Didier Raoult



  1. Colson P, La Scola B, Raoult D. Giant Viruses of Amoebae: A Journey Through Innovative Research and Paradigm Changes. Annu Rev Virol. 2017;4:61-85 pubmed publisher
    ..This new paradigm is propitious for enhanced detection and characterization of giant viruses of amoebae, and a particular focus on their role in humans is warranted. ..
  2. Morand A, Cornu F, Dufour J, Tsimaratos M, Lagier J, Raoult D. Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift. J Clin Microbiol. 2019;57: pubmed publisher
    ..The restoration of urinary tract health can occur following a fecal transplantation. The potential gut origin of the human bacterial microbiota has to be explored. ..
  3. Amanzougaghene N, Fenollar F, Davoust B, Djossou F, Ashfaq M, Bitam I, et al. Mitochondrial diversity and phylogeographic analysis of Pediculus humanus reveals a new Amazonian clade "F". Infect Genet Evol. 2019;70:1-8 pubmed publisher
    ..humanus. The discovery of new Amazonian clade F with the recovery of additional haplotypes within each of the five clades demonstrates that the levels of genetic diversity in P. humanus are higher than previously thought. ..
  4. Beltrame A, Laroche M, Degani M, Perandin F, Bisoffi Z, Raoult D, et al. Tick-borne pathogens in removed ticks Veneto, northeastern Italy: A cross-sectional investigation. Travel Med Infect Dis. 2018;26:58-61 pubmed publisher
    ..Rickettsiosis and anaplasmosis, tick-borne diseases previously not considered in northeastern Italy, should not be neglected. A new survey for a longer period is required to obtain stronger epidemiological data. ..
  5. Le Page S, Dubourg G, Baron S, Rolain J, Raoult D. No global increase in resistance to antibiotics: a snapshot of resistance from 2001 to 2016 in Marseille, France. Eur J Clin Microbiol Infect Dis. 2019;38:395-407 pubmed publisher
    ..Regarding bacteraemia involving Enterobacteriaceae and S. aureus, empirical therapy is effective in > 99% cases. Active epidemiological surveillance is necessary because antibiotic resistance remains unpredictable. ..
  6. Guedj E, Eldin C, Raoult D, Azorin J, Belzeaux R. Functional neuroimaging in patients presenting with somatoform disorders: A model for investigating persisting symptoms after tick bites and post-treatment Lyme disease syndrome?. Med Mal Infect. 2019;49:150-156 pubmed publisher
  7. Eldin C, Raffetin A, Bouiller K, Hansmann Y, Roblot F, Raoult D, et al. Review of European and American guidelines for the diagnosis of Lyme borreliosis. Med Mal Infect. 2019;49:121-132 pubmed publisher
  8. Seck E, Senghor B, Merhej V, Bachar D, Cadoret F, Robert C, et al. Salt in stools is associated with obesity, gut halophilic microbiota and Akkermansia muciniphila depletion in humans. Int J Obes (Lond). 2019;43:862-871 pubmed publisher
    ..Further studies should clarify if the gut microbiota alterations associated with high salt levels and the human halophilic microbiota could be causally related to human disease, such as obesity. ..
  9. Mailhe M, Ricaboni D, Vitton V, Gonzalez J, Bachar D, Dubourg G, et al. Repertoire of the gut microbiota from stomach to colon using culturomics and next-generation sequencing. BMC Microbiol. 2018;18:157 pubmed publisher
    ..001). Significant modifications in bacterial composition and diversity exist throughout the gastrointestinal tract. We suggest that the upper gut may be key to understanding the relationship between the gut microbiota and health. ..

More Information

Publications115 found, 100 shown here

  1. Kowalczewska M, N Djatchi A, Nappez C, Alwassouf S, Decloquement P, Armstrong N, et al. Identification of rickettsial immunoreactive proteins using a proximity ligation assay Western blotting and the traditional immunoproteomic approach. Comp Immunol Microbiol Infect Dis. 2018;58:17-25 pubmed publisher
    ..africae active infection were rOmpB β-peptide, OmpA, groEL and ORF1174, early R. conorii infection was prsA, RC0031, pepA, R. conorii active infection were ftsZ, cycM and rpoA. They are candidates for serodiagnosis of rickettsioses. ..
  2. Colson P, Ominami Y, Hisada A, La Scola B, Raoult D. Giant mimiviruses escape many canonical criteria of the virus definition. Clin Microbiol Infect. 2019;25:147-154 pubmed publisher
    ..The major cellular hallmark that is still lacking in giant viruses is the ribosome, including both ribosomal protein and RNA encoding genes, which makes them bona fide microbes without ribosomes. ..
