Senaka Rajapakse

Summary

Publications

  1. pmc Treatment of dengue fever
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    Infect Drug Resist 5:103-12. 2012
  2. ncbi request reprint Incidences and clinical outcomes of acute kidney injury in ICU: a prospective observational study in Sri Lanka
    Eranga S Wijewickrama
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    BMC Res Notes 7:305. 2014
  3. pmc Dengue shock
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    J Emerg Trauma Shock 4:120-7. 2011
  4. pmc Developing a clinically relevant classification to predict mortality in severe leptospirosis
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    J Emerg Trauma Shock 3:213-9. 2010
  5. doi request reprint Awareness of breast cancer among adolescent girls in Colombo, Sri Lanka: a school based study
    Hasanthika M Ranasinghe
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka
    BMC Public Health 13:1209. 2013
  6. doi request reprint Isolated hypomagnesemia in a patient treated with capecitabine
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    J Oncol Pharm Pract 19:254-6. 2013
  7. doi request reprint Antibiotics for human toxoplasmosis: a systematic review of randomized trials
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    Pathog Glob Health 107:162-9. 2013
  8. doi request reprint Scrub typhus: pathophysiology, clinical manifestations and prognosis
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, 25 Kynsey Road, Colombo 8, Sri Lanka
    Asian Pac J Trop Med 5:261-4. 2012
  9. pmc A retrospective analysis of cannabis use in a cohort of mentally ill patients in Sri Lanka and its implications on policy development
    Chaturaka Rodrigo
    Psychiatry Unit, Provincial General Hospital, Ratnapura, Sri Lanka
    Subst Abuse Treat Prev Policy 5:16. 2010
  10. pmc The 'hidden' burden of malaria: cognitive impairment following infection
    Sumadhya D Fernando
    Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 8, Sri Lanka
    Malar J 9:366. 2010

