially housed, premenopausal macaques
    Cynthia J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 040, USA
    Am J Clin Nutr 86:245-50. 2007
    ..It is not known whether premenopausal soy exposure initiated in adulthood can increase bone mass and thereby reduce fracture risk...
  19. pmc Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Psychosom Med 70:637-45. 2008
    ..Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac events. Little is known about the relationship between depression and CAA...
  20. ncbi request reprint Heritability of body composition measured by DXA in the diabetes heart study
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obes Res 13:312-9. 2005
    ..The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS)...
  21. doi request reprint Differential effects of estradiol on carotid artery inflammation when administered early versus late after surgical menopause
    Areepan Sophonsritsuk
    Section on Comparative Medicine, Department of Pathology, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 20:540-7. 2013
    ..The aim of this study was to determine the effects of estrogen therapy (ET) on carotid artery inflammation when initiated early and late relative to surgical menopause...
  22. pmc Relationships between serum MCP-1 and subclinical kidney disease: African American-Diabetes Heart Study
    Mariana Murea
    Department of Internal Medicine Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1053, USA
    BMC Nephrol 13:148. 2012
    ..Relationships between serum MCP-1 concentration and early nephropathy and subclinical cardiovascular disease (CVD) were assessed in African Americans (AAs) with type 2 diabetes (T2D)...
  23. pmc Plasma Dickkopf1 (DKK1) concentrations negatively associate with atherosclerotic calcified plaque in African-Americans with type 2 diabetes
    Thomas C Register
    Department of Pathology, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 98:E60-5. 2013
    ..Plasma DKK1, BMD in the spine, and CP in three arterial beds were assessed in African-Americans (AAs) to determine relationships of serum DKK1 with atherosclerotic vascular calcification...
  24. pmc Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mediators Inflamm 2010:170153. 2010
    ..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds...
  25. pmc Admixture mapping of coronary artery calcified plaque in African Americans with type 2 diabetes mellitus
    Jasmin Divers
    Departments of Biostatistical Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Circ Cardiovasc Genet 6:97-105. 2013
    ....
  26. pmc Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study
    Ryan L McKimmie
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Gastroenterol 103:3029-35. 2008
    ....
  27. pmc Force-generation capacity of single vastus lateralis muscle fibers and physical function decline with age in African green vervet monkeys
    Seung Jun Choi
    Department of Internal Medicine, Gerontology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 68:258-67. 2013
    ..Our results support a detrimental effect of aging on the intrinsic force and power generation of myofilament lattice and physical performance in vervet monkeys...
  28. ncbi request reprint Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 101:125-34. 2007
    ..These findings suggest that oral micronized progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate...
  29. ncbi request reprint Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Clin Endocrinol Metab 89:3462-8. 2004
    ..These findings suggest that high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk...
  30. ncbi request reprint Social stress, visceral obesity, and coronary artery atherosclerosis in female primates
    Carol A Shively
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 17:1513-20. 2009
    ..Further studies are needed to understand the complex and multifactorial temporal relationship among relative visceral obesity, physiological stress responses, and CAA...
  31. ncbi request reprint Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 135:2852-6. 2005
    ....
  32. pmc Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys
    Sara E Walker
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Atherosclerosis 196:106-13. 2008
    ..The negative associations of arterial ER alpha expression with atherosclerosis lend support to a mechanistic role for estrogen receptors in atherosclerosis susceptibility which merits further study...
  33. ncbi request reprint Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis)
    Paul Sikoski
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Obstet Gynecol 196:75.e1-7. 2007
    ..Assess effects of 2 novel selective estrogen receptor modulators on the reproductive system...
  34. pmc Depression and altered serum lipids in cynomolgus monkeys consuming a Western diet
    Floyd H Chilton
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Physiol Behav 104:222-7. 2011
    ....
  35. ncbi request reprint Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 92:345-52. 2007
    ....
  36. pmc Glyceollin-elicited soy protein consumption induces distinct transcriptional effects as compared to standard soy protein
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, United States
    J Agric Food Chem 60:81-6. 2012
    ..These preliminary findings suggest that glyceollin-enriched soy protein has divergent effects from standard soy with some specificity for adipocyte activity and nutrient metabolism...
  37. pmc Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice
    Jennifer A Cann
    Department of Pathology, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
    Atherosclerosis 201:43-52. 2008
    ..These results suggest that a period of estrogen deficiency followed by reintroduction alters the immunologic environment of atherosclerotic lesions as well as plaque progression...
  38. ncbi request reprint Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 90:1734-40. 2005
    ..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system...
  39. pmc Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis)
    Thomas C Register
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:766-75. 2009
    ....
  40. ncbi request reprint Social stress-associated depression in adult female cynomolgus monkeys (Macaca fascicularis)
    Carol A Shively
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Biol Psychol 69:67-84. 2005
    ..These monkeys may be a useful model of reproductive system-associated mood disorders in females...
  41. pmc Associations of BMI and adipose tissue area and density with incident mobility limitation and poor performance in older adults
    Rachel A Murphy
    Laboratory of Epidemiology, and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, MD RAM, IR, and TBH the Sections on Comparative Medicine Pathology, Radiology TCR, and Gerontology and Geriatrics SBK, Sticht Center on Aging, Wake Forest School of Medicine, Winston Salem, NC the Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA HNA the Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA ABN the Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN SS the Center for Aging and Population Health, Department of Medicine, University of Pittsburgh, Pittsburgh, PA BHG and the Translational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, MD EMS
    Am J Clin Nutr 99:1059-65. 2014
    ..Obesity is a risk factor for disability, but risk of specific adipose depots is not completely understood...
