G Bhanuprakash Reddy

Summary

Publications

  1. ncbi request reprint Suppression of DTT-induced aggregation of abrin by alphaA- and alphaB-crystallins: a model aggregation assay for alpha-crystallin chaperone activity in vitro
    G Bhanuprakash Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 007, India
    FEBS Lett 522:59-64. 2002
  2. doi request reprint Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol
    Paduru Yadagiri Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    IUBMB Life 65:472-8. 2013
  3. pmc Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
    G Bhanuprakash Reddy
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India
    Mol Vis 14:593-601. 2008
  4. ncbi request reprint Chaperone-like activity and hydrophobicity of alpha-crystallin
    G Bhanuprakash Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    IUBMB Life 58:632-41. 2006
  5. ncbi request reprint Antioxidant defense system and lipid peroxidation in patients with skeletal fluorosis and in fluoride-intoxicated rabbits
    G Bhanuprakash Reddy
    National Institute of Nutrition ICMR, Hyderabad 500 007, India
    Toxicol Sci 72:363-8. 2003
  6. ncbi request reprint Effect of long-term dietary manipulation on the aggregation of rat lens crystallins: role of alpha-crystallin chaperone function
    G Bhanuprakash Reddy
    National Institute of Nutrition ICMR, Hyderabad, India
    Mol Vis 8:298-305. 2002
  7. ncbi request reprint alphaA- and alphaB-crystallins protect glucose-6-phosphate dehydrogenase against UVB irradiation-induced inactivation
    G B Reddy
    Laboratory of Ocular Biochemistry, National Institute of Nutrition, Hyderabad, 500 007, India
    Biochem Biophys Res Commun 282:712-6. 2001
  8. ncbi request reprint Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats
    P Suryanarayana
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    Mol Vis 13:1291-7. 2007
  9. ncbi request reprint Modulation of alpha-crystallin chaperone activity in diabetic rat lens by curcumin
    P Anil Kumar
    National Institute of Nutrition, Hyderabad, India
    Mol Vis 11:561-8. 2005
  10. ncbi request reprint Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications
    Megha Saraswat
    National Institute of Nutrition, Hyderabad, India
    Asia Pac J Clin Nutr 17:558-65. 2008

Collaborators

  • M Satish Kumar
  • T N Raju
  • P Suryanarayana
  • Raghu Pullakhandam
  • Niklaus H Mueller
  • B Sreedhar
  • Kamala Krishnaswamy
  • A L Khandare
  • P Anil Kumar
  • P N B S Srinivas
  • P Muthenna
  • Megha Saraswat
  • Vakdevi Validandi
  • J Mark Petrash
  • P Yadagiri Reddy
  • Paduru Yadagiri Reddy
  • Puppala Muthenna
  • Venu Kamarthapu
  • T Mrudula
  • Ira Surolia
  • M S Moghaddam
  • Nivedita Mitra
  • Nappan Veettil Giridharan
  • Nagalla Balakrishna
  • Chandrasekhar Akileshwari
  • V Sudhakar Reddy
  • T Padma
  • S G Bhagyalaxmi
  • Shravan K Gunda
  • Vudem Dashavantha Reddy
  • Khareedu Venkateswara Rao
  • Sharmistha Sinha
  • Abdul Haseeb
  • V S Ghole
  • Nasreen Z Ehtesham
  • V R Srinivas
  • Avadhesha Surolia
  • T N C Ramya
  • Nisar Ahmad

