Coxiella burnetii infection in C57BL/6 mice aged 1 or 14 monthsMarc Leone
Unite des Rickettsies, Centre National de la Recherche Scientifique, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
FEMS Immunol Med Microbiol 50:396-400. 2007
..In addition, macrophage microbicidal competence was similar in mature and young mice. These results suggest the importance of individual host factors in the pathophysiology of an infectious disease such as Q fever...
Rickettsia conorii transcriptional response within inoculation escharPatricia Renesto
Unite des Rickettsies, IRD CNRS UMR 6236, Faculte de Medecine, Marseille, France
PLoS ONE 3:e3681. 2008
..The skin thus constitutes an important barrier for the entry and propagation of R. conorii. Given this, analysis of the survival strategies used by the bacterium within infected skin is critical for our understanding of rickettsiosis...
Actinomyces massiliensis sp. nov., isolated from a patient blood cultureAurelie Renvoise
Laboratoire de Bacteriologie virologie, Hopital de la Timone, CNRS UMR 6236, CNRS IRD, IFR48, 264 rue Saint Pierre, 13385 Marseille Cedex 05, France
Int J Syst Evol Microbiol 59:540-4. 2009
..On the basis of phenotypic data and phylogenetic inference, the novel species Actinomyces massiliensis sp. nov. is proposed; the type strain is 4401292(T) (=CSUR P18(T)=CCUG 53522(T))...
- Intracellular life of Coxiella burnetii in macrophages
Eric Ghigo
URMITE CNRS UMR 6236 IRD 3R198, Institut Federatif de Recherche 48, Universite de la Mediterranee, Marseille, France
Ann N Y Acad Sci 1166:55-66. 2009
..burnetii also depends on the functional state of myeloid cells. This review describes the mechanisms used by C. burnetii to circumvent uptake and trafficking events, and the role of cytokines on C. burnetii survival in myeloid cells...
- The influence of rickettsiologists on post-modern microbiology
Kalliopi Georgiades
Unité de Recherche en Maladies Infectieuses Tropical Emergentes, CNRS IRD UMR 6236 198, Université de la Méditerranée Marseille, France
Front Cell Infect Microbiol 1:8. 2011
....
- Plague: history and contemporary analysis
Didier Raoult
Aix Marseille Universite, Unite des Rickettsies, UMR CNRS, IRD, INSERM, IHU Méditerranée Infection, France
J Infect 66:18-26. 2013
..Analysis of past plague epidemics by using modern laboratory tools illustrated the value of epidemic buboes for the clinical diagnosis of plague; and brought new concepts regarding its transmission by human ectoparasites...
- Rapid and accurate bacterial identification in probiotics and yoghurts by MALDI-TOF mass spectrometry
Emmanouil Angelakis
CNRS UMR 6020, IFR 48, Faculte de Medecine, Univ de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
J Food Sci 76:M568-72. 2011
..Although the safety and functionality of probiotics are species and strain dependent, we found a discrepancy between the bacterial strain announced on the label and the strain identified...
- Complete genome sequence of Rickettsia slovaca, the agent of tick-borne lymphadenitis
Pierre Edouard Fournier
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, CNRS UMR 6236, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
J Bacteriol 194:1612. 2012
..The 1.27-Mb genome provides further insights into the acquisition of virulence related to genome reduction in Rickettsia species...
- Eukaryotic large nucleo-cytoplasmic DNA viruses: clusters of orthologous genes and reconstruction of viral genome evolution
Natalya Yutin
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
Virol J 6:223. 2009
....
- Pseudoclavibacter-like subcutaneous infection: a case report
François Lemaitre
Pôle des Maladies Infectieuses, Fédération de Microbiologie Clinique, Hopital de la Timone, rue Saint Pierre, 13005 Marseille, France
J Med Case Reports 5:468. 2011
..abstract:..
- Mycoplasma hominis brain abscess following uterus curettage: a case report
Mouhamad Al Masalma
Fédération de Microbiologie, Hopital de la Timone, Marseille, France
J Med Case Reports 5:278. 2011
..abstract:..
- Actinomadura meyerae osteitis following wound contamination with hay in a woman in France: a case report
Emilie Bonnet
Fédération de Microbiologie, Hopital de la Timone, Marseille, France
J Med Case Reports 5:32. 2011
..abstract:..
- Nocardia farcinica lung infection in a patient with cystic fibrosis: a case report
Fadi Bittar
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE, CNRS IRD, UMR 6236, Faculte de Medecine et de Pharmacie, Universite de la Mediterranee, Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
J Med Case Reports 4:84. 2010
..Nocardia are rarely implicated in these infections and few reports of the involvement of this species are found in the literature...
- Gene gain and loss events in Rickettsia and Orientia species
Kalliopi Georgiades
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, URMITE, CNRS IRD UMR 6236 IFR48 Faculté de Médecine, Universite de la Mediterranee, Marseille, France
Biol Direct 6:6. 2011
..In this study, we evaluated the degree to which gene loss shaped the content of some Rickettsiales genomes. We shed light on the role played by horizontal gene transfers in the genome evolution of Rickettsiales...