  3. Caputo A, Merhej V, Georgiades K, Fournier P, Croce O, Robert C, et al. Pan-genomic analysis to redefine species and subspecies based on quantum discontinuous variation: the Klebsiella paradigm. Biol Direct. 2015;10:55 pubmed publisher
    ..rhinoscleromatis are species of the Klebsiella genus, rather than subspecies of Klebsiella pneumoniae. This pan-genomic analysis, helped to develop a new tool for defining species introducing a quantic perspective for taxonomy. ..
  4. Edouard S, Prudent E, Gautret P, Memish Z, Raoult D. Cost-effective pooling of DNA from nasopharyngeal swab samples for large-scale detection of bacteria by real-time PCR. J Clin Microbiol. 2015;53:1002-4 pubmed publisher
    ..Lyophilization is required to reconcentrate DNA. This strategy yields a high specificity (86%) and a high sensitivity (96%). We estimate that compared to individual testing, 37% fewer RT-PCR tests are needed. ..
  5. Raoult D. Double paradigm shift for the antibiotics' activity on viruses: Zika's lesson. Proc Natl Acad Sci U S A. 2017;114:E1045 pubmed publisher
  6. D Amato F, Rouli L, Edouard S, Tyczka J, Million M, Robert C, et al. The genome of Coxiella burnetii Z3055, a clone linked to the Netherlands Q fever outbreaks, provides evidence for the role of drift in the emergence of epidemic clones. Comp Immunol Microbiol Infect Dis. 2014;37:281-8 pubmed publisher
    ..05) and translation proteins (15/144 vs 109/1655, bilateral Chi(2) test, p<0.05). The evolution of this strain may have been driven by mutations in critical genes. ..
  7. Dieme C, Yssouf A, Vega Rúa A, Bérenger J, Failloux A, Raoult D, et al. Accurate identification of Culicidae at aquatic developmental stages by MALDI-TOF MS profiling. Parasit Vectors. 2014;7:544 pubmed publisher
    ..With this proteomic tool, it becomes now conceivable to survey mosquito breeding sites prior to the mosquitoes' emergence and to adapt anti-vectorial measures according to the mosquito fauna detected. ..
  8. Rouli L, Robert C, Raoult D, Yagupsky P. Kingella kingae KK247, an Atypical Pulsed-Field Gel Electrophoresis Clone A Strain. Genome Announc. 2014;2: pubmed publisher
    ..kingae strains. ..
  9. Angelakis E, Yasir M, Azhar E, Papadioti A, Bibi F, Aburizaiza A, et al. MALDI-TOF mass spectrometry and identification of new bacteria species in air samples from Makkah, Saudi Arabia. BMC Res Notes. 2014;7:892 pubmed publisher
    ..Four of these were considered to be new species. During the Hajj, the air was contaminated by many environmental bacterial agents, and MALDI-TOF MS was successfully adapted for their rapid identification. ..
  10. Prudent E, Lepidi H, Angelakis E, Raoult D. Fluorescence In Situ Hybridization (FISH) and Peptide Nucleic Acid Probe-Based FISH for Diagnosis of Q Fever Endocarditis and Vascular Infections. J Clin Microbiol. 2018;56: pubmed publisher
    ..burnetii We provide evidence that PNA FISH and FISH are important assays for the diagnosis of C. burnetii endocarditis and vascular infections. ..
  11. Fournier P, Lagier J, Dubourg G, Raoult D. From culturomics to taxonomogenomics: A need to change the taxonomy of prokaryotes in clinical microbiology. Anaerobe. 2015;36:73-8 pubmed publisher
    ..In this manuscript, we briefly reviewed the pros and cons of the currently validated taxonomic tools and propose that genomic sequencing and MALDI-TOF mass spectrometry may be incorporated in the taxonomic classification of prokaryotes. ..
  12. Eldin C, Mahamat A, Djossou F, Raoult D. Rainfall and sloth births in may, Q fever in July, Cayenne, French Guiana. Am J Trop Med Hyg. 2015;92:979-81 pubmed publisher
    ..We found a 1- to 2-month lagged correlation between Q fever incidence and the number of births of three-toed sloth. This result strengthens the hypothesis that the three-toed sloth is the wild reservoir of Q fever in French Guiana. ..
  13. Abat C, Fournier P, Jimeno M, Rolain J, Raoult D. Extremely and pandrug-resistant bacteria extra-deaths: myth or reality?. Eur J Clin Microbiol Infect Dis. 2018;37:1687-1697 pubmed publisher
    ..All together, these data allowed us to conclude that there is a large discrepancy between the real count of deaths attributable to XDR/PDR bacteria and alarmist predictions. ..
  14. Lagier J, Edouard S, Pagnier I, Mediannikov O, Drancourt M, Raoult D. Current and past strategies for bacterial culture in clinical microbiology. Clin Microbiol Rev. 2015;28:208-36 pubmed publisher
  15. Fenollar F, Marth T, Lagier J, Angelakis E, Raoult D. Sewage workers with low antibody responses may be colonized successively by several Tropheryma whipplei strains. Int J Infect Dis. 2015;35:51-5 pubmed publisher
    ..Chronic T. whipplei carriers appear to be protected against reinfection, but those with low or decreasing antibody levels may be re-colonized by another strain. ..