Detail Information

Publications30

  1. ncbi request reprint Suppression of DTT-induced aggregation of abrin by alphaA- and alphaB-crystallins: a model aggregation assay for alpha-crystallin chaperone activity in vitro
    G Bhanuprakash Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 007, India
    FEBS Lett 522:59-64. 2002
    ....
  2. doi request reprint Increased risk of cataract development in WNIN-obese rats due to accumulation of intralenticular sorbitol
    Paduru Yadagiri Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    IUBMB Life 65:472-8. 2013
    ..Further, intralenticular sorbitol accumulation beyond a threshold level could lead to cataract in WNIN/Ob and WNIN/GR-Ob rats. © 2013 IUBMB Life, 65(5):472-478, 2013...
  3. pmc Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy
    G Bhanuprakash Reddy
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad, India
    Mol Vis 14:593-601. 2008
    ..We investigated the relationship between ALR2 levels and human DR by measuring ALR2 activity and its product, sorbitol, in erythrocytes...
  4. ncbi request reprint Chaperone-like activity and hydrophobicity of alpha-crystallin
    G Bhanuprakash Reddy
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    IUBMB Life 58:632-41. 2006
    ..We thus attempted to provide an overview on the role of hydrophobicity in chaperone-like activity of alpha-crystallin, the kind of evaluation done for the first time...
  5. ncbi request reprint Antioxidant defense system and lipid peroxidation in patients with skeletal fluorosis and in fluoride-intoxicated rabbits
    G Bhanuprakash Reddy
    National Institute of Nutrition ICMR, Hyderabad 500 007, India
    Toxicol Sci 72:363-8. 2003
    ....
  6. ncbi request reprint Effect of long-term dietary manipulation on the aggregation of rat lens crystallins: role of alpha-crystallin chaperone function
    G Bhanuprakash Reddy
    National Institute of Nutrition ICMR, Hyderabad, India
    Mol Vis 8:298-305. 2002
    ..To investigate the effect of food, protein, and vitamin restriction on the susceptibility of lens crystallins to aggregation and chaperone activity of alpha-crystallin...
  7. ncbi request reprint alphaA- and alphaB-crystallins protect glucose-6-phosphate dehydrogenase against UVB irradiation-induced inactivation
    G B Reddy
    Laboratory of Ocular Biochemistry, National Institute of Nutrition, Hyderabad, 500 007, India
    Biochem Biophys Res Commun 282:712-6. 2001
    ..However, alphaA- and alphaB-crystallins were equally efficient at 40 degrees C in protecting G6PD...
  8. ncbi request reprint Emblica officinalis and its enriched tannoids delay streptozotocin-induced diabetic cataract in rats
    P Suryanarayana
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    Mol Vis 13:1291-7. 2007
    ..The purpose of the current study was to investigate the effect of Emblica and its enriched tannoids on streptozotocin (STZ)-induced diabetic cataract in rats...
  9. ncbi request reprint Modulation of alpha-crystallin chaperone activity in diabetic rat lens by curcumin
    P Anil Kumar
    National Institute of Nutrition, Hyderabad, India
    Mol Vis 11:561-8. 2005
    ..In this study, we investigated whether curcumin, a dietary antioxidant, can manipulate the chaperone-like activity of alpha-crystallin in diabetic rat lens...
  10. ncbi request reprint Dietary sources of aldose reductase inhibitors: prospects for alleviating diabetic complications
    Megha Saraswat
    National Institute of Nutrition, Hyderabad, India
    Asia Pac J Clin Nutr 17:558-65. 2008
    ..The findings reported here indicate the scope of adapting life-style modifications in the form of inclusion of certain common sources in the diet for the management of diabetic complications...
  11. doi request reprint Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance
    P Muthenna
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 604, India
    FEBS Lett 583:3637-42. 2009
    ..These results suggest that curcumin holds promise as an agent to prevent or treat diabetic complications...
  12. ncbi request reprint Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats
    Palla Suryanarayana
    National Institute of Nutrition ICMR, Hyderabad, India
    Invest Ophthalmol Vis Sci 46:2092-9. 2005
    ..The purpose of this study was to investigate the effect of curcumin and its source, turmeric, on streptozotocin-induced diabetic cataract in rats...
  13. ncbi request reprint Insights into hydrophobicity and the chaperone-like function of alphaA- and alphaB-crystallins: an isothermal titration calorimetric study
    M Satish Kumar
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 007, India
    J Biol Chem 280:21726-30. 2005
    ..Our results indicate that although hydrophobicity appears to be a factor in determining the chaperone-like activity of alpha-crystallins, it does not quantitatively correlate with the chaperone function of alpha-crystallins...
  14. doi request reprint Significance of alpha-crystallin heteropolymer with a 3:1 alphaA/alphaB ratio: chaperone-like activity, structure and hydrophobicity
    P N B S Srinivas
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 604, India
    Biochem J 414:453-60. 2008
    ....
  15. ncbi request reprint Cumulative antioxidant defense against oxidative challenge in galactose-induced cataractogenesis in Wistar rats
    T N Raju
    Physiology Division, Department of Zoology, Osmania University, Hyderabad, India
    Indian J Exp Biol 44:733-9. 2006
    ..The results indicate that natural dietary ingredients are effective in combination rather than the individual administration as they are complementing each other in reducing the risk of galactose induced cataract...
  16. pmc Alphab-crystallin-assisted reactivation of glucose-6-phosphate dehydrogenase upon refolding
