Metals and apoptosis: recent developmentsSuresh Vir Singh Rana
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut, India
J Trace Elem Med Biol 22:262-84. 2008
..An understanding of metal-induced apoptosis will be helpful in the development of preventive molecular strategies...
Biochemical toxicity of benzeneS V S Rana
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut 250 004, India
J Environ Biol 26:157-68. 2005
..Though extensive studies have been performed on its toxicity, endocrinal disruption caused by benzene remains poorly known. Transgenic cytochrome P450 IIE1 mice may help in understanding further toxic manifestations of benzene...
- Inevitable glutathione, then and now
S V S Rana
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut 250 004, India
Indian J Exp Biol 40:706-16. 2002
..Immense interest makes the then "thee glutathione" as "inevitable glutathione". This article describes the role of this vital molecule in cell physiology and detoxication mechanisms in particular...
- Circadian variation in lipid peroxidation induced by benzene in rats
S V S Rana
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut 250 004, India
Indian J Exp Biol 45:253-7. 2007
..It is concluded that circadian rhythmicity in hepatic drug metabolizing enzyme system and GSH contributes in toxicity of benzene. The results are important from occupational health point of view...
- Influence of thyroxine and n-propylthiouracil on nephro-toxicity of inorganic arsenic in rat
S V S Rana
Department of Zoology, Toxicology Laboratory, Ch Charan Singh University, Meerut 250004, India
Toxicol Ind Health 22:137-45. 2006
..We attribute this response to decreased glutathione-S-transferase (GSH) activity and increased GSH synthesis in the kidney. A relationship between thyroidal activity and arsenic toxicity is suggested by present observations...
- Effect of n-propylthiouracil or thyroxine on arsenic trioxide toxicity in the liver of rat
Tanu Allen
Department of Zoology, Toxicology Laboratory, Ch Charan Singh University, Meerut, India
J Trace Elem Med Biol 21:194-203. 2007
....
- Effects of progesterone on benzene toxicity in rats
Yeshvandra Verma
Ch Charan Singh University, Meerut, India
Arh Hig Rada Toksikol 59:1-9. 2008
..Our results evidence that progesterone changes benzene toxicity (generation of ROS, oxidative stress). However, the probable antioxidative effect of progesterone needs to be confirmed by further studies...
- Melatonin inhibits benzene-induced lipid peroxidation in rat liver
Seema Sharma
Department of Zoology, Ch Charan Singh University, Meerut, India
Arh Hig Rada Toksikol 61:11-8. 2010
..Inhibition of its metabolism correlated with lower lipid peroxidation. In conclusion, melatonin was found to be protective against lipid peroxidation induced by benzene...
- Ascorbic acid improves mitochondrial function in liver of arsenic-treated rat
Sohini Singh
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut, India
Toxicol Ind Health 26:265-72. 2010
..Consequently its events led to improved ADP:O ratio, normalized ATPase activity and restored the activity of succinic dehydrogenase. Overall, results support the protective role of ascorbic acid against As( III)-induced liver injury...
- Endocrinal toxicity of industrial solvents--a mini review
Yeshvandra Verma
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut 250 004, India
Indian J Exp Biol 47:537-49. 2009
..Endocrine toxicity caused by industrial solvents deserves more attention than hitherto paid. An understanding of hormonal disorders caused by industrial solvents will be important from occupational health point of view...
- Effect of insulin on arsenic toxicity in diabetic rats—liver function studies
Neetu Singh
CCS University, Meerut, Uttar Pradesh, India
Biol Trace Elem Res 132:215-26. 2009
..This protective effect has been attributed to noninsulin-dependent carbohydrate regulatory mechanisms. Diabetes certainly alters the pharmacodynamics and pharmacokinetics of iAs in rat...
