Martin Krøyer Rasmussen
Burkina V, Zlabek V, Rasmussen M, Zamaratskaia G. End-product inhibition of skatole-metabolising enzymes CYP1A, CYP2A19 and CYP2E1 in porcine and piscine hepatic microsomes. Toxicol Lett. 2018;: pubmed publisher
..This is relevant to the evaluation of different model systems and to the reduction of off flavor of meat. ..
Burkina V, Sakalli S, Rasmussen M, Zamaratskaia G, Koba O, Thai G, et al
. Does dexamethasone affect hepatic CYP450 system of fish? Semi-static in-vivo experiment on juvenile rainbow trout. Chemosphere. 2015;139:155-62 pubmed publisher
..Based on these findings, continued investigation of the effect of DEX on fish using a battery of complementary biomarkers of exposure and effect is highly relevant. ..
Thøgersen R, Petrat Melin B, Zamaratskaia G, Grevsen K, Young J, Rasmussen M. In vitro effects of rebaudioside A, stevioside and steviol on porcine cytochrome p450 expression and activity. Food Chem. 2018;258:245-253 pubmed publisher
..In conclusion, rebaudioside A, stevioside and steviol induce only minor or no changes to the CYP expression and activity, and are not likely to cause food-drug interactions. ..
Rasmussen M, Theil P, Oksbjerg N. Constitutive expression of cytochrome P450 in foetal and adult porcine livers-Effects of body weight. Toxicol Lett. 2016;258:87-92 pubmed publisher
..Gender did not affect the mRNA expression within the different life-stages. These results indicate a similarity to what is observed in humans and porcine foetuses may therefore be a model for humans when studying expression of CYPs. ..
Burkina V, Rasmussen M, Pilipenko N, Zamaratskaia G. Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450. Toxicology. 2017;375:10-27 pubmed publisher
..Moreover, we will discuss the roles of nuclear receptors in the cellular regulation of CYP450 expression in select organisms. ..
Nielsen S, Bauhaus Y, Zamaratskaia G, Junqueira M, Blaabjerg K, Petrat Melin B, et al
. Constitutive expression and activity of cytochrome P450 in conventional pigs. Res Vet Sci. 2017;111:75-80 pubmed publisher
..Along the small intestine and colon the mRNA expression and activity of CYP1A1 and CYP3A was gradually decreased. The results demonstrated, similarity to that reported for humans, and hence adds to the use of pigs as a model for humans. ..
Rasmussen M, Daujat Chavanieu M, Gerbal Chaloin S. Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG. Toxicol Lett. 2017;277:1-8 pubmed publisher
..In conclusion, the presented results suggested that the cross-talk between PXR and AhR plays a role in the regulation of CYP3A4 gene expression. ..
Ekstrand B, Young J, Rasmussen M. Taste receptors in the gut - A new target for health promoting properties in diet. Food Res Int. 2017;100:1-8 pubmed publisher
..When ligands bind to these receptors, signalling is induced either via peptide hormones into the circulation to other organs in the body, or via nerve fibers directly to the brain. ..
Rasmussen M. Induction of cytochrome P450 mRNA in porcine primary hepatocytes cultured under serum free conditions: Comparison of freshly isolated cells and cryopreserved. Exp Cell Res. 2017;360:218-225 pubmed publisher
..Hence, it can be suggested that PPH cultured under serum free conditions provides a reliable hepatocyte model to investigate CYP gene regulation. ..