Lakshman E Rajagopalan

Summary

Publications

  1. doi request reprint Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity
    Lakshman E Rajagopalan
    Department of Discovery Biology, Inflammation Research Unit, Pfizer Global Research and Development, Pfizer Inc, Chesterfield, Missouri 63017, USA
    J Pharmacol Exp Ther 333:707-16. 2010
  2. doi request reprint Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Pfizer Inc, St Louis, MO, USA
    FEBS Lett 584:2827-32. 2010
  3. doi request reprint TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Pfizer Inc, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    J Hepatol 54:521-8. 2011
  4. pmc Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA
    J Biol Chem 285:12536-42. 2010

Detail Information

Publications4

  1. doi request reprint Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity
    Lakshman E Rajagopalan
    Department of Discovery Biology, Inflammation Research Unit, Pfizer Global Research and Development, Pfizer Inc, Chesterfield, Missouri 63017, USA
    J Pharmacol Exp Ther 333:707-16. 2010
    ..Inhibition of this pathway therefore could be strongly anti-inflammatory and provide therapeutic benefit in chronic inflammatory diseases...
  2. doi request reprint Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Pfizer Inc, St Louis, MO, USA
    FEBS Lett 584:2827-32. 2010
    ..IL-8 production was largely driven by ROCK through p38 and JNK activation, but with no involvement of NF-kappaB...
  3. doi request reprint TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Pfizer Inc, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    J Hepatol 54:521-8. 2011
    ..We then applied a pharmacologic as well as a genomics approach in a TGF-β1 activated human HSC line (LX-2) to study the involvement of Rho kinase signaling in the expression of a subset of these up-regulated fibrotic genes...
  4. pmc Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65
    Hideaki Shimada
    Inflammation Research Unit, Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA
    J Biol Chem 285:12536-42. 2010
    ..This study also provides the first evidence of the critical involvement of ROCK2 in LPA-induced CAM expression through activation of the NF-kappaB pathway in human endothelial cells...