Pranela Rameshwar



  1. Sherman L, Romagano M, Williams S, Rameshwar P. Mesenchymal stem cell therapies in brain disease. Semin Cell Dev Biol. 2019;: pubmed publisher
    ..This review discusses the use of mesenchymal stem cells in hypoxic disease (hypoxic ischemic encephalopathy), an inflammatory neurodegenerative disease (multiple sclerosis), and a malignant condition (glioma). ..
  2. Walker N, Elias M, Guiro K, Bhatia R, Greco S, Bryan M, et al. Exosomes from differentially activated macrophages influence dormancy or resurgence of breast cancer cells within bone marrow stroma. Cell Death Dis. 2019;10:59 pubmed publisher
    ..In summary, we have shown how BM stromal MΦs, through exosomes, regulate the behavior of BCCs, by either inducing or reversing dormancy. ..
  3. Conaty P, Sherman L, Naaldijk Y, Ulrich H, Stolzing A, Rameshwar P. Methods of Mesenchymal Stem Cell Homing to the Blood-Brain Barrier. Methods Mol Biol. 2018;1842:81-91 pubmed publisher
    ..Here describe how MSCs can be propagated from bone marrow aspirates and their utility in delivering small RNA to the brain. The chapter discusses the issue to enhance efficient delivery of MSCs to the brain. ..
  4. Moore C, Shah N, Smith C, Rameshwar P. 3D Bioprinting and Stem Cells. Methods Mol Biol. 2018;1842:93-103 pubmed publisher
    ..Since bioprinting is a highly customizable technique, parameters described in this method (i.e., cell-cell ratio, scaffold dimensions) can easily be altered to serve other applications, including studies on hematopoietic regulation. ..
  5. Sherman L, Condé Green A, Kotamarti V, Lee E, Rameshwar P. Enzyme-Free Isolation of Adipose-Derived Mesenchymal Stem Cells. Methods Mol Biol. 2018;1842:203-206 pubmed publisher
    ..This chapter focuses on methods of isolating ADSCs from adipose tissue without enzymatic digestion. ..
  6. Rameshwar P, Moore C, Shah N, Smith C. An Update on the Therapeutic Potential of Stem Cells. Methods Mol Biol. 2018;1842:3-27 pubmed publisher
    ..The method described in this chapter could be extrapolated to the field of chimeric antigen receptor T-cells (CAR-T). This will require application to stem cell hierarchy of memory T-cells. ..
  7. Eltoukhy H, Sinha G, Moore C, Gergues M, Rameshwar P. Secretome within the bone marrow microenvironment: A basis for mesenchymal stem cell treatment and role in cancer dormancy. Biochimie. 2018;155:92-103 pubmed publisher
    ..This article discusses the importance for parallel studies to determine how the same secretome may compromise safety during the use of stem cells in regenerative medicine. ..
  8. Sandiford O, Moore C, Du J, Boulad M, Gergues M, Eltouky H, et al. Human Aging and Cancer: Role of miRNA in Tumor Microenvironment. Adv Exp Med Biol. 2018;1056:137-152 pubmed publisher
    ..MicroRNAs (miRNAs), which are small non-coding RNA, can regulate cancer progression, recurrence and metastasis. This chapter discusses the role of miRNA in tumor microenvironment, consequent to aging. ..
  9. Munoz J, Walker N, Scotto K, Rameshwar P. Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells. Cancer Lett. 2015;367:69-75 pubmed publisher
    ..This study provides insights on the effectiveness by which TMZ competes with other P-gp substrates, thereby opening the door for combined targeted therapies. ..