- Evidence that the intra-amoebal Legionella drancourtii acquired a sterol reductase gene from eukaryotes
Claire Moliner
URMITE CNRS IRD UMR 6236, , 27 Boulevard Jean Moulin, 13385 Marseille, Cedex 05, France
BMC Res Notes 2:51. 2009
..drancourtii and Coxiella burnetii. The role of the sterol delta-7 reductase in prokaryotes is as yet unknown but we speculate that it is involved in host cholesterol parasitism...
- Pyrosequencing identification of Mycobacterium tuberculosis W-Beijing
Zoheira Djelouadji
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236, IRD 3R198, Universite de la Mediterranee, IFR 48, Faculte de Medecine, Marseille, France
BMC Res Notes 2:239. 2009
..Its identification currently relies on spoligotyping and conventional sequencing. We developed pyrosequencing as an alternative method for its identification...
- Rapid identification and typing of Yersinia pestis and other Yersinia species by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry
Saravanan Ayyadurai
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR CNRS 6236 IRD 198, Faculte de Medecine, IFR48, Universite de la Mediterranee, Marseille, France
BMC Microbiol 10:285. 2010
..The organisms were deposited on the MALDI-TOF plate after appropriate ethanol-based inactivation, and a protein profile was obtained within 6 minutes for each of the Yersinia species...
- Identification of rickettsial isolates at the species level using multi-spacer typing
Pierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille Cedex 05, France
BMC Microbiol 7:72. 2007
....
- Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis
Florence Fenollar
Unite des Rickettsies, URMITE CNRS IRD UMR 6236, IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
BMC Infect Dis 11:171. 2011
..Tropheryma whipplei, the agent of Whipple's disease, causes localised infections in the absence of histological digestive involvement. Our objective is to describe T. whipplei encephalitis...
- Coxiella burnetii vascular graft infection
Laurence Senn
Infectious Diseases Service, Department of Internal Medicine, University Hospital, Lausanne, Switzerland
BMC Infect Dis 5:109. 2005
..Coxiella burnetii, the causative agent of Q fever, may cause culture-negative vascular graft infections. Very few cases of C. burnetii infection of a vascular graft have been reported. All were diagnosed by serology...
- Insight into cross-talk between intra-amoebal pathogens
Gregory Gimenez
Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
BMC Genomics 12:542. 2011
..This characteristic is proposed to be the result of frequent gene exchanges with other bacteria that share a sympatric lifestyle and contrasts with the genome reduction observed among strict human pathogens...
- Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans
Fabrice Armougom
URMITE UMR CNRS 6236, IRD 3R198, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
BMC Genomics 9:576. 2008
..Here we present a cost-effective method that combines 16S rRNA pyrosequencing and DNA barcodes of the Firmicutes and Bacteroidetes 16S rRNA genes to determine the Firmicutes/Bacteroidetes ratio in the gut microbiota of obese humans...
- The rhizome of Reclinomonas americana, Homo sapiens, Pediculus humanus and Saccharomyces cerevisiae mitochondria
Kalliopi Georgiades
Unité de Recherche en Maladies Infectieuses Tropical Emergentes URMITE CNRS IRD UMR 6236 198, Universite de la Mediterranee, Faculté de médecine La Timone, 27, Bd Jean Moulin, 13385, Marseille Cedex 5, France
Biol Direct 6:55. 2011
..abstract:..
- The discovery and characterization of Mimivirus, the largest known virus and putative pneumonia agent
Didier Raoult
Unite des Rickettsies, Faculte de Medecine, Universite de la Mediterrannee, Marseille, France
Clin Infect Dis 45:95-102. 2007
..quot; Furthermore, the virus, now named "Mimivirus," has been implicated as an agent of pneumonia in humans and, thus, should be considered a putative emerging pathogen...
- Massive comparative genomic analysis reveals convergent evolution of specialized bacteria
Vicky Merhej
Faculty of Medicine, Unit for Research on Emergent and Tropical Infectious Diseases, CNRS IRD UMR 6236 IFR48, University of the Mediterranean, Marseilles, France
Biol Direct 4:13. 2009
..The growing number of available sequenced genomes makes it possible to perform a statistical comparative analysis of 317 genomes from bacteria with different lifestyles...
- Amoebae as genitors and reservoirs of giant viruses
Didier Raoult
URMITE CNRS IRD UMR 6236, Faculte de Medecine, Unite des Rickettsies, Marseille, France
Intervirology 53:321-9. 2010
..We conclude that phagocytic protists continuously generate new species with chimeric repertoires that may succeed later if adapted to the environmental conditions and selected in a specific niche...
- Tropheryma whipplei in children with gastroenteritis
Didier Raoult
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 16:776-82. 2010
..002). High incidence in patients and evidence of clonal circulation suggests that some cases of gastroenteritis are caused or exacerbated by T. whipplei, which may be co-transmitted with other intestinal pathogens...