  16. Lamrabet O, Ghigo E, Mège J, Lepidi H, Nappez C, Raoult D, et al. MspA-Mycobacterium tuberculosis-transformant with reduced virulence: the "unbirthday paradigm". Microb Pathog. 2014;76:10-8 pubmed publisher
    ..Lost of non-virulence genes is a mechanism for virulence in mycobacteria. Engineering non-virulence genes in M. tuberculosis may yield strains with decreased virulence and increased immunogenicity. ..
  17. Sangaré A, Boutellis A, Drali R, Audoly G, Weber P, Rolain J, et al. Doxycycline kills human lice through its activity on their bacterial symbiont. Int J Antimicrob Agents. 2015;45:675-6 pubmed publisher
  18. Edouard S, Courtois G, Gautret P, Jouve J, Minodier P, Noël G, et al. High Prevalence of Mycoplasma faucium DNA in the Human Oropharynx. J Clin Microbiol. 2016;54:194-6 pubmed publisher
    ..We evaluated its prevalence by quantitative real-time PCR (qPCR) in the oropharynxes of 644 subjects and found that 25% harbored M. faucium, probably constituting the gateway for entrance of the bacteria into cerebral abscesses. ..
  19. Dubourg G, Elsawi Z, Raoult D. Assessment of the in vitro antimicrobial activity of Lactobacillus species for identifying new potential antibiotics. Int J Antimicrob Agents. 2015;46:590-3 pubmed publisher
    ..In conclusion, considering the increasing cultivable bacterial human repertoire, these findings open the way of an effective method to screen in vitro for the production of potential antimicrobial compounds. ..
  20. Edouard S, Million M, Bachar D, Dubourg G, Michelle C, Ninove L, et al. The nasopharyngeal microbiota in patients with viral respiratory tract infections is enriched in bacterial pathogens. Eur J Clin Microbiol Infect Dis. 2018;37:1725-1733 pubmed publisher
    ..In addition to antibiotics, further studies should test preventive or therapeutic interventions for maintaining or restoring a healthy nasopharyngeal microbiota. ..
  21. Boucheikhchoukh M, Laroche M, Aouadi A, Dib L, Benakhla A, Raoult D, et al. MALDI-TOF MS identification of ticks of domestic and wild animals in Algeria and molecular detection of associated microorganisms. Comp Immunol Microbiol Infect Dis. 2018;57:39-49 pubmed publisher
    ..This study supports MALDI-TOF MS being a reliable tool for the identification of arthropods and brings new data that sheds light on tick species diversity and tick-borne diseases in Algeria. ..
  22. Mourembou G, Fenollar F, Socolovschi C, Lemamy G, Nzoughe H, Kouna L, et al. Molecular Detection of Fastidious and Common Bacteria as Well as Plasmodium spp. in Febrile and Afebrile Children in Franceville, Gabon. Am J Trop Med Hyg. 2015;92:926-32 pubmed publisher
    ..Two fastidious bacteria, Rickettsia felis and Borrelia spp., were found. Inclusion of controls should improve the understanding of the causes of fever in sub-Saharan Africa. ..
  23. D Amato F, Eldin C, Georgiades K, Edouard S, Delerce J, Labas N, et al. Loss of TSS1 in hypervirulent Coxiella burnetii 175, the causative agent of Q fever in French Guiana. Comp Immunol Microbiol Infect Dis. 2015;41:35-41 pubmed publisher
    ..0000001). Loss of genes implicated in secretion systems has been observed in other epidemic bacterial strains. Thus, the virulence of Cb175 may be linked to this genome reduction. ..
  24. Raoult D, Forterre P. Redefining viruses: lessons from Mimivirus. Nat Rev Microbiol. 2008;6:315-9 pubmed publisher
  25. Thuny F, Grisoli D, Collart F, Habib G, Raoult D. Management of infective endocarditis: challenges and perspectives. Lancet. 2012;379:965-975 pubmed publisher
  26. Raoult D, Mouffok N, Bitam I, Piarroux R, Drancourt M. Plague: history and contemporary analysis. J Infect. 2013;66:18-26 pubmed publisher
    ..Analysis of past plague epidemics by using modern laboratory tools illustrated the value of epidemic buboes for the clinical diagnosis of plague; and brought new concepts regarding its transmission by human ectoparasites. ..
  27. Keita A, Fenollar F, Socolovschi C, Ratmanov P, Bassene H, Sokhna C, et al. The detection of vector-borne-disease-related DNA in human stool paves the way to large epidemiological studies. Eur J Epidemiol. 2015;30:1021-6 pubmed publisher
    ..This preliminary report provides a proof of concept for the use of feces for detecting human pathogens, including microorganisms that do not cause gastroenteritis, in epidemiological studies. ..
