Pentti M Rautaharju

Summary

Publications

  1. doi request reprint Electrocardiographic estimates of regional action potential durations and repolarization time subintervals reveal ischemia-induced abnormalities in acute coronary syndrome not evident from global QT
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Electrocardiol 44:718-24. 2011
  2. ncbi request reprint New age- and sex-specific criteria for QT prolongation based on rate correction formulas that minimize bias at the upper normal limits
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA Electronic address
    Int J Cardiol 174:535-40. 2014
  3. ncbi request reprint Race- and sex-associated differences in rate-adjusted QT, QTpeak, ST elevation and other regional measures of repolarization: The Atherosclerosis Risk in Communities (ARIC) Study
    Pentti M Rautaharju
    Epidemiological Cardiology Research Center EPICARE, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    J Electrocardiol 47:342-50. 2014
  4. pmc Normal standards for computer-ECG programs for prognostically and diagnostically important ECG variables derived from a large ethnically diverse female cohort: the Women's Health Initiative (WHI)
    Pentti M Rautaharju
    Epidemiological Cardiology Research Center EPICARE, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA Electronic address
    J Electrocardiol 46:707-16. 2013
  5. pmc Electrocardiographic predictors of coronary heart disease and sudden cardiac deaths in men and women free from cardiovascular disease in the Atherosclerosis Risk in Communities study
    Pentti M Rautaharju
    Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Am Heart Assoc 2:e000061. 2013
  6. pmc Electrocardiographic predictors of incident heart failure in men and women free from manifest cardiovascular disease (from the Atherosclerosis Risk in Communities [ARIC] study)
    Pentti M Rautaharju
    Division of Public Health Sciences, Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
    Am J Cardiol 112:843-9. 2013
  7. doi request reprint Isolated negative T waves as independent predictors of short-term and long-term coronary heart disease mortality in men free of manifest heart disease in the Seven Countries Study
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Electrocardiol 45:717-22. 2012
  8. doi request reprint Heart rate, gender differences, and presence versus absence of diagnostic ST elevation as determinants of spatial QRS|T angle widening in acute coronary syndrome
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina, USA
    Am J Cardiol 107:1744-50. 2011
  9. pmc Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study)
    Zhu Ming Zhang
    Department of Epidemiology, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 100:844-9. 2007
  10. pmc Different patterns of bundle-branch blocks and the risk of incident heart failure in the Women's Health Initiative (WHI) study
    Zhu Ming Zhang
    Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Circ Heart Fail 6:655-61. 2013

