A Raue

Summary

Publications

  1. ncbi Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood
    A Raue
    Physics Institute, University of Freiburg, 79104 Freiburg, Germany
    Bioinformatics 25:1923-9. 2009
  2. ncbi Addressing parameter identifiability by model-based experimentation
    A Raue
    University of Freiburg, Physics Institute, Freiburg, Germany
    IET Syst Biol 5:120-30. 2011
  3. ncbi Predictive mathematical models of cancer signalling pathways
    J Bachmann
    Systems Biology of Signal Transduction, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    J Intern Med 271:155-65. 2012
  4. ncbi Comprehensive estimation of input signals and dynamics in biochemical reaction networks
    M Schelker
    Institute for Physics, University of Freiburg, D 79104 Freiburg, Germany
    Bioinformatics 28:i529-i534. 2012
  5. ncbi Identifiability and observability analysis for experimental design in nonlinear dynamical models
    A Raue
    Physics Institute, University of Freiburg, 79104 Freiburg, Germany
    Chaos 20:045105. 2010

Collaborators

  • M Schilling
  • J Timmer
  • M Schelker
  • J Bachmann
  • U Klingmuller
  • V Becker
  • C Kreutz

Detail Information

Publications5

  1. ncbi Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood
    A Raue
    Physics Institute, University of Freiburg, 79104 Freiburg, Germany
    Bioinformatics 25:1923-9. 2009
    ..This knowledge is essential for further investigation of model predictions. For this reason a major topic in modeling is identifiability analysis...
  2. ncbi Addressing parameter identifiability by model-based experimentation
    A Raue
    University of Freiburg, Physics Institute, Freiburg, Germany
    IET Syst Biol 5:120-30. 2011
    ..Both strategies enhance model predictability and will be elucidated by an example application. [Includes supplementary material]...
  3. ncbi Predictive mathematical models of cancer signalling pathways
    J Bachmann
    Systems Biology of Signal Transduction, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    J Intern Med 271:155-65. 2012
    ..Finally, we review the current understanding of how systems biology could foster the development of new treatment strategies in the context of lung cancer and anaemia...
  4. ncbi Comprehensive estimation of input signals and dynamics in biochemical reaction networks
    M Schelker
    Institute for Physics, University of Freiburg, D 79104 Freiburg, Germany
    Bioinformatics 28:i529-i534. 2012
    ..This procedure is suboptimal since the input uncertainties are not considered in the estimation process which often leads to overoptimistic confidence intervals of the inferred parameters and the model dynamics...
  5. ncbi Identifiability and observability analysis for experimental design in nonlinear dynamical models
    A Raue
    Physics Institute, University of Freiburg, 79104 Freiburg, Germany
    Chaos 20:045105. 2010
    ..The results will be utilized to design new experiments that enhance model predictiveness, illustrating the iterative cycle between modeling and experimentation in systems biology...