  28. Melenotte C, Bart G, Kraeber Bodéré F, Cammilleri S, Le Goff B, Raoult D. Isolation of Coxiella burnetii from an acromioclavicular infection with low serological titres. Int J Infect Dis. 2018;73:27-29 pubmed publisher
    ..Positron emission tomography had a crucial role in identifying the deep infectious focus, even when C. burnetii serological titres were low. ..
  29. Fournier A, Gouriet F, Fournier P, Casalta J, Saby L, Habib G, et al. A case of infectious endocarditis due to BCG. Int J Infect Dis. 2015;35:27-8 pubmed publisher
    ..A fatal case of native aortic valve infectious endocarditis with septicemia due to BCG in a patient treated with intravesical instillation is reported herein. ..
  30. Jos S, Angelakis E, Caus T, Raoult D. Positron emission tomography in the diagnosis of Whipple's endocarditis: a case report. BMC Res Notes. 2015;8:56 pubmed publisher
    ..whipplei was also positive. The localization of infectious foci by positron emission tomography and systematically testing valve specimens for T. whipplei are promising for diagnosing Whipple's disease. ..
  31. Melenotte C, Edouard S, Lepidi H, Raoult D. [Diagnosis of infectious lymphadenitis]. Rev Med Interne. 2015;36:668-76 pubmed publisher
    ..PCR has become an essential tool in the diagnostic process of infectious lymphadenitis. Here, we propose a literature review on infectious adenitis and we emphasize the diagnostic strategy of adenitis. ..
  32. Drali R, Mumcuoglu K, Yesilyurt G, Raoult D. Studies of Ancient Lice Reveal Unsuspected Past Migrations of Vectors. Am J Trop Med Hyg. 2015;93:623-5 pubmed publisher
    ..Our results suggest that these eggs belonged to people originating from west Africa based on identification of the louse mitochondrial sub-clade specific to that region. ..
  33. Drali R, Shako J, Davoust B, Diatta G, Raoult D. A New Clade of African Body and Head Lice Infected by Bartonella quintana and Yersinia pestis-Democratic Republic of the Congo. Am J Trop Med Hyg. 2015;93:990-3 pubmed publisher
    ..Clade D may be a vector of B. quintana and Y. pestis, which is prevalent in a highly plague-endemic area near the Rethy Health District, Orientale Province, Democratic Republic of the Congo. ..
  34. Mediannikov O, Socolovschi C, Million M, Sokhna C, Bassene H, Diatta G, et al. Molecular identification of pathogenic bacteria in eschars from acute febrile patients, Senegal. Am J Trop Med Hyg. 2014;91:1015-9 pubmed publisher
    ..Finally, we confirmed that Senegal is an endemic region for R. felis, which is found in both eschars and healthy skin swabs. ..
  35. Dubourg G, Abat C, Rolain J, Raoult D. Correlation between sputum and bronchoalveolar lavage fluid cultures. J Clin Microbiol. 2015;53:994-6 pubmed publisher
    ..7% and 96.5%, respectively, suggesting that the culture of readily collectable sputum specimens may result in useful microbiologic diagnosis. ..
  36. Lagier J, Hugon P, Khelaifia S, Fournier P, La Scola B, Raoult D. The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota. Clin Microbiol Rev. 2015;28:237-64 pubmed publisher
    ..We provide a comprehensive review on these topics, demonstrating that both empirical and hypothesis-driven approaches will enable a rapid increase in the identification of the human prokaryote repertoire. ..
  37. Million M, Raoult D. Recent advances in the study of Q fever epidemiology, diagnosis and management. J Infect. 2015;71 Suppl 1:S2-9 pubmed publisher
    ..Finally, IgG anticardiolipin antibodies, part of the auto-immune response during acute Q fever, were recently added to the risk factors for endocarditis, due to their ability to promote acute valvular lesions and endocarditis. ..
  38. Bilen M, Dufour J, Lagier J, Cadoret F, Daoud Z, Dubourg G, et al. The contribution of culturomics to the repertoire of isolated human bacterial and archaeal species. Microbiome. 2018;6:94 pubmed publisher
    ..2% towards updating this repertoire by reporting 400 species, of which 288 were novel. This demonstrates the need to continue the culturing work, which seems essential in order to decipher the hidden human microbial content. ..
  39. D Amato F, Robert C, Azhar E, Fournier P, Raoult D. Draft Genome Sequence of Coxiella burnetii Strain Cb196, an Agent of Endocarditis in Saudi Arabia. Genome Announc. 2014;2: pubmed publisher
    ..It belongs to the genotype MST51, which was detected for the first time only in this country. Cb196 shows more similarity to C. burnetii CbuK_Q154, belonging to genotype 8, which was phylogenetically close to MST51. ..