Detail Information

Publications29

  1. doi request reprint Electrocardiographic estimates of regional action potential durations and repolarization time subintervals reveal ischemia-induced abnormalities in acute coronary syndrome not evident from global QT
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Electrocardiol 44:718-24. 2011
    ..These substantial differences in ischemia-induced regional manifestations of repolarization abnormalities revealed by the repolarization model were not evident from evaluation of the global QT...
  2. ncbi request reprint New age- and sex-specific criteria for QT prolongation based on rate correction formulas that minimize bias at the upper normal limits
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA Electronic address
    Int J Cardiol 174:535-40. 2014
    ..Age- and sex-related differences in QTc are also often overlooked. Our goal was to establish criteria for prolonged QTc using formulas that minimize QTc bias at the upper normal limits...
  3. ncbi request reprint Race- and sex-associated differences in rate-adjusted QT, QTpeak, ST elevation and other regional measures of repolarization: The Atherosclerosis Risk in Communities (ARIC) Study
    Pentti M Rautaharju
    Epidemiological Cardiology Research Center EPICARE, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, NC Electronic address
    J Electrocardiol 47:342-50. 2014
    ..Data are limited about race-and sex-associated differences in prognostically important ECG measures of regional repolarization...
  4. pmc Normal standards for computer-ECG programs for prognostically and diagnostically important ECG variables derived from a large ethnically diverse female cohort: the Women's Health Initiative (WHI)
    Pentti M Rautaharju
    Epidemiological Cardiology Research Center EPICARE, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA Electronic address
    J Electrocardiol 46:707-16. 2013
    ..The objective of the present study was to establish reference standards for these novel risk predictors in a large, ethnically diverse cohort of healthy women from the Women's Health Initiative (WHI) study...
  5. pmc Electrocardiographic predictors of coronary heart disease and sudden cardiac deaths in men and women free from cardiovascular disease in the Atherosclerosis Risk in Communities study
    Pentti M Rautaharju
    Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Am Heart Assoc 2:e000061. 2013
    ..We evaluated predictors of coronary heart disease (CHD) death and sudden cardiac death (SCD) in the Atherosclerosis Risk in Communities (ARIC) study...
  6. pmc Electrocardiographic predictors of incident heart failure in men and women free from manifest cardiovascular disease (from the Atherosclerosis Risk in Communities [ARIC] study)
    Pentti M Rautaharju
    Division of Public Health Sciences, Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, NC, USA
    Am J Cardiol 112:843-9. 2013
    ....
  7. doi request reprint Isolated negative T waves as independent predictors of short-term and long-term coronary heart disease mortality in men free of manifest heart disease in the Seven Countries Study
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Electrocardiol 45:717-22. 2012
    ..We conclude that inverted T waves with even a minor degree of negativity as an isolated ECG finding in men with no evidence of heart disease predict an excess short-term and long-term risk of CHD death...
  8. doi request reprint Heart rate, gender differences, and presence versus absence of diagnostic ST elevation as determinants of spatial QRS|T angle widening in acute coronary syndrome
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina, USA
    Am J Cardiol 107:1744-50. 2011
    ..In conclusion, the initial and terminal RS and ES orientations differ drastically and their deviant orientation accounts for the widened QRS|T angle in patients with ACS, differences not revealed by evaluation of the mean QRS|T angle...
  9. pmc Comparison of the prognostic significance of the electrocardiographic QRS/T angles in predicting incident coronary heart disease and total mortality (from the atherosclerosis risk in communities study)
    Zhu Ming Zhang
    Department of Epidemiology, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 100:844-9. 2007
    ..In conclusion, frontal plane QRS/T angle as an easily derived risk measure is a suitable clinical substitute for spatial QRS/T angle for risk prediction...
  10. pmc Different patterns of bundle-branch blocks and the risk of incident heart failure in the Women's Health Initiative (WHI) study
    Zhu Ming Zhang
    Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Circ Heart Fail 6:655-61. 2013
    ..We evaluated the risk of incident heart failure (HF) associated with bundle-branch blocks (BBBs) in postmenopausal women...
  11. ncbi request reprint Electrocardiographic predictors of incident congestive heart failure and all-cause mortality in postmenopausal women: the Women's Health Initiative
    Pentti M Rautaharju
    The EPICARE Center, Department of Public Health Sciences, Wake Forest University, Winston Salem, NC, USA
    Circulation 113:481-9. 2006
    ..Information is limited about ECG predictors of the risk of incident congestive heart failure (CHF), particularly in women without overt manifestations of cardiovascular disease (CVD)...
  12. ncbi request reprint Electrocardiographic predictors of new-onset heart failure in men and in women free of coronary heart disease (from the Atherosclerosis in Communities [ARIC] Study)
    Pentti M Rautaharju
    Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston Salem, NC, USA
    Am J Cardiol 100:1437-41. 2007
    ..In conclusion, several ECG abnormalities are manifestations of evolving HF in men and women considered free of coronary heart disease...
  13. doi request reprint Heart rate adjustment of PR interval in middle-aged and older adults
    Elsayed Z Soliman
    Division of Public Health Sciences, Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center EPICARE, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Electrocardiol 45:66-9. 2012
    ..The prognostic significance of the rate-adjusted PR needs to be investigated...
  14. doi request reprint Electrocardiographic estimates of action potential durations and transmural repolarization time gradients in healthy subjects and in acute coronary syndrome patients--profound differences by sex and by presence vs absence of diagnostic ST elevation
    Pentti M Rautaharju
    Division of Public Health Sciences, Wake Forest University, Winston Salem, NC 33327, USA
    J Electrocardiol 44:309-19. 2011