- Molecular identification of lice from pre-Columbian mummies
Didier Raoult
Unite des Rickettsies CNRS UMR 6020, Faculté de Médecine Université de la Méditerranée, Marseille, France
J Infect Dis 197:535-43. 2008
..The other 2 (types B and C) include only head lice and are geographically restricted. It was hypothesized that head louse phylotypes were exchanged only recently, after European exploration and colonization (after Columbus)...
- Redefining viruses: lessons from Mimivirus
Didier Raoult
Unite des Rickettsies, IRD CNRS UMR 6236, IFR 48, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille, France
Nat Rev Microbiol 6:315-9. 2008
....
- Eschar and neck lymphadenopathy caused by Francisella tularensis after a tick bite: a case report
Sophie Edouard
Faculte de Medecine et de Pharmacie, URMITE UMR 6236, CNRS IRD, 27 Bd Jean Moulin 13385 Marseille Cedex 05, France
J Med Case Reports 5:108. 2011
..abstract:..
- Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens
Hiroyuki Ogata
Structural and Genomic Information Laboratory, Centre National de la Recherche Scientifique UPR 2589, Institut de Biologie Structurale et Microbiologie, Parc Scientifique de Luminy, Marseille, France
PLoS Genet 2:e76. 2006
....
- Molecular genetic methods for the diagnosis of fastidious microorganisms
Florence Fenollar
, , , Marseille, France
APMIS 112:785-807. 2004
..Ehrlichia spp., Coxiella burnetii, Bartonella spp., Tropheryma whipplei and Yersinia pestis...
- Genomic, proteomic, and transcriptomic analysis of virulent and avirulent Rickettsia prowazekii reveals its adaptive mutation capabilities
Yassina Bechah
Unit for Research on Emergent and Tropical Infectious Diseases URMITE, Faculty of Medicine, Centre National de la Recherche Scientifique Institut de Recherche pour le Développement, University of the Mediterranean, 13005 Marseille, France
Genome Res 20:655-63. 2010
..An area of genomic plasticity appears to determine virulence in R. prowazekii and represents an example of adaptive mutation for this pathogen...
- Rickettsia tamurae sp. nov., isolated from Amblyomma testudinarium ticks
Pierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Int J Syst Evol Microbiol 56:1673-5. 2006
..Such genotypic and phenotypic characteristics warrant its classification as a representative of a novel species, for which the name Rickettsia tamurae sp. nov. is proposed, with the type strain AT-1(T) (=CSUR R1(T))...
- Genomic analysis of an emerging multiresistant Staphylococcus aureus strain rapidly spreading in cystic fibrosis patients revealed the presence of an antibiotic inducible bacteriophage
Jean Marc Rolain
URMITE CNRS IRD UMR 6236, Faculte de Medecine et de Pharmacie, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Biol Direct 4:1. 2009
..We also conducted a retrospective epidemiological analysis on all S. aureus isolated from 2002 to 2007 in CF patients from our institution...
- rpoB gene sequence-based characterization of emerging non-tuberculous mycobacteria with descriptions of Mycobacterium bolletii sp. nov., Mycobacterium phocaicum sp. nov. and Mycobacterium aubagnense sp. nov
Toidi Adekambi
Unite des Rickettsies, CNRS UMR 6020 IFR 48, Faculte de Medecine, 27, Boulevard Jean Moulin, Université de la Méditerranée and Assistance Publique Hôpitaux de Marseille Timone, Fédération de Microbiologie Clinique, Marseille, France
Int J Syst Evol Microbiol 56:133-43. 2006
....
- Coxiella burnetii in humans and ticks in rural Senegal
Oleg Mediannikov
URMITE, UMR IRD 198 CNRS 6236, Mediterranean University, Medical Faculty, Marseille, France
PLoS Negl Trop Dis 4:e654. 2010
..Q fever is a worldwide zoonotic disease caused by Coxiella burnetii. Epidemiologically, animals are considered reservoirs and humans incidental hosts...
- Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction
Pierre Edouard Fournier
Unite des Rickettsies, IFR 48 CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, Marseille Cedex 05, France
BMC Genomics 10:166. 2009
..prowazekii, which causes epidemic typhus and kills its arthropod host, to the mild pathogen R. africae, the agent of African tick-bite fever, which does not affect the fitness of its tick vector...
- Rapid comparative genomic analysis for clinical microbiology: the Francisella tularensis paradigm
Bernard La Scola
Unite des Rickettsies CNRS UMR 6020, IFR 48, Faculte de Medecine de Marseille, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Genome Res 18:742-50. 2008
..In the bioterrorism context, it allows the rapid detection of strain manipulation, including intentionally added virulence genes and genes that support antibiotic resistance...
- Evidence for louse-transmitted diseases in soldiers of Napoleon's Grand Army in Vilnius
Didier Raoult
Unite des Rickettsies, Centre National de la Recherche Scientifique CNRS Unite Mixte de Recherche UMR 6020, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
J Infect Dis 193:112-20. 2006
..Because soldiers were commonly infested with body lice, it has been speculated that louse-borne infectious diseases, such as epidemic typhus (caused by Rickettsia prowazekii), were common...