  40. Caputo A, Dubourg G, Croce O, Gupta S, Robert C, Papazian L, et al. Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool. Biol Direct. 2015;10:5 pubmed publisher
    ..This work highlights the potential of metagenomics to facilitate the assembly of genomes directly from human stool. ..
  41. Gouriet F, Levy P, Casalta J, Zandotti C, Collart F, Lepidi H, et al. Etiology of Pericarditis in a Prospective Cohort of 1162 Cases. Am J Med. 2015;128:784.e1-8 pubmed publisher
    ..In many cases, the etiologies were still identified. Long-term follow-up in the management of idiopathic pericarditis should remain of great interest for the future diagnosis of other disorders that remain hidden. ..
  42. Pagnier I, Yutin N, Croce O, Makarova K, Wolf Y, Benamar S, et al. Babela massiliensis, a representative of a widespread bacterial phylum with unusual adaptations to parasitism in amoebae. Biol Direct. 2015;10:13 pubmed publisher
    ..Characterization of B. massiliensis, a representative of a distinct bacterial phylum, thanks to its ability to grow in amoeba, reaffirms the critical role of diverse culture approaches in microbiology. ..
  43. Drissi F, Labas N, Merhej V, Raoult D. Draft Genome Sequence of the Lactobacillus agilis Strain Marseille. Genome Announc. 2015;3: pubmed publisher
    ..This strain can use two metabolic pathways allowing the assimilation of glucose and xylose. Here, we present the first draft genome of the Lactobacillus agilis species. ..
  44. Murillo N, Mediannikov O, Aubert J, Raoult D. Bartonella quintana detection in Demodex from erythematotelangiectatic rosacea patients. Int J Infect Dis. 2014;29:176-7 pubmed publisher
    ..Demodex are arthropods associated with acnea. Bartonella quintana was found by broad Spectrum 16rDNA PCR amplification and sequencing, and confirmed by specific PCR. Bartonella quintana may parasite several arthropods and not only lice. ..
  45. Edouard S, Nabet C, Lepidi H, Fournier P, Raoult D. Bartonella, a common cause of endocarditis: a report on 106 cases and review. J Clin Microbiol. 2015;53:824-9 pubmed publisher
    ..There is no real increase in the incidence of these infections but rather a better understanding and interest in the disease resulting from the improvement of diagnostic tools. ..
  46. Lagier J, Dubourg G, Million M, Cadoret F, Bilen M, Fenollar F, et al. Culturing the human microbiota and culturomics. Nat Rev Microbiol. 2018;:540-550 pubmed publisher
    ..We describe how culturomics has extended our understanding of bacterial diversity and then explore how culturomics can be applied to the study of the human microbiota and the potential implications for human health. ..
  47. Angelakis E, Armstrong N, Nappez C, Richez M, Chabriere E, Raoult D. Doxycycline assay hair samples for testing long-term compliance treatment. J Infect. 2015;71:511-7 pubmed publisher
    ..We detected two patients who did not have antibiotic in the hair, indicating a lack of compliance that was also confirmed by interview. Hair samples can be used to test long-term compliance in patients to explain failures or relapses. ..
  48. Raoult D. How the virophage compels the need to readdress the classification of microbes. Virology. 2015;477:119-124 pubmed publisher
    ..Their existence forces us to create new classifications, the most recent being TRUC, to accommodate the existence of four branches of microorganisms, i.e., bacteria, archaea, eukaryotes and giant viruses. ..
  49. Drissi F, Merhej V, Blanc Tailleur C, Raoult D. Draft Genome Sequence of the Lactobacillus mucosae Strain Marseille. Genome Announc. 2015;3: pubmed publisher
    ..The draft genome sequence of this strain is presented here. ..
  50. Dione N, Khelaifia S, Lagier J, Raoult D. The aerobic activity of metronidazole against anaerobic bacteria. Int J Antimicrob Agents. 2015;45:537-40 pubmed publisher
    ..In future, both culture and antibiotic susceptibility testing of strictly anaerobic bacteria will be performed in an aerobic atmosphere using antioxidants in clinical microbiology laboratories. ..
  51. Balique F, Lecoq H, Raoult D, Colson P. Can plant viruses cross the kingdom border and be pathogenic to humans?. Viruses. 2015;7:2074-98 pubmed publisher
  52. Raoult D. The post-Darwinist rhizome of life. Lancet. 2010;375:104-5 pubmed publisher
  53. Drali R, Abi Rached L, Boutellis A, Djossou F, Barker S, Raoult D. Host switching of human lice to new world monkeys in South America. Infect Genet Evol. 2016;39:225-231 pubmed publisher
    ..Because this phylogenetic group forms a separate branch within the clade of lice from humans that were of American origin, this finding indicates that human lice have transferred to New World monkeys. ..