More Information


  1. Munoz J, Rodriguez Cruz V, Greco S, Nagula V, Scotto K, Rameshwar P. Temozolomide induces the production of epidermal growth factor to regulate MDR1 expression in glioblastoma cells. Mol Cancer Ther. 2014;13:2399-411 pubmed publisher
    ..Pharmacologic inhibition of EGFR kinase blunted the ability of GBM cells to resist temozolomide. These findings may explain reports on the common occurrence of mutant EGFR (EGFRvIII) and EGFR expansion in the resistance of GBM cells. ..
  2. Bliss S, Paul S, Pobiarzyn P, Ayer S, Sinha G, Pant S, et al. Evaluation of a developmental hierarchy for breast cancer cells to assess risk-based patient selection for targeted treatment. Sci Rep. 2018;8:367 pubmed publisher
    ..Analyses of 20 post-treatment blood indicated that circulating CSCs and early BC progenitors may be associated with recurrence or early death. These results suggest that the novel hierarchy may predict treatment response and prognosis. ..
  3. request reprint
    Bliss S, Sinha G, Sandiford O, Williams L, Engelberth D, Guiro K, et al. Mesenchymal Stem Cell-Derived Exosomes Stimulate Cycling Quiescence and Early Breast Cancer Dormancy in Bone Marrow. Cancer Res. 2016;76:5832-5844 pubmed
    ..Cancer Res; 76(19); 5832-44. ©2016 AACR. ..
  4. Patel J, Hu M, Sinha G, Walker N, Sherman L, Gallagher A, et al. Non-coding RNA as mediators in microenvironment-breast cancer cell communication. Cancer Lett. 2016;380:289-95 pubmed publisher
    ..We also include the advances and possible confounds of using these methods. Overall, this review article provides a potential method by which MSCs can be used for effective delivery of nucleic acid to treat cancer. ..
  5. Walker N, Patel J, Munoz J, Hu M, Guiro K, Sinha G, et al. The bone marrow niche in support of breast cancer dormancy. Cancer Lett. 2016;380:263-71 pubmed publisher
    ..The challenges of studying BC dormancy in 2-dimensional (2-D) system are also incorporated by proposing 3-D system by engineering methods to recapitulate the BM microenvironment. ..
  6. Fernandez Moure J, Corradetti B, Chan P, Van Eps J, Janecek T, Rameshwar P, et al. Enhanced osteogenic potential of mesenchymal stem cells from cortical bone: a comparative analysis. Stem Cell Res Ther. 2015;6:203 pubmed publisher
  7. Walker N, Mourad Y, Liu K, Buxhoeveden M, Schoenberg C, Eloy J, et al. Steroid-Mediated Decrease in Blood Mesenchymal Stem Cells in Liver Transplant could Impact Long-Term Recovery. Stem Cell Rev. 2017;13:644-658 pubmed publisher
    ..In total, the study indicated that GC usage in transplant needs to be examined to determine if this could be reduced or avoided with adjuvant cell therapy. ..
  8. Eltoukhy H, Sinha G, Moore C, Sandiford O, Rameshwar P. Immune modulation by a cellular network of mesenchymal stem cells and breast cancer cell subsets: Implication for cancer therapy. Cell Immunol. 2018;326:33-41 pubmed publisher
    ..We discuss the immunomodulatory mechanisms of MSC-CSC interaction in the context of therapeutic outcomes in oncology. We also discuss immunotherapy as a potential to circumventing this immune modulation. ..
  9. Greco S, Yehia G, Potian J, Molina C, Rameshwar P. Constitutive Expression of Inducible Cyclic Adenosine Monophosphate Early Repressor (ICER) in Cycling Quiescent Hematopoietic Cells: Implications for Aging Hematopoietic Stem Cells. Stem Cell Rev. 2017;13:116-126 pubmed publisher
    ..These findings are relevant to gene therapy that require engineering of HSCs, age-related disorders that are associated with hematopoietic dysfunction and other hematological disorders. ..
  10. Nahas G, Murthy R, Patel S, Ganta T, Greco S, Rameshwar P. The RNA-binding protein Musashi 1 stabilizes the oncotachykinin 1 mRNA in breast cancer cells to promote cell growth. FASEB J. 2016;30:149-59 pubmed publisher
    ..In summary, the RNA-binding protein Msi1 competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation. Consequently, these interactions increase tumor growth. ..
  11. Sherman L, Shaker M, Mariotti V, Rameshwar P. Mesenchymal stromal/stem cells in drug therapy: New perspective. Cytotherapy. 2017;19:19-27 pubmed publisher
    ..The review stresses the use of MSC as vehicles for drug delivery and discusses the accompanying challenges, based on the influence of the microenvironment on MSC. ..