- Reductive genome evolution from the mother of Rickettsia
Guillaume Blanc
Structural and Genomic Information Laboratory, Institut de Biologie Structurale et Microbiologie, Parc Scientifique de Luminy, Marseille, France
PLoS Genet 3:e14. 2007
....
- Multispacer typing to study the genotypic distribution of Bartonella henselae populations
Wenjun Li
, IFR 48, CNRS UMR 6020, , , 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
J Clin Microbiol 44:2499-506. 2006
..Finally, we provide a free-access MST-Rick online software program (http://ifr48.timone.univ-mrs.fr/MST_BHenselae/mst) that investigators may use to compare their own MST sequences to our database...
- The 1.2-megabase genome sequence of Mimivirus
Didier Raoult
Unite des Rickettsies, Faculte de Medecine, CNRS UMR6020, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Science 306:1344-50. 2004
..This new sequence data might help shed a new light on the origin of DNA viruses and their role in the early evolution of eukaryotes...
- Persistent Coxiella burnetii infection in mice overexpressing IL-10: an efficient model for chronic Q fever pathogenesis
Soraya Meghari
Unite des Rickettsies, CNRS UMR 6020, Institut Federatif de Recherche 48, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
PLoS Pathog 4:e23. 2008
..To our knowledge, this is the first efficient model for chronic Q fever pathogenesis...
- Staphylococcus massiliensis sp. nov., isolated from a human brain abscess
Mouhamad Al Masalma
Laboratoire de Bacteriologie virologie, Hopital de la Timone, URMITE CNRS IRD UMR 6236, IFR48, 264 rue Saint Pierre, 13385 Marseille, Cedex 05, France
Int J Syst Evol Microbiol 60:1066-72. 2010
..8 %). On the basis of phenotypic and genotypic data, this isolate represents a novel species for which the name Staphylococcus massiliensis sp. nov. is proposed (type strain 5402776(T)=CCUG 55927(T)=CSUR P23(T))...
- Molecular detection of Bartonella spp. in the dental pulp of stray cats buried for a year
Gerard Aboudharam
Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27, Boulevard Jean Moulin, Marseille Cedex 05 13385, France
Microb Pathog 38:47-51. 2005
..grahamii (one cat). Our study indicates that dental pulp from the teeth of cats, especially the canine teeth, may be used for the PCR detection of Bartonella in animals buried for a year...
- A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus
Yassina Bechah
Unite des Rickettsies, CNRS UMR 6020, Universite de la Mediterranee, Faculte de Medecine, 27 Bld J Moulin, 13385 Marseille Cedex 05, France
Microbes Infect 9:898-906. 2007
..We concluded that the BALB/c mouse strain provides a useful model for studying the pathogenic mechanisms of epidemic typhus and its control by the immune system...
- Identification of two putative rickettsial adhesins by proteomic analysis
Patricia Renesto
Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille, France
Res Microbiol 157:605-12. 2006
..Both proteins are highly conserved within the Rickettsia genus and might play a critical role in their pathogenicity. These data may have important implications for the development of future vaccines against rickettsial infections...
- Outbreak of Corynebacterium pseudodiphtheriticum infection in cystic fibrosis patients, France
Fadi Bittar
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 16:1231-6. 2010
..Our study reemphasizes the conclusion that correctly identifying bacteria at the species level facilitates detection of an outbreak of new or emerging infections in humans...
- Detection of a rickettsia closely related to Rickettsia aeschlimannii, "Rickettsia heilongjiangensis," Rickettsia sp. strain RpA4, and Ehrlichia muris in ticks collected in Russia and Kazakhstan
Stanislav Shpynov
Unite des Rickettsies, IFR48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseille Cedex 5, France
J Clin Microbiol 42:2221-3. 2004
..In Kazakhstan, we detected Rickettsia sp. strain RpA4 and a rickettsia closely related to Rickettsia aeschlimannii. These agents should be considered in a differential diagnosis of tick-borne infections in these areas...
- Detection of Acinetobacter baumannii in human head and body lice from Ethiopia and identification of new genotypes
Marie Kempf
URMITE, UMR IRD 198 CNRS 6236, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
Int J Infect Dis 16:e680-3. 2012
..The objectives of this study were to determine the presence of this bacterium in head and body lice collected from healthy individuals in Ethiopia by molecular methods and to characterize the genotype...
- Pig liver sausage as a source of hepatitis E virus transmission to humans
Philippe Colson
Pôle des Maladies Infectieuses et Tropicales Clinique et Biologique, Fédération de Bactériologie Hygiène Virologie, Centre Hospitalo Universitaire Timone, Marseille, France
J Infect Dis 202:825-34. 2010
..We investigated the role of figatellu, a traditional pig liver sausage widely eaten in France and commonly consumed raw, as a source of HEV infection...