  54. Antinori S, Mediannikov O, Corbellino M, Raoult D. Louse-borne relapsing fever among East African refugees in Europe. Travel Med Infect Dis. 2016;14:110-4 pubmed publisher
    ..We review here the cases observed so far together with a critical reappraisal of several issues regarding clinical presentation, diagnosis and treatment. ..
  55. Niare S, Bérenger J, Dieme C, Doumbo O, Raoult D, Parola P, et al. Identification of blood meal sources in the main African malaria mosquito vector by MALDI-TOF MS. Malar J. 2016;15:87 pubmed publisher
    ..The MALDI-TOF MS technique appears to be an efficient tool for large epidemiological surveillance of vector-borne diseases and outbreak source identification. ..
  56. Abat C, Chaudet H, Rolain J, Colson P, Raoult D. Traditional and syndromic surveillance of infectious diseases and pathogens. Int J Infect Dis. 2016;48:22-8 pubmed publisher
    ..Concurrently with the expansion of computer resources and networks, these data will allow the optimization of real-time detection and notification of infections. ..
  57. Lagier J, Papazian L, Fenollar F, Edouard S, Melenotte C, Laroumagne S, et al. Tropheryma whipplei DNA in bronchoalveolar lavage samples: a case control study. Clin Microbiol Infect. 2016;22:875-879 pubmed publisher
    ..This study adds evidence for a causative role of T. whipplei in pneumonia. In the future, an experimental model of pneumonia induced by T. whipplei will prove its role in pneumonia. ..
  58. Drancourt M, Raoult D. Molecular history of plague. Clin Microbiol Infect. 2016;22:911-915 pubmed publisher
    ..Answering these questions will broaden our understanding of plague epidemiology so we may better face the actuality of this deadly infection in countries where it remains epidemic. ..
  59. Merhej V, Royer Carenzi M, Pontarotti P, Raoult D. Massive comparative genomic analysis reveals convergent evolution of specialized bacteria. Biol Direct. 2009;4:13 pubmed publisher
    ..This comparative genomic analysis helps to explore the strategies by which obligate intracellular genomes specialize to particular host-associations and contributes to advance our knowledge about the mechanisms of bacterial evolution. ..
  60. Tamalet C, Colson P, Decroly E, Dhiver C, Ravaux I, Stein A, et al. Reevaluation of possible outcomes of infections with human immunodeficiency virus. Clin Microbiol Infect. 2016;22:299-311 pubmed publisher
    ..Finally, we propose a definition of spontaneous cure of HIV infection based on clinical, immunologic and virologic criteria. ..
  61. Sangaré A, Rolain J, Gaudart J, Weber P, Raoult D. Synergistic activity of antibiotics combined with ivermectin to kill body lice. Int J Antimicrob Agents. 2016;47:217-23 pubmed publisher
    ..0008). These data demonstrate that the synergistic effect of combinations of antibiotics and ivermectin could be used to achieve complete eradication of lice and to avoid selection of a resistant louse population. ..
  62. Dubourg G, Lagier J, Robert C, Armstrong N, Couderc C, Fournier P, et al. Risungbinella massiliensis sp. nov., a new member of Thermoactinomycetaceae isolated from human gut. Antonie Van Leeuwenhoek. 2016;109:773-84 pubmed publisher
    ..To date, strain GD1(T) is the first member of the family Thermoactinomycetaceae isolated from human gut and the fourth from a human specimen. ..
  63. Khelaifia S, Lagier J, Nkamga V, Guilhot E, Drancourt M, Raoult D. Aerobic culture of methanogenic archaea without an external source of hydrogen. Eur J Clin Microbiol Infect Dis. 2016;35:985-91 pubmed publisher
    ..This changes the ability to routinely study methanogens, which have been neglected in clinical microbiology laboratories and may be useful for biogas production. ..
  64. Rolain J, Abat C, Jimeno M, Fournier P, Raoult D. Do we need new antibiotics?. Clin Microbiol Infect. 2016;22:408-15 pubmed publisher
    ..This heritage should be managed in a non-profit model with international regulatory approval. ..
  65. Hugon P, Lagier J, Colson P, Bittar F, Raoult D. Repertoire of human gut microbes. Microb Pathog. 2017;106:103-112 pubmed publisher
    ..Rational and comprehensive establishment of this ecosystem will allow the understanding of human health associated with gut microbiota and the potential to change this. ..
  66. Dubourg G, Raoult D. The challenges of preexposure prophylaxis for bacterial sexually transmitted infections. Clin Microbiol Infect. 2016;22:753-756 pubmed publisher
    ..The choice of antimicrobial agents is crucial, as antimicrobial susceptibility of STI agents is heterogeneous. Finally, we discuss challenges to improve the control of STIs through the use of PrEP. ..
