Mapping directionality specific volume changes using tensor based morphometry: an application to the study of gyrogenesis and lateralization of the human fetal brainVidya Rajagopalan
Biomedical Image Computing Group, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
Neuroimage 63:947-58. 2012
..The most significant changes in the directionality of growth occur in the cortical plate at major sulci. Our analysis also detected directional growth asymmetry in the peri-Sylvian region and the medial frontal lobe of the fetal brain...
Spatiotemporal morphometry of adjacent tissue layers with application to the study of sulcal formationVidya Rajagopalan
Biomedical Image Computing Group, University of Washington, Seattle, USA
Med Image Comput Comput Assist Interv 14:476-83. 2011
..Results show that the method detects differential growth of tissue layers adjacent to the cortical surface, particularly at sulcal locations, as early as 22 gestational weeks...
Early folding patterns and asymmetries of the normal human brain detected from in utero MRIPiotr A Habas
Biomedical Image Computing Group, University of California San Francisco, San Francisco, CA 94143, USA
Cereb Cortex 22:13-25. 2012
..The study provides the missing starting point for their developmental trajectories and extends our understanding of normal cortical folding...
- Local tissue growth patterns underlying normal fetal human brain gyrification quantified in utero
Vidya Rajagopalan
Biomedical Image Computing Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94143 0628, USA
J Neurosci 31:2878-87. 2011
..These maps of fetal brain growth patterns construct a spatially specific baseline of developmental biomarkers with which to correlate abnormal development in the human...
- 3D morphometric analysis of human fetal cerebellar development
Julia A Scott
Biomedical Image Computing Group, Departments of Pediatrics, Bioengineering, and Radiology, University of Washington, Seattle, WA 98195, USA
Cerebellum 11:761-70. 2012
..In this 3D morphometric analysis of the human fetal cerebellum, we have shown that cerebellar growth is accelerating at a greater pace than the cerebrum and described how cerebellar growth impacts the shape of the structure...
- Measures for characterizing directionality specific volume changes in TBM of brain growth
Vidya Rajagopalan
Biomedical Image Computing Group, University of California San Francisco, San Francisco, CA 94143, USA
Med Image Comput Comput Assist Interv 13:339-46. 2010
..We illustrate the use of these methods by studying brain developmental patterns in fetuses. Results show that this approach detects early changes local growth that are related to the early stages of sulcal and gyral formation...
- Growth trajectories of the human fetal brain tissues estimated from 3D reconstructed in utero MRI
Julia A Scott
Biomedical Image Computing Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
Int J Dev Neurosci 29:529-36. 2011
..Further application of the automated fetal brain segmentation to later gestational ages will bridge the gap between volumetric studies of premature brain development and normal brain development in utero...