- Emended description of Rickettsia felis (Bouyer et al. 2001), a temperature-dependent cultured bacterium
Bernard La Scola
Unite des Rickettsies, CNRS UPRESA 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille 05, France
Int J Syst Evol Microbiol 52:2035-41. 2002
..felis and those observed for the isolate in this study indicated some differences, although concurrent analysis of the two was not possible as no extant isolates of the first isolate of R. felis exist...
- Isolation of a rickettsia related to Astrakhan fever rickettsia from a patient in Chad
Pierre Edouard Fournier
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 13385 Marseilles Cedex 05, France
Ann N Y Acad Sci 990:152-7. 2003
..Although Astrakhan fever rickettsia is transmitted by Rhipicephalus ticks in Europe, further studies are indicated to identify its vector in Africa where these ticks are also prevalent...
- Nanobacteria are mineralo fetuin complexes
Didier Raoult
Unite des Rickettsies, Centre National de la Recherche Scientifique UMR 6020, IFR 48, Faculte de Medecine, Marseille, France
PLoS Pathog 4:e41. 2008
..quot; The presence of fetuin within renal calculi was also evidenced, suggesting its role as a hydroxyapatite nucleating factor...
- TLR2 is necessary to inflammatory response in Coxiella burnetii infection
Soraya Meghari
Unité des Rickerrsies, CNRS UMR 6020, Université de Méditerranée, 13005 Marseille, France
Ann N Y Acad Sci 1063:161-6. 2005
..These results show that TLR2 is required for inflammatory and immune response to C. burnetii, but is dispensable for bacterial clearance...
- Frequent transmission of hepatitis E virus among piglets in farms in Southern France
Mamadou Kaba
URMITE CNRS IRD UMR 6236, Facultes de Medecine et de Pharmacie, Universite de la Mediterranee Aix Marseille II, Marseille, France
J Med Virol 81:1750-9. 2009
..The present data indicate that 3-month-old pigs from Southern France might represent a potential source of HEV transmission to humans, and stress the potential of HEV to cause epizootic infections in population of farm pigs...
- Heterogeneity of susceptibility to fluoroquinolones in Bartonella isolates from Australia reveals a natural mutation in gyrA
Emmanouil Angelakis
Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculté de Médecine et de Pharmacie Université de la Méditerranée, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
J Antimicrob Chemother 61:1252-5. 2008
..Our objective was to evaluate in vitro antibiotic susceptibilities of 20 new Bartonella isolates from animals in Australia...
- Molecular identification of a collection of spotted Fever group rickettsiae obtained from patients and ticks from Russia
Stanislav N Shpynov
Unite des Rickettsies, Faculte de Medecine, Marseille, France
Am J Trop Med Hyg 74:440-3. 2006
..Clinicians should be aware that several spotted fever rickettsioses with different prognoses coexist in Russia in areas where NATT was the only previously recognized rickettsiosis...
- Investigation of blood culture-negative early prosthetic valve endocarditis reveals high prevalence of fungi
Franck Thuny
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, CNRS IRD UMR 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Blvd Jean Moulin, 13385 Marseille Cedex 05, France
Heart 96:743-7. 2010
..Therefore, fungi should be investigated particularly by molecular methods on surgical specimens and an antifungal drug might be added to the empiric treatment...
- MALDI-TOF-mass spectrometry applications in clinical microbiology
Piseth Seng
Pôle des Maladies Infectieuses, Assistance Publique Hôpitaux de Marseille et URMITE UMR CNRS IRD 6236, IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
Future Microbiol 5:1733-54. 2010
..We will also discuss the application of MALDI-TOF-MS tools in the identification of Archaea, eukaryotes and viruses. Pathogenic identification from colony-cultured, blood-cultured, urine and environmental samples is also reviewed...
- The transcriptional programme of human heart valves reveals the natural history of infective endocarditis
Marie Benoit
Unité de Recherche sur les Maladies Infectieuses Transmissibles et Emergentes, Faculte de Medecine, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Universite de la Mediterranee, Marseille, France
PLoS ONE 5:e8939. 2010
..Some parameters identified in this work could become tools for measuring the disease activity and should be tested as biomarkers for diagnosis or prognosis assessment in future studies...
- Genotyping, Orientalis-like Yersinia pestis, and plague pandemics
Michel Drancourt
, Marseille, France
Emerg Infect Dis 10:1585-92. 2004
..pestis Orientalis. These data indicate that Y. pestis caused cases of Justinian plague. The two historical plague pandemics were likely caused by Orientalis-like strains...
- Novel virus influenza A (H1N1sw) in South-Eastern France, April-August 2009
Antoine Nougairede
Unité Mixte de Recherche 190 Unité des Virus Emergents, Université de la Méditerranée et Institut de Recherche pour le Développement, Marseille, France
PLoS ONE 5:e9214. 2010
..In April 2009, the first cases of pandemic (H1N1)-2009 influenza [H1N1sw] virus were detected in France. Virological surveillance was undertaken in reference laboratories of the seven French Defence Zones...