- Effect of arsenic (AsIII) on glutathione-dependent enzymes in liver and kidney of the freshwater fish Channa punctatus
Tanu Allen
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut-250004, India
Biol Trace Elem Res 100:39-48. 2004
..Because arsenic manifests its toxicity by inducing oxidative stress, the antioxidant enzymes, especially the glutathione-dependent enzymes, play a protective role in arsenic toxicity...
- Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection
H C Goel
Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig SK Majumdar Marg, Delhi 110 054
Indian J Exp Biol 40:727-34. 2002
..The results reveal that the direct and indirect antioxidant actions of T. cordifolia probably act in corroboration to manifest the overall radioprotective effects...
- Oxidative stress by inorganic arsenic: modulation by thyroid hormones in rat
Tanu Allen
Department of Environmental Science, Ch. Charan Singh University, Meerut 250004, India
Comp Biochem Physiol C Toxicol Pharmacol 135:157-62. 2003
..Arsenic is less toxic in hyperthyroid than in hypothyroid rats. A physiological antagonism between arsenic and thyroxine is discussed...
- Amelioration of arsenic toxicity by L-Ascorbic acid in laboratory rat
Sohini Singh
Department of Zoology, Toxicology Laboratory, Ch Charan Singh University, Meerut 250 004, India
J Environ Biol 28:377-84. 2007
....
- Biological monitoring of exposure to benzene in traffic policemen of north India
Yeshvandra Verma
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut-250004, India
Ind Health 41:260-4. 2003
..It was noticed that cigarette smoke synergizes the effect of benzene whereas antagonistic effects of alcohol were observed...
- Protective effect of ascorbic acid against oxidative stress induced by inorganic arsenic in liver and kidney of rat
S V S Rana
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut 250 004, India
Indian J Exp Biol 45:371-5. 2007
..It is also concluded that ascorbic acid protection is influenced by gender dependent factors. Arsenic poisoning is a global problem now. Gender differences need to be considered while applying therapeutic measures...
- Gender differences in the metabolism of benzene, toluene and trichloroethylene in rat with special reference to certain biochemical parameters
Yeshvandra Verma
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut-250 004, India
J Environ Biol 24:135-40. 2003
..Results have been discussed with quantitative profiles of other enzymes established in the liver of male and female rats...
- Resistance to oxidative stress in a freshwater fish Channa punctatus after exposure to inorganic arsenic
Tanu Allen
Department of Environmental Science, Department of Zoology, Ch. Charan Singh University, Meerut-250004, India
Biol Trace Elem Res 98:63-72. 2004
..Values of reduced glutathione (GSH) reflected the observations of lipid peroxidation. The role of GSH in this adaptive response has been discussed...
- Sex differences in oxidative stress induced by benzene in rats
Yeshvandra Verma
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut 250 004, India
Indian J Exp Biol 42:117-20. 2004
..Decrease of GSH and CYTP(450)2E1 was higher in female rats than male rats except lungs. The results suggest that oxidative stress induced by benzene is higher in female rats...
- Influence of antioxidants on metallothionein-mediated protection in cadmium-fed rats
Rajul Singh
Department of Zoology, Ch. Charan Singh University, Meerut, India
Biol Trace Elem Res 88:71-7. 2002
..It is concluded that MT and antioxidants employ different mechanisms of protection. Genes maintaining the intracellular level of GSH seem to control the entire process of protection by these antioxidants...
- Induction of DNA-protein cross-links by Hippophae rhamnoides: implications in radioprotection and cytotoxicity
H C Goel
Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig S K Majumdar Marg, Delhi, India
Mol Cell Biochem 245:57-67. 2003
....
- Enhancement of radiation-induced apoptosis by Podophyllum hexandrum
I Prem Kumar
Department of Radiation Biology, Institute of Nuclear Medicine and Allied Sciences, Brig S. K. Majumdar Marg, Delhi, India
J Pharm Pharmacol 55:1267-73. 2003
..Depending on its concentration in the milieu, RP-1 acted as a pro- or antioxidant modifying the radiation-induced apoptosis and therefore could be exploited for cancer management...