    M Satish Kumar
    National Institute of Nutrition ICMR, Jamai Osmania, Hyderabad 500 007, India
    Biochem J 391:335-41. 2005
    ..Diminished chaperone-like activity of alpha-crystallin due to post-translational modifications may thus result in the accumulation of aggregated/inactivated proteins...
  17. doi request reprint Prevention of non-enzymic glycation of proteins by dietary agents: prospects for alleviating diabetic complications
    Megha Saraswat
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 604, India
    Br J Nutr 101:1714-21. 2009
    ..These findings indicate the potential of some dietary components to prevent and/or inhibit protein glycation. Thus these dietary agents may be able to be exploited for controlling AGE-mediated diabetic pathological conditions in vivo...
  18. ncbi request reprint Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat
    P Anil Kumar
    National Institute of Nutrition, Hyderabad 500 007, India
    Arch Biochem Biophys 444:77-83. 2005
    ..The results indicate that elevated expression of alpha-crystallins in some tissues may have implications in pathophysiology of diabetic complications...
  19. ncbi request reprint Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract
    P Suryanarayana
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    Mol Vis 10:148-54. 2004
    ..In the present study we have assessed the inhibition of AR by constituents of Emblica officinalis both in vitro and in lens organ culture...
  20. pmc Effect of dicarbonyl-induced browning on alpha-crystallin chaperone-like activity: physiological significance and caveats of in vitro aggregation assays
    M Satish Kumar
    National Institute of Nutrition, Hyderabad 500 007, India
    Biochem J 379:273-82. 2004
    ....
  21. ncbi request reprint Insulin resistance mediated biochemical alterations in eye lens of neonatal streptozotocin-induced diabetic rat
    P Suryanarayana
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 604, India
    Indian J Exp Biol 49:749-55. 2011
    ....
  22. pmc Effect of glycation on alpha-crystallin structure and chaperone-like function
    P Anil Kumar
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 007, India
    Biochem J 408:251-8. 2007
    ..We also describe the effects of glycation on the structure and chaperone-like activity of alpha-crystallin...
  23. ncbi request reprint Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina
    T Mrudula
    National Institute of Nutrition, Indian Council of Medical Research, Hyderabad 500 007, India
    Biochem Biophys Res Commun 361:528-32. 2007
    ..This study highlights the importance of biologically active compounds derived from dietary agents that could be explored further for the prevention and/or treatment of diabetic retinopathy...
  24. ncbi request reprint Effect of Diabecon on sugar-induced lens opacity in organ culture: mechanism of action
    M S Moghaddam
    Biochemistry Division, Department of Chemistry, University of Pune, Pune 411007, India
    J Ethnopharmacol 97:397-403. 2005
    ..These results suggest that Diabecon protect the lens against sugar-induced cataract by multiple mechanisms...
  25. doi request reprint Temperature-dependent structural and functional properties of a mutant (F71L) αA-crystallin: molecular basis for early onset of age-related cataract
    Vakdevi Validandi
    Biochemistry Division, National Institute of Nutrition, Hyderabad, India
    FEBS Lett 585:3884-9. 2011
    ..Therefore, F71L may lead to earlier onset of cataract due to interaction with several environmental factors (e.g., temperature in this case) along with the aging process...
  26. doi request reprint Structural and kinetic properties of Bacillus subtilis S-adenosylmethionine synthetase expressed in Escherichia coli
    Venu Kamarthapu
    Center for Plant Molecular Biology, Osmania University, Hyderabad 500 007, India
    Biochim Biophys Acta 1784:1949-58. 2008
    ..Concordance between results of SEC and enzyme activity in the presence of urea amply establishes that tetramer alone with intersubunit active site(s) exhibits enzyme activity...
  27. doi request reprint Ellagic acid, a new antiglycating agent: its inhibition of Nϵ-(carboxymethyl)lysine
    Puppala Muthenna
    Biochemistry Division, National Institute of Nutrition, Tarnaka, Hyderabad 500 604, India
    Biochem J 442:221-30. 2012
    ..These findings establish the antiglycating potential of EA and its in vivo utility in controlling AGE-mediated diabetic pathologies...
  28. ncbi request reprint Hierarchy and the mechanism of fibril formation in ADan peptides
    Ira Surolia
    National Institute of Nutrition, Hyderabad, India
    J Neurochem 99:537-48. 2006
    ..Neurotoxicity assays performed on both the forms reveal that the toxicity bears proportionality with the aggregate size...
  29. doi request reprint Binding and stabilization of transthyretin by curcumin
    Raghu Pullakhandam
    National Institute of Nutrition, Jamai Osmania, Tarnaka, Hyderabad 500604, India
    Arch Biochem Biophys 485:115-9. 2009
    ..These results suggest that curcumin binds to and stabilizes TTR thereby highlight the importance of the side chain conformations of the ligand in binding to TTR...
  30. ncbi request reprint Conformational stability of legume lectins reflect their different modes of quaternary association: solvent denaturation studies on concanavalin A and winged bean acidic agglutinin
    Nivedita Mitra
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
    Biochemistry 41:9256-63. 2002
    ..Ionic interactions and hydrogen bonding between the monomers of the two proteins also seem to play a significant role in the observed stability differences between these two proteins...