- Looking for Tropheryma whipplei source and reservoir in rural Senegal
Alpha Kabinet Keita
Aix Marseille Universite, Unite des Rickettsies, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE, UM63, CNRS 7278, IRD 198, INSERM 1095, 13005 Marseille, France
Am J Trop Med Hyg 88:339-43. 2013
..Humans are currently the predominant identified reservoir and source of T. whipplei in these populations. Limited access to toilets and exposure to human feces facilitate the fecal-oral transmission of T. whipplei...
- Yersinia pestis Orientalis in remains of ancient plague patients
Michel Drancourt
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 13:332-3. 2007
..We have now sequenced Y pestis glpD gene in such remains, showing a 93-bp deletion specific for biotype Orientalis. These data show that only Orientalis type caused the 3 plague pandemics...
- Lipopolysaccharide from Coxiella burnetii is involved in bacterial phagocytosis, filamentous actin reorganization, and inflammatory responses through Toll-like receptor 4
Amélie Honstettre
Unite des Rickettsies, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6020, Institut Federatif de Recherche 48 Université de la Méditerranée, Marseille, France
J Immunol 172:3695-703. 2004
..Taken together, these results demonstrate that TLR4 controls early events of C. burnetii infection such as macrophage phagocytosis, granuloma formation, and cytokine production...
- Yersinia massiliensis sp. nov., isolated from fresh water
Vicky Merhej
AP HM Timone, Fédération de Microbiologie Clinique and Unité des Rickettsies CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
Int J Syst Evol Microbiol 58:779-84. 2008
..The name Yersinia massiliensis sp. nov. is proposed for this new taxon (type strain 50640T=CIP 109351T=CCUG 53443T; isolate 823=CIP 109352=CCUG 53444)...
- Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2/alternatively activated macrophages
Benoit Desnues
Unite des Rickettsies, Centre National de la Recherche Scientifique, Institut Federatif de Recherche 48, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
J Infect Dis 192:1642-6. 2005
..This transcriptional pattern corresponds to that of M2/alternatively activated macrophages. Our results suggest that the T helper 2 response in the intestinal environment may account for the pathophysiological properties of WD...
- Deleterious effect of ciprofloxacin on Rickettsia conorii-infected cells is linked to toxin-antitoxin module up-regulation
Elisabeth Botelho-Nevers
URMITE UMR 6236, CNRS IRD, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
J Antimicrob Chemother 67:1677-82. 2012
..To confirm and better understand the deleterious effect of fluoroquinolones reported during Rickettsia conorii infection in humans...
- Tropheryma whipplei: a common bacterium in rural Senegal
Alpha Kabinet Keita
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, URMITE CNRS IRD 198 UMR 6236, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
PLoS Negl Trop Dis 5:e1403. 2011
....
- Lymph node biopsy specimens and diagnosis of cat-scratch disease
Jean-Marc Rolain
, Marseille, France
Emerg Infect Dis 12:1338-44. 2006
..Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis...
- Bartonella quintana in domestic cat
Vu Dang La
, CNRS UMR 6020, IFR 48, Marseille, France
Emerg Infect Dis 11:1287-9. 2005
..This study, the first to detect B. quintana in a nonhuman mammal, changes our understanding of the epidemiology of this infection and proposes that cats may be an emerging source of human infection...
- Coxiella burnetii stimulates production of RANTES and MCP-1 by mononuclear cells: modulation by adhesion to endothelial cells and its implication in Q fever
Soraya Meghari
, CNRS UMR 6020, , , , 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
Eur Cytokine Netw 17:253-9. 2006
..We suggest that the overproduction of RANTES and MCP-1 secondary to the contact of PBMC with endothelium may perpetuate exaggerated inflammatory responses leading to inappropriate PBMC trafficking and to the pathogenesis of Q fever...
- Molecular detection of microorganisms in distal airways of patients undergoing lung cancer surgery
Xavier Benoit D'Journo
Department of Thoracic Surgery and Diseases of the Esophagus, Aix Marseille University and Assistance Publique Hôpitaux de Marseille, Hopital Nord, Marseille, France
Ann Thorac Surg 93:413-22. 2012
....
- Murine model of infection by Tropheryma whipplei
Sèverine Genot
Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 bld Jean Moulin, 13385 Marseille Cedex 05, France
Infect Immun 74:4915-7. 2006
..SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity...
- Bartonella and Rickettsia in arthropods from the Lao PDR and from Borneo, Malaysia
Tahar Kernif
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes URMITE, Universite de la Mediterranee, Marseille, France
Comp Immunol Microbiol Infect Dis 35:51-7. 2012
..felis and B. clarridgeiae. Further investigations are needed in order to isolate these agents and to determine their epidemiology and aetiological role in unknown fever in patients from these areas...
- Are clinical isolates of Pseudomonas aeruginosa more virulent than hospital environmental isolates in amebal co-culture test?