Collaborators

Detail Information

Publications48

  1. pmc Treatment of dengue fever
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    Infect Drug Resist 5:103-12. 2012
    ..This review provides an overview on the epidemiology, natural history, management strategies, and future directions for research on dengue, including the potential for development of a vaccine...
  2. ncbi request reprint Incidences and clinical outcomes of acute kidney injury in ICU: a prospective observational study in Sri Lanka
    Eranga S Wijewickrama
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    BMC Res Notes 7:305. 2014
    ..The aim of this study was to describe the incidence, severity and outcome of AKI among patients admitted to the medical ICU, National Hospital, Colombo, Sri Lanka (NHSL)...
  3. pmc Dengue shock
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    J Emerg Trauma Shock 4:120-7. 2011
    ..Careful fluid management and supportive therapy is the mainstay of management. Corticosteroids and intravenous immunoglobulins are of no proven benefit. No specific therapy has been shown to be effective in improving survival...
  4. pmc Developing a clinically relevant classification to predict mortality in severe leptospirosis
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    J Emerg Trauma Shock 3:213-9. 2010
    ....
  5. doi request reprint Awareness of breast cancer among adolescent girls in Colombo, Sri Lanka: a school based study
    Hasanthika M Ranasinghe
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka
    BMC Public Health 13:1209. 2013
    ....
  6. doi request reprint Isolated hypomagnesemia in a patient treated with capecitabine
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    J Oncol Pharm Pract 19:254-6. 2013
    ..The approach to diagnosis and treatment is discussed. We postulate that capecitabine may cause isolated hypomagnesemia, possibly due to renal magnesium loss. ..
  7. doi request reprint Antibiotics for human toxoplasmosis: a systematic review of randomized trials
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    Pathog Glob Health 107:162-9. 2013
    ..Treatment with either oral or intravitreal antibiotics seems reasonable for ocular toxoplasmosis. Overall, trial evidence for the efficacy of these drugs for toxoplasmosis is poor, and further well-designed trials are needed. ..
  8. doi request reprint Scrub typhus: pathophysiology, clinical manifestations and prognosis
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, 25 Kynsey Road, Colombo 8, Sri Lanka
    Asian Pac J Trop Med 5:261-4. 2012
    ..Prognostic indicators for severe disease have not yet been clearly established...
  9. pmc A retrospective analysis of cannabis use in a cohort of mentally ill patients in Sri Lanka and its implications on policy development
    Chaturaka Rodrigo
    Psychiatry Unit, Provincial General Hospital, Ratnapura, Sri Lanka
    Subst Abuse Treat Prev Policy 5:16. 2010
    ..Several epidemiological studies have shown that cannabis; the most widely used illegal drug in the world, is associated with schizophrenia spectrum disorders (SSD)...
  10. pmc The 'hidden' burden of malaria: cognitive impairment following infection
    Sumadhya D Fernando
    Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 8, Sri Lanka
    Malar J 9:366. 2010
    ....
  11. pmc Symptoms of anxiety and depression in adolescent students; a perspective from Sri Lanka
    Chaturaka Rodrigo
    Psychiatry Unit, Provincial General Hospital, Ratnapura, Sri Lanka
    Child Adolesc Psychiatry Ment Health 4:10. 2010
    ..Policy decisions are made to reduce competition for higher education3. A nationally coordinated survey on mental health of adolescent students is carried out utilizing the island-wide network of medical officers of mental health...
  12. pmc A kidney transplant patient on cyclosporine therapy presenting with dural venous sinus thrombosis: a case report
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 08, Sri Lanka
    Cases J 2:9139. 2009
    ..Therapy with cyclosporine has been reported to result in thrombotic events. We report an unusual case of superior sagittal and transverse sinus thrombosis associated with cyclosporine therapy in a kidney transplant patient...
  13. pmc The 'antisocial' person: an insight in to biology, classification and current evidence on treatment
    Chaturaka Rodrigo
    Mental Health Unit, Provincial General Hospital, Ratnapura, Sri Lanka
    Ann Gen Psychiatry 9:31. 2010
    ....
  14. doi request reprint Venlafaxine-associated serotonin syndrome causing severe rhabdomyolysis and acute renal failure in a patient with idiopathic Parkinson disease
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    J Clin Psychopharmacol 30:620-2. 2010
    ..The differential diagnosis, atypical features in this presentation, and possible mechanisms are discussed...
  15. doi request reprint Intravenous immunoglobulins in the treatment of dengue illness
    Senaka Rajapakse
    Faculty of Medicine, University of Colombo, Colombo 8, Sri Lanka
    Trans R Soc Trop Med Hyg 103:867-70. 2009
    ..However, evidence is very limited, and there is clearly a place for well-designed randomized controlled trials investigating the beneficial effects of IVIG in the various life-threatening manifestations of dengue...
  16. doi request reprint Management of yellow oleander poisoning
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo 8, Sri Lanka
    Clin Toxicol (Phila) 47:206-12. 2009
    ..High cost and lack of availability limit the widespread use of digoxin-specific antibody fragments in developing countries...
  17. doi request reprint Age bias in clinical trials in sepsis: how relevant are guidelines to older people?
    Senaka Rajapakse
