Johannes G Ramaekers

Summary

Publications

  1. doi request reprint Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit
    J G Ramaekers
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 229:219-26. 2013
  2. pmc Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 215:321-32. 2011
  3. pmc Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
    Johannes G Ramaekers
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 214:391-401. 2011
  4. doi request reprint Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1641-8. 2009
  5. doi request reprint Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Clin Psychopharmacol 31:294-301. 2011
  6. ncbi request reprint Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg
    Tim R M Leufkens
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 191:951-9. 2007
  7. ncbi request reprint The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers
    Marleen Wingen
    Faculty of Psychology, Department of Neurocognition Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 190:391-400. 2007
  8. ncbi request reprint High-potency marijuana impairs executive function and inhibitory motor control
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2296-303. 2006
  9. doi request reprint Comparing the stimulant effects of the H1-antagonist fexofenadine with 2 psychostimulants, modafinil and methylphenidate
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Facultyof Psychology and Neuroscience, Maastricht University, The Netherlands
    J Clin Psychopharmacol 29:439-43. 2009
  10. pmc Psychomotor function in chronic daily Cannabis smokers during sustained abstinence
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e53127. 2013

Detail Information

Publications30

  1. doi request reprint Methylphenidate reduces functional connectivity of nucleus accumbens in brain reward circuit
    J G Ramaekers
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 229:219-26. 2013
    ..It is concluded that methylphenidate directly affects the limbic reward circuit. Drug-induced changes in FC of the NAcc may serve as a useful marker of drug activity in in the brain reward circuit...
  2. pmc Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 215:321-32. 2011
    ..Esmirtazapine is evaluated as a novel drug for treatment of insomnia...
  3. pmc Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
    Johannes G Ramaekers
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 214:391-401. 2011
    ..Animal studies suggest that chronic cannabis consumption may also produce cross-tolerance for the impairing effects of alcohol, but supportive data in humans is scarce...
  4. doi request reprint Involvement of inferior parietal lobules in prospective memory impairment during acute MDMA (ecstasy) intoxication: an event-related fMRI study
    Johannes G Ramaekers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 34:1641-8. 2009
    ..It is concluded that the loss of deactivation in inferior parietal lobules may account for increments in memory failures observed during MDMA intoxication...
  5. doi request reprint Short-term effects of morning versus evening dose of hydroxyzine 50 mg on cognition in healthy volunteers
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Clin Psychopharmacol 31:294-301. 2011
    ....
  6. ncbi request reprint Cognitive, psychomotor and actual driving performance in healthy volunteers after immediate and extended release formulations of alprazolam 1 mg
    Tim R M Leufkens
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 191:951-9. 2007
    ..The effect of alprazolam XR on potentially dangerous daily activities, such as driving a car, is expected to be less as compared to alprazolam IR...
  7. ncbi request reprint The role of 5-HT1a and 5-HT2a receptors in attention and motor control: a mechanistic study in healthy volunteers
    Marleen Wingen
    Faculty of Psychology, Department of Neurocognition Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Psychopharmacology (Berl) 190:391-400. 2007
    ..Various studies have demonstrated a modulating role for serotonin in attention. Selective serotonin inhibitors have repeatedly been shown to impair performance in sustained attention tasks...
  8. ncbi request reprint High-potency marijuana impairs executive function and inhibitory motor control
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2296-303. 2006
    ..Use of higher doses of THC in controlled studies may offer a reliable indication of THC induced impairment as compared to lower doses of THC that have traditionally been used in performance studies...
  9. doi request reprint Comparing the stimulant effects of the H1-antagonist fexofenadine with 2 psychostimulants, modafinil and methylphenidate
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Facultyof Psychology and Neuroscience, Maastricht University, The Netherlands
    J Clin Psychopharmacol 29:439-43. 2009
    ..These stimulant effects were rather mild in magnitude and were only demonstrated in tasks with a high workload...
  10. pmc Psychomotor function in chronic daily Cannabis smokers during sustained abstinence
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 8:e53127. 2013
    ..We hypothesized that psychomotor performance would improve during abstinence of chronic, daily cannabis smokers...
  11. doi request reprint Medicinal Δ(9) -tetrahydrocannabinol (dronabinol) impairs on-the-road driving performance of occasional and heavy cannabis users but is not detected in Standard Field Sobriety Tests
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Faculty Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Addiction 107:1837-44. 2012
    ..It was hypothesized that occasional users would be impaired on these tests and that heavy users would show less impairment due to tolerance...
  12. pmc Neurophysiological functioning of occasional and heavy cannabis users during THC intoxication
    Eef L Theunissen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, P O Box 616, 6200MD Maastricht, The Netherlands
    Psychopharmacology (Berl) 220:341-50. 2012
    ..Experienced cannabis users demonstrate tolerance to some of the impairing acute effects of cannabis...
  13. ncbi request reprint Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on behavioral measures of impulsivity: alone and in combination with alcohol
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:1048-55. 2006
    ..The lack of interaction indicated that the CNS stimulant effects of MDMA were never sufficient to overcome alcohol-induced impairment of impulse control or risk-taking behavior...
  14. doi request reprint Sustained attention and serotonin: a pharmaco-fMRI study
    Marleen Wingen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology, Maastricht University, The Netherlands