Lukas Fenner
Unite des Rickettsies, Service de Reanimation Medicale, Hopital Sainte Marguerite, Faculte de Medecine de Marseille, Universite de la Mediterranee, France
Crit Care Med 34:823-8. 2006
..aeruginosa strains. In this study we have developed a simple amebal co-culture test with Acanthamoeba polyphaga to compare the virulence of P. aeruginosa between human and environmental isolates...
- Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening
Florence Fenollar
Unite des Rickettsies, Universite de la Mediterranee, Centre National de Recherche Scientifique, Marseille, France
Clin Infect Dis 47:659-67. 2008
..Whipple disease (WD) is a chronic infectious disease caused by Tropheryma whipplei. WD DNA has been found in stool and saliva specimens from patients and asymptomatic carriers...
- Paenibacillus provencensis sp. nov., isolated from human cerebrospinal fluid, and Paenibacillus urinalis sp. nov., isolated from human urine
Veronique Roux
Laboratoire de Bacteriologie virologie, Hopital de la Timone, CNRS UMR 6020, IFR48, 264 rue Saint Pierre, 13385 Marseille Cedex 05, France
Int J Syst Evol Microbiol 58:682-7. 2008
..nov. (type strain 5402403(T) =CIP 109357(T) =CCUG 53521(T)) and Paenibacillus provencensis sp. nov. (type strain 4401170(T) =CIP 109358(T) =CCUG 53519(T))...
- Prevalence of Bartonella clarridgeiae and Bartonella henselae in domestic cats from France and detection of the organisms in erythrocytes by immunofluorescence
Jean-Marc Rolain
, IFR 48, , , 13385 Marseille Cedex 05, France
Clin Diagn Lab Immunol 11:423-5. 2004
..1% (8 of 99 cats). The intraerythrocytic location of Bartonella clarridgeiae is shown for the first time, and we show that immunofluorescence detection of the organism in erythrocytes correlates with the number of bacteria in blood...
- Development of a method for recovering rickettsial RNA from infected cells to analyze gene expression profiling of obligate intracellular bacteria
My Van La
Unite des Rickettsies, CNRS UMR6020, IFR48, Faculte de Medecine, 27, Bd Jean Moulin, Marseille, France
J Microbiol Methods 71:292-7. 2007
..We conclude that this approach has great potential for the study of mechanisms behind the virulence and intracellular survival of members of the genus Rickettsia...
- Gene repertoire of amoeba-associated giant viruses
Philippe Colson
URMITE UMR CNRS 6236 IRD 198, Facultes de Medecine et de Pharmacie, Universite de la Mediterranee, Marseille, France
Intervirology 53:330-43. 2010
..Altogether, the data so far accumulated on amoeba-associated giant viruses are a powerful incentive to isolate and study additional strains to gain better understanding of their pangenome...
- Genotyping reveals a wide heterogeneity of Tropheryma whipplei
Wenjun Li
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, Marseille Cedex 05, France
Microbiology 154:521-7. 2008
..whipplei strains that is apparently independent of geographical distribution and unrelated to bacterial pathogenicity. Genotyping in Whipple's disease may, however, be useful in epidemiological studies...
- Multispacer typing of Rickettsia prowazekii enabling epidemiological studies of epidemic typhus
Yong Zhu
, CNRS UMR 6020, IFR 48, , , Marseille, France
J Clin Microbiol 43:4708-12. 2005
..This may help to discriminate between natural and intentional outbreaks. Our study supports the usefulness of MST as a versatile method for rickettsial strain genotyping...
- Proposal to create subspecies of Rickettsia conorii based on multi-locus sequence typing and an emended description of Rickettsia conorii
Yong Zhu
Unite des Rickettsies, IFR 48, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
BMC Microbiol 5:11. 2005
..Then, we selected a representative of each MLST genotype and used multi-spacer typing (MST) and mouse serotyping to estimate their degree of taxonomic relatedness...
- False positive PCR detection of Tropheryma whipplei in the saliva of healthy people
Jean Marc Rolain
Universite de la Mediterranee, Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Marseille Cedex 05, France
BMC Microbiol 7:48. 2007
..whipplei in a series of 57 saliva from healthy people...
- Corynebacterium timonense sp. nov. and Corynebacterium massiliense sp. nov., isolated from human blood and human articular hip fluid
Vicky Merhej
Laboratoire de Bacteriologie virologie, Hopital de la Timone, URMITE CNRS IRD UMR6236, 264 rue Saint Pierre, 13385 Marseille, Cedex 05, France
Int J Syst Evol Microbiol 59:1953-9. 2009
..nov. (type strain, 5401744T=CSUR P20T=CIP 109424T=CCUG 53856T) and Corynebacterium massiliense sp. nov. (type strain, 5402485T=CSUR P19T=CIP 109423T=CCUG 53857T) are proposed...
