Sherman L, Romagano M, Williams S, Rameshwar P. Mesenchymal stem cell therapies in brain disease. Semin Cell Dev Biol. 2019;: pubmed publisher
..This review discusses the use of mesenchymal stem cells in hypoxic disease (hypoxic ischemic encephalopathy), an inflammatory neurodegenerative disease (multiple sclerosis), and a malignant condition (glioma). ..
Walker N, Elias M, Guiro K, Bhatia R, Greco S, Bryan M, et al
. Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma. Cell Death Dis. 2019;10:59 pubmed publisher
..In summary, we have shown how BM stromal MΦs, through exosomes, regulate the behavior of BCCs, by either inducing or reversing dormancy. ..
Conaty P, Sherman L, Naaldijk Y, Ulrich H, Stolzing A, Rameshwar P. Methods of Mesenchymal Stem Cell Homing to the Blood-Brain Barrier. Methods Mol Biol. 2018;1842:81-91 pubmed publisher
..Here describe how MSCs can be propagated from bone marrow aspirates and their utility in delivering small RNA to the brain. The chapter discusses the issue to enhance efficient delivery of MSCs to the brain. ..
Moore C, Shah N, Smith C, Rameshwar P. 3D Bioprinting and Stem Cells. Methods Mol Biol. 2018;1842:93-103 pubmed publisher
..Since bioprinting is a highly customizable technique, parameters described in this method (i.e., cell-cell ratio, scaffold dimensions) can easily be altered to serve other applications, including studies on hematopoietic regulation. ..
Sherman L, Condé Green A, Kotamarti V, Lee E, Rameshwar P. Enzyme-Free Isolation of Adipose-Derived Mesenchymal Stem Cells. Methods Mol Biol. 2018;1842:203-206 pubmed publisher
..This chapter focuses on methods of isolating ADSCs from adipose tissue without enzymatic digestion. ..
Rameshwar P, Moore C, Shah N, Smith C. An Update on the Therapeutic Potential of Stem Cells. Methods Mol Biol. 2018;1842:3-27 pubmed publisher
..The method described in this chapter could be extrapolated to the field of chimeric antigen receptor T-cells (CAR-T). This will require application to stem cell hierarchy of memory T-cells. ..
Eltoukhy H, Sinha G, Moore C, Gergues M, Rameshwar P. Secretome within the bone marrow microenvironment: A basis for mesenchymal stem cell treatment and role in cancer dormancy. Biochimie. 2018;155:92-103 pubmed publisher
..This article discusses the importance for parallel studies to determine how the same secretome may compromise safety during the use of stem cells in regenerative medicine. ..
Sandiford O, Moore C, Du J, Boulad M, Gergues M, Eltouky H, et al
. Human Aging and Cancer: Role of miRNA in Tumor Microenvironment. Adv Exp Med Biol. 2018;1056:137-152 pubmed publisher
..MicroRNAs (miRNAs), which are small non-coding RNA, can regulate cancer progression, recurrence and metastasis. This chapter discusses the role of miRNA in tumor microenvironment, consequent to aging. ..
Munoz J, Walker N, Scotto K, Rameshwar P. Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells. Cancer Lett. 2015;367:69-75 pubmed publisher
..This study provides insights on the effectiveness by which TMZ competes with other P-gp substrates, thereby opening the door for combined targeted therapies. ..