  67. Leulmi H, Diatta G, Sokhna C, Rolain J, Raoult D. Assessment of oral ivermectin versus shampoo in the treatment of pediculosis (head lice infestation) in rural areas of Sine-Saloum, Senegal. Int J Antimicrob Agents. 2016;48:627-632 pubmed publisher
    ..This study demonstrates that oral ivermectin is highly effective for the treatment of pediculosis compared with shampoo, but also suggests that ivermectin resistance may emerge during treatment. ..
  68. Dione N, Khelaifia S, La Scola B, Lagier J, Raoult D. A quasi-universal medium to break the aerobic/anaerobic bacterial culture dichotomy in clinical microbiology. Clin Microbiol Infect. 2016;22:53-58 pubmed publisher
  69. Leulmi H, Aouadi A, Bitam I, Bessas A, Benakhla A, Raoult D, et al. Detection of Bartonella tamiae, Coxiella burnetii and rickettsiae in arthropods and tissues from wild and domestic animals in northeastern Algeria. Parasit Vectors. 2016;9:27 pubmed publisher
    ..In this study, we expanded knowledge about the repertoire of ticks and flea-borne bacteria present in ectoparasites and/or tissues of domestic and wild animals in Algeria. ..
  70. Temmam S, Monteil Bouchard S, Robert C, Baudoin J, Sambou M, Aubadie Ladrix M, et al. Characterization of Viral Communities of Biting Midges and Identification of Novel Thogotovirus Species and Rhabdovirus Genus. Viruses. 2016;8:77 pubmed publisher
    ..African horse sickness, bluetongue and epizootic haemorrhagic disease viruses were also detected. This study highlights the interest in monitoring the emergence and circulation of zoonoses and epizooties using their arthropod vectors. ..
  71. Diatta G, Mediannikov O, Boyer S, Sokhna C, Bassene H, Fenollar F, et al. An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. Am J Trop Med Hyg. 2016;95:537-45 pubmed publisher
    ..Public health authorities or any development stakeholders should adopt this effective tool for promoting rural health through national prevention programs. ..
  72. Abat C, Huart M, Garcia V, Dubourg G, Raoult D. Enterococcus faecalis urinary-tract infections: Do they have a zoonotic origin?. J Infect. 2016;73:305-13 pubmed publisher
    ..faecalis epidemiological events. ..
  73. Gouriet F, Ghiab F, Couderc C, Bittar F, Tissot Dupont H, Flaudrops C, et al. Evaluation of a new extraction protocol for yeast identification by mass spectrometry. J Microbiol Methods. 2016;129:61-65 pubmed publisher
    ..9 and in 99% (2123/2131) of the strains at the genus level. The new protocol is a rapid, reliable and safe procedure for the accurate identification of pathogenic Candida strains and requires minimal handling. ..
  74. Aherfi S, Colson P, Audoly G, Nappez C, Xerri L, Valensi A, et al. Marseillevirus in lymphoma: a giant in the lymph node. Lancet Infect Dis. 2016;16:e225-e234 pubmed publisher
    ..Our observations suggest that consideration should be given to marseillevirus infections as an additional viral cause or consequence of Hodgkin's lymphoma, and that this hypothesis should be tested further. ..
  75. Eldin C, Melenotte C, Mediannikov O, Ghigo E, Million M, Edouard S, et al. From Q Fever to Coxiella burnetii Infection: a Paradigm Change. Clin Microbiol Rev. 2017;30:115-190 pubmed
    ..Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection. ..
  76. Zaratzian C, Gouriet F, Tissot Dupont H, Casalta J, Million M, Bardin N, et al. Antiphospholipid antibodies proposed in the diagnosis of infective endocarditis. Eur J Clin Microbiol Infect Dis. 2017;36:1159-1162 pubmed publisher
    ..aPL could be helpful in difficult cases of IE diagnosis. ..
  77. Drancourt M, Aboudharam G, Croce O, Armougom F, Robert C, Raoult D. Dental pulp as a source of low-contaminated DNA. Microb Pathog. 2017;105:63-67 pubmed publisher
    ..35% reads assigned to H. sapiens. This study indicates that the dental pulp is a useful for detecting the significant nucleic sequences in both modern and ancient samples. ..
  78. Abrahão J, Silva L, Silva L, Khalil J, Rodrigues R, Arantes T, et al. Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere. Nat Commun. 2018;9:749 pubmed publisher
    ..The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses. ..
  79. Million M, Diallo A, Raoult D. Gut microbiota and malnutrition. Microb Pathog. 2017;106:127-138 pubmed publisher
  80. Mourembou G, Nzondo S, Ndjoyi Mbiguino A, Lekana Douki J, Kouna L, Matsiegui P, et al. Co-circulation of Plasmodium and Bacterial DNAs in Blood of Febrile and Afebrile Children from Urban and Rural Areas in Gabon. Am J Trop Med Hyg. 2016;95:123-32 pubmed publisher
    ..whipplei in Gabon and shows that malaria decreases in urban areas but not in rural areas. Co-infections in febrile patients are common, highlighting the need to improve fever management strategies in Gabon. ..