    Faculty of Medicine, University of Colombo, Colombo 00800, Sri Lanka
    J Crit Care 24:609-13. 2009
    ..In view of the pharmacokinetic and pharmacodynamic differences in older people, and the higher incidence of comorbidity in the elderly, there is a need for clinical trials in severe sepsis to specifically include older patients...
  18. ncbi request reprint Renal replacement therapy in sepsis-induced acute renal failure
    Senaka Rajapakse
    Faculty of Medicine, University of Colombo, Sri Lanka
    Saudi J Kidney Dis Transpl 20:553-9. 2009
    ..Higher doses of RRT are more likely to be beneficial. Use of bio-compatible membranes and bicarbonate buffer in the dialysate are preferred. Anticoagulation during dialysis must be carefully adjusted and monitored...
  19. doi request reprint Atypical manifestations of chikungunya infection
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka
    Trans R Soc Trop Med Hyg 104:89-96. 2010
    ..In this context, considering CHIKV infection a benign and non fatal illness has to be revisited...
  20. doi request reprint Corticosteroids in the treatment of dengue illness
    Senaka Rajapakse
    Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 8, Sri Lanka
    Trans R Soc Trop Med Hyg 103:122-6. 2009
    ..The possible beneficial effects of corticosteroids on the various manifestations of dengue infection need evaluation by adequately powered, well designed, randomised controlled trials...
  21. ncbi request reprint Non-dialytic management of sepsis-induced acute kidney injury
    Senaka Rajapakse
    Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Saudi J Kidney Dis Transpl 20:975-83. 2009
    ..Among the remaining pharmacological options, N-acetylcysteine (NAC) may have a role in the prevention of radiocontrast induced AKI...
  22. ncbi request reprint Management of acute coronary syndrome in a tertiary care general medical unit in Sri Lanka: how closely do we follow the guidelines?
    S Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    J Clin Pharm Ther 35:421-7. 2010
    ..Correct implementation of evidence-based guidelines should improve outcome. We conducted this study to determine to what extent management of ACS in a tertiary care medical ward in Sri Lanka adhered to current guidelines...
  23. doi request reprint Drug treatment of scrub typhus
    Senaka Rajapakse
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka
    Trop Doct 41:1-4. 2011
    ..Most clinical evidence on drug treatment is from cases of mild-to-moderate scrub typhus. Further study is needed on the efficacy of different antibiotics in the treatment of severe, life-threatening scrub typhus...
  24. pmc Work related complaints of neck, shoulder and arm among computer office workers: a cross-sectional evaluation of prevalence and risk factors in a developing country
    Priyanga Ranasinghe
    Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Environ Health 10:70. 2011
    ..Complaints of arms, neck and shoulders (CANS) is common among computer office workers. We evaluated an aetiological model with physical/psychosocial risk-factors...
  25. doi request reprint Electrocardiographic and echocardiographic manifestations of cardiac involvement in leptospirosis
    Tharanga Fernando
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25 Kynsey Road, Colombo 08, Sri Lanka
    Trans R Soc Trop Med Hyg 107:457-9. 2013
    ..Cardiac involvement is known to occur in leptospirosis, however, data on the significance of electrocardiographic and echocardiographic findings is very limited...
  26. pmc Low serum total nitrite and nitrate levels in severe leptospirosis
    Thilini Kalugalage
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka
    BMC Infect Dis 13:206. 2013
    ..We assessed the correlation of NOx with disease severity in patients with leptospirosis, compared with healthy controls and non-leptospirosis fever patients...
  27. doi request reprint Kidney disease in the elderly: a Sri Lankan perspective
    Chaturaka Rodrigo
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Saudi J Kidney Dis Transpl 24:1285-90. 2013
    ..Based on our findings, we have made several pertinent recommendations regarding the care of the elderly with renal disease in Sri Lanka that may be relevant to other developing nations as well. ..
  28. ncbi request reprint A two-year retrospective analysis of renal transplant patients in Sri Lanka
    Chaturaka Rodrigo
    Department of Clinical Medicine, Faculty of Medicine, Colombo 08, Colombo, Sri Lanka
    Saudi J Kidney Dis Transpl 22:174-8. 2011
    ..5%) being reported over the study period. Of late complications, most were due to immunosuppression. Overall, the 2-year survival was 75%. There was no significant difference between the centers of transplant...
  29. pmc Primaquine in vivax malaria: an update and review on management issues
    Deepika Fernando
    Department of Parasitology, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo 8, Sri Lanka
    Malar J 10:351. 2011
    ....
  30. ncbi request reprint Patient satisfaction and uptake of private-sector run malaria diagnosis clinics in a post-conflict district in Sri Lanka
    Deepika Fernando
    Department of Parasitology, Faculty of Medicine, University of Colombo, Kynsey Road, Colombo, Sri Lanka
    BMC Public Health 14:641. 2014
    ....
  31. doi request reprint Lower estimated glomerular filtration rates in patients on long term lithium: a comparative study and a meta-analysis of literature
    Chaturaka Rodrigo
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    BMC Psychiatry 14:4. 2014
    ..This study compared mean estimated glomerular filtration rates (eGFR) in patients on long term lithium, against matched controls...