  42. pmc Age-related degenerative functional, radiographic, and histological changes of the shoulder in nonhuman primates
    Johannes F Plate
    Department of Orthopaedic Surgery, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Shoulder Elbow Surg 22:1019-29. 2013
    ..We hypothesized that age-related degenerative changes in the shoulders of nonhuman primates would resemble those observed in aging humans...
  43. pmc Review of the Diabetes Heart Study (DHS) family of studies: a comprehensively examined sample for genetic and epidemiological studies of type 2 diabetes and its complications
    Donald W Bowden
    Center for Diabetes Research, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina, USA
    Rev Diabet Stud 7:188-201. 2010
    ..The aim of this review is to provide a collective overview of the major results from the DHS family of studies, and relate them to the larger body of biomedical investigations of diabetes and its complications...
  44. pmc Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation
    Carol A Shively
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina NC 27157 1040, USA
    Am J Primatol 71:742-51. 2009
    ..Social stress may be engaging these same physiological systems, increasing the visceral deposition of fat and its sequelae, which increase CHD risk...
  45. ncbi request reprint Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys
    Carol A Shively
    Comparative Medicine Section, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 11:389-99. 2004
    ..To evaluate the effects of social subordination stress and chronic moderate alcohol consumption on indices of breast and endometrial cancer risk...
  46. doi request reprint Effect of race and genetics on vitamin D metabolism, bone and vascular health
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC 27157 1053, USA
    Nat Rev Nephrol 8:459-66. 2012
    ..Ultimately, in our opinion, a new mechanistic understanding of the relationships between bone mineralization and vascular calcification will produce novel approaches for disease prevention in aging populations...
  47. pmc Aging and physical mobility in group-housed Old World monkeys
    Carol A Shively
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 1040, USA
    Age (Dordr) 34:1123-31. 2012
    ..Thus, walking speed may be a useful indicator of decline in physical mobility in nonhuman primate models of aging...
  48. pmc Genetic analysis of adiponectin variation and its association with type 2 diabetes in African Americans
    S Sandy An
    Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston Salem, NC, USA Center for Diabetes Research, Wake Forest School of Medicine, Winston Salem, NC, USA
    Obesity (Silver Spring) 21:E721-9. 2013
    ..Studies evaluating genetic variants in ADIPOQ have been contradictory when testing association with T2D in different ethnic groups...
  49. ncbi request reprint Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism
    Thomas C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Chem 50:2185-7. 2004
  50. pmc Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 29:1471-7. 2009
    ..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent...
  51. pmc Sertraline effects on cerebrospinal fluid monoamines and species-typical socioemotional behavior of female cynomolgus monkeys
    Carol A Shively
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1040, USA
    Psychopharmacology (Berl) 231:1409-16. 2014
    ..Although widely prescribed, little is known about the effects of selective serotonin reuptake inhibitors (SSRIs) on social behavior and cerebrospinal fluid (CSF) monoamines in female primates...
  52. pmc Altered expression of glial and synaptic markers in the anterior hippocampus of behaviorally depressed female monkeys
    Stephanie L Willard
    Neuroscience Graduate Program, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA Electronic address
    Neurosci Lett 563:1-5. 2014
    ..Moreover, these findings indicate a potential role for estrogen in modulating astrocyte-mediated impairments in synaptic plasticity. ..
  53. pmc Effect of depression and sertraline treatment on cardiac function in female nonhuman primates
    Leanne Groban
    Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040
    Psychosom Med 76:137-46. 2014
    ..Depression is a proposed risk factor for heart failure based largely on epidemiological data; few experimental data addressing this hypothesis are available...
  54. pmc Methylomics of gene expression in human monocytes
    Yongmei Liu
    Wake Forest School of Medicine, Winston Salem, NC, USA
    Hum Mol Genet 22:5065-74. 2013
    ..These data may help prioritize interrogation of biologically relevant methylation loci and provide new insights into the epigenetic basis of human health and diseases. ..
  55. ncbi request reprint Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography
    Leon Lenchik
    Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston Salem, NC 27157, USA
    J Comput Assist Tomogr 28:134-9. 2004
    ..To develop a method and evaluate the performance of thoracic bone mineral density (BMD) measurement using cardiac gated quantitative computed tomography (QCT)...
  56. pmc Myosin heavy chain isoform expression in the Vastus Lateralis muscle of aging African green vervet monkeys
    Xin Feng
    Department of Otolaryngology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Exp Gerontol 47:601-7. 2012
    ....
  57. ncbi request reprint Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 89:2319-25. 2004
    ..These findings suggest that long-term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state...
  58. ncbi request reprint Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
    Konduru S R Sastry
    Department of Cancer Biology, Section on Comparative Medicine, and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 282:14094-100. 2007
    ..Antiapoptotic signaling by epinephrine could be one of the mechanisms by which stress promotes tumorigenesis and decreases the efficacy of anti-cancer therapies...