    ..These repolarization abnormalities are not revealed by QT alone but readily by the repolarization model...
  15. doi request reprint Mortality risk associated with bundle branch blocks and related repolarization abnormalities (from the Women's Health Initiative [WHI])
    Zhu Ming Zhang
    Epidemiological Cardiology Research Center, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 110:1489-95. 2012
    ..In conclusion, prevalent LBBB in CVD-free women and LBBB and RBBB in women with CVD were significant predictors of CHD death. In women with LBBB, ST J-point depression in lead aVL was a strong independent predictor of CHD death...
  16. ncbi request reprint Linearly scaled, rate-invariant normal limits for QT interval: eight decades of incorrect application of power functions
    Pentti M Rautaharju
    EpiCare Center, Department of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina, USA
    J Cardiovasc Electrophysiol 13:1211-8. 2002
    ..Normal limits for QT traditionally are derived as mean +/- 2*SD, with rate adjustment done by dividing QT values by power functions such as RR 1/2 (proportional scaling)...
  17. ncbi request reprint Long-term prognostic significance of isolated minor electrocardiographic T-wave abnormalities in middle-aged men free of clinical cardiovascular disease (The Multiple Risk Factor Intervention Trial [MRFIT])
    Ronald J Prineas
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27104, USA
    Am J Cardiol 90:1391-5. 2002
  18. ncbi request reprint Usefulness of ventricular premature complexes to predict coronary heart disease events and mortality (from the Atherosclerosis Risk In Communities cohort)
    Mark W Massing
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Cardiol 98:1609-12. 2006
    ..In conclusion, a clinical finding of VPCs on electrocardiography of even apparently healthy patients may warrant a heightened awareness of and attention to cardiovascular risk assessment and management...
  19. ncbi request reprint Normal standards for QT and QT subintervals derived from a large ethnically diverse population of women aged 50 to 79 years (the Women's Health Initiative [WHI])
    Pentti M Rautaharju
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 97:730-7. 2006
    ..Bazett's formula is inappropriate for testing new drugs or other applications...
  20. ncbi request reprint Usefulness of Electrocardiographic QRS/T Angles With Versus Without Bundle Branch Blocks to Predict Heart Failure (from the Atherosclerosis Risk in Communities Study)
    Zhu Ming Zhang
    Epidemiological Cardiology Research Center EPICARE, Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina Electronic address
    Am J Cardiol 114:412-8. 2014
    ..These findings suggest that repolarization abnormalities in the setting of BBB should not be considered benign or an expected consequence of BBB. ..
  21. ncbi request reprint Comparability of 12-lead ECGs derived from EASI leads with standard 12-lead ECGS in the classification of acute myocardial ischemia and old myocardial infarction
    Pentti M Rautaharju
    Department of Public Health Sciences, Wake Forest University, Winston Salem, NC, USA
    J Electrocardiol 35:35-9. 2002
    ..We conclude that the EASI-derived 12-lead ECG deserves serious consideration as an alternative to the standard 12-lead ECG in emergency situations and for monitoring in acute-care setting...
  22. ncbi request reprint Electrocardiographic abnormalities that predict coronary heart disease events and mortality in postmenopausal women: the Women's Health Initiative
    Pentti M Rautaharju
    The EPICARE Center, Department of Public Health Sciences, Wake Forest University, Winston Salem, NC, USA
    Circulation 113:473-80. 2006
    ..Information is limited about the independent prognostic value of repolarization abnormalities in women...
  23. ncbi request reprint Comparison of mortality risk for electrocardiographic abnormalities in men and women with and without coronary heart disease (from the Cardiovascular Health Study)
    Pentti M Rautaharju
    the Department of Public Health Sciences, Wake Forest University, Winston Salem, North Carolina, USA
    Am J Cardiol 97:309-15. 2006
    ..In conclusion, we found no evidence that the relative risk of mortality for ECG abnormalities is lower in women than in men...
  24. ncbi request reprint Assessment of prolonged QT and JT intervals in ventricular conduction defects
    Pentti M Rautaharju
    EpiCare Center, Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Cardiol 93:1017-21. 2004
    ..Thus, detection of prolonged repolarization in VCD requires the use of the JT interval or a bivariate model for QT with RR and QRS intervals as covariates...
  25. ncbi request reprint A simple procedure for estimation of the spatial QRS/T angle from the standard 12-lead electrocardiogram
    Pentti M Rautaharju
    EpiCare Center, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Electrocardiol 40:300-4. 2007
    ..It is concluded that this simple method may provide a satisfactory substitute for QRS/T from the matrix transformation method...
  26. ncbi request reprint Electrocardiographic QT interval prolongation and risk of primary cardiac arrest in diabetic patients
    Eric A Whitsel
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Diabetes Care 28:2045-7. 2005
  27. ncbi request reprint Inter-relationship between electrocardiographic left ventricular hypertrophy and QT prolongation as predictors of increased risk of mortality in the general population
    Elsayed Z Soliman
    From the Division of Public Health Sciences, Department of Epidemiology and Prevention, Epidemiological Cardiology Research Center EPICARE E Z S, Y L, P M R and Section on Cardiology, Department of Internal Medicine E Z S, Wake Forest School of Medicine, Winston Salem, NC Department of Epidemiology, Emory University, Atlanta, GA A J S and Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston Salem, NC A B
    Circ Arrhythm Electrophysiol 7:400-6. 2014
    ....
  28. ncbi request reprint Why did QT dispersion die?
    Pentti M Rautaharju
    EpiCare Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Card Electrophysiol Rev 6:295-301. 2002
    ..The working hypothesis of the present paper was that the necessary although not sufficient condition for the validity of QTD concept is the association of QTD with nondipolar voltage (NDPV) in T waves of the 12-lead ECG...
  29. ncbi request reprint Otto Schmitt: an electrocardiographer with multifaceted talents
    Pentti M Rautaharju
    Department of Public Health Sciences, Wake Forest University School of Medicine, EpiCare Center, Winston Salem, NC 27104, USA
    J Electrocardiol 39:235-7. 2006