Emmanuelle Reboul

Summary

Publications

  1. pmc Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins
    Emmanuelle Reboul
    INRA, UMR1260, Nutrition, Obesity and Risk of Thrombosis, Marseille F 13385, France
    Nutrients 5:3563-81. 2013
  2. doi request reprint Cholesterol transport via ABCA1: new insights from solid-phase binding assay
    Emmanuelle Reboul
    INRA, UMR1260 Nutrition Obesity and Risk of Thrombosis, F 13385 Marseille, France
    Biochimie 95:957-61. 2013
  3. doi request reprint Phytosterols can impair vitamin D intestinal absorption in vitro and in mice
    Aurélie Goncalves
    INRA, UMR 1260 Lipid Nutriments and Prevention of Metabolique Dieases, Marseille, France
    Mol Nutr Food Res 55:S303-11. 2011
  4. ncbi request reprint Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer p
    Patrick Borel
    INRA, UMR 1260 Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, France
    Br J Nutr 101:680-7. 2009
  5. ncbi request reprint Respective contributions of intestinal Niemann-Pick C1-like 1 and scavenger receptor class B type I to cholesterol and tocopherol uptake: in vivo v. in vitro studies
    Emmanuelle Reboul
    INRA, UMR1260 Lipid Nutrients and Prevention of Metabolic Diseases, Marseille F 13385, France
    Br J Nutr 107:1296-304. 2012
  6. ncbi request reprint Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1
    Myriam Moussa
    Institut National de la Recherche Agronomique, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, F 13385 Marseille, France
    J Nutr 138:1432-6. 2008
  7. doi request reprint ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice
    Emmanuelle Reboul
    INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, INSERM, U476, Université Aix Marseille 1, Université Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, France
    Am J Clin Nutr 89:177-84. 2009
  8. doi request reprint Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes
    Emmanuelle Reboul
    INRA, UMR1260 Lipid Nutrients and Prevention of Metabolic Diseases, F 13385 Marseille Cedex 5, France
    Prog Lipid Res 50:388-402. 2011
  9. doi request reprint Fatty acids affect micellar properties and modulate vitamin D uptake and basolateral efflux in Caco-2 cells
    Aurélie Goncalves
    INRA, UMR 1260 Nutrition, Obesity and Risk of Thrombosis, F 13385 Marseille, France INSERM, UMR U1062, F 13385 Marseille, France Aix Marseille University, F 13385 Marseille, France Lesieur, Asnières sur Seine, France
    J Nutr Biochem 24:1751-7. 2013
  10. doi request reprint Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells
    Jean Francois Landrier
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Free Radic Res 42:523-30. 2008