  81. Wurtz N, Papa A, Hukic M, Di Caro A, Leparc Goffart I, Leroy E, et al. Survey of laboratory-acquired infections around the world in biosafety level 3 and 4 laboratories. Eur J Clin Microbiol Infect Dis. 2016;35:1247-58 pubmed publisher
    ..Today, most risks from biological hazards can be reduced through the use of appropriate procedures and techniques, containment devices and facilities, and the training of personnel. ..
  82. Fenollar F, Minodier P, Boutin A, Laporte R, Bremond V, Noel G, et al. Tropheryma whipplei associated with diarrhoea in young children. Clin Microbiol Infect. 2016;22:869-874 pubmed publisher
    ..16%) children without diarrhoea (p 0.26). Tropheryma whipplei was found more commonly in autumn. Tropheryma whipplei is significantly associated with diarrhoea in children, suggesting that the bacterium may be a cause of acute diarrhoea. ..
  83. Dubourg G, Abat C, Raoult D. Why new antibiotics are not obviously useful now. Int J Antimicrob Agents. 2017;49:549-553 pubmed publisher
  84. Amrane S, Bachar D, Lagier J, Raoult D. Clostridium scindens is present in the gut microbiota during Clostridium difficile infection. A metagenomic and culturomic analysis. J Clin Microbiol. 2018;: pubmed publisher
    ..i>Clostridium scindens was first isolated in 1984 during works on the gut microbiota's steroid production (1).…. ..
  85. Fenollar F, Nicoli F, Paquet C, Lepidi H, Cozzone P, Antoine J, et al. Progressive dementia associated with ataxia or obesity in patients with Tropheryma whipplei encephalitis. BMC Infect Dis. 2011;11:171 pubmed publisher
    ..Tropheryma whipplei, the agent of Whipple's disease, causes localised infections in the absence of histological digestive involvement. Our objective is to describe T. whipplei encephalitis...
  86. Fournier P, El Karkouri K, Leroy Q, Robert C, Giumelli B, Renesto P, et al. Analysis of the Rickettsia africae genome reveals that virulence acquisition in Rickettsia species may be explained by genome reduction. BMC Genomics. 2009;10:166 pubmed publisher
    ..We also speculate that in Rickettsia species virulence is mostly associated with gene loss.The genome sequence was deposited in GenBank under accession number [GenBank: NZ_AAUY01000001]. ..
  87. Gimenez G, Bertelli C, Moliner C, Robert C, Raoult D, Fournier P, et al. Insight into cross-talk between intra-amoebal pathogens. BMC Genomics. 2011;12:542 pubmed publisher
    ..Therefore it contributes to improve our knowledge on the intra-amoebal gene properties associated to their specific lifestyle. ..
  88. Armougom F, Raoult D. Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans. BMC Genomics. 2008;9:576 pubmed publisher
    ..Here we present a cost-effective method that combines 16S rRNA pyrosequencing and DNA barcodes of the Firmicutes and Bacteroidetes 16S rRNA genes to determine the Firmicutes/Bacteroidetes ratio in the gut microbiota of obese humans...
  89. Le P, Ramulu H, Guijarro L, Paganini J, Gouret P, Chabrol O, et al. An automated approach for the identification of horizontal gene transfers from complete genomes reveals the rhizome of Rickettsiales. BMC Evol Biol. 2012;12:243 pubmed publisher
    ..Our analysis provides a comprehensive, systematic approach for the automated detection of HGTs from several complete proteome sequences that can be applied to detect instances of HGT within other genomes of interest. ..
  90. Pinos S, Pontarotti P, Raoult D, Merhej V. Identification of constraints influencing the bacterial genomes evolution in the PVC super-phylum. BMC Evol Biol. 2017;17:75 pubmed publisher
    ..The presence of an intracytoplasmic membrane in PVC species seems to affect the genome's evolution through the selection of transferred DNA, according to their encoded functions. ..
  91. request reprint
    Raoult D, La Scola B, Birtles R. The discovery and characterization of Mimivirus, the largest known virus and putative pneumonia agent. Clin Infect Dis. 2007;45:95-102 pubmed
    ..quot; Furthermore, the virus, now named "Mimivirus," has been implicated as an agent of pneumonia in humans and, thus, should be considered a putative emerging pathogen. ..
  92. Raoult D, Reed D, Dittmar K, Kirchman J, Rolain J, Guillen S, et al. Molecular identification of lice from pre-Columbian mummies. J Infect Dis. 2008;197:535-43 pubmed publisher
    ..The other 2 (types B and C) include only head lice and are geographically restricted. It was hypothesized that head louse phylotypes were exchanged only recently, after European exploration and colonization (after Columbus)...