  32. doi request reprint Serum nitrite levels in Sri Lankan patients with leptospirosis
    Rohini I Gunaratna
    Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Sri Lanka
    Asian Pac J Trop Med 5:75-8. 2012
    ..To determine whether blood nitrite levels are elevated in patients with leptospirosis...
  33. doi request reprint Cardiac involvement in leptospirosis
    Mitrakrishnan Rayno Navinan
    National Hospital of Sri Lanka, Regent Street, Colombo 8, Sri Lanka
    Trans R Soc Trop Med Hyg 106:515-20. 2012
    ....
  34. ncbi request reprint Preliminary audit on early identification and management of chronic kidney disease in adults in an acute general medical unit in Sri Lanka
    Suneth De Silva
    Department of Clinical Medicine, University of Colombo, Sri Lanka
    Saudi J Kidney Dis Transpl 22:1285-8. 2011
    ..Although follow-up was indicated in all these patients, it was arranged only in 17%. The concurrence with NICE guidelines on CKD prevention was found to be poor. Strategies for improvement are discussed...
  35. doi request reprint Chemoprophylaxis in malaria: drugs, evidence of efficacy and costs
    Sumadhya Deepika Fernando
    Department of Parasitology, Faculty of Medicine, Colombo, Sri Lanka
    Asian Pac J Trop Med 4:330-6. 2011
    ..Impact of prophylaxis in pregnancy and the cost considerations are discussed under two separate sub topics...
  36. ncbi request reprint Cerebral infarction 3 weeks after intravenous immunoglobulin for Miller Fisher syndrome: a case report
    Thashi Chang
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, 25, Kynsey Road, Colombo, Sri Lanka
    J Med Case Rep 8:100. 2014
    ..This is the first report of cerebral infarction occurring after a longer latency of 3 weeks following intravenous immunoglobulin therapy in a patient presenting with Miller Fisher syndrome...
  37. ncbi request reprint Low uptake of Pap smear testing among medical clinic attendees in a tertiary care hospital in Sri Lanka
    Mitrakrishnan C Shivanthan
    University Medical Unit, National Hospital of Sri Lanka, Regent Street, Colombo 08, Sri Lanka
    Int Health 6:138-43. 2014
    ..The test is offered free of charge through well-woman clinics in Sri Lanka, but previous studies have shown poor awareness and uptake...
  38. doi request reprint Dengue fever presenting with acute cerebellitis: a case report
    Milinda Withana
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    BMC Res Notes 7:125. 2014
    ..With the increasing numbers, rare manifestations of dengue are occasionally encountered. We report a patient who presented with bilateral cerebellar signs as the presenting feature of dengue...
  39. doi request reprint HIV, poverty and women
    Chaturaka Rodrigo
    University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka
    Int Health 2:9-16. 2010
    ..The specific impact of poverty on females in families living with HIV is less explored. Though microfinance initiatives to empower women are a good idea in theory, the actual outcome of such a programme is less convincing. ..
  40. pmc Addressing the relationship between cardiac hypertrophy and ischaemic stroke: an observational study
    Chaturaka Rodrigo
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Int Arch Med 5:32. 2012
    ..abstract:..
  41. pmc Caregiver strain and symptoms of depression among principal caregivers of patients with schizophrenia and bipolar affective disorder in Sri Lanka
    Chaturaka Rodrigo
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka
    Int J Ment Health Syst 7:2. 2013
    ..abstract:..
  42. pmc Work-related complaints of arm, neck and shoulder among computer office workers in an Asian country: prevalence and validation of a risk-factor questionnaire
    Priyanga Ranasinghe
    Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka
    BMC Musculoskelet Disord 12:68. 2011
    ..We evaluated the 1-year prevalence of CANS among computer office workers in Sri Lanka and tested the psychometric properties of a translated risk factor questionnaire...
  43. pmc Hypokalemic paralysis associated with cystic disease of the kidney: case report
    Champika S S S K Gamakaranage
    University Medical Unit, National Hospital, Colombo 08, Sri Lanka
    BMC Nephrol 12:16. 2011
    ..Severe hypokalemia is known to cause muscle paralysis, and renal tubular acidosis is a recognized cause. Cystic disease of the kidney is associated with severe hypokalemia...
  44. pmc Hypothyroidism causing paralytic ileus and acute kidney injury - case report
    Chaturaka Rodrigo
    University Medical Unit, National Hospital of Sri Lanka, Colombo, Sri Lanka
    Thyroid Res 4:7. 2011
    ..It is important that clinicians are aware of these rare manifestations of hypothyroidism as in most occasions, thyroxine deficiency may be missed, and treatment can reverse the complications...
  45. pmc Improving diagnosis of trichomonas vaginalis infection in resource limited health care settings in sri lanka
    Sumadhya D Fernando
    Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka
    J Glob Infect Dis 3:324-8. 2011
    ..This study was designed to compare diagnosis of trichomoniasis by culture, wet smear examination, and Giemsa stain. A modified technique was used to transport and prepare the specimen to ensure parasite viability prior to Giemsa staining...
  46. pmc Current evidence on the use of antifilarial agents in the management of bancroftian filariasis
    Sumadhya Deepika Fernando
    Department of Parasitology, Faculty of Medicine, University of Colombo, Colombo 08, Sri Lanka
    J Trop Med 2011:175941. 2011
    ..Followup studies on mass drug administration (MDA) are yet to show a complete interruption of transmission, though the infection rates are reduced to a very low level...