    Hum Psychopharmacol 23:221-30. 2008
    ..The present study assessed the influence of increased serotonin levels on brain areas involved in sustained attention...
  15. pmc Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Br J Clin Pharmacol 61:79-86. 2006
    ..It is unknown, however, whether acute sedation persists after repeated dosing. Therefore, this study assessed the effects of repeated dosing of these antihistamines on driving and psychomotor performance...
  16. pmc MDMA (ecstasy) effects on actual driving performance before and after sleep deprivation, as function of dose and concentration in blood and oral fluid
    Wendy M Bosker
    Department Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 222:367-76. 2012
    ..In real life, however, MDMA is taken during the night, and driving may likely occur early in the morning after a night of "raving" and sleep loss...
  17. ncbi request reprint A combined neurophysiological and behavioural study into the stimulating effects of fexofenadine on performance
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 20:496-505. 2006
    ....
  18. ncbi request reprint Driving impairment in depressed patients receiving long-term antidepressant treatment
    Marleen Wingen
    Experimental Psychopharmacology Unit, Faculty of Psychology, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
    Psychopharmacology (Berl) 188:84-91. 2006
    ..Depression is a common mental disorder with cognitive deficits, but little information is available on the effects of antidepressant treatment on driving performance in depressed patients...
  19. doi request reprint MDMA intoxication and verbal memory performance: a placebo-controlled pharmaco-MRI study
    Kim P C Kuypers
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 25:1053-61. 2011
    ..It appeared that EWL performance caused BOLD signal change in BA10 during placebo treatment but not during MDMA intoxication. It is concluded that MDMA influences middle frontal gyrus processes resulting in impoverished memory encoding...
  20. doi request reprint The role of P-glycoprotein in CNS antihistamine effects
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 229:9-19. 2013
    ..Studies in rodents have demonstrated that antihistamines that are substrates of the P-gp transporter display no or minor central nervous system (CNS) effects as compared to antihistamines that are not P-gp transporter substrates...
  21. pmc Dose-related effects of MDMA on psychomotor function and mood before, during, and after a night of sleep loss
    Wendy M Bosker
    Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 209:69-76. 2010
    ..3,4-methylenedioxymethamphetamine (MDMA) is known to improve psychomotor function and mood when measured during daytime. However, MDMA users tend to take this drug at dance parties while staying awake for prolonged periods of time...
  22. ncbi request reprint Actual driving performance and psychomotor function in healthy subjects after acute and subchronic treatment with escitalopram, mirtazapine, and placebo: a crossover trial
    Marleen Wingen
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, University of Maastricht, Maastricht, The Netherlands
    J Clin Psychiatry 66:436-43. 2005
    ....
  23. pmc Effects of acute MDMA intoxication on mood and impulsivity: role of the 5-HT2 and 5-HT1 receptors
    Janelle H P van Wel
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    PLoS ONE 7:e40187. 2012
    ..In conclusion, 5-HT(2) receptors mediate positive moods induced by MDMA but not negative moods or impulsivity. 5-HT(1) receptors do not appear to be involved in MDMA effects on mood and impulse control...
  24. doi request reprint Acute and subchronic effects of bilastine (20 and 40 mg) and hydroxyzine (50 mg) on actual driving performance in healthy volunteers
    Silke Conen
    Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, The Netherlands
    J Psychopharmacol 25:1517-23. 2011
    ..Bilastine did not produce any driving impairment after single and repeated doses and can be safely used in traffic in doses up to 40 mg...
  25. ncbi request reprint Antidepressants and driver impairment: empirical evidence from a standard on-the-road test
    Johannes G Ramaekers
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Maastricht University, Maastricht, The Netherlands
    J Clin Psychiatry 64:20-9. 2003
    ..That test measures driving impairment from vehicular "weaving" (i.e., standard deviation of lateral position [SDLP]) during 1 hour of on-the-road driving in normal traffic...
  26. ncbi request reprint Effects of emedastine and cetirizine, alone and with alcohol, on actual driving of males and females
    Annemiek Vermeeren
    Experimental Psychopharmacology Unit, Brain and Behaviour Institute, Faculty of Psychology, Maastricht University, The Netherlands
    J Psychopharmacol 16:57-64. 2002
    ..Emedastine, in oral doses of 2 mg and 4 mg twice daily, is sedating and impairs driving. The drug could therefore constitute a traffic hazard and its users should be warned accordingly...
  27. ncbi request reprint Acute dose of MDMA (75 mg) impairs spatial memory for location but leaves contextual processing of visuospatial information unaffected
    Kim P C Kuypers
    Experimental Psychopharmacology Unit, Department of Neurocognition, Faculty of Psychology, Maastricht University, Maastricht, The Netherlands
    Psychopharmacology (Berl) 189:557-63. 2007
    ..Two factors may have confounded results in abstinent users: memory task characteristics and polydrug use...
  28. ncbi request reprint An experimental study of catechol-o-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition
    Cecile Henquet
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Neuropsychopharmacology 31:2748-57. 2006
    ..The association between cannabis and psychosis may represent higher order gene-environment and gene-gene interactions...
  29. ncbi request reprint Stimulating effects of H1-antagonists
    Eef L Theunissen
    Experimental Psychopharmacology Unit, Brain and Behavior Institute, Faculty of Psychology, Maastricht University, The Netherlands
    Curr Pharm Des 12:2501-9. 2006
    ..In addition, it would be useful to determine whether terfenadine, ebastine, fexofenadine and desloratadine can return allergic patient's performance back to their preclinical level...
  30. ncbi request reprint Modulation of the critical flicker fusion effects of serotonin reuptake inhibitors by concomitant pupillary changes
    Jeroen A J Schmitt
    Department of Psychiatry and Neuropsychology, Universiteit Maastricht, Maastricht, The Netherlands
    Psychopharmacology (Berl) 160:381-6. 2002
    ..However, such an interpretation may be questioned since CFF elevations may also be due to SSRI-induced increases in pupil diameter...