Helge H Rasmussen
Garcia A, Fry N, Karimi K, Liu C, Apell H, Rasmussen H, et al
. Extracellular allosteric Na(+) binding to the Na(+),K(+)-ATPase in cardiac myocytes. Biophys J. 2013;105:2695-705 pubmed publisher
..Based on published crystal structures, a possible location of the allosteric site is within a cleft between the ?- and ?-subunits of the enzyme. ..
Chia K, Liu C, Hamilton E, Garcia A, Fry N, Hannam W, et al
. Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition. Am J Physiol Cell Physiol. 2015;309:C239-50 pubmed publisher
..This could account for pump stimulation with neurohormonal oxidative stress expected in vivo. ..
Karimi Galougahi K, Liu C, Garcia A, Fry N, Hamilton E, Figtree G, et al
. Î²3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade. Am J Physiol Cell Physiol. 2015;309:C286-95 pubmed publisher
..In vivo Î²3-AR activation relieves oxidative inhibition of key cardiac myocyte proteins in hyperglycemia and may be effective in targeting the deleterious cardiac effects of diabetes. ..
Liu C, Teh R, Mozar C, Baxter R, Rasmussen H. Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and Î³-radiation on Na(+)/K(+)-ATPase and cell survival. Breast Cancer Res Treat. 2016;155:203-13 pubmed publisher
..Overexpression of FXYD3 may be a marker of resistance to cancer treatments and a potentially important therapeutic target. ..
Garcia A, Liu C, Cornelius F, Clarke R, Rasmussen H. Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion. Biophys J. 2016;110:1099-109 pubmed publisher
..We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect of conformation-dependent Î²1 pump subunit glutathionylation, not restricted subsarcolemmal diffusion of Na(+). ..