Collaborators

Detail Information

Publications17

  1. pmc Absorption of vitamin A and carotenoids by the enterocyte: focus on transport proteins
    Emmanuelle Reboul
    INRA, UMR1260, Nutrition, Obesity and Risk of Thrombosis, Marseille F 13385, France
    Nutrients 5:3563-81. 2013
    ..Further progress in the identification of the proteins involved in intestinal transport of vitamin A and carotenoids across the enterocyte is of major importance for optimizing their bioavailability. ..
  2. doi request reprint Cholesterol transport via ABCA1: new insights from solid-phase binding assay
    Emmanuelle Reboul
    INRA, UMR1260 Nutrition Obesity and Risk of Thrombosis, F 13385 Marseille, France
    Biochimie 95:957-61. 2013
    ..Overall, our data support the hypothesis that ABCA1 is able to mediate the transport of cholesterol from cells without direct interaction and that apo A-I primarily binds to membrane surface or accessory protein(s)...
  3. doi request reprint Phytosterols can impair vitamin D intestinal absorption in vitro and in mice
    Aurélie Goncalves
    INRA, UMR 1260 Lipid Nutriments and Prevention of Metabolique Dieases, Marseille, France
    Mol Nutr Food Res 55:S303-11. 2011
    ....
  4. ncbi request reprint Human fasting plasma concentrations of vitamin E and carotenoids, and their association with genetic variants in apo C-III, cholesteryl ester transfer protein, hepatic lipase, intestinal fatty acid binding protein and microsomal triacylglycerol transfer p
    Patrick Borel
    INRA, UMR 1260 Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille, France
    Br J Nutr 101:680-7. 2009
    ..These results suggest that apo C-III, CETP and hepatic lipase play a role in determining the plasma concentrations of tocopherols while hepatic lipase and I-FABP may modulate plasma concentrations of carotenoids...
  5. ncbi request reprint Respective contributions of intestinal Niemann-Pick C1-like 1 and scavenger receptor class B type I to cholesterol and tocopherol uptake: in vivo v. in vitro studies
    Emmanuelle Reboul
    INRA, UMR1260 Lipid Nutrients and Prevention of Metabolic Diseases, Marseille F 13385, France
    Br J Nutr 107:1296-304. 2012
    ..Thus, cholesterol and tocopherol uptakes share common pathways in cell culture models, but display different in vivo absorption patterns associated with distinct contributions of SR-BI and NPC1L1...
  6. ncbi request reprint Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1
    Myriam Moussa
    Institut National de la Recherche Agronomique, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, F 13385 Marseille, France
    J Nutr 138:1432-6. 2008
    ..Thus, the present data show that lycopene absorption is, at least in part, mediated by SR-BI but not by NPC1L1...
  7. doi request reprint ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice
    Emmanuelle Reboul
    INRA, UMR1260, Nutriments Lipidiques et Prévention des Maladies Métaboliques, INSERM, U476, Université Aix Marseille 1, Université Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, France
    Am J Clin Nutr 89:177-84. 2009
    ..It has long been assumed that newly absorbed vitamin A and E enter the body only via enterocyte-produced chylomicrons. However, recent results in cell cultures have shown that a fraction of alpha-tocopherol is secreted with intestinal HDL...
  8. doi request reprint Proteins involved in uptake, intracellular transport and basolateral secretion of fat-soluble vitamins and carotenoids by mammalian enterocytes
    Emmanuelle Reboul
    INRA, UMR1260 Lipid Nutrients and Prevention of Metabolic Diseases, F 13385 Marseille Cedex 5, France
    Prog Lipid Res 50:388-402. 2011
    ..Indeed, these drugs may also interfere with lipid vitamin uptake. A better understanding of the molecular mechanisms involved in fat-soluble vitamin and carotenoid absorption is a priority to better optimize their bioavailability...
  9. doi request reprint Fatty acids affect micellar properties and modulate vitamin D uptake and basolateral efflux in Caco-2 cells
    Aurélie Goncalves
    INRA, UMR 1260 Nutrition, Obesity and Risk of Thrombosis, F 13385 Marseille, France INSERM, UMR U1062, F 13385 Marseille, France Aix Marseille University, F 13385 Marseille, France Lesieur, Asnières sur Seine, France
    J Nutr Biochem 24:1751-7. 2013
    ..Cholecalciferol intestinal absorption may thus be optimized according to oil FA composition. ..
  10. doi request reprint Comparison of different vehicles to study the effect of tocopherols on gene expression in intestinal cells
    Jean Francois Landrier
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Free Radic Res 42:523-30. 2008
    ..This study establishes mixed micelles as the best vehicle to deliver tocopherols to intestinal cell monolayers in culture...
  11. doi request reprint Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters
    Emmanuelle Reboul
    INRA, UMR1260 Nutriments Lipidiques et Prevention des Maladies Metaboliques, Marseille, France
    Mol Nutr Food Res 55:691-702. 2011
    ..It is assumed that vitamin D is absorbed by passive diffusion. However, since cholecalciferol (vitamin D(3) ) and cholesterol display similar structures, we hypothesized that common absorption pathways may exist...
  12. ncbi request reprint Human plasma levels of vitamin E and carotenoids are associated with genetic polymorphisms in genes involved in lipid metabolism
    Patrick Borel
    INSERM, U476 Nutrition Humaine et Lipides, INRA, UMR1260, and Univ Méditerranée Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, F 13385 France
    J Nutr 137:2653-9. 2007
    ..These results suggest that genes involved in lipid metabolism influence the plasma concentrations of these fat-soluble micronutrients...
  13. ncbi request reprint β-Lactoglobulin as a Vector for β-Carotene Food Fortification
    Azza Mensi
    Biopolymères Interactions Assemblages, INRA, UR 1268, F 44316 Nantes, France
    J Agric Food Chem 62:5916-24. 2014
    ..Overall, we showed that β-Lg would be a good vector for β-carotene food fortification. ..
  14. pmc Scavenger receptor class B type I (SR-BI) is involved in vitamin E transport across the enterocyte
    Emmanuelle Reboul
    INSERM U476, 27 Boulevard Jean Moulin, 1260 Institut National de la Recherche Agronomique INRA, Université AixMarseille, and Institut de Physiopathologie Humaine de Marseille IPMH, Marseille F 13385, France
    J Biol Chem 281:4739-45. 2006
    ..7-fold higher in mice overexpressing SR-BI than in wild-type mice (p < 0.05). The present data show for the first time that vitamin E intestinal absorption is, at least in part, mediated by SR-BI...
  15. doi request reprint CD36 and SR-BI are involved in cellular uptake of provitamin A carotenoids by Caco-2 and HEK cells, and some of their genetic variants are associated with plasma concentrations of these micronutrients in humans
    Patrick Borel
    INRA, UMR1260 Nutrition, Obesity and Risk of Thrombosis, Marseille, France
    J Nutr 143:448-56. 2013
    ..In conclusion, SR-BI and CD36 are involved in cellular uptake of provitamin A carotenoids, and genetic variations in their encoding genes may modulate plasma concentrations of provitamin A carotenoids at a population level...
  16. doi request reprint Simple and fast HPLC method for simultaneous determination of retinol, tocopherols, coenzyme Q(10) and carotenoids in complex samples
    Béatrice Gleize
    INRA, UMR 1260 Nutriments Lipidiques et Prévention des Maladies Métaboliques, Marseille F 13385, France
    Food Chem 134:2560-4. 2012
    ..The intra-day and inter-day coefficients of variation are suitable for routine clinical and scientific applications for the determination of lipid micronutrients from various sample types...
  17. ncbi request reprint Enrichment of tomato paste with 6% tomato peel increases lycopene and beta-carotene bioavailability in men
    Emmanuelle Reboul
    INSERM, U476 Nutrition Humaine et Lipides, INRA, UMR 1260, Univ Méditerranée Aix Marseille 2, Marseille F 13385, France
    J Nutr 135:790-4. 2005
    ..1%, P = 0.093). Peel enrichment of tomato paste with tomato peel is an interesting option for increasing lycopene and beta-carotene intakes...