- A novel alpha-Proteobacterium, Nordella oligomobilis gen. nov., sp. nov., isolated by using amoebal co-cultures
Bernard La Scola
Unite des Rickettsies, CNRS UMR 6020, Faculte de Medecine, Universite de la Mediterrannee, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 05, France
Res Microbiol 155:47-51. 2004
..nov., sp. nov. The genus Nordella forms a well separated taxon in the order Rhizobiales within the alpha-2 subgroup of Proteobacteria. Its close relatives are environmental uncultured bacteria...
- Bacteroides massiliensis sp. nov., isolated from blood culture of a newborn
Lukas Fenner
, CNRS UPRESA 6020, , , Marseille, France
Int J Syst Evol Microbiol 55:1335-7. 2005
..8 % 16S rRNA similarity to Bacteroides vulgatus and a DNA G + C content of 49 mol%. The major cellular fatty acid is anteiso-branched C(15 : 0). The type strain of B. massiliensis sp. nov. is B84634(T) (=CIP 107942(T) = CCUG 48901(T))...
- The uptake of apoptotic cells drives Coxiella burnetii replication and macrophage polarization: a model for Q fever endocarditis
Marie Benoit
Unité de Recherche sur les Maladies Infectieuses Transmissibles et Emergentes, CNRS UMR 6236, Institut Federatif de Recherche 48, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
PLoS Pathog 4:e1000066. 2008
..burnetii. We suggest that leukocyte apoptosis associated with valvulopathy may be critical for the pathogenesis of Q fever endocarditis by deactivating immune cells and creating a favorable environment for bacterial persistence...
- Tropheryma whipplei bacteremia during fever in rural West Africa
Florence Fenollar
Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, Universite de la Mediterranee, Faculte de Medecine, 1Marseille, France
Clin Infect Dis 51:515-21. 2010
..We investigated the role of T. whipplei in febrile patients from rural Senegal who had a negative test result for malaria...
- Genome-based design of a cell-free culture medium for Tropheryma whipplei
Patricia Renesto
, CNRS UMR 6020, , 27 Boulevard Jean Moulin, 13385, Marseille, France
Lancet 362:447-9. 2003
..Genomic information can, therefore, provide sufficient clues for designing axenic media for fastidious and uncultured pathogens...
- Autoimmunohistochemistry: a new method for the histologic diagnosis of infective endocarditis
Hubert Lepidi
Unite des Rickettsies et des Pathogenes Emergents, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 6020, Institut Federatif de Recherche 48, Universite de la Mediterranee, Marseille, France
J Infect Dis 193:1711-7. 2006
..We describe a novel method for the detection of microorganisms in valve specimens from patients with infective endocarditis...
- PCR detection of bacteria on cardiac valves of patients with treated bacterial endocarditis
Clarisse Rovery
, , , , Marseille, France
J Clin Microbiol 43:163-7. 2005
....
- Experimental infection models of ticks of the Rhipicephalus sanguineus group with Rickettsia conorii
Koutaro Matsumoto
, CNRS UMR 6020 IFR 48, , Marseille, France
Vector Borne Zoonotic Dis 5:363-72. 2005
..The harmful effect of R. conorii on Rh. sanguineus group ticks from Thailand is discussed including the role of the geographic origin of the ticks and the difficulties to identify ticks within this group to the species level...
- Rickettsia felis and Bartonella clarridgeiae in fleas from New Caledonia
Oleg Mediannikov
Unité de Recherche en Maladies Infectieuses et Tropicales Emergentes URMITE, UMR CNRS IRD 6236, Faculte de Medecine, Marseille, France
Vector Borne Zoonotic Dis 11:181-3. 2011
..Dog fleas collected in New Caledonia harbored flea-borne pathogens Rickettsia felis and Bartonella clarridgeiae in 81% and 5%, respectively...
- The virophage as a unique parasite of the giant mimivirus
Bernard La Scola
URMITE, Centre National de la Recherche Scientifique UMR IRD 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
Nature 455:100-4. 2008
..Considering its functional analogy with bacteriophages, we classify this virus as a virophage. The virophage could be a vehicle mediating lateral gene transfer between giant viruses...
- Circulating matrix metalloproteinases in infective endocarditis: a possible marker of the embolic risk
Franck Thuny
Departement de Cardiologie, Hopital de la Timone, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Marseille, France
PLoS ONE 6:e18830. 2011
..We aimed to determine whether, in addition to the vegetation size, circulating MMPs could provide accurate predictive value of embolism in IE...
- Ultrastructural characterization of the giant volcano-like virus factory of Acanthamoeba polyphaga Mimivirus
Marie Suzan-Monti
Unite des Rickettsies, Centre National de la Recherche Scientifique CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France
PLoS ONE 2:e328. 2007
....
- Tropheryma whipplei Twist: a human pathogenic Actinobacteria with a reduced genome
Didier Raoult
Unite des Rickettsies, Faculte de Medecine, CNRS UMR6020, Universite de la Mediterranee, 13385 Marseille Cedex 05, France
Genome Res 13:1800-9. 2003
..The analysis of the genome sequence of this previously largely unknown human pathogen is now guiding the development of molecular diagnostic tools and more convenient culture conditions...
